Cardiac Energetics

Author : R. Jacob,Hanjoerg Just,C. Holubarsch
Publisher : Springer Science & Business Media
Page : 410 pages
File Size : 51,6 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9783662112892

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Cardiac Energetics by R. Jacob,Hanjoerg Just,C. Holubarsch Pdf

Assessment of cardiac energetics at the level of ATP-synthesis, chemomechanical energy transformation and whole organ dynamics as a function of haemodynamic load, ventricular configuration and oxygen- and substrates supply is basic to understanding cardiac function under physiological and pathophysiological (hypertrophy, hypoxia, ischaemia and heart failure) conditions. Moreover, cardiac energetics should be an important consideration in the choice and application of drugs especially in the case of vasodilators, inotropic agents and in cardioprotective measures. Only by considering energetics at the subcellular, cellular, and whole-heart level we can arrive at a better understanding of cardiac performance and ultimately better clinical judgement and drug therapy. Quantification of myocardial energetics will also help to determine the optimal time for surgical interventions such as valvular replacement or aneurysm resection. The present volume is the outcome of an international symposium on cardiac energetics held in Gargellen/Montafon (Austria), June 1986. The contributions will certainly help bridge the existing gap between basic research involving isolated structures and that involving the whole organ, on the one hand, and render the results derived from basic research applicable to clinical problems, on the other hand.

Author : Robert Jacob,Hanjörg Just,Christian Holubarsch
Publisher : Springer
Page : 425 pages
File Size : 40,9 Mb
Release : 1987-01-01
Category : Energy metabolism
ISBN : 3798507341

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Cardiac Energetics by Robert Jacob,Hanjörg Just,Christian Holubarsch Pdf

Author : Martin M. LeWinter,Hiroyuki Suga,Matthew W. Watkins
Publisher : Springer Science & Business Media
Page : 291 pages
File Size : 50,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461520214

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Cardiac Energetics: From Emax to Pressure-Volume Area by Martin M. LeWinter,Hiroyuki Suga,Matthew W. Watkins Pdf

Most of the progress in cardiac energetics in recent years has been spurred by the pressure-volume area concept, the natural extension into energetics of earlier pioneering work delineating the time-varying elastance framework for ventricular contraction. The book draws together a broad spectrum of researchers - basic, applied and clinical - having a shared interest in the energetics of cardiac muscle and ventricle, providing an overview of the current state of the art.

Author : Robert Jacob
Publisher : Springer Verlag
Page : 425 pages
File Size : 41,6 Mb
Release : 1987
Category : Medical
ISBN : 0387912940

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Cardiac Energetics by Robert Jacob Pdf

Author : Gary D. Lopaschuk,Naranjan S. Dhalla
Publisher : Springer
Page : 301 pages
File Size : 53,8 Mb
Release : 2014-08-22
Category : Science
ISBN : 9781493912278

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Cardiac Energy Metabolism in Health and Disease by Gary D. Lopaschuk,Naranjan S. Dhalla Pdf

The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.

Author : Thomas Pulinilkunnil,Petra Kienesberger,Jeevan Nagendran
Publisher : Frontiers Media SA
Page : 89 pages
File Size : 48,9 Mb
Release : 2019-08-08
Category : Electronic
ISBN : 9782889459384

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Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease by Thomas Pulinilkunnil,Petra Kienesberger,Jeevan Nagendran Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Leopold Dintenfass
Publisher : Springer Science & Business Media
Page : 697 pages
File Size : 43,5 Mb
Release : 2013-03-09
Category : Science
ISBN : 9781475703931

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Heart Perfusion, Energetics, and Ischemia by Leopold Dintenfass Pdf

