Bugs As Drugs

Author : Robert A. Britton,Patrice D. Cani
Publisher : John Wiley & Sons
Page : 514 pages
File Size : 44,9 Mb
Release : 2020-07-02
Category : Medical
ISBN : 9781555819705

Get Book

Bugs as Drugs by Robert A. Britton,Patrice D. Cani Pdf

Examining the enormous potential of microbiome manipulation to improve health Associations between the composition of the intestinal microbiome and many human diseases, including inflammatory bowel disease, cardiovascular disease, metabolic disorders, and cancer, have been elegantly described in the past decade. Now, whole-genome sequencing, bioinformatics, and precision gene-editing techniques are being combined with centuries-old therapies, such as fecal microbiota transplantation, to translate current research into new diagnostics and therapeutics to treat complex diseases. Bugs as Drugs provides a much-needed overview of microbes in therapies and will serve as an excellent resource for scientists and clinicians as they carry out research and clinical studies on investigating the roles the microbiota plays in health and disease. In Bugs as Drugs, editors Robert A. Britton and Patrice D. Cani have assembled a fascinating collection of reviews that chart the history, current efforts, and future prospects of using microorganisms to fight disease and improve health. Sections cover traditional uses of probiotics, next-generation microbial therapeutics, controlling infectious diseases, and indirect strategies for manipulating the host microbiome. Topics presented include: How well-established probiotics support and improve host health by improving the composition of the intestinal microbiota of the host and by modulating the host immune response. The use of gene editing and recombinant DNA techniques to create tailored probiotics and to characterize next-generation beneficial microbes. For example, engineering that improves the anti-inflammatory profile of probiotics can reduce the number of colonic polyps formed, and lactobacilli can be transformed into targeted delivery systems carrying therapeutic proteins or bioengineered bacteriophage. The association of specific microbiota composition with colorectal cancer, liver diseases, osteoporosis, and inflammatory bowel disease. The gut microbiota has been proposed to serve as an organ involved in regulation of inflammation, immune function, and energy homeostasis. Fecal microbiota transplantation as a promising treatment for numerous diseases beyond C. difficile infection. Practical considerations for using fecal microbiota transplantation are provided, while it is acknowledged that more high-quality evidence is needed to ascertain the importance of strain specificity in positive treatment outcomes. Because systems biology approaches and synthetic engineering of microbes are now high-throughput and cost-effective, a much wider range of therapeutic possibilities can be explored and vetted.

Author : Fredrik Brouneus,Nina Erixon-Lindroth
Publisher : BoD - Books on Demand
Page : 41 pages
File Size : 45,7 Mb
Release : 2020-08-31
Category : Juvenile Nonfiction
ISBN : 9789180071048

Get Book

Drugs and Bugs - a little book about medicines by Fredrik Brouneus,Nina Erixon-Lindroth Pdf

In Drugs and Bugs you will read about everything that is exciting about medicines - from crocodile poo and hippo fat in ancient Egypt, to today's injections and tablets. You will find out how vaccines work, why antibiotics are useless against the common cold and how scientists go about inventing new medicines. You will also learn about viruses, bacteria, fungi and parasites, how they attack the body and how we defend ourselves - both with and without medicines. And lots more! Drugs and Bugs is written by Fredrik Brouneus, pharmacist and writer. The book is richly illustrated by Nina Erixon-Lindroth, illustrator and neuroscientist.

Author : Frances R. Balkwill,Mic Rolph,V. M. Darley-Usmar
Publisher : Ashgate Publishing
Page : 136 pages
File Size : 44,9 Mb
Release : 1995
Category : Bacteria
ISBN : UOM:39076001782403

Get Book

Microbes, Bugs and Wonder Drugs by Frances R. Balkwill,Mic Rolph,V. M. Darley-Usmar Pdf

Aims to introduce the subject of disease, and the history of drugs and their use and abuse. 9-11 yrs.

Author : Loch K. Johnson
Publisher : NYU Press
Page : 510 pages
File Size : 50,8 Mb
Release : 2002
Category : Intelligence service
ISBN : 9780814771730

Get Book

Bombs, Bugs, Drugs, and Thugs by Loch K. Johnson Pdf

Johnson, author of the acclaimed Secret Agencies and ""an experienced overseer of intelligence"" (Foreign Affairs), here examines the present state and future challenges of American strategic intelligence.

