Calcium Entry Channels In Non Excitable Cells

Author : Juliusz Ashot Kozak,James W. Putney, Jr.
Publisher : CRC Press
Page : 343 pages
File Size : 52,6 Mb
Release : 2017-07-14
Category : Science
ISBN : 9781498752732

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Calcium Entry Channels in Non-Excitable Cells by Juliusz Ashot Kozak,James W. Putney, Jr. Pdf

Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.

Author : Juliusz Ashot Kozak,James W. Putney, Jr.
Publisher : CRC Press
Page : 328 pages
File Size : 45,9 Mb
Release : 2021-03-30
Category : Electronic
ISBN : 0367657902

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Calcium Entry Channels in Non-Excitable Cells by Juliusz Ashot Kozak,James W. Putney, Jr. Pdf

Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.

Author : Juliusz Ashot Kozak,James W. Putney, Jr.
Publisher : CRC Press
Page : 428 pages
File Size : 49,9 Mb
Release : 2017-07-14
Category : Science
ISBN : 9781351648639

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Calcium Entry Channels in Non-Excitable Cells by Juliusz Ashot Kozak,James W. Putney, Jr. Pdf

Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.

Author : Juan A. Rosado
Publisher : Springer
Page : 471 pages
File Size : 50,7 Mb
Release : 2016-05-09
Category : Science
ISBN : 9783319269740

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Calcium Entry Pathways in Non-excitable Cells by Juan A. Rosado Pdf

Calcium entry pathways in non-excitable cells presents a concise synthesis of thoughtfully selected topics covering from the different calcium entry mechanisms in non-excitable cells to the cellular microdomains and organelles regulating the calcium entry process. Particular attention is given to the fascinating group of ion channels involved in different calcium entry pathways as well as the emerging role of these channels in human disease. Calcium entry is an essential mechanism for cellular function in non-excitable cells. In general, two main calcium entry pathways exist in non-excitable cells: one pathway, named store-operated calcium entry (SOCE) requires store depletion and the second pathway is regulated by receptor occupation, but independently on calcium store depletion. The search for the molecular components of calcium entry has identified the stromal interaction molecule 1 (STIM1), as the calcium sensor of the intracellular calcium stores, and Orai as well as TRP channels as the calcium-permeable channels located in the plasma membrane. The location, interactions and function of these channels are finely regulated by a number of scaffolding proteins, membrane microdomains and cellular organelles that fine tune the amount of calcium entering the cell. Cutting-edge and user-friendly, this volume presents relevant background information, critical analysis of the current observations and directions for future research. The book is intended for basic scientists specializing in cellular biology or ion transport, as well as for biomedical researchers.

Author : Anonim
Publisher : Academic Press
Page : 298 pages
File Size : 46,7 Mb
Release : 2013-07-24
Category : Science
ISBN : 9780124079380

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Store-Operated Calcium Channels by Anonim Pdf

Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels. Contributors are authoritative researchers who have produced important advances in the field. The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject.

Author : Malhotra, Ashim,Soni, Shivani
Publisher : IGI Global
Page : 439 pages
File Size : 40,6 Mb
Release : 2017-01-25
Category : Medical
ISBN : 9781522520931

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Emerging Applications, Perspectives, and Discoveries in Cardiovascular Research by Malhotra, Ashim,Soni, Shivani Pdf

Scientific developments in recent years have led to significant strides and advancements within the medical field. By integrating these findings into medical practice, optimal healthcare can be delivered to the public. Emerging Applications, Perspectives, and Discoveries in Cardiovascular Research is a comprehensive reference source for the latest academic material on the exploration of cardiovascular diseases and provides an interdisciplinary examination of novel developments and applications for cardiovascular sciences. Highlighting a range of diverse topics, such as pharmacology, pathophysiology, and alternative medicine, this book is ideally designed for researchers, professionals, practitioners, graduate students, and academics interested in the latest medical advancements.

Author : James W. Putney
Publisher : Springer
Page : 238 pages
File Size : 49,5 Mb
Release : 1997-06-15
Category : Juvenile Nonfiction
ISBN : WISC:89058899543

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Capacitative Calcium Entry by James W. Putney Pdf

Author : Jose C. Jimenez-Lopez
Publisher : BoD – Books on Demand
Page : 344 pages
File Size : 44,9 Mb
Release : 2017-05-17
Category : Science
ISBN : 9789535131694

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Cytoskeleton by Jose C. Jimenez-Lopez Pdf

The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.