The principal purpose of a NATO (North Atlantic Treaty Organization) Advanced Research Workshop, a part of the NATO Advanced Study Institutes Programme, is to: (a) exchange thoughts at the frontiers of knowledge or at the frontiers of two (or more) fields or sectors; (b) review and assess the state of the art; (c) formulate recommendations for future research directions; (d) formulate plans for large international scientific experiments. The aim of the ARW on "Microvascular, rheological, metabolic and heat-transfer aspects of the heart: relation to ischaemia and thrombosis", convened in Chateau de Bonas, July 4-11, 1982, was to describe functions and performance of the heart in an interdisciplin ary effort, involving cardiologists, pathologists, biochemists, haemorheologists, physiologists, pharmacologists and bioengineers; to explore interactions between such subfields as blood rheology, micro circulation and ischaemia of the myocardium, heat transfer, heat work and performance as a pump, effect of -metabolites and ion transfer, mechanism of sudden death, protein synthesis and protein molecular transformations. One of the purposes of the Convenor was to relate clinical haemorheology to the heart energetics and heart metabolism. This was only partly established, as difficulties of communications between different fields, difficulties of semantics and of specialized out looks could not be overcome within a -few days. Nevertheless, a gate was opened for communications interchange in the future. There was even a problem within each specialty, and as is rather common, quite diverse views have been expressed. This, of course, is quite normal in the progress of science.

Author : Paul P. Pearsall
Publisher : Harmony
Page : 304 pages
File Size : 50,5 Mb
Release : 1999-03-10
Category : Health & Fitness
ISBN : 9780767999427

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The Heart's Code by Paul P. Pearsall Pdf

A fascinating synthesis of ancient wisdom, modern medicine, scientific research, and personal experiences that proves that the human heart, not the brain, holds the secrets that link body, mind, and spirit. You know that the heart loves and feels, but did you know that the heart also thinks, remembers, communicates with other hearts, helps regulate immunity, and contains stored information that continually pulses through your body? In The Heart's Code, Dr. Paul Pearsall explains the theory and science behind energy cardiology, the emerging field that is uncovering one of the most significant medical, social, and spiritual discoveries of our time: The heart is more than just a pump; it conducts the cellular symphony that is the very essence of our being. Full of amazing anecdotes and data, The Heart's Code presents the latest research on cellular memory and the power of the heart's energy and explores what these breakthroughs mean about how we should live our lives. By unlocking the heart's code we can discover new ways of understanding human healing and consciousness and create a new model for living that leads to better health, happiness, and self-knowledge.

Author : S. Sideman,Rafael Beyar
Publisher : Springer Science & Business Media
Page : 448 pages
File Size : 42,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400949928

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Simulation and Imaging of the Cardiac System by S. Sideman,Rafael Beyar Pdf

The ultrasound velocity tomography allows measurement of cardiac geometries for various phases in the cardiac cycle. The present tomograph makes reconstruc tions at intervals of 20 ms. Because of a lack of clear (intramural) landmarks (except the roots of the papillairy muscle), it is difficult to pinpoint spatial trajectories of particular points in the heart. Therefore, a second method was developed of injecting radiopaque markers in the heart and following their motion patterns during the cardiac cycle with help of a biplane X-ray equipment. The data obtained with both methods can be implemented in our finite element model of the heart to compute intramural stresses and strains. The results obtained sofar with the extended Darcy equation to account for the interaction of blood rheology and tissue mechanics look promising. Further testing with more sophisticated subjects than mentioned in Figure 9 is required before it will be implemented in our finite element model of the heart. We conclude that analysis of regional cardiac function, including regional myocardial blood flow, requires still a major research effort but the results obtained sofar justify, to our opinion, a continuation in this direction. Acknowledgement The authors acknowledge Dr. C. Borst and coworkers for doing the animal experiments and prof. Van Campen and dr. Grootenboer for their participation is some aspects of this work.

