Cancer Genetics For The Clinician

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Cancer Genetics for the Clinician

Gail L. Shaw
Cancer Genetics for the Clinician Book PDF

Author : Gail L. Shaw
Publisher : Springer Science & Business Media
Page : 209 pages
File Size : 45,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461546993

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Cancer Genetics for the Clinician by Gail L. Shaw Pdf

Cancer genetics is a quickly growing field within oncology. The ability to identify individuals at high risk for cancer improves the chance of early prevention and detection of cancer. The results of genetic testing affect quality of life, employment, and ability to be insured. This volume will provide an overview of cancer genetics, inherited cancer susceptibility, and available services and testing, including both the risks and benefits of testing. Some of the topics covered include: genetics of breast and ovarian cancer, testing minors for inherited cancer risk, chemoprevention of heritable cancer risk, genetics of colorectal cancer, insurance issues in genetic testing for cancer, ethical and legal issues in genetic testing for cancer susceptibility, testing for breast cancer risk in the Ashkenazim, estimating individualized risk of breast cancer, genetic counseling for the individual with inherited cancer susceptibility, and components of a genetic cancer risk clinic. While heritable cancers account for between five and ten percent of all cancer cases, molecular alterations attributable to specific inherited cancer susceptibility may give us important clues into the mechanism by which cancer occurs, not only in predisposed individuals, but also for sporadic cases.

Principles of Clinical Cancer Genetics

Daniel C. Chung,Daniel A. Haber
Principles of Clinical Cancer Genetics Book PDF

Author : Daniel C. Chung,Daniel A. Haber
Publisher : Springer Science & Business Media
Page : 234 pages
File Size : 40,7 Mb
Release : 2010-07-20
Category : Medical
ISBN : 9780387938462

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Principles of Clinical Cancer Genetics by Daniel C. Chung,Daniel A. Haber Pdf

Advances in genetics are transforming estimates of an individual’s risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a complex clinical, scientific and social challenge. This textbook, by leading experts at Massachusetts General Hospital Cancer Center, highlights the current understanding of the genetics of hereditary cancers of the breast, ovary, colorectum, stomach, pancreas, kidney, skin, and endocrine organs. Practical guidelines for the use of genetic testing, cancer screening and surveillance, prophylactic surgery, and promising targeted therapeutic agents are discussed. In addition, ongoing research involving genome-wide screens to identify novel modest risk-associated genetic loci are explored, along with new approaches to the application of genetic markers in guiding therapeutic options.

Medical Genetics for the Modern Clinician

Judith A. Westman
Medical Genetics for the Modern Clinician Book PDF

Author : Judith A. Westman
Publisher : Lippincott Williams & Wilkins
Page : 218 pages
File Size : 51,9 Mb
Release : 2006
Category : Medical
ISBN : 0781757606

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Medical Genetics for the Modern Clinician by Judith A. Westman Pdf

Medical Genetics for the Modern Clinician is a concise, clinically oriented introductory genetics text for medical and allied health students, residents, and clinicians. The book focuses sharply on concepts that are most applicable to clinical practice. Ethics sections in each chapter discuss ethical issues facing today's practitioner, such as counseling, risk assessment, and testing. More than 120 illustrations help students visualize concepts. Each chapter ends with USMLE-style review questions. Appendices include a glossary and a Table of Genes that lists all genes covered in the text by chapter. Faculty resources, case studies, and downloadable full-color images will be available on connection.LWW.com/go/westman.

Cancer Genomics for the Clinician

Ramaswamy Govindan, MD,Ashiq Masood, MD
Cancer Genomics for the Clinician Book PDF

Author : Ramaswamy Govindan, MD,Ashiq Masood, MD
Publisher : Springer Publishing Company
Page : 184 pages
File Size : 47,8 Mb
Release : 2019-01-28
Category : Medical
ISBN : 9780826168689

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Cancer Genomics for the Clinician by Ramaswamy Govindan, MD,Ashiq Masood, MD Pdf

