Cell Signaling In Host Pathogen Interactions The Host Point Of View

Author : Diana Bahia,Abhay Satoskar,Olivier Dussurget
Publisher : Frontiers Media SA
Page : 414 pages
File Size : 44,6 Mb
Release : 2018-03-23
Category : Electronic
ISBN : 9782889454556

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Cell Signaling in Host–Pathogen Interactions: The Host Point of View by Diana Bahia,Abhay Satoskar,Olivier Dussurget Pdf

The ability of pathogens, such as parasites, bacteria, fungi and viruses to invade, persist and adapt in both invertebrate and vertebrate hosts is multifactorial and depends on both pathogen and host fitness. Communication between a pathogen and its host relies on a wide and dynamic array of molecular interactions. Through this constant communication most pathogens evolved to be relatively benign, whereas killing of its host by a pathogen represents a failure to adapt. Pathogens are lethal to their host when their interaction has not been long enough for adaptation. Evolution has selected conserved immune receptors that recognize signature patterns of pathogens as non-self elements and initiate host innate responses aimed at eradicating infection. Conversely, pathogens evolved mechanisms to evade immune recognition and subvert cytokine secretion in order to survive, replicate and cause disease. The cell signaling machinery is a critical component of the immune system that relays information from the receptors to the nucleus where transcription of key immune genes is activated. Host cells have developed signal transduction systems to maintain homeostasis with pathogens. Most cellular processes and cell signaling pathways are tightly regulated by protein phosphorylation in which protein kinases are key protagonists. Pathogens have developed multiple mechanisms to subvert important signal transduction pathways such as the mitogen activated protein kinase (MAPK) and the nuclear factor kB (NF-kB) pathways. Pathogens also secrete effectors that manipulate actin cytoskeleton and its regulators, hijack cell cycle machinery and alter vesicular trafficking. This research topic focuses on the cellular signaling mechanisms that are essential for host immunity and their subversion by pathogens.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 40,5 Mb
Release : 2018
Category : Electronic
ISBN : OCLC:1368415131

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Cell Signaling in Host-Pathogen Interactions: The Host Point of View by Anonim Pdf

The ability of pathogens, such as parasites, bacteria, fungi and viruses to invade, persist and adapt in both invertebrate and vertebrate hosts is multifactorial and depends on both pathogen and host fitness. Communication between a pathogen and its host relies on a wide and dynamic array of molecular interactions. Through this constant communication most pathogens evolved to be relatively benign, whereas killing of its host by a pathogen represents a failure to adapt. Pathogens are lethal to their host when their interaction has not been long enough for adaptation. Evolution has selected conserved immune receptors that recognize signature patterns of pathogens as non-self elements and initiate host innate responses aimed at eradicating infection. Conversely, pathogens evolved mechanisms to evade immune recognition and subvert cytokine secretion in order to survive, replicate and cause disease. The cell signaling machinery is a critical component of the immune system that relays information from the receptors to the nucleus where transcription of key immune genes is activated. Host cells have developed signal transduction systems to maintain homeostasis with pathogens. Most cellular processes and cell signaling pathways are tightly regulated by protein phosphorylation in which protein kinases are key protagonists. Pathogens have developed multiple mechanisms to subvert important signal transduction pathways such as the mitogen activated protein kinase (MAPK) and the nuclear factor kB (NF-kB) pathways. Pathogens also secrete effectors that manipulate actin cytoskeleton and its regulators, hijack cell cycle machinery and alter vesicular trafficking. This research topic focuses on the cellular signaling mechanisms that are essential for host immunity and their subversion by pathogens.

Author : Richard J. Lamont
Publisher : Cambridge University Press
Page : 344 pages
File Size : 52,9 Mb
Release : 2004-03-29
Category : Science
ISBN : 0521809541

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Bacterial Invasion of Host Cells by Richard J. Lamont Pdf

Understanding the molecular basis of bacterial invasion and of host cell adaptation to intracellular bacteria will provide fundamental insights into the pathophysiology of bacteria and the cell biology of the host. This book details specific examples of bacteria that are masters of manipulation of eukaryotic cell signaling and relates these events to the broader context of host-pathogen interaction. Written by experts in the field, it will be of interest to researchers and graduate students in microbiology, immunology, and biochemistry, as well as in molecular medicine and dentistry.

