Cancer Chemoprevention

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Natural Products for Cancer Chemoprevention

John M. Pezzuto,Ole Vang
Natural Products for Cancer Chemoprevention Book PDF

Author : John M. Pezzuto,Ole Vang
Publisher : Springer Nature
Page : 639 pages
File Size : 43,5 Mb
Release : 2020-04-03
Category : Medical
ISBN : 9783030398552

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Natural Products for Cancer Chemoprevention by John M. Pezzuto,Ole Vang Pdf

This book discusses the efficacy of various naturally occurring chemopreventive agents in preventing or delaying cancer. It focuses on the holistic chemopreventive concept, demonstrating the relevant response is the combined effect of a series of compounds that alone have been shown to have some effect in different experimental models. Written by leading experts in the field, the contributions provide details of research on various chemopreventive agents. Offering insights into the unique molecular targets and mechanisms, safety issues, molecular efficacy, and occurrence in nature of these compounds, the book is a valuable resource for all scientists working in biomedicine, and specifically in cancer research.

Pharmacotherapeutic Botanicals for Cancer Chemoprevention

Manish Kumar,Ashita Sharma,Praveen Kumar
Pharmacotherapeutic Botanicals for Cancer Chemoprevention Book PDF

Author : Manish Kumar,Ashita Sharma,Praveen Kumar
Publisher : Springer Nature
Page : 344 pages
File Size : 51,8 Mb
Release : 2020-07-20
Category : Medical
ISBN : 9789811559990

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Pharmacotherapeutic Botanicals for Cancer Chemoprevention by Manish Kumar,Ashita Sharma,Praveen Kumar Pdf

The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.

Holland-Frei Cancer Medicine

Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Holland Frei Cancer Medicine Book PDF

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 40,7 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Cancer Chemoprevention

Gary J. Kelloff,Ernest T. Hawk,Caroline C. Sigman
Cancer Chemoprevention Book PDF

Author : Gary J. Kelloff,Ernest T. Hawk,Caroline C. Sigman
Publisher : Springer Science & Business Media
Page : 543 pages
File Size : 44,6 Mb
Release : 2008-08-17
Category : Medical
ISBN : 9781592597680

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Cancer Chemoprevention by Gary J. Kelloff,Ernest T. Hawk,Caroline C. Sigman Pdf

Despite significant advances in cancer treatment and measures of neoplastic progression, drug effect (or early detection, overall cancer incidence has increased, pharmacodynamic markers), and markers that measure cancer-associated morbidity is considerable, and overall prognosis as well as predict responses to specific therapy. cancer survival has remained relatively flat over the past All these biomarkers have the potential to greatly augment several decades (1,2). However, new technology the development of successful chemoprevention therapies, allowing exploration of signal transduction pathways, but two specific types of biomarkers will have the most identification of cancer-associated genes, and imaging of immediate impact on successful chemopreventive drug tissue architecture and molecular and cellular function is development—those that measure the risk of developing increasing our understanding of carcinogenesis and cancer invasive life-threatening disease, and those whose mo- progression. This knowledge is moving the focus of cancer lation can “reasonably predict” clinical benefit and, therapeutics, including cancer preventive treatments, to therefore, serve as surrogate endpoints for later-occurring drugs that take advantage of cellular control mechanisms clinical disease. Thus far, the biomarker that best measures to selectively suppress cancer progression. these two phenomena is intraepithelial neoplasia (IEN) Carcinogenesis is now visualized as a multifocal, because it is a near obligate precursor to cancer.

