Biomarkers In Bone Disease

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Biomarkers in Bone Disease

Author : Victor R. Preedy,Vinood B. Patel
Publisher : Springer
Page : 0 pages
File Size : 49,6 Mb
Release : 2017-07-14
Category : Medical
ISBN : 9400776926

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Biomarkers in Bone Disease by Victor R. Preedy,Vinood B. Patel Pdf

In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.

Biomarkers in Bone Disease

Author : Victor R. Preedy
Publisher : Unknown
Page : 128 pages
File Size : 54,6 Mb
Release : 2024-05-21
Category : Bones
ISBN : 9400777450

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Biomarkers in Bone Disease by Victor R. Preedy Pdf

Bone Markers

Author : Matthias Baumann,Richard Eastell,Nicholas Hoyle,Lothar Wieczorek
Publisher : CRC Press
Page : 240 pages
File Size : 51,7 Mb
Release : 2001-03-01
Category : Medical
ISBN : 1841840238

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Bone Markers by Matthias Baumann,Richard Eastell,Nicholas Hoyle,Lothar Wieczorek Pdf

This monograph brings together the proceedings of a workshop held in Geneva, Switzerland in March 2000 under the joint sponsorship of the University of Sheffield and F Hoffmann La Roche Ltd. Chapters by leading scientists present the latest research on biochemical markers of bone remodelling as well as their clinical applications in the management of osteoporosis. The text focuses on four major areas of interest: 1) potential candidates for markers of bone remodelling, 2) sources of biological bone marker variability, 3) use of biochemical markers in monitoring treatment of osteoporosis, and 4) use of biochemical markers in the prediction of bone loss and fractures. The book also includes transcripts of the lively panel discussions from the Geneva workshop.

Endocrine Biomarkers

Author : Hossein Sadrzadeh,Gregory Kline
Publisher : Elsevier
Page : 478 pages
File Size : 46,6 Mb
Release : 2017-09-25
Category : Medical
ISBN : 9780128034187

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Endocrine Biomarkers by Hossein Sadrzadeh,Gregory Kline Pdf

Endocrine Biomarkers: Clinical Aspects and Laboratory Determination covers all the pre-analytical variables that can affect test results, both in the clinic and laboratory. Biomarkers of endocrine and bone diseases are discussed from both clinical and laboratory perspectives, and the authors elaborate on the teamwork-based app+roach between the clinician and the laboratory professional in the diagnosis and management of endocrine and bone disorders. Discussions include test utilization, laboratory measurement methods, harmonization and standardization, interpretation of results, and reference intervals. Each chapter ends with a discussion of one or two relevant cases with shared opinions from both a clinician and a clinical chemist. Each chapter also includes a summary box outlining key points and common pitfalls in the use of specific disease biomarkers and tests. Focuses on the traditional, current, and emerging clinical chemistry tests for endocrine and bone diseases, along with their application in individual clinical management Presents a brief discussion of each disorder and its respective interrelationships, along with laboratory methodologies that can be used to aid in evaluation of disorders Reviews common approaches to the measurement of the relevant hormones, with a special focus on measures that require a structured clinical testing scenario Reviews novel chemistry tests as potential means of future diagnostic tests Provides an overview of the current methodology and controversies in the concept of target lipid levels, paying particular attention to the role of clinical chemistry in helping to implement population health targets

Bone Markers

Author : Richard Eastell,Matthias Baumann,Nicholas R. Hoyle
Publisher : CRC PressI Llc
Page : 252 pages
File Size : 43,6 Mb
Release : 2001-01-01
Category : Medical
ISBN : 184184067X

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Bone Markers by Richard Eastell,Matthias Baumann,Nicholas R. Hoyle Pdf

Biomarkers of Disease

Author : Andrew K. Trull,Lawrence M. Demers,David W. Holt,Atholl Johnston,J. Michael Tredger,Christopher P. Price
Publisher : Cambridge University Press
Page : 518 pages
File Size : 41,9 Mb
Release : 2002-06-06
Category : Medical
ISBN : 9781139437936

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Biomarkers of Disease by Andrew K. Trull,Lawrence M. Demers,David W. Holt,Atholl Johnston,J. Michael Tredger,Christopher P. Price Pdf

This publication takes a critical, evidence-based look at the efficacy of diagnostic tests which are increasingly being used to evaluate organ damage and dysfunction. The use of biomarkers is growing, with a steady stream of products being brought out by the pharmaceutical industry. Some of these assist in diagnosis, others provide a means of monitoring the state of progression of disease and the effectiveness of therapeutic options. However, in many cases the evidence which supports the use of these methods as opposed to traditional biochemical tests has not yet been demonstrated, and it is intended that this volume will help clarify the strengths and weaknesses of using these biomarkers across a wide range of applications and in the various organs of the body. This approach will provide pathologists, clinical biochemists and medical laboratory scientists with an invaluable overview of the diverse applications of biomarkers in medicine.