Author : World Health Organization
Publisher : Unknown
Page : 151 pages
File Size : 53,7 Mb
Release : 2011
Category : Medical
ISBN : 9241564369

Get Book

Bugs, Drugs, & Smoke by World Health Organization Pdf

Since the World Health Organization (WHO) was founded in 1948, the world has changed dramatically and so too has its health. But while some scourges (e.g. smallpox and polio) have subsided, others have made a comeback (e.g. tuberculosis) and frightening new diseases (e.g. Ebola and Marburg) have appeared. This book is primarily for young people, especially those interested in working in public health. It explains in simple, non-technical language how humankind developed techniques to protect the health of communities, drawing on first-hand interviews with leading public health figures. It covers a wide range of topics, from the control of infectious disease outbreaks to fighting the stigma attached to mental health conditions. These narratives, told from many parts of the world, show how individuals, communities, institutions and countries can improve people's health when they work together. They show the role that WHO has played in providing countries with the technical support and coordination to make progress in health possible.

Author : William Hall
Publisher : Harvard University Press
Page : 236 pages
File Size : 55,6 Mb
Release : 2018-04-09
Category : Medical
ISBN : 9780674985070

Get Book

Superbugs by William Hall Pdf

Antibiotics are powerful drugs that can prevent and treat infections, but they are becoming less effective as a result of drug resistance. Resistance develops because the bacteria that antibiotics target can evolve ways to defend themselves against these drugs. When antibiotics fail, there is very little else to prevent an infection from spreading. Unnecessary use of antibiotics in both humans and animals accelerates the evolution of drug-resistant bacteria, with potentially catastrophic personal and global consequences. Our best defenses against infectious disease could cease to work, surgical procedures would become deadly, and we might return to a world where even small cuts are life-threatening. The problem of drug resistance already kills over one million people across the world every year and has huge economic costs. Without action, this problem will become significantly worse. Following from their work on the Review on Antimicrobial Resistance, William Hall, Anthony McDonnell, and Jim O’Neill outline the major systematic failures that have led to this growing crisis. They also provide a set of solutions to tackle these global issues that governments, industry, and public health specialists can adopt. In addition to personal behavioral modifications, such as better handwashing regimens, Superbugs argues for mounting an offense against this threat through agricultural policy changes, an industrial research stimulus, and other broad-scale economic and social incentives.

Author : Fredrik Brouneus,Nina Erixon-Lindroth
Publisher : BoD - Books on Demand
Page : 42 pages
File Size : 46,5 Mb
Release : 2020-04-27
Category : Juvenile Nonfiction
ISBN : 9789177855453

Get Book

Drugs and Bugs - a little book about medicines by Fredrik Brouneus,Nina Erixon-Lindroth Pdf

In Drugs and Bugs you will read about everything that is exciting about medicines - from crocodile poo and hippo fat in ancient Egypt, to today's injections and tablets. You will find out how vaccines work, why antibiotics are useless against the common cold and how scientists go about inventing new medicines. You will also learn about viruses, bacteria, fungi and parasites, how they attack the body and how we defend ourselves - both with and without medicines. And lots more! Drugs and Bugs is written by Fredrik Brouneus, pharmacist and writer. The book is richly illustrated by Nina Erixon-Lindroth, illustrator and neuroscientist.

Author : Brad Case
Publisher : Unknown
Page : 0 pages
File Size : 48,5 Mb
Release : 2010-10-15
Category : Alternative medicine
ISBN : 0981989500

Get Book

Thugs, Drugs and the War on Bugs by Brad Case Pdf

What is the number one killer in the United States? Medical treatment. Western medicine has cures for surprisingly few diseases and actually causes illness with its drugs for every disease approach. Infectious diseases are making a comeback due to the overuse of antibiotics and our war on germs. We've seen an exponential rise in autism while vaccinating more than any other country. According to the Journal of the American Medical Association, properly prescribed medication is the fourth leading cause of death, hospitals are the third, and medical doctors kill more than all other forms of accidental death combined. This first book in the Why We're Sick series exposes the myths, lies, greed, and just plain bungling that is the untold story of Western medicine. Deeply researched, deadly serious, yet often humorous and irreverent, no other work so thoroughly explains how we got into this mess and what we can do to be truly healthy.