Author : Fatima Shad Kaneez
Publisher : BoD – Books on Demand
Page : 204 pages
File Size : 45,9 Mb
Release : 2018-10-10
Category : Science
ISBN : 9781789842272

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Ion Channels in Health and Sickness by Fatima Shad Kaneez Pdf

Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.

Author : Gonzalo Alarcón,Antonio Valentín
Publisher : Cambridge University Press
Page : 641 pages
File Size : 55,9 Mb
Release : 2012-04-26
Category : Medical
ISBN : 9780521691581

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Introduction to Epilepsy by Gonzalo Alarcón,Antonio Valentín Pdf

Covers all aspects of epilepsy, from basic mechanisms to diagnosis and management, as well as legal and social considerations.

Author : Richard W. Tsien,Jean-Paul Clozel,Joël Nargeot
Publisher : Unknown
Page : 420 pages
File Size : 44,7 Mb
Release : 1998
Category : Calcium
ISBN : UOM:39015047707891

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Low-voltage-activated T-type Calcium Channels by Richard W. Tsien,Jean-Paul Clozel,Joël Nargeot Pdf

Author : Tomohiro Kurosaki,Jürgen Wienands
Publisher : Springer
Page : 231 pages
File Size : 42,8 Mb
Release : 2015-12-26
Category : Medical
ISBN : 9783319261331

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B Cell Receptor Signaling by Tomohiro Kurosaki,Jürgen Wienands Pdf

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.

Author : Jie Zheng,Matthew C. Trudeau
Publisher : CRC Press
Page : 682 pages
File Size : 50,6 Mb
Release : 2015-02-25
Category : Medical
ISBN : 9781466551428

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Handbook of Ion Channels by Jie Zheng,Matthew C. Trudeau Pdf

The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce

Author : T. Narahashi
Publisher : Springer Science & Business Media
Page : 299 pages
File Size : 52,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461573050

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Ion Channels by T. Narahashi Pdf

In the past few years, the scientific community has witnessed rapid and significant progress in the study of ion channels. Technological advance ment in biophysics, molecular biology, and immunology has been greatly accelerated, making it possible to conduct experiments that were deemed very difficult if not impossible in the past. For example, patch-clamp tech niques can now be used to measure ionic currents generated by almost any type of cell, thereby allowing us to analyze single-channel events. It is now possible to incorporate purified ion channel components into lipid bilayers to reconstitute an "excitable membrane." Gene cloning and monoclonal antibody techniques provide us with new approaches to the study of the molecular structure of ion channels. A variety of drugs have now been found or are suspected to interact with ion channels to exert therapeutic effects. In addition to the classical exam ples, as represented by local anesthetics, many other drugs, including cal cium antagonists, psychoactive drugs, cardiac drugs, and anticonvulsants, have been shown to alter the ion channel function. For certain pesticides such as pyrethroids and DDT, sodium channels are clearly the major target site. Many diseases of excitable tissues are known to be associated with, if not caused by, dysfunction of ion channels; these include cardiac ar rhythmias, angina pectoris, cystic fibrosis, myotonia, and epilepsies, to men tion only a few. Channel dysfunction can now be studied due to theoretical and technological developments in this area.

Author : Marcelo González
Publisher : BoD – Books on Demand
Page : 230 pages
File Size : 47,7 Mb
Release : 2020-11-11
Category : Medical
ISBN : 9781839690358

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Vascular Biology by Marcelo González Pdf

The two main causes of death in the world are directly related to cardiovascular system disorders, ischemic heart disease, and stroke. These pathological conditions are caused by complex molecular mechanisms related to endothelial dysfunction and, finally, structural and functional alterations of blood vessels. Clinical evidence demonstrates the relevance of knowledge about vascular biology, from molecular mechanisms to clinical applications, especially for students of medical sciences or basic sciences. This book is an international effort of collaboration, with the purpose to create an academic tool for students or people interested in learning about vascular biology. I invite the readers to check the chapters and explore the topics developed by experts in the field.