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Calcium Ions in Nerve Cell Function by Platon Grigorʹevich Kosti͡uk Pdf
Calcium ions play a central role in regulating the activity of all cells, and particularly their ability to respond to external stimuli. Their role in the triggering of impulses in nerve cells is the subject of intensive study. This book discusses all aspects of this important area of research.
Calcium Ions in Nerve Cell Function by P. G. Kosti︠u︡k Pdf
Calcium ions play a central role in regulating the activity of all cells, and particularly their ability to respond to external stimuli. Their role in the triggering of impulses in nerve cells is the subject of intensive study. This book discusses aspects of this important area of research.
Calcium, Neuronal Function and Transmitter Release by Rami Rahamimoff,Bernard Katz Pdf
This symposium entitled Calcium, Neuronal Function and Transmitter Re lease, was in the framework of the regional meeting of the International Union of Physiological Sciences, that took place in Jerusalem between August 26-31, 1984. The symposium dealt with the role of calcium ions in regulation of a large number of important processes in modern neurobiology, from molecular and cellular points of view. In this context, we consider heart and most cells as 'honorary neurons'. The meeting was comprised of lectures and quite intense discussions. We hope that the transcription of the discussions which follow the articles will give the reader a feeling of the intense, but pleasant atmosphere that per vaded during this symposium. It is our pleasure to thank Mrs. Miriam Silber, the assistant editor of this book, for her hard work in transcribing the discussions, retyping large portions of the book, and getting the approval of the authors. We express our thanks to Dr. Halina Meiri and Dr. Simona Ginsburg for their editorial assis tance. The unfailing help of Ms. Rachel Klein and Ms. Shoshana Wineberg is greatly appreciated. xxvii SECTION 1 CALCIUM CHANNELS, TRANSPORTERS & CALCIUM REGULATED CHANNELS EFFECTS OF TEMPERATURE ON SINGLE CHANNEL AND WHOLE CELL Ca CURRENTS A. M. BROWN, D. L. KUNZE, H.D. LUX AND D. L. WILSON INTRODUCTION Calcium tall currents have a large,fast component which Is not detectable when the currents are turned on or acti vated from the completely rested state (Brown et aI, 1983).
Understanding the mechanisms that underlie brain activity and function remains one of the major frontiers of biology. All the processes of how we co-ordinate our movements, sense our surroundings, react to stimuli and learn and retain information rely on complicated networks of neurons thatcommunicate with each other and their targets. This fast and accurate intercellular signalling most occurs at synapses, specialized processes of neurons that release chemical signals, called neurotransmitters. Neurotransmitters: Frontiers in Molecular Biology will provide the reader withextensive background information on neurotransmitter release. It takes a multidisciplinary approach, but does not assume previous knowledge having basic introductions to most topics. Topics however are covered in enough detail to be of interest to experts in the field. Throughout, emphasis is placedon the rationale by which proteins are assigned specific functions rather than just providing facts about function. The first chapter provides an introduction to the basic features and properties of the synapse and is followed by a chapter detailing several important techniques used to elucidatevarious aspects of release. Chapters 3 describes many of the biochemical approaches used to identify proteins involved in neurotransmitter release and then chapters 4 and 5 focus on more specific aspects of synaptic transmission: the proteins that transport neurotransmitters and the role ofphosphlipids in the process. The next five chapters concentrate on approaches to unravel the function of many proteins in vivo by using toxins, giant squid axons, C. elegans, Drosophila, and mice. The final chapter summarizes current knowledge on endocytosis and recycling. Knowledge of themolecular mechanisms underlying neurotransmitter release has expanded tremendously over the last 10 years. Many of the proteins involved have been isolated, but their roles have yet to be determined. These discoveries will be a major challenge and it is therefore the major aim of this book not onlyto provide information but also to generate excitement.
Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels Contributors are authoritative researchers who have produced important advances in the field The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject
Calcium Signalling in the Nervous System by P. G. Kostyuk,Alexei Verkhratsky Pdf
Calcium ions play an important role in the function of excitable cells, from the triggering of impulses in nerve cells to the regulation of biochemical pathways and basic cellular functions of all cell types in the nervous system. Calcium signalling is the main coupling mechanism linking external stimuli, via the membrane, with intracellular processes. Calcium Signalling in the Nervous System provides an up-to-date account of the most fundamental aspects of calcium signal generation in the nervous system, including pathways for Ca2+ influx, buffering in the cytosol, involvement of intracellular calcium stores and Ca2+ extrusion. The book also gives an overview of the most important aspects of interaction of Ca2+ ions with other messenger systems, the functional meaning of Ca2+ ions, as well as the pharmaceutical tools used for their dissection and modulation. The role of calcium in a variety of neural cell types and implications in brain function are also discussed, including the control of gene expression, cell differentiation and programmed cell death.
Plasticity in Nerve Cell Function by Platon Kostyuk Pdf
This book summarizes the most recent data on the molecular and cellular mechanisms which determine the unique properties of nerve cells - their ability to differentiate, establish connections to each other, and to form the nervous system with its immense capability for receiving, analysing,and storing information about our external and internal world. The key role of calcium ions in this process is particularly explored, along with nervous system function in aging and neural pathology. The author, based at a high-profile research unit in the Ukraine, is able to draw on significantnew research which has not been widely published. Plasticity in nerve cell function will be of interest to researchers and research students in the fields of neurophysiology, cellular physiology, biophysics, and neurochemistry in particular. It will also be of relevance to researchers and medicaldoctors interested in neuropathology and aging.
Ion Channels in Health and Sickness by Fatima Shad Kaneez Pdf
Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.
Author : Gary G. Matthews Publisher : John Wiley & Sons Page : 248 pages File Size : 41,9 Mb Release : 2013-06-03 Category : Medical ISBN : 9781118687871
Cellular Physiology of Nerve and Muscle by Gary G. Matthews Pdf
Cellular Physiology of Nerve and Muscle, Fourth Editionoffers a state of the art introduction to the basic physical,electrical and chemical principles central to the function of nerveand muscle cells. The text begins with an overview of the origin ofelectrical membrane potential, then clearly illustrates thecellular physiology of nerve cells and muscle cells. Throughout,this new edition simplifies difficult concepts with accessiblemodels and straightforward descriptions of experimentalresults. An all-new introduction to electrical signaling in the nervoussystem. Expanded coverage of synaptic transmission and synapticplasticity. A quantitative overview of the electrical properties ofcells. New detailed illustrations.
The second volume of the Handbook does not parallel any volume of the first edition; it is one more sign, or reflection, of the expansion of the field. By emphasizing the experimental approach, it illustrates the tools that have re cently become available for investigating the nervous system. Also, perhaps even more than other volumes, it illustrates the multidisciplinary nature of the field, requiring multidisciplinary methodology. It is now recognized that the availability of methodology is often the rate-limiting determinant of studies and that improvements or innovations in instrumentation can open up new avenues. A new improved method, although opening up new possibilities and being crucial to making advances, is only a tool whose use will determine its use fulness. If we do not recognize its possibilities, its use will be limited; if we do not recognize its limitations, it will mislead us. It is the possibilities and limitations and the results obtained that are illustrated here.
Calcium Entry Channels in Non-Excitable Cells by Juliusz Ashot Kozak,James W. Putney, Jr. Pdf
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young
Author : J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young Publisher : Unknown Page : 0 pages File Size : 45,9 Mb Release : 2013-04-25 Category : Electronic ISBN : 1947172808
Anatomy and Physiology by J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young Pdf
Calcium Ions in Nerve Cell Function by Platon Grigorʹevich Kosti͡uk Pdf
This work reviews the progress that has been made in recent years in understanding the mechanisms by which calcium ions regulate nerve cell function. It covers all aspects of the topic in detail, from the interaction of calcium ions with the external surface of the plasma membrane, to the function of transient changes in cytoplasmic calcium concentration. Much of the book is devoted to a discussion of the different types of receptor- and voltage-operated calcium channels, and the basis of their selectivity, gating, inactivation, and pharmacological modulation. The development of calcium conductance during ontogenesis is described and the fate of calcium ions in the cell is discussed. This volume clearly assesses the contribution made by the release of calcium from internal stores to cytoplasmic calcium transients, and analyses mechanisms by which this release may be controlled. The first book in the Oxford Neuroscience Series, Calcium Ions in Nerve Cell Function meets the need for a comprehensive account that draws together the enormous body of research on this important topic. It will be an indispensable to specialists in the field, and will also provide an accessible review for non-specialists.