Author : Robert A. Britton,Patrice D. Cani
Publisher : ASM Press
Page : 0 pages
File Size : 55,7 Mb
Release : 2018-02-21
Category : Medical
ISBN : 1555819699

Get Book

Bugs as Drugs by Robert A. Britton,Patrice D. Cani Pdf

Examining the enormous potential of microbiome manipulation to improve health Associations between the composition of the intestinal microbiome and many human diseases, including inflammatory bowel disease, cardiovascular disease, metabolic disorders, and cancer, have been elegantly described in the past decade. Now, whole-genome sequencing, bioinformatics, and precision gene-editing techniques are being combined with centuries-old therapies, such as fecal microbiota transplantation, to translate current research into new diagnostics and therapeutics to treat complex diseases. Bugs as Drugs provides a much-needed overview of microbes in therapies and will serve as an excellent resource for scientists and clinicians as they carry out research and clinical studies on investigating the roles the microbiota plays in health and disease. In Bugs as Drugs, editors Robert A. Britton and Patrice D. Cani have assembled a fascinating collection of reviews that chart the history, current efforts, and future prospects of using microorganisms to fight disease and improve health. Sections cover traditional uses of probiotics, next-generation microbial therapeutics, controlling infectious diseases, and indirect strategies for manipulating the host microbiome. Topics presented include: How well-established probiotics support and improve host health by improving the composition of the intestinal microbiota of the host and by modulating the host immune response. The use of gene editing and recombinant DNA techniques to create tailored probiotics and to characterize next-generation beneficial microbes. For example, engineering that improves the anti-inflammatory profile of probiotics can reduce the number of colonic polyps formed, and lactobacilli can be transformed into targeted delivery systems carrying therapeutic proteins or bioengineered bacteriophage. The association of specific microbiota composition with colorectal cancer, liver diseases, osteoporosis, and inflammatory bowel disease. The gut microbiota has been proposed to serve as an organ involved in regulation of inflammation, immune function, and energy homeostasis. Fecal microbiota transplantation as a promising treatment for numerous diseases beyond C. difficile infection. Practical considerations for using fecal microbiota transplantation are provided, while it is acknowledged that more high-quality evidence is needed to ascertain the importance of strain specificity in positive treatment outcomes. Because systems biology approaches and synthetic engineering of microbes are now high-throughput and cost-effective, a much wider range of therapeutic possibilities can be explored and vetted. If you are looking for online access to the latest clinical microbiology content, please visit www.wiley.com/learn/clinmicronow.

Author : David N Gilbert, Ed.,Robert C. Moellering,Merle A. Sande
Publisher : Antimicrobial Therapy
Page : 156 pages
File Size : 51,7 Mb
Release : 2004-04-15
Category : Medical
ISBN : 1930808097

Get Book

Sanford Guide to Antimicrobial Therapy 2003 by David N Gilbert, Ed.,Robert C. Moellering,Merle A. Sande Pdf

Author : FDA,United States. Food and Drug Administration
Publisher : Imp
Page : 356 pages
File Size : 55,9 Mb
Release : 2004
Category : Medical
ISBN : UOM:39015059182850

Get Book

The Bad Bug Book by FDA,United States. Food and Drug Administration Pdf

This handbook provides basic facts regarding foodborne pathogenic microorganisms and natural toxins.

Author : Institute of Medicine,Board on Global Health,Committee on Emerging Microbial Threats to Health in the 21st Century
Publisher : National Academies Press
Page : 397 pages
File Size : 44,7 Mb
Release : 2003-08-25
Category : Medical
ISBN : 9780309185547

Get Book

Microbial Threats to Health by Institute of Medicine,Board on Global Health,Committee on Emerging Microbial Threats to Health in the 21st Century Pdf

