Cardiac Electrophysiology Methods And Models

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Cardiac Electrophysiology Methods and Models

Author : Daniel C. Sigg,Paul A. Iaizzo,Yong-Fu Xiao,Bin He
Publisher : Springer Science & Business Media
Page : 492 pages
File Size : 40,7 Mb
Release : 2010-09-11
Category : Medical
ISBN : 9781441966582

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Cardiac Electrophysiology Methods and Models by Daniel C. Sigg,Paul A. Iaizzo,Yong-Fu Xiao,Bin He Pdf

Cardiovascular disease is the major cause of mortality and morbidity in the Western Hemisphere. While significant progress has been made in treating a major sub-category of cardiac disease, arrhythmias, significant unmet needs remain. In particular, every day, thousands of patients die because of arrhythmias in the US alone, and atrial fibrillation is the most common arrhythmia affecting millions of patients in the US alone at a given time. Therefore, there is a public need to continue to develop new and better therapies for arrhythmias. Accordingly, an ever increasing number of biomedical, pharmaceutical, and medical personnel is interested in studying various aspects of arrhythmias at a basic, translational, and applied level, both in industry (ie Biotech, Pharmaceutical and device), and in academia. Not only has our overall understanding of molecular bases of disease dramatically increased, but so has the number of available and emerging molecular, pharmacological or device treatment based therapies. This practical, state-of-the art handbook will summarize and review key research methods and protocols, their advantages and pitfalls, with a focus on practical implementation, and collaborative cross-functional research. The volume will include visual and easy-to-use graphics, bulleted summaries, boxed summary paragraphs, links to reference websites, equipment manufacturers where appropriate, photographs of typical experimental setups and so forth, to keep this book very focused on practical methods and implementation, and yet, provide enough theory that the principles are clearly understood and can be easily applied.

Mathematical Cardiac Electrophysiology

Author : Piero Colli Franzone,Luca Franco Pavarino,Simone Scacchi
Publisher : Springer
Page : 397 pages
File Size : 54,8 Mb
Release : 2014-10-30
Category : Mathematics
ISBN : 9783319048017

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Mathematical Cardiac Electrophysiology by Piero Colli Franzone,Luca Franco Pavarino,Simone Scacchi Pdf

This book covers the main mathematical and numerical models in computational electrocardiology, ranging from microscopic membrane models of cardiac ionic channels to macroscopic bidomain, monodomain, eikonal models and cardiac source representations. These advanced multiscale and nonlinear models describe the cardiac bioelectrical activity from the cell level to the body surface and are employed in both the direct and inverse problems of electrocardiology. The book also covers advanced numerical techniques needed to efficiently carry out large-scale cardiac simulations, including time and space discretizations, decoupling and operator splitting techniques, parallel finite element solvers. These techniques are employed in 3D cardiac simulations illustrating the excitation mechanisms, the anisotropic effects on excitation and repolarization wavefronts, the morphology of electrograms in normal and pathological tissue and some reentry phenomena. The overall aim of the book is to present rigorously the mathematical and numerical foundations of computational electrocardiology, illustrating the current research developments in this fast-growing field lying at the intersection of mathematical physiology, bioengineering and computational biomedicine. This book is addressed to graduate student and researchers in the field of applied mathematics, scientific computing, bioengineering, electrophysiology and cardiology.

Computational Methods in Cardiac Electrophysiology

Author : Matthijs Cluitmans,Richard David Walton,Gernot Plank
Publisher : Frontiers Media SA
Page : 229 pages
File Size : 47,9 Mb
Release : 2023-07-06
Category : Science
ISBN : 9782832529256

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Computational Methods in Cardiac Electrophysiology by Matthijs Cluitmans,Richard David Walton,Gernot Plank Pdf

Josephson's Clinical Cardiac Electrophysiology

Author : Callans, David
Publisher : Lippincott Williams & Wilkins
Page : 2034 pages
File Size : 55,5 Mb
Release : 2023-09-19
Category : Medical
ISBN : 9781975201173

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Josephson's Clinical Cardiac Electrophysiology by Callans, David Pdf

Widely regarded as the premier text in this complex field, Josephson’s Clinical Cardiac Electrophysiology, Seventh Edition, provides a thorough understanding of the mechanisms of cardiac arrhythmias and the therapeutic interventions used to treat them. Dr. David J. Callans, personally chosen and trained by Dr. Mark Josephson, provides expert clinical insights and superb illustrations that highlight proven approaches and methods. With its strong focus on physiologic investigation and its role in clinical decision making, this comprehensive text is a must-have reference for cardiology fellows, electrophysiologists, and others in the EP lab.