Author : Saliha Durmuş,Tunahan Çakır,Reinhard Guthke,Emrah Nikerel,Arzucan Özgür
Publisher : Frontiers Media SA
Page : 200 pages
File Size : 49,8 Mb
Release : 2016-05-30
Category : Electronic book
ISBN : 9782889198214

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Computational Systems Biology of Pathogen-Host Interactions by Saliha Durmuş,Tunahan Çakır,Reinhard Guthke,Emrah Nikerel,Arzucan Özgür Pdf

A thorough understanding of pathogenic microorganisms and their interactions with host organisms is crucial to prevent infectious threats due to the fact that Pathogen-Host Interactions (PHIs) have critical roles in initiating and sustaining infections. Therefore, the analysis of infection mechanisms through PHIs is indispensable to identify diagnostic biomarkers and next-generation drug targets and then to develop strategic novel solutions against drug-resistance and for personalized therapy. Traditional approaches are limited in capturing mechanisms of infection since they investigate hosts or pathogens individually. On the other hand, the systems biology approach focuses on the whole PHI system, and is more promising in capturing infection mechanisms. Here, we bring together studies on the below listed sections to present the current picture of the research on Computational Systems Biology of Pathogen-Host Interactions: - Computational Inference of PHI Networks using Omics Data - Computational Prediction of PHIs - Text Mining of PHI Data from the Literature - Mathematical Modeling and Bioinformatic Analysis of PHIs Computational Inference of PHI Networks using Omics Data Gene regulatory, metabolic and protein-protein networks of PHI systems are crucial for a thorough understanding of infection mechanisms. Great advances in molecular biology and biotechnology have allowed the production of related omics data experimentally. Many computational methods are emerging to infer molecular interaction networks of PHI systems from the corresponding omics data. Computational Prediction of PHIs Due to the lack of experimentally-found PHI data, many computational methods have been developed for the prediction of pathogen-host protein-protein interactions. Despite being emerging, currently available experimental PHI data are far from complete for a systems view of infection mechanisms through PHIs. Therefore, computational methods are the main tools to predict new PHIs. To this end, the development of new computational methods is of great interest. Text Mining of PHI Data from Literature Despite the recent development of many PHI-specific databases, most data relevant to PHIs are still buried in the biomedical literature, which demands for the use of text mining techniques to unravel PHIs hidden in the literature. Only some rare efforts have been performed to achieve this aim. Therefore, the development of novel text mining methods specific for PHI data retrieval is of key importance for efficient use of the available literature. Mathematical Modeling and Bioinformatic Analysis of PHIs After the reconstruction of PHI networks experimentally and/or computationally, their mathematical modeling and detailed computational analysis is required using bioinformatics tools to get insights on infection mechanisms. Bioinformatics methods are increasingly applied to analyze the increasing amount of experimentally-found and computationally-predicted PHI data.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 47,9 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Reinhard Krämer,Kirsten Jung
Publisher : John Wiley & Sons
Page : 513 pages
File Size : 50,9 Mb
Release : 2009-12-09
Category : Science
ISBN : 9783527629244

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Bacterial Signaling by Reinhard Krämer,Kirsten Jung Pdf

Providing a comprehensive insight into cellular signaling processes in bacteria with a special focus on biotechnological implications, this is the first book to cover intercellular as well as intracellular signaling and its relevance for biofilm formation, host pathogen interactions, symbiotic relationships, and photo- and chemotaxis. In addition, it deals in detail with principal bacterial signaling mechanisms -- making this a valuable resource for all advanced students in microbiology. Dr. Krämer is a world-renowned expert in intracellular signaling and its implications for biotechnology processes, while Dr. Jung is an expert on intercellular signaling and its relevance for biomedicine and agriculture.

Author : Pascale Cossart
Publisher : Unknown
Page : 642 pages
File Size : 40,6 Mb
Release : 2005
Category : Bacterial genomes
ISBN : UOM:39015058805253

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Cellular Microbiology by Pascale Cossart Pdf

A comprehensive examination of this burgeoning area of important research.

Author : Vikas Sood,Binod Kumar,Clement Adebajo Meseko,Anurodh Shankar Agrawal,Tom Gallagher
Publisher : Frontiers Media SA
Page : 250 pages
File Size : 53,8 Mb
Release : 2022-02-07
Category : Science
ISBN : 9782889743469

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Severe Acute Respiratory Syndrome Coronavirus 2: Host-Pathogen Interactions and Cellular Signaling by Vikas Sood,Binod Kumar,Clement Adebajo Meseko,Anurodh Shankar Agrawal,Tom Gallagher Pdf

Author : Anonim
Publisher : Academic Press
Page : 1571 pages
File Size : 43,5 Mb
Release : 2020-08-24
Category : Science
ISBN : 9780128160787

