Cell Therapy

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Cell Therapy

Adrian Gee
Cell Therapy Book PDF

Author : Adrian Gee
Publisher : Springer Science & Business Media
Page : 256 pages
File Size : 47,7 Mb
Release : 2009-09-18
Category : Science
ISBN : 9780387895840

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Cell Therapy by Adrian Gee Pdf

Cell Therapy: cGMP Facilities and Manufacturing is the source for a complete discussion of facility design and operation with practical approaches to a variety of day-to-day activities, such as staff training and competency, cleaning procedures, and environmental monitoring. This in-depth book also includes detailed reviews of quality, the framework of regulations, and professional standards. It meets a previously unmet need for a thorough facility-focused resource, Cell Therapy: cGMP Facilities and Manufacturing will be an important addition to the cell therapy professional’s library. Additional topics in Cell Therapy: cGMP Facilities and Manufacturing...Standard operating procedures - Supply management - Facility equipment - Product manufacturing, review, release and administration - Facility master file.

Cell Therapy

Dwaine F. Emerich,Gorka Orive
Cell Therapy Book PDF

Author : Dwaine F. Emerich,Gorka Orive
Publisher : Springer
Page : 328 pages
File Size : 40,7 Mb
Release : 2017-08-25
Category : Medical
ISBN : 9783319571539

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Cell Therapy by Dwaine F. Emerich,Gorka Orive Pdf

This volume provides a comprehensive, state-of-the art review of the field of cell therapy. The volume begins with an overview of the breadth of the field and then turns to overviews of imaging technologies that can aid in both safety and efficacy evaluations. The book then turns to numerous contributions detailing the rapidly growing field of stem cell therapies. These sections cover our understanding of the natural roles of stem cells in biology and human disease and then touches on several of the more prominent areas where stem cells are moving rapidly into clinical evaluation including neurodegenerative diseases, muscular dystrophy, cardiac repair, and diabetes. The volume concludes with contributions from experts in oncology, ophthalmology, stem cells, 3-D printing, and biomaterials where the convergence of expertise is leading to unprecedented insights into how to minutely control the in vivo fate and function of transplanted and/or endogeneously mobilized cells. Finally, the book provides insights into the pivotal relationship between academic and industrial partnerships. This volume is designed to touch on the major areas where the field will make its greatest and most immediate clinical impacts. This text will provide a useful resource for physicians and researchers interested in the rapidly changing filed of cell therapy.

Gene and Cell Therapy: Biology and Applications

Giridhara R. Jayandharan
Gene and Cell Therapy Biology and Applications Book PDF

Author : Giridhara R. Jayandharan
Publisher : Springer
Page : 305 pages
File Size : 41,9 Mb
Release : 2018-09-12
Category : Medical
ISBN : 9789811304811

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Gene and Cell Therapy: Biology and Applications by Giridhara R. Jayandharan Pdf

Recent advances in stem cell biology, nanotechnology and gene therapy have opened new avenues for therapeutics. The availability of molecular therapeutics that rely on the delivery of DNA, RNA or proteins, harnessing enhanced delivery with nanoparticles, and the regenerative potential of stem cells (adult, embryonic or induced pluripotent stem cells) has had a tremendous impact on translational medicine. The chapters in this book cover a range of strategies for molecular and cellular therapies for human disease, their advantages, and central challenges to their widespread application. Potential solutions to these issues are also discussed in detail. Further, the book addresses numerous advances in the field of molecular therapeutics that will be of interest to the general scientific community. Lastly, the book provides specific examples of disease conditions for which these strategies have been transferred to the clinic. As such, it will be extremely useful for all students, researchers and clinicians working in the field of translational medicine and molecular therapeutics.

Progenitor and Stem Cell Technologies and Therapies

Anthony Atala
Progenitor and Stem Cell Technologies and Therapies Book PDF

Author : Anthony Atala
Publisher : Elsevier
Page : 568 pages
File Size : 44,8 Mb
Release : 2012-03-15
Category : Medical
ISBN : 9780857096074

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Progenitor and Stem Cell Technologies and Therapies by Anthony Atala Pdf