Author : G. Michael Felker,Douglas L. Mann
Publisher : Elsevier Health Sciences
Page : 784 pages
File Size : 48,5 Mb
Release : 2019-02-06
Category : Medical
ISBN : 9780323609883

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Heart Failure: A Companion to Braunwald's Heart Disease E-Book by G. Michael Felker,Douglas L. Mann Pdf

Up-to-date, authoritative and comprehensive, Heart Failure, 4th Edition, provides the clinically relevant information you need to effectively manage and treat patients with this complex cardiovascular problem. This fully revised companion to Braunwald’s Heart Disease helps you make the most of new drug therapies such as angiotensin receptor neprilysin inhibitors (ARNIs), recently improved implantable devices, and innovative patient management strategies. Led by internationally recognized heart failure experts Dr. G. Michael Felker and Dr. Douglas Mann, this outstanding reference gives health care providers the knowledge to improve clinical outcomes in heart failure patients. Focuses on a clinical approach to treating heart failure, resulting from a broad variety of cardiovascular problems. Covers the most recent guidelines and protocols, including significant new updates to ACC, AHA, and HFSA guidelines. Covers key topics such as biomarkers and precision medicine in heart failure and new data on angiotensin receptor neprilysin inhibitors (ARNIs). Contains four new chapters: Natriuretic Peptides in Heart Failure; Amyloidosis as a Cause of Heart Failure; HIV and Heart Failure; and Neuromodulation in Heart Failure. Covers the pathophysiological basis for the development and progression of heart failure. Serves as a definitive resource to prepare for the ABIM’s Heart Failure board exam. 2016 British Medical Association Award: First Prize, Cardiology (3rd Edition).

Author : Michael Schwarzer,Torsten Doenst
Publisher : Academic Press
Page : 240 pages
File Size : 51,5 Mb
Release : 2015-11-04
Category : Medical
ISBN : 9780128026144

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The Scientist's Guide to Cardiac Metabolism by Michael Schwarzer,Torsten Doenst Pdf

The Scientists Guide to Cardiac Metabolism combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism. This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding of the metabolic processes and enabling the newcomer to immediately communicate with the expert as substrate/energy metabolism becomes part of projects. The book is written by established experts in the field, bringing together all the concepts of cardiac metabolism, its regulation, and the impact of disease. Provides a quick and comprehensive introduction into cardiac metabolism Contains an integrated view on cardiac metabolism and its interrelation in metabolism with other organs Presents insights into substrate metabolism in relation to intracellular organization and structure as well as whole organ function Includes historical perspectives that reference important investigators that have contributed to the development of the field

Author : Stephen Devries,James E. Dalen
Publisher : OUP USA
Page : 345 pages
File Size : 41,9 Mb
Release : 2011-02-03
Category : Medical
ISBN : 9780195383461

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Integrative Cardiology by Stephen Devries,James E. Dalen Pdf

Integrative Cardiology is an exploration of a new and much-needed perspective in cardiac care: the intelligent synthesis of conventional medicine with alternative approaches not typically part of Western medical curriculum. More than a blending of two approaches, this new perspective in cardiology highlights specific gaps in conventional heart care, and examines how alternative approaches may be ideally suited to address these missed opportunities.Cardiology is an ideal specialty for an integrative approach. Heart disease is largely preventable. The influence of nutrition, physical activity, metabolic factors, and emotional state on heart health is unmistakable, and the wide-angle lens of integrative medicine is an ideal model to address these multi-faceted needs. Most importantly, the focus of this work is directed at prevention. The approaches described in this book emphasize collaboration of the patient and health care provider--both seeking to obtain the best possible outcome taking into account the intangible, but vital, nuances of the patient's culture, beliefs, and preferences.The first section in this book describes the core elements of integrative cardiology, beginning with nutrition. Foundational chapters that follow include exercise, botanicals, aspirin, metabolic cardiology, acupuncture, spirituality, mind/body approaches, and energy medicine. Contributing authors, all of whom have a background in academic medicine, share the approaches they have found most effective in their own practices, referencing their work with the best scientific evidence available.