Cancer Chemoprevention

Raymond C. Bergan
Cancer Chemoprevention Book PDF

Author : Raymond C. Bergan
Publisher : Springer
Page : 336 pages
File Size : 48,9 Mb
Release : 2001
Category : Medical
ISBN : UOM:39015052471755

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Cancer Chemoprevention by Raymond C. Bergan Pdf

Great advances were made in the pharmacologic-based treatment of cancer in prior decades. However, despite a marked increase in our understanding ofcell and molecular mechanisms underlying the neoplastic process, therapy for advanced disease remains limited. While the reasons for this are many, it is generally accepted that advanced neoplasms contain a relatively large number of genetic and molecularalterations contributingto the maintenanceofthe neoplastic process. Such a situation precludes easy pharmacologic intervention. However, our ability to detect cancer at an earlier stage, coupled with our increased understandingofcarcinogenesis, are propellingboth basic and clinical scientiststo pursue early intervention/chemopreventive approaches. This is based upon the notion that fewer molecularaberrations are presentearlyon inthedisease process. It also takes advantage ofthe fact that advances in both technology, and in the field ofcancer biology, coupled with a heightened vigilance, have increased our ability to detect early disease more readily. The chemopreventive approach is highly attractive for a number ofreasons. First, treatment ofpre-neoplastic, or early neoplastic, lesions would prevent the significant mobility and mortality associated with advanced neoplastic disorders.

Chemoprevention of Cancer

H.-J. Senn,Alberto Costa,Craig Jordan
Chemoprevention of Cancer Book PDF

Author : H.-J. Senn,Alberto Costa,Craig Jordan
Publisher : Springer Science & Business Media
Page : 183 pages
File Size : 53,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642599453

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Chemoprevention of Cancer by H.-J. Senn,Alberto Costa,Craig Jordan Pdf

Pharmacologic interventions to prevent the evolution of human cancers are still in its infancy, although a good number o- mostly controlled - clinical studies have been performed in the past two decades. However, regarding the partially stagnating therapeutic results of major epithelial cancer types such as breast-, lung-, colon- and ENT-cancer types, the problem of in terference with the evolution of disease at a preclinical level is an intriguing one, and the field seems to develop into one of the fastest growing domaines of modern oncology. This process is fa cilitated by the developments of molecular on co-genetics and the gowing existence of family cancer units, allowing to better identi fy and inform respective high risk groups, thus enabling re searchers and clinicians to more realistically target their chemo preventive efforts to the true populations at risk. On this changing background, the newly formed International Society of Cancer Chemoprevention (ISCaC) together with the Swiss Cancer League and the Interdisciplinary Oncology Center of St. Gallen/Switzerland organized an international Symposium in September 1997, inviting basic researchers, epidemiologists and clinical oncologists of related disciplines to discuss pertinent issues of experimental and clinical chemo- and bio-prevention in a scientific workshop.

Cancer Chemoprevention

Gary J. Kelloff,Ernest T. Hawk,Caroline C. Sigman
Cancer Chemoprevention Book PDF

Author : Gary J. Kelloff,Ernest T. Hawk,Caroline C. Sigman
Publisher : Springer Science & Business Media
Page : 1337 pages
File Size : 46,5 Mb
Release : 2004-06-04
Category : Medical
ISBN : 9781592597673

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Cancer Chemoprevention by Gary J. Kelloff,Ernest T. Hawk,Caroline C. Sigman Pdf

Accompanying CD-ROM in pocket at end of v. 2 contains a compact e-book version of v. 2.

Chemoprevention of Cancer

Daniel W. Nixon
Chemoprevention of Cancer Book PDF

Author : Daniel W. Nixon
Publisher : CRC Press
Page : 160 pages
File Size : 54,9 Mb
Release : 1994-11-08
Category : Medical
ISBN : 0849368502

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Chemoprevention of Cancer by Daniel W. Nixon Pdf

Chemoprevention of Cancer guides you through the exciting new field of cancer chemoprevention. It covers epidemiology, known chemopreventive compounds, development of new chemopreventive agents, specific examples of preventive agents and their mechanisms of action, and current prevention clinical trials.