Progenitor and stem cells have the ability to renew themselves and change into a variety of specialised types, making them ideal materials for therapy and regenerative medicine. Progenitor and stem cell technologies and therapies reviews the range of progenitor and stem cells available and their therapeutic application. Part one reviews basic principles for the culture of stem cells before discussing technologies for particular cell types. These include human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells. Part two discusses wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies. The final part of the book considers the therapeutic use of stem and progenitor cells. Chapters review the use of adipose tissue-derived stem cells, umbilical cord blood (UCB) stem cells, bone marrow, auditory and oral cavity stem cells. Other chapters cover the use of stem cells in therapies in various clinical areas, including lung, cartilage, urologic, nerve and cardiac repair. With its distinguished editor and international team of contributors, Progenitor and stem cell technologies and therapies is a standard reference for both those researching in cell and tissue biology and engineering as well as medical practitioners investigating the therapeutic use of this important technology. Reviews the range of progenitor and stem cells available and outlines their therapeutic application Examines the basic principles for the culture of stem cells before discussing technologies for particular cell types, including human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells Includes a discussion of wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies

Cell Therapy for Brain Injury

David C. Hess
Cell Therapy for Brain Injury Book PDF

Author : David C. Hess
Publisher : Springer
Page : 369 pages
File Size : 46,8 Mb
Release : 2015-05-15
Category : Science
ISBN : 9783319150635

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Cell Therapy for Brain Injury by David C. Hess Pdf

Cell Therapy for Brain Injury is a thorough examination of using state-of-the-art cell therapy in the treatment of strokes and other traumatic brain injuries. This invaluable book covers this niche topic in depth from basic stem cell biology and principles of cell therapy through proposed mechanisms of action of cell therapy in stroke, pre-clinical data in stroke models, ongoing clinical trials, imaging and tracking of cells with MRI, neural stem cells in stroke and the "big pharma" perspective of cell therapy. Each chapter is written by well-known leaders in each field, thus providing a wealth of expertise. The breadth of this book makes it essential reading for neuroscientists, stem cell biologists, researchers or clinical trialists at pharmaceutical or biotechnology companies. It also serves as a thorough introduction for graduate students or post-doctoral fellows who hope to work in these fields.

Chimeric Antigen Receptor T-Cell Therapies for Cancer E-Book

Daniel W. Lee,Nirali N. Shah
Chimeric Antigen Receptor T Cell Therapies for Cancer E Book Book PDF

Author : Daniel W. Lee,Nirali N. Shah
Publisher : Elsevier Health Sciences
Page : 246 pages
File Size : 53,6 Mb
Release : 2019-11-30
Category : Medical
ISBN : 9780323755979

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Chimeric Antigen Receptor T-Cell Therapies for Cancer E-Book by Daniel W. Lee,Nirali N. Shah Pdf

From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy.

Stem Cell and Gene Therapy for Cardiovascular Disease

Emerson C. Perin,Leslie W. Miller,Doris Taylor,James T. Willerson
Stem Cell and Gene Therapy for Cardiovascular Disease Book PDF

Author : Emerson C. Perin,Leslie W. Miller,Doris Taylor,James T. Willerson
Publisher : Academic Press
Page : 538 pages
File Size : 50,8 Mb
Release : 2015-08-21
Category : Science
ISBN : 9780128018637

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Stem Cell and Gene Therapy for Cardiovascular Disease by Emerson C. Perin,Leslie W. Miller,Doris Taylor,James T. Willerson Pdf

Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic. As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials. Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic. Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPC's, and organogenesis Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI Covers the prevailing opinions on how to harness the body’s natural repair mechanisms Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals

Molecular and Cellular Therapies for Motor Neuron Diseases

Nicholas M Boulis,Deirdre O’Connor,Anthony Donsante
Molecular and Cellular Therapies for Motor Neuron Diseases Book PDF

Author : Nicholas M Boulis,Deirdre O’Connor,Anthony Donsante
Publisher : Academic Press
Page : 336 pages
File Size : 48,5 Mb
Release : 2017-01-18
Category : Psychology
ISBN : 9780128025246

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Molecular and Cellular Therapies for Motor Neuron Diseases by Nicholas M Boulis,Deirdre O’Connor,Anthony Donsante Pdf

Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases Edited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevance Presents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy

Gene and Cell Therapy

Nancy Smyth Templeton
Gene and Cell Therapy Book PDF

Author : Nancy Smyth Templeton
Publisher : CRC Press
Page : 894 pages
File Size : 51,9 Mb
Release : 2003-12-17
Category : Science
ISBN : 9780824758608

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Gene and Cell Therapy by Nancy Smyth Templeton Pdf

This reference is completely revised and expanded to reflect the most critical studies, controversies, and technologies impacting the medical field, including probing research on lentivirus, gutless adenovirus, bacterial and baculovirus vectors, retargeted viral vectors, in vivo electroporation, in vitro and in vivo gene detection systems, and all inducible gene expression systems. Scrutinizing every tool, technology, and issue impacting the future of gene and cell research, it is specifically written and organized for laymen, scholars, and specialists from varying backgrounds and disciplines to understand the current status of gene and cell therapy and anticipate future developments in the field.