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Systems Medicine by Anonim Pdf

Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information

Author : Gerhard Krauss
Publisher : John Wiley & Sons
Page : 558 pages
File Size : 46,6 Mb
Release : 2006-03-06
Category : Science
ISBN : 9783527605767

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Biochemistry of Signal Transduction and Regulation by Gerhard Krauss Pdf

This all-new edition of a classic text has been thoroughly revised to keep pace with the rapid progress in signal transduction research. With didactic skill and clarity the author relates the observed biological phenomena to the underlying biochemical processes. Directed to advanced students, teachers, and researchers in biochemistry and molecular biology, this book describes the molecular basis of signal transduction, regulated gene expression, the cell cycle, tumorigenesis and apoptosis. "Provides a comprehensive account of cell signaling and signal transduction and, where possible, explains these processes at the molecular level" (Angewandte Chemie) "The clear and didactic presentation makes it a textbook very useful for students and researchers not familiar with all aspects of cell regulation." (Biochemistry) "This book is actually two books: Regulation and Signal Transduction." (Drug Research)

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 43,9 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Author : Vijay Kumar
Publisher : BoD – Books on Demand
Page : 394 pages
File Size : 52,6 Mb
Release : 2022-12-14
Category : Medical
ISBN : 9781803556246

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Macrophages by Vijay Kumar Pdf

Macrophages were first discovered in 1882 when Elia Metchnikoff recognized them as important phagocytic cells that can engulf any foreign material, including fungal spores. This discovery has proved to be a milestone in establishing the field of innate immunity. Macrophages are still ruling the area after 140 years of their discovery. This book explores the diverse role of macrophages in vertebrate immunity, parasitic, bacterial, and viral infections, regeneration, inflammation, and neurological diseases.

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer Nature
Page : 242 pages
File Size : 41,6 Mb
Release : 2022-02-08
Category : Medical
ISBN : 9783030851132

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Coronavirus Therapeutics – Volume II by Alexzander A. A. Asea,Punit Kaur Pdf

The book Coronavirus Therapeutics Volume II provides the most comprehensive review on contemporary knowledge on the consequences during the outbreak of Coronavirus. This also describes the clinical features, diagnostic evaluation and management of Coronavirus patients. Using an integrative approach to the understanding of paradigm gap in host-pathogen interaction studies to the management of Coronavirus patients in the Intensive Care Unit to the current challenges for the effective management of Coronavirus pandemic risk factors including diabetes, hypertension, obesity and repercussion on the central and peripheral nervous system. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Author : Kenneth Wilson,Andy Fenton,Dan Tompkins
Publisher : Cambridge University Press
Page : 693 pages
File Size : 47,7 Mb
Release : 2019-11-14
Category : Mathematics
ISBN : 9781107136564

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Wildlife Disease Ecology by Kenneth Wilson,Andy Fenton,Dan Tompkins Pdf

Introduces readers to key case studies that illustrate how theory and data can be integrated to understand wildlife disease ecology.

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 306 pages
File Size : 49,6 Mb
Release : 2006-07-09
Category : Medical
ISBN : 9780309096010

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Ending the War Metaphor by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Infectious diseases have existed longer than us, as long as us, or are relatively newer than us. It may be the case that a disease has existed for many, many years but has only recently begun affecting humans. At the turn of the century the number of deaths caused by infections in the United States had been falling steadily but since the '80s has seen an increase. In the past 30 years alone 37 new pathogens have been identified as human disease threats and 12% of known human pathogens have been classified as either emerging or remerging. Whatever the story, there is currently a "war" on infectious diseases. This war is simply the systematic search for the microbial "cause" of each disease, followed by the development of antimicrobial therapies. The "war" on infectious diseases, however, must be revisited in order to develop a more realistic and detailed picture of the dynamic interactions among and between host organisms and their diverse populations of microbes. Only a fraction of these microbes are pathogens. Thus, in order to explore the crafting of a new metaphor for host-microbe relationships, and to consider how such a new perspective might inform and prioritize biomedical research, the Forum on Microbial Threats of the Institute of Medicine (IOM) convened the workshop, Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship on March 16-17, 2005. Workshop participants examined knowledge and approaches to learning about the bacterial inhabitants of the human gut, the best known host-microbe system, as well as findings from studies of microbial communities associated with other mammals, fish, plants, soil, and insects. The perspective adopted by this workshop is one that recognizes the breadth and diversity of host-microbe relationships beyond those relative few that result in overt disease. Included in this summary are the reports and papers of individuals participating in the Forum as well as the views of the editors.