Infectious diseases are a global hazard that puts every nation and every person at risk. The recent SARS outbreak is a prime example. Knowing neither geographic nor political borders, often arriving silently and lethally, microbial pathogens constitute a grave threat to the health of humans. Indeed, a majority of countries recently identified the spread of infectious disease as the greatest global problem they confront. Throughout history, humans have struggled to control both the causes and consequences of infectious diseases and we will continue to do so into the foreseeable future. Following up on a high-profile 1992 report from the Institute of Medicine, Microbial Threats to Health examines the current state of knowledge and policy pertaining to emerging and re-emerging infectious diseases from around the globe. It examines the spectrum of microbial threats, factors in disease emergence, and the ultimate capacity of the United States to meet the challenges posed by microbial threats to human health. From the impact of war or technology on disease emergence to the development of enhanced disease surveillance and vaccine strategies, Microbial Threats to Health contains valuable information for researchers, students, health care providers, policymakers, public health officials. and the interested public.

Author : Arnold van Huis,Food and Agriculture Organization of the United Nations
Publisher : Bright Sparks
Page : 0 pages
File Size : 53,7 Mb
Release : 2013
Category : Conservation of natural resources
ISBN : 9251075956

Get Book

Edible Insects by Arnold van Huis,Food and Agriculture Organization of the United Nations Pdf

Edible insects have always been a part of human diets, but in some societies there remains a degree of disdain and disgust for their consumption. Although the majority of consumed insects are gathered in forest habitats, mass-rearing systems are being developed in many countries. Insects offer a significant opportunity to merge traditional knowledge and modern science to improve human food security worldwide. This publication describes the contribution of insects to food security and examines future prospects for raising insects at a commercial scale to improve food and feed production, diversify diets, and support livelihoods in both developing and developed countries. It shows the many traditional and potential new uses of insects for direct human consumption and the opportunities for and constraints to farming them for food and feed. It examines the body of research on issues such as insect nutrition and food safety, the use of insects as animal feed, and the processing and preservation of insects and their products. It highlights the need to develop a regulatory framework to govern the use of insects for food security. And it presents case studies and examples from around the world. Edible insects are a promising alternative to the conventional production of meat, either for direct human consumption or for indirect use as feedstock. To fully realise this potential, much work needs to be done by a wide range of stakeholders. This publication will boost awareness of the many valuable roles that insects play in sustaining nature and human life, and it will stimulate debate on the expansion of the use of insects as food and feed.

Author : Mark Walderhaug
Publisher : Createspace Independent Publishing Platform
Page : 292 pages
File Size : 51,9 Mb
Release : 2014-01-14
Category : Medical
ISBN : 1495203611

Get Book

Bad Bug Book by Mark Walderhaug Pdf

The Bad Bug Book 2nd Edition, released in 2012, provides current information about the major known agents that cause foodborne illness.Each chapter in this book is about a pathogen—a bacterium, virus, or parasite—or a natural toxin that can contaminate food and cause illness. The book contains scientific and technical information about the major pathogens that cause these kinds of illnesses.A separate “consumer box” in each chapter provides non-technical information, in everyday language. The boxes describe plainly what can make you sick and, more important, how to prevent it.The information provided in this handbook is abbreviated and general in nature, and is intended for practical use. It is not intended to be a comprehensive scientific or clinical reference.The Bad Bug Book is published by the Center for Food Safety and Applied Nutrition (CFSAN) of the Food and Drug Administration (FDA), U.S. Department of Health and Human Services.

Author : Per-Ulf Tunn
Publisher : Springer Science & Business Media
Page : 372 pages
File Size : 50,8 Mb
Release : 2008-12-28
Category : Medical
ISBN : 9783540779605

Get Book

Treatment of Bone and Soft Tissue Sarcomas by Per-Ulf Tunn Pdf

Bone and soft tissue sarcomas represent only about 2% of all malignancies; however, their treatment – with the goal of curing the patient while preserving the functionality of the affected body part – can, unlike other malignancies, only be successful with therapy concepts devised by interdisciplinary teams. This volume provides an extensive up-to-date overview of the specific diagnostics and current treatment standards of these rare entities, presenting the various limb-sparing modalities for patients with bone and soft tissue sarcomas with special regard to innovative reconstructive options. The evaluation of quality of life based on validated scores and the individual methods of coping with the illness through creative artistic projects are also acknowledged and integrated in the whole concept.