Bone Markers

Author : Victor R. Preedy,Vinood B. Patel
Publisher : Springer
Page : 0 pages
File Size : 49,8 Mb
Release : 2017-07-14
Category : Medical
ISBN : 9400776926

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Biomarkers in Bone Disease by Victor R. Preedy,Vinood B. Patel Pdf

In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.

Author : R. Coleman,R. D. Rubens
Publisher : Parthenon Publishing
Page : 83 pages
File Size : 55,6 Mb
Release : 1992-06
Category : Bone and bones
ISBN : 1850704414

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Metastatic Bone Disease by R. Coleman,R. D. Rubens Pdf

Author : Markus J. Seibel,Simon P. Robins,John P. Bilezikian
Publisher : Elsevier
Page : 920 pages
File Size : 40,9 Mb
Release : 2006-07-24
Category : Medical
ISBN : 008045626X

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Dynamics of Bone and Cartilage Metabolism by Markus J. Seibel,Simon P. Robins,John P. Bilezikian Pdf

This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, Dynamics of Bone and Cartilage Metabolism, Second Edition, is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases. Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components Part II covers the organizational structure and cellular metabolism of bone and cartilage Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease

Author : Matthias Baumann,Richard Eastell,Nicholas Hoyle,Lothar Wieczorek
Publisher : CRC Press
Page : 240 pages
File Size : 49,9 Mb
Release : 2001-03-01
Category : Medical
ISBN : 1841840238

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Bone Markers by Matthias Baumann,Richard Eastell,Nicholas Hoyle,Lothar Wieczorek Pdf

This monograph brings together the proceedings of a workshop held in Geneva, Switzerland in March 2000 under the joint sponsorship of the University of Sheffield and F Hoffmann La Roche Ltd. Chapters by leading scientists present the latest research on biochemical markers of bone remodelling as well as their clinical applications in the management of osteoporosis. The text focuses on four major areas of interest: 1) potential candidates for markers of bone remodelling, 2) sources of biological bone marker variability, 3) use of biochemical markers in monitoring treatment of osteoporosis, and 4) use of biochemical markers in the prediction of bone loss and fractures. The book also includes transcripts of the lively panel discussions from the Geneva workshop.

Author : Richard Eastell,Matthias Baumann,Nicholas R. Hoyle
Publisher : CRC PressI Llc
Page : 252 pages
File Size : 53,5 Mb
Release : 2001-01-01
Category : Medical
ISBN : 184184067X

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Bone Markers by Richard Eastell,Matthias Baumann,Nicholas R. Hoyle Pdf

Author : Bozzano G Luisa
Publisher : Academic Press
Page : 362 pages
File Size : 45,5 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780080984353

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Clinical Impact of Bone and Connective Tissue Markers by Bozzano G Luisa Pdf

For many years, biochemical tests have been widely used for the diagnosis, classification, and monitoring of bone and connective tissue disease. However, shortcomings in terms of the specificity and sensitivity of such tests have prompted continual questioning about their clinical usefulness.This book, based on a meeting organized jointly by the University of Uppsala and Pharmacia Diagnostics AB, reviews our current understanding of basic bone and connective tissue biochemistry and the clinical role of biochemical markers specific to related diseases, with special reference to rheumatoid arthritis and osteoporosis.

Author : United States Public Health Service,Surgeon General of the United States
Publisher : Unknown
Page : 0 pages
File Size : 52,5 Mb
Release : 2004-12
Category : Health & Fitness
ISBN : 1410219275

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Bone Health and Osteoporosis by United States Public Health Service,Surgeon General of the United States Pdf

This first-ever Surgeon General's Report on bone health and osteoporosis illustrates the large burden that bone disease places on our Nation and its citizens. Like other chronic diseases that disproportionately affect the elderly, the prevalence of bone disease and fractures is projected to increase markedly as the population ages. If these predictions come true, bone disease and fractures will have a tremendous negative impact on the future well-being of Americans. But as this report makes clear, they need not come true: by working together we can change the picture of aging in America. Osteoporosis, fractures, and other chronic diseases no longer should be thought of as an inevitable part of growing old. By focusing on prevention and lifestyle changes, including physical activity and nutrition, as well as early diagnosis and appropriate treatment, Americans can avoid much of the damaging impact of bone disease and other chronic diseases. This Surgeon General's Report brings together for the first time the scientific evidence related to the prevention, assessment, diagnosis, and treatment of bone disease. More importantly, it provides a framework for moving forward. The report will be another effective tool in educating Americans about how they can promote bone health throughout their lives. This first-ever Surgeon General's Report on bone health and osteoporosis provides much needed information on bone health, an often overlooked aspect of physical health. This report follows in the tradition of previous Surgeon Generals' reports by identifying the relevant scientific data, rigorously evaluating and summarizing the evidence, and determining conclusions.