Cancer Genomics for the Clinician is a practical guide to cancer genomics and its application to cancer diagnosis and care. The book begins with a brief overview of the various types of genetic alterations that are encountered in cancer, followed by accessible and applicable information on next generation sequencing technology and bioinformatics; tumor heterogeneity; whole genome, exome, and transcriptome sequencing; epigenomics; and data analysis and interpretation. Each chapter provides essential explanations of concepts, terminology, and methods. Also included are tips for interpreting and analyzing molecular data, as well as a discussion of molecular predictors for targeted therapies covering hematologic malignancies and solid tumors. The final chapter explains the use of FDA-approved genomic-based targeted therapies for breast cancer, lung cancer, sarcomas, gastrointestinal cancers, urologic cancers, head and neck cancer, thyroid cancer, and many more. Assembled in an accessible format specifically designed for the non-expert, this book provides the clinical oncologist, early career practitioner, and trainee with an essential understanding of the molecular and genetic basis of cancer and the clinical aspects that have led to advancements in diagnosis and treatment. With this resource, physicians and trainees will increase their breadth of knowledge and be better equipped to educate patients and families who want to know more about their genetic predispositions to cancer and the targeted therapies that could be considered and prescribed. Key Features: Describes how cancer genomics and next generation sequencing informs cancer screening, risk factors, therapeutic options, and clinical management across cancer types Explains what mutations are, what tests are needed, and how to interpret the results Provides information on FDA-approved targeted therapies that are being used in the clinic Covers different sequencing platforms and technologies and how they perform in research settings Includes access to the fully searchable eBook

Cancer Genetics: A Clinical Approach

Xavier Llor,Erin Wysong Hofstatter
Cancer Genetics A Clinical Approach Book PDF

Author : Xavier Llor,Erin Wysong Hofstatter
Publisher : McGraw Hill Professional
Page : 474 pages
File Size : 53,7 Mb
Release : 2021-11-19
Category : Medical
ISBN : 9781260440287

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Cancer Genetics: A Clinical Approach by Xavier Llor,Erin Wysong Hofstatter Pdf

The ultimate guide to caring for and communicating with patients suffering with hereditary cancer syndromes Providing the essential tools needed to understand clinical cancer genetics, Cancer Genetics: A Clinical Approach builds your mastery of differential diagnosis formulation, all the available genetic testing options at your disposal, interpreting results logically and accurately, and educating patients and their families about effective cancer prevention methods. This unparalleled resource walks you through the process of effectively and thoughtfully counseling patients—from pre-test counseling and relaying test results to navigating the legal implications of hereditary conditions and coping with the resulting psychological challenges. Cancer Genetics: A Clinical Approach is ideal for both specialized cancer genetics clinics or any healthcare professional seeking to improve their skills in identifying patients with possible hereditary cancer syndromes and recognizing which ones should be referred to a high-risk/clinical genetics specialty program.

A Practical Guide to Human Cancer Genetics

Shirley V. Hodgson,William D. Foulkes,Charis Eng,Eamonn R. Maher
A Practical Guide to Human Cancer Genetics Book PDF

Author : Shirley V. Hodgson,William D. Foulkes,Charis Eng,Eamonn R. Maher
Publisher : Springer Science & Business Media
Page : 420 pages
File Size : 45,6 Mb
Release : 2013-11-22
Category : Medical
ISBN : 9781447123750

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A Practical Guide to Human Cancer Genetics by Shirley V. Hodgson,William D. Foulkes,Charis Eng,Eamonn R. Maher Pdf

This is a comprehensive and up-to-date guide to the diagnosis, clinical features and management of inherited disorders conferring cancer susceptibility. It is fully updated with much molecular, screening and management information. It covers risk analysis and genetic counselling for individuals with a family history of cancer. It also discusses predictive testing and the organisation of the cancer genetics service. There is information about the genes causing Mendelian cancer predisposing conditions and their mechanism of action. It aims to provide such details in a practical format for geneticists and clinicians in all disciplines.

A Guide to Cancer Genetics in Clinical Practice

Sue Clark,
A Guide to Cancer Genetics in Clinical Practice Book PDF

Author : Sue Clark,
Publisher : tfm Publishing Limited
Page : 246 pages
File Size : 53,7 Mb
Release : 2009-05-01
Category : Medical
ISBN : 9781908986337

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A Guide to Cancer Genetics in Clinical Practice by Sue Clark, Pdf

FIRST PRIZE Winner in the Oncology category of the 2010 BMA Medical Book Competition. Intensive research over the last fifteen years has yielded a vast expansion in our understanding of the role of inheritance and genetics in a variety of cancers. Several inherited conditions have been identified which result in a high risk of various cancers; some of these were previously recognized, but the genetic basis underlying them has now been elucidated. This knowledge is now entering the sphere of routine clinical care. Surgeons, gastroenterologists, gynaecologists, oncologists, endocrinologists and many others need an awareness of these disorders, an understanding of genetic testing and when it is indicated, and how to manage patients with inherited cancer predisposition and their families. This book covers the basic concepts of cancer genetics. The common inherited cancer syndromes are each dealt with in greater depth, with the current management outlined. This book is aimed at all clinicians who may encounter these conditions in their practice. It aims to facilitate identification of high-risk individuals and families, to inform interaction with geneticists and other subspecialists, to provide a basis for patient management and to stimulate interest in these fascinating conditions.