Cancer Chemoprevention

Lee Wattenberg,Martin Lipkin,Charles W. Boone,Gary J. Kelloff
Cancer Chemoprevention Book PDF

Author : Lee Wattenberg,Martin Lipkin,Charles W. Boone,Gary J. Kelloff
Publisher : CRC Press
Page : 654 pages
File Size : 40,7 Mb
Release : 1992-08-20
Category : Medical
ISBN : 0849347157

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Cancer Chemoprevention by Lee Wattenberg,Martin Lipkin,Charles W. Boone,Gary J. Kelloff Pdf

The ultimate goal of cancer chemoprevention research and development is the identification of pharmaceutical or dietary constituents that will prevent cancer. Cancer Chemoprevention presents the proceedings of a large workshop on cancer chemoprevention that highlights the latest knowledge in the field, in addition to issues and ideas concerning future directions. Retinoids, sulfur compounds, and a large number of many naturally occurring cancer inhibitors in the diet are discussed, including green tea, garlic constituents, citrus fruit oils, and beans and seeds containing protease inhibitors. Compounds that may prevent the formation of carcinogens in food are covered, and the mechanisms by which chemical or dietary agencts produce cancer inhibitors are discussed.

Critical Dietary Factors in Cancer Chemoprevention

Mohammad Fahad Ullah,Aamir Ahmad
Critical Dietary Factors in Cancer Chemoprevention Book PDF

Author : Mohammad Fahad Ullah,Aamir Ahmad
Publisher : Springer
Page : 373 pages
File Size : 46,9 Mb
Release : 2015-10-06
Category : Science
ISBN : 9783319214610

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Critical Dietary Factors in Cancer Chemoprevention by Mohammad Fahad Ullah,Aamir Ahmad Pdf

This book focuses on the prophylactic potential of diet-derived factors in primary prevention of cancer. It is written by a group of highly reputed experts in the area of dietary agents and cancer chemoprevention. The translational potential of dietary factors from epidemiological, laboratory and clinical studies as prevention strategy in normal and risk populations is highlighted. The work presents options of routine inclusion of specific dietary regimens for prevention as well as therapeutic strategy for better management through adjuvant interventions in cancer treatment.

Cancer and Chemoprevention: An Overview

Summya Rashid
Cancer and Chemoprevention An Overview Book PDF

Author : Summya Rashid
Publisher : Springer
Page : 173 pages
File Size : 54,6 Mb
Release : 2017-07-05
Category : Medical
ISBN : 9789811025792

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Cancer and Chemoprevention: An Overview by Summya Rashid Pdf

This book focuses on the most recent, relevant, comprehensive and significant advances in cancer and chemo prevention. It broadly discusses cancer, its hallmarks and classification, molecular mechanisms of outbreak, contributing factors, role of oxidative stress, inflammatory mediators and evading apoptosis, which leads to the progression of disease. Though modern medicine has left us with no option to treat this deadly disease due to drawbacks associated with conventional treatment – like its non-targeted nature, drug resistance, varied organ toxicities and unaffordability – chemoprevention offers a viable therapeutic window. Given chemoprevention’s importance in the present scenario, the book highlights various chemo preventive strategies currently used in the management of cancer; a selection of novel chemo preventive agents used at clinics and in the pre-clinical stage; hurdles to effective chemoprevention; future prospects and the road ahead. It offers a valuable guide for all graduate students and researchers seeking information on cancer and chemoprevention in general, irrespective of the specific type/pathways involved in its onset.

Chemoprevention in Cancer Control

Matti Hakama
Chemoprevention in Cancer Control Book PDF

Author : Matti Hakama
Publisher : Unknown
Page : 164 pages
File Size : 46,6 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015036051004

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Chemoprevention in Cancer Control by Matti Hakama Pdf

This book is a collection of discussions and presentations made by leading experts during a workshop to review the results of recent empirical studies on the effectiveness of chemopreventive agents on the reduction of cancer risk. The topics selected were intended to cover the main areas of research in this field over the last 5-10 years, as well as important issues concerning the design of research studies, cost-effectiveness of chemoprevention, and ethical concerns. A set of conclusions and recommendations are included to provide a guide to formulating future public health policy and research strategy.