Bone Disease in Rheumatology

Author : Michael J. Maricic,Oscar S. Gluck
Publisher : Lippincott Williams & Wilkins
Page : 226 pages
File Size : 42,9 Mb
Release : 2005
Category : Medical
ISBN : 0781753015

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Bone Disease in Rheumatology by Michael J. Maricic,Oscar S. Gluck Pdf

Geared toward rheumatologists, this book examines the diagnosis, prevention, and treatment of bone loss in patients with inflammatory diseases. Drs. Maricic and Gluck—along with contributors from bone biology, diagnosis, imaging, biomarkers, and treatment—have developed a comprehensive, practical text on this specific aspect of rheumatology. Bone Disease in Rheumatology provides cutting-edge information on the pathophysiology of systemic and focal bone loss (erosions) in inflammatory disorders, the tools used to assess and measure bone loss, and the medications used in management of bone loss associated with rheumatic diseases. The book also discusses common and uncommon metabolic bone disorders, emphasizing state-of-the-art management techniques.

Clinical Impact of Bone and Connective Tissue Markers

Author : Gerard Meurant
Publisher : Academic Press
Page : 349 pages
File Size : 48,9 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780080984353

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Clinical Impact of Bone and Connective Tissue Markers by Gerard Meurant Pdf

For many years, biochemical tests have been widely used for the diagnosis, classification, and monitoring of bone and connective tissue disease. However, shortcomings in terms of the specificity and sensitivity of such tests have prompted continual questioning about their clinical usefulness. This book, based on a meeting organized jointly by the University of Uppsala and Pharmacia Diagnostics AB, reviews our current understanding of basic bone and connective tissue biochemistry and the clinical role of biochemical markers specific to related diseases, with special reference to rheumatoid arthritis and osteoporosis.

Marcus and Feldman's Osteoporosis

Author : David W. Dempster,Jane A. Cauley,Mary L. Bouxsein,Felicia Cosman
Publisher : Academic Press
Page : 1950 pages
File Size : 47,8 Mb
Release : 2020-10-08
Category : Science
ISBN : 9780128130742

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Marcus and Feldman's Osteoporosis by David W. Dempster,Jane A. Cauley,Mary L. Bouxsein,Felicia Cosman Pdf

Marcus and Feldman's Osteoporosis, Fifth Edition, is the most comprehensive, authoritative reference on this disease. Led by a new editorial team, this fifth edition offers critical information on reproductive and hormonal risk factors, new therapeutics, ethnicity, nutrition, therapeutics, management and economics, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume reference is a must-have for biomedical researchers, research clinicians, fellows, academic and medical libraries, and any company involved in osteoporosis drug research and development. Summarizes the latest research in bone biology and translational applications in a range of new therapeutic agents, including essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, parathyroid hormone, and new therapeutic agents Recognizes the critical importance of new signaling pathways for bone health, including Wnt, OPG and RANK, of interest to both researchers who study bone biology and clinicians who treat osteoporosis Offers new insights into osteoporosis associated with menopause, pre-menopause, chronic kidney disease, diabetes, HIV and other immune disorders

Osteoporosis

Author : Catherine A. Hammett-Stabler
Publisher : Amer. Assoc. for Clinical Chemistry
Page : 124 pages
File Size : 46,5 Mb
Release : 2004
Category : Medical
ISBN : 1594250057

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Osteoporosis by Catherine A. Hammett-Stabler Pdf

Clinical Impact of Bone and Connective Tissue Markers

Author : Erik Lindh,Jan I. Thorell
Publisher : Academic Press
Page : 376 pages
File Size : 52,9 Mb
Release : 1989-01-28
Category : Medical
ISBN : UOM:39015017958094

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Clinical Impact of Bone and Connective Tissue Markers by Erik Lindh,Jan I. Thorell Pdf

For many years, biochemical tests have been widely used for the diagnosis, classification, and monitoring of bone and connective tissue disease. However, shortcomings in terms of the specificity and sensitivity of such tests have prompted continual questioning about their clinical usefulness.This book, based on a meeting organized jointly by the University of Uppsala and Pharmacia Diagnostics AB, reviews our current understanding of basic bone and connective tissue biochemistry and the clinical role of biochemical markers specific to related diseases, with special reference to rheumatoid arthritis and osteoporosis.