Cancer Principles and Practice of Oncology: Handbook of Clinical Cancer Genetics

Ellen Matloff
Cancer Principles and Practice of Oncology Handbook of Clinical Cancer Genetics Book PDF

Author : Ellen Matloff
Publisher : Lippincott Williams & Wilkins
Page : 348 pages
File Size : 46,5 Mb
Release : 2013-03-25
Category : Medical
ISBN : 9781469833880

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Cancer Principles and Practice of Oncology: Handbook of Clinical Cancer Genetics by Ellen Matloff Pdf

This practical, user-friendly guidebook will allow the clinician to search under disease site for the hereditary cancer syndromes relevant for his/her patient's cancer. For example, a gynecologist oncologist whose patient has ovarian cancer can turn to the Ovary chapter and quickly read a summary of all of the hereditary cancer syndromes that include ovarian cancer. She can learn the questions she should be asking when expanding that patient's personal and family history, which genes are most relevant, whether to refer that patient on for genetic counseling and testing, and how to manage that patient long-term if the patient is mutation positive or negative. The same holds true for the practicing oncologist, surgeon, urologist, endocrinologist, gynecologist, primary care physician, physician's assistant, advanced practice nurse and any other clinician seeing a patient who has had cancer. This guidebook also contains an overview article on genetic counseling and testing and several in depth articles on issues that are up and coming in the field of hereditary cancer.

Hereditary Colorectal Cancer

Laura Valle,Stephen B. Gruber,Gabriel Capellá
Hereditary Colorectal Cancer Book PDF

Author : Laura Valle,Stephen B. Gruber,Gabriel Capellá
Publisher : Springer
Page : 505 pages
File Size : 55,7 Mb
Release : 2018-05-04
Category : Medical
ISBN : 9783319742595

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Hereditary Colorectal Cancer by Laura Valle,Stephen B. Gruber,Gabriel Capellá Pdf

This book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.

Clinical Precision Medicine

Judy S. Crabtree
Clinical Precision Medicine Book PDF

Author : Judy S. Crabtree
Publisher : Academic Press
Page : 114 pages
File Size : 50,6 Mb
Release : 2019-11-15
Category : Medical
ISBN : 9780128204023

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Clinical Precision Medicine by Judy S. Crabtree Pdf

Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care. Contributions by Stephanie Kramer, a Clinical Genetic Counselor, also provide current information on prenatal diagnostics and adult genetics that highlight the critical role of genetic counselors in the era of precision medicine. Includes applied discussions of chromosomes and chromosomal abnormalities, molecular genetics, epigenetic regulation, heredity, clinical genetics, pharmacogenomics and immunogenomics Features chapter contributions from leaders in the field Consolidates fundamental concepts and current practices of precision medicine in one convenient resource

Clinical Cancer Genetics

Kenneth Offit
Clinical Cancer Genetics Book PDF

Author : Kenneth Offit
Publisher : Wiley-Blackwell
Page : 452 pages
File Size : 47,8 Mb
Release : 2030-05-07
Category : Medical
ISBN : 0471458937

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Clinical Cancer Genetics by Kenneth Offit Pdf

Written by a world-recognized leader in this emerging field, Clinical Cancer Genetics provides an updated and expanded treatment of Kenneth Offit's seminal text on the clinical management associated with syndromes of cancer predisposition, with a thorough review of the relevant molecular genetics. This second edition features new coverage of pharmacogenetics, gene therapy trials, high throughput genotyping, and microarrays and includes a new focus on epigenetic events in carcinogenesis within background chapter on cancer genetics. Expanded coverage highlights more uncommon and rare cancer predisposition syndromes.

A Practical Guide to Human Cancer Genetics

S. V. Hodgson,E. R. Maher
A Practical Guide to Human Cancer Genetics Book PDF

Author : S. V. Hodgson,E. R. Maher
Publisher : Cambridge University Press
Page : 258 pages
File Size : 44,6 Mb
Release : 1993-02-25
Category : Medical
ISBN : 0521409519

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A Practical Guide to Human Cancer Genetics by S. V. Hodgson,E. R. Maher Pdf

This extensively up-dated and expanded edition provides the busy clinician with an essential overview of the latest developments in human cancer genetics - an area that has made significant advances since publication of the first edition. The opening section presents the principles of cancer genetics and introduces the basic concepts and mechanisms of tumorigenesis and inherited predisposition to cancer. The second part of the book provides information, on a systems basis, on the incidence, significance and management of predisposition to individual cancers. The final section then deals with specific inherited cancer syndromes, giving practical guidance on clinical investigation, screening and management of affected patients and relatives at risk. Up-to-date details of the genetic mapping of inherited cancer syndromes and the molecular genetic changes in individual cancers are also provided. Finally, an appendix provides a helpful revision guide to the fundamental principles of genetics. This practical and clear account will benefit clinicians and research workers in oncology, genetics, surgery and general medicine.

