Multiscale Modeling Of Cardiac Electrophysiology Adaptation To Atrial And Ventricular Rhythm Disorders And Pharmacological Treatment

Author : Mathias Wilhelms
Publisher : KIT Scientific Publishing
Page : 206 pages
File Size : 54,8 Mb
Release : 2014-05-22
Category : Technology & Engineering
ISBN : 9783731500452

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Multiscale Modeling of Cardiac Electrophysiology: Adaptation to Atrial and Ventricular Rhythm Disorders and Pharmacological Treatment by Mathias Wilhelms Pdf

Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.AbstractEnglisch = Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.

Author : Nagel, Claudia
Publisher : KIT Scientific Publishing
Page : 280 pages
File Size : 41,5 Mb
Release : 2023-04-24
Category : Electronic
ISBN : 9783731512813

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Multiscale Cohort Modeling of Atrial Electrophysiology : Risk Stratification for Atrial Fibrillation through Machine Learning on Electrocardiograms by Nagel, Claudia Pdf

An early detection and diagnosis of atrial fibrillation sets the course for timely intervention to prevent potentially occurring comorbidities. Electrocardiogram data resulting from electrophysiological cohort modeling and simulation can be a valuable data resource for improving automated atrial fibrillation risk stratification with machine learning techniques and thus, reduces the risk of stroke in affected patients.

Author : Loewe, Axel
Publisher : KIT Scientific Publishing
Page : 344 pages
File Size : 41,6 Mb
Release : 2016-08-03
Category : Electronic
ISBN : 9783731505280

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Modeling Human Atrial Patho-Electrophysiology from Ion Channels to ECG - Substrates, Pharmacology, Vulnerability, and P-Waves by Loewe, Axel Pdf

Author : Sánchez Arciniegas, Jorge Patricio
Publisher : KIT Scientific Publishing
Page : 162 pages
File Size : 49,8 Mb
Release : 2022-05-30
Category : Medical
ISBN : 9783731511700

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A Multiscale In Silico Study to Characterize the Atrial Electrical Activity of Patients With Atrial Fibrillation : A Translational Study to Guide Ablation Therapy by Sánchez Arciniegas, Jorge Patricio Pdf

The atrial substrate undergoes electrical and structural remodeling during atrial fibrillation. Detailed multiscale models were used to study the effect of structural remodeling induced at the cellular and tissue levels. Simulated electrograms were used to train a machine-learning algorithm to characterize the substrate. Also, wave propagation direction was tracked from unannotated electrograms. In conclusion, in silico experiments provide insight into electrograms' information of the substrate.

Author : Pollnow, Stefan
Publisher : KIT Scientific Publishing
Page : 296 pages
File Size : 40,7 Mb
Release : 2019-04-23
Category : Electronic
ISBN : 9783731508861

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Characterizing Cardiac Electrophysiology during Radiofrequency Ablation : An Integrative Ex vivo, In silico, and In vivo Approach by Pollnow, Stefan Pdf

Author : Keller, Matthias
Publisher : KIT Scientific Publishing
Page : 266 pages
File Size : 49,6 Mb
Release : 2014-09-09
Category : Electronic
ISBN : 9783731502289

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Formation of Intracardiac Electrograms under Physiological and Pathological Conditions by Keller, Matthias Pdf

Author : Schulze, Walther H. W.
Publisher : KIT Scientific Publishing
Page : 238 pages
File Size : 43,5 Mb
Release : 2015-08-12
Category : Technology (General)
ISBN : 9783731503743

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ECG Imaging of Ventricular Activity in Clinical Applications by Schulze, Walther H. W. Pdf

ECG imaging was performed in humans to reconstruct ventricular activation patterns and localize their excitation origins. The precision of the non-invasive reconstructions was evaluated against invasive measurements and found to be in line with the state-of-the-art literature. Statistics were produced for various excitation origins and reveal the beat-to-beat robustness of the imaging method.

Author : Douglas P. Zipes,Jose Jalife,William Gregory Stevenson
Publisher : Elsevier Health Sciences
Page : 1429 pages
File Size : 40,5 Mb
Release : 2017-05-13
Category : Medical
ISBN : 9780323448888

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Cardiac Electrophysiology: From Cell to Bedside E-Book by Douglas P. Zipes,Jose Jalife,William Gregory Stevenson Pdf

Rapid advancements in cardiac electrophysiology require today’s health care scientists and practitioners to stay up to date with new information both at the bench and at the bedside. The fully revised 7th Edition of Cardiac Electrophysiology: From Cell to Bedside, by Drs. Douglas Zipes, Jose Jalife, and William Stevenson, provides the comprehensive, multidisciplinary coverage you need, including the underlying basic science and the latest clinical advances in the field. An attractive full-color design features color photos, tables, flow charts, ECGs, and more. All chapters have been significantly revised and updated by global leaders in the field, including 19 new chapters covering both basic and clinical topics. New topics include advances in basic science as well as recent clinical technology, such as leadless pacemakers; catheter ablation as a new class I recommendation for atrial fibrillation after failed medical therapy; current cardiac drugs and techniques; and a new video library covering topics that range from basic mapping (for the researcher) to clinical use (implantations). Each chapter is packed with the latest information necessary for optimal basic research as well as patient care, and additional figures, tables, and videos are readily available online. New editor William G. Stevenson, highly regarded in the EP community, brings a fresh perspective to this award-winning text. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.