Author : Hideaki E. Takahashi,David B. Burr,Noriaki Yamamoto
Publisher : Springer Nature
Page : 569 pages
File Size : 51,5 Mb
Release : 2021-11-30
Category : Medical
ISBN : 9789811656132

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Osteoporotic Fracture and Systemic Skeletal Disorders by Hideaki E. Takahashi,David B. Burr,Noriaki Yamamoto Pdf

This edited book describes what fragile bone is, how the condition is assessed, and how it can be treated. It is intended for multi-professional trainees and practitioners in health and social care fields who care for and treat the elderly. Chapters within the book provide the latest advances in cell and molecular biology, morphology, radiology, and the biomechanics of bone in health and disease. The basic concept of “Remodeling” and “Modeling” is described for better understanding of the mechanisms of osteoporosis. Methods of identifying and assessing osteoporosis are described, as are risk factors for bone fracture and non-unions. Furthermore, the effects of various drugs used to treat osteoporosis at both material and structural levels of bone and their cost effectiveness are described. Operative treatments for fracture that maintain or improve the quality of life of patients are included Treatment of Osteoporotic Fracture and Systemic Skeletal Disorders attempts to provide a holistic and translational view of the pathogenesis and treatment of osteoporosis and some other musculoskeletal diseases, with an overview of treatment modalities in various clinical settings.

Author : Andrea Giustina,Alberto Angeli,Ernesto Canalis
Publisher : Karger Medical and Scientific Publishers
Page : 213 pages
File Size : 55,8 Mb
Release : 2002
Category : Medical
ISBN : 9783805572965

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Glucocorticoid-induced Osteoporosis by Andrea Giustina,Alberto Angeli,Ernesto Canalis Pdf

Osteoporosis is one of the most clinically relevant disabling chronic disease encountered in clinical practice. A common cause of osteoporosis is glucocorticoid excess, as glucocorticoids may increase bone resorption, inhibit bone formation, have indirect actions on bone by decreasing intestinal calcium absorption and induce hypercalciuria. This book presents a comprehensive overview of the effects of glucocorticoids on bone metabolism and structure and on the diagnosis and treatment of glucocorticoid-induced osteoporosis. It aims at providing updated information on the pathogenesis, diagnosis and treatment of this often dramatic complication of glucocorticoid excess. Being one of the few publications completely devoted to glucocorticoid-induced osteoporosis it will heighten the awareness of specialists who prescribe glucocorticoids of the clinical relevance of this treatment complication. 'Glucocorticoid-Induced Osteoporosis' is addressed to clinical experts as well as to general practitioners who will both benefit from the comprehensive and integrative view of the management of patients exposed to glucocorticoids.

Author : Gordon L. Klein
Publisher : Springer Science & Business Media
Page : 233 pages
File Size : 42,8 Mb
Release : 2014-04-02
Category : Medical
ISBN : 9781489974365

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Bone Drugs in Pediatrics by Gordon L. Klein Pdf

Bone Drugs in Pediatrics brings together in one place the evidence for the use of certain drugs in the treatment and prevention of bone loss in children, as well as the reservations still present in the pediatric community regarding their use. Beginning with a discussion of developmental pharmacokinetics and drug development for pediatric diseases where bone loss occurs, such as osteogenesis imperfecta, the physiology of pediatric bone and how best to monitor the safety and efficacy of these drugs is presented. The pros and cons of utilizing the drugs themselves – such as bisphosphonates, antiresorptives and anabolic agents – within the pediatric population are carefully considered, with an eye toward safe and effective integration. The potential use of drugs in future treatment is also highlighted. On the whole, Bone Drugs in Pediatrics is a cogent presentation of the ongoing debate surrounding the potential for pharmacological interventions in pediatric bone loss.