A Practical Guide to Human Cancer Genetics

Shirley V. Hodgson,Eamonn R. Maher
A Practical Guide to Human Cancer Genetics Book PDF

Author : Shirley V. Hodgson,Eamonn R. Maher
Publisher : Cambridge University Press
Page : 354 pages
File Size : 55,6 Mb
Release : 1999-07-22
Category : Medical
ISBN : 0521649617

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A Practical Guide to Human Cancer Genetics by Shirley V. Hodgson,Eamonn R. Maher Pdf

This extensively updated and expanded edition provides the busy clinician with an essential overview of the latest developments in human cancer genetics--an area that has made significant advances since publication of the first edition. The opening section presents the principles of cancer genetics and introduces the basic concepts and mechanisms of tumorigenesis and inherited predisposition to cancer. The second part of the book provides information, on a systems basis, on the incidence, significance and management of predisposition to individual cancers. The final section deals with specific inherited cancer syndromes, giving practical guidance on clinical investigation, screening and management of affected patients and relatives at risk. The authors also provide up-to-date details of the genetic mapping of inherited cancer syndromes and the molecular genetic changes in individual cancers. Finally, an appendix provides a helpful revision guide to the fundamental principles of genetics. This practical and clear account will benefit clinicians and research workers in oncology, genetics, surgery and general medicine.

New Clinical Genetics, fourth edition

Andrew Read,Dian Donnai
New Clinical Genetics fourth edition Book PDF

Author : Andrew Read,Dian Donnai
Publisher : Scion Publishing Ltd
Page : 470 pages
File Size : 53,8 Mb
Release : 2020-10-23
Category : Medical
ISBN : 9781911510741

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New Clinical Genetics, fourth edition by Andrew Read,Dian Donnai Pdf

New Clinical Genetics continues to offer the most innovative case-based approach to investigation, diagnosis, and management in genomic medicine. New Clinical Genetics is used worldwide as a textbook for medical students, but also as an essential guide to the field for genetic counselors, physician assistants, clinical and nurse geneticists, and students studying healthcare courses allied to medicine. Readers love the integrated case-based approach which ties the science to real-life clinical scenarios to really aid understanding. Clinical genetics is a fast-moving field and there have been many advances in the few years since the previous edition was published. This 4th edition has been completely updated and revised to reflect new science, new techniques and new ways of thinking. Nowhere is this more clear than in the chapter discussing genetics services which is now significantly expanded to reflect the increasing role of genomic medicine and the use of multidisciplinary teams in the management of patients with genetic disorders. The unique case-based structure and format remains the same, but substantial new material has been added to cover: polygenic risk scores – now starting to become useful clinical service tools preimplantation diagnosis noninvasive prenatal diagnosis companion diagnostics for prescribed drugs liquid biopsies in cancer epigenetics and gene regulation the widespread use of next-generation sequencing as a routine diagnostic tool the checking of a patient’s whole exome for the cause of their problem

Inherited Susceptibility to Cancer

William D. Foulkes,Shirley V. Hodgson
Inherited Susceptibility to Cancer Book PDF

Author : William D. Foulkes,Shirley V. Hodgson
Publisher : Cambridge University Press
Page : 480 pages
File Size : 53,6 Mb
Release : 1998-06-28
Category : Medical
ISBN : 0521563402

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Inherited Susceptibility to Cancer by William D. Foulkes,Shirley V. Hodgson Pdf

Many cancers, both common and rare, are known to have a hereditary predisposition and advances in genetics have clarified the risks and in some cases the mechanisms of cancer developing in an individual. First published in 1998, this important contribution to the literature of cancer genetics covers all the key issues, reviewing both the technology behind genetic risk assessment and the ethical dilemmas it poses. It is divided into two parts. The first deals with ethical, legal and social issues. The second systematically outlines current knowledge of the inheritance patterns of many different cancer types, both from a site-by-site perspective and for special groups. This authoritative volume will be of interest to oncologists, physicians and surgeons in other specialities and to health professionals in the areas of primary care, counselling and cancer risk assessment.