A Handbook of Gene and Cell Therapy

Clévio Nóbrega,Liliana Mendonça,Carlos A. Matos
A Handbook of Gene and Cell Therapy Book PDF

Author : Clévio Nóbrega,Liliana Mendonça,Carlos A. Matos
Publisher : Springer Nature
Page : 195 pages
File Size : 53,8 Mb
Release : 2020-06-27
Category : Medical
ISBN : 9783030413330

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A Handbook of Gene and Cell Therapy by Clévio Nóbrega,Liliana Mendonça,Carlos A. Matos Pdf

This is a reference handbook for young researchers exploring gene and cell therapy. Gene therapy could be defined as a set of strategies modifying gene expression or correcting mutant/defective genes through the administration of DNA (or RNA) to cells, in order to treat disease. Important advances like the discovery of RNA interference, the completion of the Human Genome project or the development of induced pluripotent stem cells (iPSc) and the basics of gene therapy are covered. This is a great book for students, teachers, biomedical researchers delving into gene/cell therapy or researchers borrowing skills from this scientific field.

Stem Cell Therapy for Vascular Diseases

Tulio Pinho Navarro,Lara Lellis Navarro Minchillo Lopes,Alan Dardik
Stem Cell Therapy for Vascular Diseases Book PDF

Author : Tulio Pinho Navarro,Lara Lellis Navarro Minchillo Lopes,Alan Dardik
Publisher : Springer Nature
Page : 425 pages
File Size : 46,7 Mb
Release : 2020-11-05
Category : Medical
ISBN : 9783030569549

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Stem Cell Therapy for Vascular Diseases by Tulio Pinho Navarro,Lara Lellis Navarro Minchillo Lopes,Alan Dardik Pdf

Vascular diseases are the leading cause of death worldwide. Distinguished clinical and surgical approaches have attempted to overcome its morbidity and mortality; still 17.9 million people die every year due to vascular affections. Stem cell therapy has emerged as a promising therapeutic strategy. Stem cells synthesize and secrete cytokines that promote cell recruitment, immunomodulation, extracellular matrix remodeling, angiogenesis, and neuroregeneration, all of which promote regeneration. Besides that, stem cells are also capable of differentiating in various cell types, being employed in tissue engineering. Preclinical and clinical investigations have reported efficacy of stem cell therapy for various vascular diseases. Even though results are encouraging, the studies demonstrate variation in stem cell type and origin, route and protocol for administration, and concomitant use of other treatment strategies, impairing easy interpretation of results and clinical application. The purpose of this book is to compile and comprise the current state of the evidence regarding stem cell therapy for each vascular disease, elucidating possible clinical applications. More than an objective guide for readers on the use of this novel treatment strategy, this publication will advocate for stem cell therapy use and development and will be of significant interest to physicians in a wide range of disciplines as well as researchers.

Ex Vivo Cell Therapy

Klaus Schindhelm,Robert Nordon
Ex Vivo Cell Therapy Book PDF

Author : Klaus Schindhelm,Robert Nordon
Publisher : Academic Press
Page : 392 pages
File Size : 41,9 Mb
Release : 1999
Category : Health & Fitness
ISBN : UOM:39015042794654

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Ex Vivo Cell Therapy by Klaus Schindhelm,Robert Nordon Pdf

R.E. Nordon and K. Schindhelm, Introduction. -- L. Robb, A.G. Elefanty, and C.G. Begley, Transcriptional Control of Hematopoieses. -- R. Starr and N.A. Nicola, Cell Signaling by Hemopoietic Growth Factor Receptors. -- P.J. Simmons, D.N. Haylock, and J.-P. Lévesque, Influence of Cytokines and Adhesion Molecules on Hematopoietic Stem Cell Development. -- P.A. Rowlings, Allogeneic Hematopoietic Stem Cell Transplantation. -- U. Hahn and L.B. To, Autologous Stem Cell Transplantation. -- M.R. Vowels, Cord Blood Stem Cell Transplantation. -- S.R. Riddell, E.H. Warren, D. Lewinsohn, C. Yee, and P.D. Greenberg, Reconstitution of Immunity by Adoptive Immunotherapy with T Cells. -- L.Q. Sun, M. Miller, and G. Symonds, Exogenous Gene Transfer into Lymphoid and Hematopoietic Progenitor Cells. -- C. Dowding, T. Leemhuis, A. Jakubowski, and C. Reading, Process Development for Ex Vivo Cell Therapy. -- R.E. Nordon and K. Schindhelm, Cell Separation. -- P.W. Zandstra, C.J. Eaves, and J.M. Piret, Environ ...