Author : Francesco Bertoldo,Francesco Boccardo,Emilio Bombardieri,Laura Evangelista,Riccardo Valdagni
Publisher : Springer
Page : 293 pages
File Size : 48,8 Mb
Release : 2016-11-07
Category : Medical
ISBN : 9783319423272

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Bone Metastases from Prostate Cancer by Francesco Bertoldo,Francesco Boccardo,Emilio Bombardieri,Laura Evangelista,Riccardo Valdagni Pdf

This book presents up-to-date information on one of the hottest topics in prostate cancer, namely bone metastases. The most recent developments with respect to biology, pathology, diagnosis, and treatment are described, providing readers with an excellent understanding of the mechanisms of metastasis formation, the characteristics of metastases, their aggressiveness, and prognostic factors for treatment response. The coverage includes discussion of all of the best available options (laboratory, radiology, and nuclear medicine) for achieving early diagnosis and both established and novel therapeutic approaches. Detailed information is provided on hormonal manipulations, bone-targeted agents, vaccines, taxanes, and other treatments that are enriching the therapeutic armamentarium. The editors can be considered leaders in the field, with great experience in diagnostic and clinical oncology and research, and the authors are experts in diverse specialties. This ensures a multidisciplinary approach, mirroring the current situation in which treatment in patients with bone metastases is undertaken by a team of specialists and health professionals in a variety of fields.

Author : Richard Eastell,Christopher P. Price
Publisher : Unknown
Page : 42 pages
File Size : 40,7 Mb
Release : 1998-01-01
Category : Biochemical markers
ISBN : 0948722053

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Biochemical Markers of Bone Turnover by Richard Eastell,Christopher P. Price Pdf

Author : David W. Dempster,Jane A. Cauley,Mary L. Bouxsein,Felicia Cosman
Publisher : Academic Press
Page : 1950 pages
File Size : 49,7 Mb
Release : 2020-10-08
Category : Science
ISBN : 9780128130742

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Marcus and Feldman's Osteoporosis by David W. Dempster,Jane A. Cauley,Mary L. Bouxsein,Felicia Cosman Pdf

Marcus and Feldman's Osteoporosis, Fifth Edition, is the most comprehensive, authoritative reference on this disease. Led by a new editorial team, this fifth edition offers critical information on reproductive and hormonal risk factors, new therapeutics, ethnicity, nutrition, therapeutics, management and economics, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume reference is a must-have for biomedical researchers, research clinicians, fellows, academic and medical libraries, and any company involved in osteoporosis drug research and development. Summarizes the latest research in bone biology and translational applications in a range of new therapeutic agents, including essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, parathyroid hormone, and new therapeutic agents Recognizes the critical importance of new signaling pathways for bone health, including Wnt, OPG and RANK, of interest to both researchers who study bone biology and clinicians who treat osteoporosis Offers new insights into osteoporosis associated with menopause, pre-menopause, chronic kidney disease, diabetes, HIV and other immune disorders

Author : John P. Bilezikian,Lawrence G. Raisz,T. John Martin
Publisher : Academic Press
Page : 2074 pages
File Size : 44,7 Mb
Release : 2008-09-29
Category : Medical
ISBN : 9780080568751

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Principles of Bone Biology by John P. Bilezikian,Lawrence G. Raisz,T. John Martin Pdf

Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition

Author : Benjamin Z. Leder,Marc N. Wein
Publisher : Springer Nature
Page : 518 pages
File Size : 44,5 Mb
Release : 2020-01-31
Category : Medical
ISBN : 9783319692876

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Osteoporosis by Benjamin Z. Leder,Marc N. Wein Pdf

Completely revised and updated, and utilizing the most current evidence and practice guidelines for the treatment of osteoporosis, this comprehensive third edition discusses the basic aspects of bone metabolism, the pathophysiology of osteoporosis, current diagnostic techniques and medical treatment strategies. Osteoporosis is a common disorder that is prevalent in over 20 million Americans over the age of 60. One and a half million osteoporotic fractures occur in the United States every year, including 300,000 hip fractures. Mortality rates after hip fracture approach 25%, with another 50% of patients experiencing a major decrease in their prior level of independence and quality of life. Despite the wide prevalence and severe consequences of osteoporosis, it remains a disorder that is severely under-diagnosed and treated. In this context, specialists and primary care physicians alike are having increasing difficulty keeping up with the rapid changes to the field and incorporating these advances to clinical care. In the years since the last edition of this book was published, the osteoporosis field has changed drastically. In addition to revising and updating existing chapters and removing a few that are no longer as relevant, new chapters discuss an advanced understanding of the cellular and molecular mechanisms underlying the disorder, the introduction of new diagnostic imaging techniques, a more nuanced appreciation of the risks and benefits of osteoporosis therapies, and the introduction of two new classes of osteoporosis medications. Following the format of the second edition, and including helpful key points at the opening of each chapter, this text will present a comprehensive overview of both the basic and clinical concepts relating to each topic, when appropriate. Chapter authors were chosen based on their high level of expertise and leadership in the field. Taken together, this text should thus be of great interest to physicians of multiple specialties, allied health professionals, as well as basic and clinical researchers.