Multiscale Modeling of Cardiac Electrophysiology: Adaptation to Atrial and Ventricular Rhythm Disorders and Pharmacological Treatment

Author : Mathias Wilhelms
Publisher : KIT Scientific Publishing
Page : 206 pages
File Size : 54,6 Mb
Release : 2014-05-22
Category : Technology & Engineering
ISBN : 9783731500452

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Multiscale Modeling of Cardiac Electrophysiology: Adaptation to Atrial and Ventricular Rhythm Disorders and Pharmacological Treatment by Mathias Wilhelms Pdf

Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.AbstractEnglisch = Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.

Cardiac Electrophysiology: From Cell to Bedside E-Book

Author : Douglas P. Zipes,Jose Jalife,William Gregory Stevenson
Publisher : Elsevier Health Sciences
Page : 1429 pages
File Size : 41,8 Mb
Release : 2017-05-13
Category : Medical
ISBN : 9780323448888

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Cardiac Electrophysiology: From Cell to Bedside E-Book by Douglas P. Zipes,Jose Jalife,William Gregory Stevenson Pdf

Rapid advancements in cardiac electrophysiology require today’s health care scientists and practitioners to stay up to date with new information both at the bench and at the bedside. The fully revised 7th Edition of Cardiac Electrophysiology: From Cell to Bedside, by Drs. Douglas Zipes, Jose Jalife, and William Stevenson, provides the comprehensive, multidisciplinary coverage you need, including the underlying basic science and the latest clinical advances in the field. An attractive full-color design features color photos, tables, flow charts, ECGs, and more. All chapters have been significantly revised and updated by global leaders in the field, including 19 new chapters covering both basic and clinical topics. New topics include advances in basic science as well as recent clinical technology, such as leadless pacemakers; catheter ablation as a new class I recommendation for atrial fibrillation after failed medical therapy; current cardiac drugs and techniques; and a new video library covering topics that range from basic mapping (for the researcher) to clinical use (implantations). Each chapter is packed with the latest information necessary for optimal basic research as well as patient care, and additional figures, tables, and videos are readily available online. New editor William G. Stevenson, highly regarded in the EP community, brings a fresh perspective to this award-winning text. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.

Functional Imaging and Modelling of the Heart

Author : Mihaela Pop,Graham A Wright
Publisher : Springer
Page : 517 pages
File Size : 40,8 Mb
Release : 2017-05-22
Category : Computers
ISBN : 9783319594484

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Functional Imaging and Modelling of the Heart by Mihaela Pop,Graham A Wright Pdf

This book constitutes the refereed proceedings of the 9th International Conference on Functional Imaging and Modeling of the Heart, held in Toronto, ON, Canada, in June 2017. The 48 revised full papers were carefully reviewed and selected from 63 submissions. The focus of the papers is on following topics: novel imaging and analysis methods for myocardial tissue characterization and remodeling; advanced cardiac image analysis tools for diagnostic and interventions; electrophysiology: mapping and biophysical modeling; biomechanics and flow: modeling and tissue property measurements.

Computational Cardiology

Author : Frank B. Sachse
Publisher : Springer
Page : 364 pages
File Size : 44,8 Mb
Release : 2005-01-12
Category : Medical
ISBN : 9783540259268

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Computational Cardiology by Frank B. Sachse Pdf

This book is devoted to computer-based modeling in cardiology, by taking an educational point of view, and by summarizing knowledge from several, commonly considered delimited areas of cardiac research in a consistent way. First, the foundations and numerical techniques from mathematics are provided, with a particular focus on the finite element and finite differences methods. Then, the theory of electric fields and continuum mechanics is introduced with respect to numerical calculations in anisotropic biological media. In addition to the presentation of digital image processing techniques, the following chapters deal with particular aspects of cardiac modeling: cardiac anatomy, cardiac electro physiology, cardiac mechanics, modeling of cardiac electro mechanics. This book was written for researchers in modeling and cardiology, for clinical cardiologists, and for advanced students.

Patient-Specific Modeling of the Cardiovascular System

Author : Roy C.P. Kerckhoffs
Publisher : Springer Science & Business Media
Page : 240 pages
File Size : 41,6 Mb
Release : 2010-09-03
Category : Science
ISBN : 9781441966919

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Patient-Specific Modeling of the Cardiovascular System by Roy C.P. Kerckhoffs Pdf

Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.

Clinical Cardiac Electrophysiology

Author : Mark E. Josephson
Publisher : Lippincott Williams & Wilkins
Page : 902 pages
File Size : 44,6 Mb
Release : 2002
Category : Medical
ISBN : 0683306936

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Clinical Cardiac Electrophysiology by Mark E. Josephson Pdf

The gold standard in electrophysiology, Dr. Josephson's book brings to light current relevant practices aimed at medical internists, clinical cardiologists, and electrophysiologists, emphasizing the capabilities and limitations of clinical cardiac electrophysiology techniques. Thoroughly revised, the Third Edition includes increased coverage of catheter ablation and the latest information on new catheters and computers that measure electrical activity in the heart. Full-color heart maps and illustrations of electrophysiologic concepts help clarify the text. A Brandon-Hill recommended title.

Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside

Author : Jose Jalife,William Gregory Stevenson
Publisher : Elsevier Health Sciences
Page : 1709 pages
File Size : 50,5 Mb
Release : 2021-12-16
Category : Medical
ISBN : 9780323757461

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Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside by Jose Jalife,William Gregory Stevenson Pdf

Fully updated from cover to cover, Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside, 8th Edition, provides the comprehensive, multidisciplinary coverage you need—from new knowledge in basic science to the latest clinical advances in the field. Drs. José Jalife and William Gregory Stevenson lead a team of global experts who provide cutting-edge content and step-by-step instructions for all aspects of cardiac electrophysiology. Packs each chapter with the latest information necessary for optimal basic research as well as patient care. Covers new technologies such as CRISPR, protein research, improved cardiac imaging, optical mapping, and wearable devices. Contains significant updates in the areas of molecular biology and genetics, iPSCs (induced pluripotent stem cells), embryonic stem cells, precision medicine, antiarrhythmic drug therapy, cardiac mapping with advanced techniques, and ablation technologies including stereotactic radioablation. Includes 47 new standalone chapters that are organized into discrete topics for improved access. Discusses extensive recent progress in the understanding, diagnosis, and management of arrhythmias, including new clinical insights on atrial fibrillation and stroke prevention, new advances in the understanding of ventricular arrythmias in genetic disease, and advances in implantable devises and infection management. Features 1,600 high-quality photographs, anatomic and radiographic images, electrocardiograms, tables, algorithms, and more., with additional figures, tables, and videos online. Recipient of a 2018 Highly Commended award from the British Medical Association.

Artificial Intelligence for Computational Modeling of the Heart

Author : Tommaso Mansi,Tiziano Passerini,Dorin Comaniciu
Publisher : Academic Press
Page : 274 pages
File Size : 47,8 Mb
Release : 2019-11-25
Category : Science
ISBN : 9780128168950

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Artificial Intelligence for Computational Modeling of the Heart by Tommaso Mansi,Tiziano Passerini,Dorin Comaniciu Pdf

Artificial Intelligence for Computational Modeling of the Heart presents recent research developments towards streamlined and automatic estimation of the digital twin of a patient’s heart by combining computational modeling of heart physiology and artificial intelligence. The book first introduces the major aspects of multi-scale modeling of the heart, along with the compromises needed to achieve subject-specific simulations. Reader will then learn how AI technologies can unlock robust estimations of cardiac anatomy, obtain meta-models for real-time biophysical computations, and estimate model parameters from routine clinical data. Concepts are all illustrated through concrete clinical applications. Presents recent advances in computational modeling of heart function and artificial intelligence technologies for subject-specific applications Discusses AI-based technologies for robust anatomical modeling from medical images, data-driven reduction of multi-scale cardiac models, and estimations of physiological parameters from clinical data Illustrates the technology through concrete clinical applications and discusses potential impacts and next steps needed for clinical translation

Functional Imaging and Modeling of the Heart

Author : Frank B. Sachse,Gunnar Seemann
Publisher : Springer
Page : 488 pages
File Size : 55,6 Mb
Release : 2007-05-31
Category : Computers
ISBN : 3540729062

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Functional Imaging and Modeling of the Heart by Frank B. Sachse,Gunnar Seemann Pdf

This book constitutes the refereed proceedings of the 4th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2007, held in Salt Lake City, UT, USA in June 2007. The contributions describe both experimental and computational studies and cover topics such as imaging and image analysis, cardiac electrophysiology, electro- and magnetocardiography, cardiac mechanics and clinical application, imaging and anatomical modeling.

Advanced HPC-based Computational Modeling in Biomechanics and Systems Biology

Author : Mariano Vázquez,Peter V. Coveney,Hernan Edgardo Grecco,Alfons Hoekstra,Bastien Chopard
Publisher : Frontiers Media SA
Page : 449 pages
File Size : 54,8 Mb
Release : 2019-04-04
Category : Electronic
ISBN : 9782889458172

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Advanced HPC-based Computational Modeling in Biomechanics and Systems Biology by Mariano Vázquez,Peter V. Coveney,Hernan Edgardo Grecco,Alfons Hoekstra,Bastien Chopard Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Experimental models and model organisms in cardiac electrophysiology: Opportunities and challenges

Author : Ruben Coronel,Igor R. Efimov,Fanny Vaillant,Chris Jopling,Yoram Etzion,Bianca J. J. M. Brundel,Jolanda Van Der Velden,Flavien Charpentier
Publisher : Frontiers Media SA
Page : 96 pages
File Size : 44,7 Mb
Release : 2023-10-05
Category : Science
ISBN : 9782832535233

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Experimental models and model organisms in cardiac electrophysiology: Opportunities and challenges by Ruben Coronel,Igor R. Efimov,Fanny Vaillant,Chris Jopling,Yoram Etzion,Bianca J. J. M. Brundel,Jolanda Van Der Velden,Flavien Charpentier Pdf