Metastatic Bone Disease

Author : R. Coleman,R. D. Rubens
Publisher : Parthenon Publishing
Page : 83 pages
File Size : 48,7 Mb
Release : 1992-06
Category : Bone and bones
ISBN : 1850704414

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Metastatic Bone Disease by R. Coleman,R. D. Rubens Pdf

Monitoring Metabolic Status

Author : Institute of Medicine,Food and Nutrition Board,Standing Committee on Military Nutrition Research,Committee on Metabolic Monitoring for Military Field Applications
Publisher : National Academies Press
Page : 469 pages
File Size : 43,7 Mb
Release : 2004-08-29
Category : Social Science
ISBN : 9780309091596

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Monitoring Metabolic Status by Institute of Medicine,Food and Nutrition Board,Standing Committee on Military Nutrition Research,Committee on Metabolic Monitoring for Military Field Applications Pdf

The U.S. military's concerns about the individual combat service member's ability to avoid performance degradation, in conjunction with the need to maintain both mental and physical capabilities in highly stressful situations, have led to and interest in developing methods by which commanders can monitor the status of the combat service members in the field. This report examines appropriate biological markers, monitoring technologies currently available and in need of development, and appropriate algorithms to interpret the data obtained in order to provide information for command decisions relative to the physiological "readiness" of each combat service member. More specifically, this report also provides responses to questions posed by the military relative to monitoring the metabolic regulation during prolonged, exhaustive efforts, where nutrition/hydration and repair mechanisms may be mismatched to intakes and rest, or where specific metabolic derangements are present.

Diabetic Bone Disease

Author : Beata Lecka-Czernik,John L. Fowlkes
Publisher : Springer
Page : 241 pages
File Size : 48,8 Mb
Release : 2015-10-12
Category : Medical
ISBN : 9783319164021

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Diabetic Bone Disease by Beata Lecka-Czernik,John L. Fowlkes Pdf

Providing the most up-to-date research and current clinical knowledge of diabetic bone disease and the challenges still facing the research and clinical care communities, this book unites insights from endocrinology and orthopedics to create a truly unique text. The first part covers clinical and pre-clinical applications and research. The first two chapters present the clinical and epidemiological data about diabetic bone disease, evaluated and reviewed for type 1 and type 2, respectively. This is followed by discussions of how the propensity to fracture in diabetic bone disease can impact fracture risk assessments and how it can be adjusted for using current clinically relevant fracture risk models. A comprehensive overview of orthopedic complications observed in diabetes is next, as well as a focus on the consequences of diabetes on periodontal disease. Other topics include the utility of skeletal biomarkers in assessing diabetic bone disease, how drugs used to treat diabetes may also have skeletal consequences, and the possibility that diabetes may fundamentally impact early progenitor cells of various bone lineages and thus globally impact bone. The second part covers biomechanics and bone quality in diabetes: how diabetes ultimately may impact the architecture, integrity, and quality of bone. Utilizing the expertise of top researcher and clinicians in diabetic bone disease in one comprehensive text, this volume will be a useful and thought-provoking resource for endocrinologists and orthopedic surgeons alike.

Osteoporosis Treatment

Author : Elaine Dennison
Publisher : Springer Nature
Page : 229 pages
File Size : 44,7 Mb
Release : 2021-08-16
Category : Medical
ISBN : 9783030781286

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Osteoporosis Treatment by Elaine Dennison Pdf

This book provides a practical overview of osteoporosis for the wide spectrum of clinicians that might encounter the osteoporotic patient. Concise and well-structured chapters examine the public health importance of the condition, the current treatment gap, how to identify individuals who would benefit from treatment, bone turnover and how this can be modified by osteoporosis therapies, adjuvant lifestyle modification, the calcium and vitamin D story, antiresorptive therapies, anabolic therapies, emerging therapies, adherence and compliance with therapy and the perception of fracture risk. Osteoporosis Treatment: A Clinical Overview meets the need for a book that improves awareness of this major public health problem and possible therapeutic approaches. Primary care physicians, endocrinologists, rheumatologists, orthopaedic surgeons and those providing specialist care for the elderly will all benefit from this highly accessible and informative guide to treating osteoporosis.