Cell Therapy Against Cerebral Stroke

Author : Kiyohiro Houkin,Koji Abe,Satoshi Kuroda
Publisher : Springer
Page : 156 pages
File Size : 44,6 Mb
Release : 2017-01-06
Category : Medical
ISBN : 9784431560593

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Cell Therapy Against Cerebral Stroke by Kiyohiro Houkin,Koji Abe,Satoshi Kuroda Pdf

This book presents comprehensive reviews for both translational research and clinical trials on cell therapy for stroke. Cerebral stroke is still a leading cause of death and disability. However, despite intensive research, few treatment options are available. The therapeutic potential of cell transplantation has been studied for various pathological conditions of the central nervous system (CNS) including traumatic brain injury, traumatic spinal cord injury, degenerative disease, demyelinating disease and ischemic stroke, as the injured neural tissue in the CNS has only a limited regenerative capacity. Recently, a growing body of evidence in this field suggests that cell transplantation holds great potential as a form of stroke therapy. The authors, who are experts in the field of neurosurgery, review and discuss optimal cell sources and various issues involved in translational research; further, they outline ongoing clinical trials in Japan.

Author : Jukka Jolkkonen,Piotr Walczak
Publisher : Springer Science & Business Media
Page : 205 pages
File Size : 48,7 Mb
Release : 2013-01-30
Category : Medical
ISBN : 9783709111758

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Cell-Based Therapies in Stroke by Jukka Jolkkonen,Piotr Walczak Pdf

Stroke remains one of the main causes of death and disability worldwide. While effective therapy for stroke recovery remains an unmet need. Much hope and promises are placed on cell-based therapies. The aim of this book is to provide focused yet comprehensive reviews on the current state of cell-based approaches in the treatment of stroke. The topics covered include experimental data on functional outcome after intravascular and intracerebral delivery of cells in stroke animals, followed by translational chapters which will rely heavily on the use of different imaging modalities in the tracking of cells. The last and most challenging part will describe the early phase of clinical studies, providing guidelines for future research and clinical applications. Clearly and concisely written, this text will be a useful resource for neurologists, radiologists, and neuroscientists interested in cell transplantation as a therapeutic strategy for stroke patients.

Author : Kunlin Jin,Xunming Ji,Qichuan Zhuge
Publisher : Springer
Page : 332 pages
File Size : 50,6 Mb
Release : 2016-12-13
Category : Science
ISBN : 9789811029295

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Bone marrow stem cell therapy for stroke by Kunlin Jin,Xunming Ji,Qichuan Zhuge Pdf

This book covers recent advances in all aspects of bone marrow-derived stem cells (BMSCs) for stroke treatment, while also providing comprehensive information on human clinical trials and animal models of stroke. In addition, it reviews the optimal conditions of transplantation for stroke therapy and potential mechanisms underlying transplanted cell-mediated functional recovery after stroke. As the first book to focus on BMSC therapy for stroke, it also discusses in depth the unique challenges of BMSCs-based therapy in this context.

Author : Li-Ru Zhao,John H. Zhang
Publisher : Springer
Page : 337 pages
File Size : 52,6 Mb
Release : 2014-11-24
Category : Medical
ISBN : 9783319114811

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Cellular Therapy for Stroke and CNS Injuries by Li-Ru Zhao,John H. Zhang Pdf

Cellular therapy for stroke and neural trauma has gained worldwide attention during the last decade and has shown some promising results. Various cells, including neural stem cells, bone marrow stem cells, endothelial progenitor cells, and many others have had protective or regenerative effects in animal models. The proposed book will address recent research on all relevant cell types. In addition, it will provide information on cell isolation and culture skills, transplantation methods, and neurological functional evaluations. This is the first book to focus on cellular therapy for stroke and other CNS injuries.

Author : David C. Hess
Publisher : Springer
Page : 369 pages
File Size : 45,5 Mb
Release : 2015-05-15
Category : Science
ISBN : 9783319150635

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Cell Therapy for Brain Injury by David C. Hess Pdf

Cell Therapy for Brain Injury is a thorough examination of using state-of-the-art cell therapy in the treatment of strokes and other traumatic brain injuries. This invaluable book covers this niche topic in depth from basic stem cell biology and principles of cell therapy through proposed mechanisms of action of cell therapy in stroke, pre-clinical data in stroke models, ongoing clinical trials, imaging and tracking of cells with MRI, neural stem cells in stroke and the "big pharma" perspective of cell therapy. Each chapter is written by well-known leaders in each field, thus providing a wealth of expertise. The breadth of this book makes it essential reading for neuroscientists, stem cell biologists, researchers or clinical trialists at pharmaceutical or biotechnology companies. It also serves as a thorough introduction for graduate students or post-doctoral fellows who hope to work in these fields.