Author : Euan A. Ashley,Euan Ashley,Josef Niebauer
Publisher : Remedica
Page : 258 pages
File Size : 41,8 Mb
Release : 2004
Category : Cardiology
ISBN : 9781901346220

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Cardiology Explained by Euan A. Ashley,Euan Ashley,Josef Niebauer Pdf

One of the most time-consuming tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure not only to make referrals appropriate but also to summarize the case in the language of the specialist. This book explains basic physiologic and pathophysiologic mechanisms of cardiovascular disease in a straightforward manner, gives guidelines as to when referral is appropriate, and, uniquely, explains what the specialist is likely to do. It is ideal for any hospital doctor, generalist, or even senior medical student who may need a cardiology opinion, or for that ma.

Author : Ingrid Kohlstadt
Publisher : CRC Press
Page : 894 pages
File Size : 40,5 Mb
Release : 2012-12-10
Category : Medical
ISBN : 9781439887745

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Advancing Medicine with Food and Nutrients by Ingrid Kohlstadt Pdf

Food and nutrients are the original medicine and the shoulders on which modern medicine stands. But in recent decades, food and medicine have taken divergent paths and the natural healing properties of food have been diminished in the wake of modern technical progress. With contributions from highly regarded experts who work on the frontlines of disease management, the bestselling first edition of Advancing Medicine with Food and Nutrients, Food and Nutrients in Disease Management effectively brought food back into the clinical arena, helping physicians put food and nutrients back on the prescription pad. Board-certified in General Preventive Medicine, Ingrid Kohlstadt, MD, MPH has been elected a Fellow of the American College of Nutrition and a Fellow of the American College of Preventive Medicine. Guided by Dr. Kohlstadt, this authoritative reference equips clinicians with the information they need to fully utilize nutritional medicine in their practice. New in the Second Edition Toxic exposures such as molds, microbial infections, xenoestrogens, heavy metals, and inert nanoparticles Food safety issues: precautions for patients with preexisting medical conditions, adequate labeling of food allergens such as gluten, potential adverse effects of artificial sweeteners, consequences of applying ionizing radiation to food, food-borne mycotoxins, critical food restrictions following bariatric surgery, precautions for preparing food in the home Consumer advocacy issues on navigating claims of medical foods and dietary supplements Physical forces on nutritional needs, such as ultraviolet light initiating vitamin D synthesis, non-ionizing radiation’s effects on brain glucose metabolism and excess body fat’s effects on inflammation and hydration Preventive medicine and how to preserve resiliency at the individual and public health levels Written by doctors for doctors, Advancing Medicine with Food and Nutrients, Second Edition reunites food and medicine. Buttressed with new evidence, leading physicians on the frontlines of disease management apply the latest scientific advances to the clinical practice of medicine. Each chapter offers adjuncts to standard care, fewer side effects, improved risk reduction, or added quality of life. An article by Ingrid Kohlstadt on education and nutrition appeared in TIME Magazine online on November 12, 2014.

Author : Bodh I. Jugdutt,Naranjan S. Dhalla
Publisher : Springer Science & Business Media
Page : 566 pages
File Size : 42,8 Mb
Release : 2013-02-15
Category : Medical
ISBN : 9781461459309

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Cardiac Remodeling by Bodh I. Jugdutt,Naranjan S. Dhalla Pdf

The main objective of Cardiac Remodeling: Molecular Mechanisms is to summarize the major research advances in molecular, biochemical and translational aspects of cardiac remodeling over the last 2 to 3 decades under one cover and touch on future directions. It provides a high profile and valuable publication resource on molecular mechanisms of cardiac remodeling for both the present and future generations of researchers, teachers, students and trainees. This book should stimulate future translational research targeted towards discovery and development for preventing, limiting and reversing bad remodeling over the next few decades, with the ultimate goal of preventing progression to systolic and/or diastolic heart failure. The chapters suggest potential novel strategies that should receive attention for translating basic research knowledge to application in patients at the bedside.