Cancer Chemoprevention and Treatment by Diet Therapy

William C.S. Cho
Cancer Chemoprevention and Treatment by Diet Therapy Book PDF

Author : William C.S. Cho
Publisher : Springer Science & Business Media
Page : 316 pages
File Size : 40,7 Mb
Release : 2014-07-08
Category : Medical
ISBN : 9789400764439

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Cancer Chemoprevention and Treatment by Diet Therapy by William C.S. Cho Pdf

Cancer is one of the leading killers in the world and the incidence is increasing, but most cancer patients and cancer survivors suffer much from the disease and its conventional treatments’ side effects. In the past, clinical data showed that some complementary and alternative medicine (CAM) possessed anticancer abilities, but some clinicians and scientists have queried about the scientific validity of CAM due to the lack of scientific evidence. There is great demand in the knowledge gap to explore the scientific and evidence-based knowledge of CAM in the anticancer field. With this aim, a book series is needed to structurally deliver the knowledge to readers. Throughout the past few years, the cancer chemopreventive potencies and treatment effects of a number of natural dietary agents present in different food sources have been evaluated by various experiments. Some of them have progressed to early clinical trials. This volume is a specialized book presenting the research evidence relevant to the use of specific diet therapy in cancer chemoprevention and treatment. We begin with lessons learned from dietary resveratrol as an effective agent with anticancer properties against malignancies, followed examples of flavonoids from fruits and vegetables in the prevention and treatment of cancer. Evidence for the beneficial influence of diet enriched with flax seed oil and green tea on cancer will be reviewed. Soy food intake may enhance the effects on anticancer treatment for breast cancer, whereas lycopene-rich foods may possess chemopreventive efficacy. There are also discussions on the contribution of the cancer preventive effects of the antioxidant-rich foods and Mediterranean diet. In addition, the modulation of proteasome pathways by nutraceuticals is highlighted. Finally, we close the book with a discussion on the attenuation of cell survival signaling by bioactive phytochemicals in the prevention and therapy cancer.

Principles of Chemoprevention

B. W. Stewart,Bernard W. Stewart,D. McGregor,Paul Kleihues
Principles of Chemoprevention Book PDF

Author : B. W. Stewart,Bernard W. Stewart,D. McGregor,Paul Kleihues
Publisher : Unknown
Page : 364 pages
File Size : 50,5 Mb
Release : 1996
Category : Medical
ISBN : UCSD:31822023273584

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Principles of Chemoprevention by B. W. Stewart,Bernard W. Stewart,D. McGregor,Paul Kleihues Pdf

The result of the discussion of leading experts in the field of chemoprevention aimed at generating guidelines for the evaluation of putative strategies for chemoprevention for the forthcoming IARC Handbooks of Cancer Prevention. The resulting guidelines are presented in this book as a consensus document, alongside 27 authored papers dealing with topical issues in this exciting area of research.

Cancer Epidemiology and Prevention

David Schottenfeld,Joseph F. Fraumeni Jr.
Cancer Epidemiology and Prevention Book PDF

Author : David Schottenfeld,Joseph F. Fraumeni Jr.
Publisher : Oxford University Press
Page : 1416 pages
File Size : 42,5 Mb
Release : 2006-08-24
Category : Medical
ISBN : 0199747970

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Cancer Epidemiology and Prevention by David Schottenfeld,Joseph F. Fraumeni Jr. Pdf

This much anticipated Third Edition provides a comprehensive presentation of the global burden and patterns of cancer occurrence, along with new developments in our understanding of cancer causation and prevention. Special attention is given to epidemiologic approaches that incorporate molecular biomarkers based on genomic and other emerging technologies, providing new insights into the role of genetic predisposition and gene-environment interactions in cancer induction. In addition, new chapters are included on social class disparities in cancer incidence and mortality, the role of obesity and physical inactivity in cancer etiology, the potential effects of electromagnetic fields and rediofrequency radiation, and the principles of cancer chemoprevention. The textbook is organized into five sections: Basic Concepts; The Magnitude of Cancer; The Causes of Cancer; Cancer by Tissue of Origin; Cancer Prevention and Control. In this new edition, Drs. David Schottenfeld and Joseph F. Fraumeni, Jr. have enlisted three distinguished Associate Editors: Drs. Jonathan Samet of Johns Hopkins University, Graham Colditz of Harvard University and Alice Whittemore of Stanford University.