The EBMT/EHA CAR-T Cell Handbook

Nicolaus Kröger,John Gribben,Christian Chabannon,Ibrahim Yakoub-Agha,Hermann Einsele
The EBMT EHA CAR T Cell Handbook Book PDF

Author : Nicolaus Kröger,John Gribben,Christian Chabannon,Ibrahim Yakoub-Agha,Hermann Einsele
Publisher : Springer Nature
Page : 221 pages
File Size : 50,9 Mb
Release : 2022-02-07
Category : Medical
ISBN : 9783030943530

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The EBMT/EHA CAR-T Cell Handbook by Nicolaus Kröger,John Gribben,Christian Chabannon,Ibrahim Yakoub-Agha,Hermann Einsele Pdf

This first open access European CAR-T Handbook, co-promoted by the European Society for Blood and Marrow Transplantation (EBMT) and the European Hematology Association (EHA), covers several aspects of CAR-T cell treatments, including the underlying biology, indications, management of side-effects, access and manufacturing issues. This book, written by leading experts in the field to enhance readers’ knowledge and practice skills, provides an unparalleled overview of the CAR-T cell technology and its application in clinical care, to enhance readers’ knowledge and practice skills.

Stem Cells and the Future of Regenerative Medicine

Institute of Medicine,Board on Neuroscience and Behavioral Health,National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on the Biological and Biomedical Applications of Stem Cell Research
Stem Cells and the Future of Regenerative Medicine Book PDF

Author : Institute of Medicine,Board on Neuroscience and Behavioral Health,National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on the Biological and Biomedical Applications of Stem Cell Research
Publisher : National Academies Press
Page : 112 pages
File Size : 42,8 Mb
Release : 2002-01-25
Category : Science
ISBN : 9780309170420

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Stem Cells and the Future of Regenerative Medicine by Institute of Medicine,Board on Neuroscience and Behavioral Health,National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on the Biological and Biomedical Applications of Stem Cell Research Pdf

Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.

Stem Cell Biology and Gene Therapy

Peter J. Quesenberry,Gary S. Stein,Bernard G. Forget,Sherman M. Weissman
Stem Cell Biology and Gene Therapy Book PDF

Author : Peter J. Quesenberry,Gary S. Stein,Bernard G. Forget,Sherman M. Weissman
Publisher : John Wiley & Sons
Page : 586 pages
File Size : 48,7 Mb
Release : 1998-09-10
Category : Science
ISBN : 0471146560

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Stem Cell Biology and Gene Therapy by Peter J. Quesenberry,Gary S. Stein,Bernard G. Forget,Sherman M. Weissman Pdf

STEM CELL BIOLOGY AND GENE THERAPY Edited by Peter J. Quesenberry, Gary S. Stein, Bernard Forget, and Sherman Weissman Advances in molecular genetics and recombinant DNA technology have ushered in a new era in medical therapeutic research. New insights into the molecular basis of human disease and the role played by biological regulatory mechanisms have precipitated tremendous drug development efforts backed by intensive research into human gene therapy worldwide. Stem Cell Biology and Gene Therapy is the first book to thoroughly cover major advances in the field and their applications to novel molecular therapies. This self-contained volume integrates biological and clinical components of stem cell biology, examines some of the most difficult aspects of gene therapy, and provides a systematic review of advanced gene modification techniques. Twenty essays by leading researchers address some of the most compelling topics in contemporary medical research, including: * Fundamental regulatory mechanisms that operate in stem cells * Stem cells from a therapeutic perspective, including preparations of stem cells and their therapeutic potential as vehicles for gene therapy * Delivery systems for therapeutic genes, including an overview of the most promising vectors * Clinical applications for gene therapy, covering a broad range of diseases such as hemophilia, cancers, neurological disease, and more Complete with illustrations and real-world examples of a variety of disorders, Stem Cell Biology and Gene Therapy is essential for researchers in gene therapy and members of the biotechnology industry who are developing human molecular therapies for commercial use. It is also an important reference for molecular biologists, cell biologists, immunologists, molecular geneticists, hematologists, cancer researchers, biochemists, and anyone working in internal medicine.