Author : Anonim
Publisher : Academic Press
Page : 2972 pages
File Size : 43,9 Mb
Release : 2015-08-07
Category : Science
ISBN : 9780123947963

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Encyclopedia of Cell Biology by Anonim Pdf

The Encyclopedia of Cell Biology, Four Volume Set offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences. Fully annotated color images and videos for full comprehension of concepts, with layered content for readers from different levels of experience Includes information on cytokinesis, cell biology, cell mechanics, cytoskeleton dynamics, stem cells, prokaryotic cell biology, RNA biology, aging, cell growth, cell Injury, and more In-depth linking to Academic Press/Elsevier content and additional links to outside websites and resources for further reading A one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences

Author : Sabine Attinger,Petros Koumoutsakos
Publisher : Springer Science & Business Media
Page : 304 pages
File Size : 45,9 Mb
Release : 2004-07-12
Category : Mathematics
ISBN : 3540211802

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Multiscale Modelling and Simulation by Sabine Attinger,Petros Koumoutsakos Pdf

In August 2003, ETHZ Computational Laboratory (CoLab), together with the Swiss Center for Scientific Computing in Manno and the Università della Svizzera Italiana (USI), organized the Summer School in "Multiscale Modelling and Simulation" in Lugano, Switzerland. This summer school brought together experts in different disciplines to exchange ideas on how to link methodologies on different scales. Relevant examples of practical interest include: structural analysis of materials, flow through porous media, turbulent transport in high Reynolds number flows, large-scale molecular dynamic simulations, ab-initio physics and chemistry, and a multitude of others. Though multiple scale models are not new, the topic has recently taken on a new sense of urgency. A number of hybrid approaches are now created in which ideas coming from distinct disciplines or modelling approaches are unified to produce new and computationally efficient techniques.

Author : Peter Pivonka
Publisher : Springer
Page : 287 pages
File Size : 46,9 Mb
Release : 2017-06-20
Category : Science
ISBN : 9783319588452

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Multiscale Mechanobiology of Bone Remodeling and Adaptation by Peter Pivonka Pdf

The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.

Author : Michel R. Labrosse
Publisher : CRC Press
Page : 386 pages
File Size : 48,6 Mb
Release : 2018-09-13
Category : Medical
ISBN : 9781315280288

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Cardiovascular Mechanics by Michel R. Labrosse Pdf

The objective of this book is to illustrate in specific detail how cardiovascular mechanics stands as a common pillar supporting such different clinical successes as drugs for high blood pressure, prosthetic heart valves and coronary artery bypass grafting, among others. This information is conveyed through a comprehensive treatment of the overarching principles and theories that are behind mechanobiological processes, aortic and arterial mechanics, atherosclerosis, blood and microcirculation, hear valve mechanics, as well as medical devices and drugs. Examines all major theoretical and practical aspects of mechanical forces related to the cardiovascular system. Discusses a unique coverage of mechanical changes related to an aging cardiovascular system. Provides an overview of experimental methods in cardiovascular mechanics. Written by world-class researchers from Canada, the US and EU. Extensive references are provided at the end of each chapter to enhance further study. Michel R. Labrosse is the founder of the Cardiovascular Mechanics Laboratory at the University of Ottawa, where he is a full professor within the Department of Mechanical Engineering. He has been an active researcher in academia along with being heavily associated with the University of Ottawa Heart Institute. He has authored or co-authored over 90 refereed communications, and supervised or co-supervised over 40 graduate students and post-docs.

Author : Augustus Désiré Waller
Publisher : Unknown
Page : 168 pages
File Size : 40,9 Mb
Release : 1897
Category : Electrophysiology
ISBN : NYPL:33433081632469

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On Animal Electricity by Augustus Désiré Waller Pdf

Author : Hans G. Vogel,Wolfgang H. Vogel
Publisher : Springer Science & Business Media
Page : 790 pages
File Size : 40,6 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9783662033333

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Drug Discovery and Evaluation by Hans G. Vogel,Wolfgang H. Vogel Pdf

This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.

Author : David J. Christini,Trine Krogh-Madsen
Publisher : Unknown
Page : 0 pages
File Size : 49,8 Mb
Release : 2020
Category : Electrocardiography
ISBN : 0750320648

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Modeling and Simulating Cardiac Electrical Activity by David J. Christini,Trine Krogh-Madsen Pdf

This book provides a thorough introduction to the topic of mathematical modeling of electrical activity in the heart, from molecular details of ionic channel dynamics to clinically derived patient-specific models. It discusses how cellular ionic models are formulated, introduces commonly used models and explains why there are so many different models available. The chapters cover modeling of the intracellular calcium handling that underlies cellular contraction as well as modeling molecular-level details of cardiac ion channels, and also focus on specialized topics such as cardiomyocyte energetics and signalling pathways. It is an excellent resource for experienced and specialised researchers in the field, but also biological scientists with a limited background in mathematical modelling and computational methods. Part of Biophysical Society-IOP series.