Author : Paulo Henrique Rosado-de-Castro,Andrew N. Clarkson,Johannes Boltze,Koji Abe,Miroslaw Janowski,Pedro M. Pimentel-Coelho,Olivier Detante
Publisher : Frontiers Media SA
Page : 132 pages
File Size : 52,9 Mb
Release : 2020-05-22
Category : Electronic
ISBN : 9782889637386

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Cell-based Therapies for Stroke: Promising Solution or Dead End? by Paulo Henrique Rosado-de-Castro,Andrew N. Clarkson,Johannes Boltze,Koji Abe,Miroslaw Janowski,Pedro M. Pimentel-Coelho,Olivier Detante Pdf

Author : Syed Shadab Raza
Publisher : Springer Nature
Page : 360 pages
File Size : 42,7 Mb
Release : 2022-07-09
Category : Medical
ISBN : 9789811685620

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Regenerative Therapies in Ischemic Stroke Recovery by Syed Shadab Raza Pdf

This book illustrates the importance and significance of regenerative medicine in stroke recovery. It discusses stem-cell-based treatment strategies and offers mechanistic insights into their role in neurological recovery. It also examines the challenges and advances in using adult stem cells for enhanced therapeutic efficacy. Further, it presents the strategies as well as the strengths and weaknesses of various delivery methods to administer stem cells in ischemic stroke. It examines the role of non-coding RNA in our understanding the stroke pathogenesis, their regulatory role in ischemic stroke and potential as biomarkers and therapeutic targets. Lastly, it explores exosomes in the treatment of stroke, and the underlying mechanism of their action as therapeutic vectors for stroke. Given its scope, it is an excellent resource for neurologists, neuroscientists and researchers involved in regenerative therapy for stroke.

Author : Sean I. Savitz,Daniel M. Rosenbaum
Publisher : Springer Science & Business Media
Page : 166 pages
File Size : 50,6 Mb
Release : 2007-12-26
Category : Medical
ISBN : 9781603270571

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Stroke Recovery with Cellular Therapies by Sean I. Savitz,Daniel M. Rosenbaum Pdf

Stroke is the leading cause of serious, long term disability. This book proposes different cellular therapies under investigation to promote neural regeneration after stroke. Authored by an international panel of scientists and clinicians, this volume is a vital, one-of-a-kind resource for all scientists interested in regenerative medicine.

Author : Paul A. Lapchak,John H. Zhang
Publisher : Springer
Page : 541 pages
File Size : 42,6 Mb
Release : 2017-11-04
Category : Medical
ISBN : 9783319666792

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Cellular and Molecular Approaches to Regeneration and Repair by Paul A. Lapchak,John H. Zhang Pdf

This book discusses recent advances in the field of translational stroke research. The editors have designed the book to provide new insight into the importance of regeneration and repair mechanisms for stroke victims. The editors have brought together a talented group of international stroke researchers and clinicians to contribute to this volume, which is written for students, researchers and physicians in biotechnology, neurosciences, neurology, neuroradiology and neurosurgery. Throughout the world, stroke is still a leading cause of mortality and morbidity; there are 152,000 strokes in the United Kingdom, 62,000 in Canada, and approximately 15 million people worldwide. Large communities of stroke survivors are eagerly awaiting scientific advances in translational stroke research related to regeneration and recovery of function that would offer new therapeutics for rehabilitation and regeneration utilizing novel stem cell and molecular-based approaches. This volume will allow the reader to undersnd the future of stroke treatment from its inception in the laboratory through to clinical trial design. The reader will learn about the recent advances made in these areas related to basic and applied stroke research and their translational potential. Dr. Paul A. Lapchak is Professor of Neurology and Director of Translational Research in the Departments of Neurology & Neurosurgery at Cedars-Sinai Medical Center in Los Angeles CA, USA. Dr. Lapchak is an internationally recognized expert conducting translational drug development research for ischemic and hemorrhagic stroke. Dr. John H. Zhang is Professor of Anesthesiology, Neurosurgery, Neurology, and Physiology, and Director, Center for Neuroscience Research at Loma Linda University School of Medicine, Loma Linda, CA, USA. Dr. Zhang is an internationally recognized expert working on drug development for hemorrhagic stroke.

Author : Ranjana Patnaik,Amit Kumar Tripathi,Ashish Dwivedi
Publisher : Springer
Page : 189 pages
File Size : 52,8 Mb
Release : 2019-05-13
Category : Medical
ISBN : 9789811314537

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Advancement in the Pathophysiology of Cerebral Stroke by Ranjana Patnaik,Amit Kumar Tripathi,Ashish Dwivedi Pdf

This book provides detailed and comprehensive mechanistic insights of the various risk factors that lead to the ischemic stroke and the novel therapeutic interventions against it. The first section discusses the different ischemic cerebral stroke-induced inflammatory pathways and dysfunctionality of blood-brain barrier. The later sections of the book deals with the role of endoplasmic reticulum stress and mitophagy in cerebral stroke and introduces the different neuroimaging techniques such as Computed tomography (CT), Magnetic resonance imaging (MRI), Positron emission tomography (PET) and Single-Photon emission computed tomography (SPECT) that are used to identify the arterial blockages. The final section comprises of chapters that focus on various neuroprotective strategies and emerging therapeutic interventions for combating stroke pathophysiology. The chapters cover the role of stem cell therapy, the therapeutic effect of low-frequency electromagnetic radiations (LF-EMR), and implications of non-coding RNAs such as micro-RNAs as the biomarkers for diagnosis, prognosis, and therapy in ischemic stroke.

Author : Tulio Pinho Navarro,Lara Lellis Navarro Minchillo Lopes,Alan Dardik
Publisher : Springer Nature
Page : 425 pages
File Size : 45,6 Mb
Release : 2020-11-05
Category : Medical
ISBN : 9783030569549

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Stem Cell Therapy for Vascular Diseases by Tulio Pinho Navarro,Lara Lellis Navarro Minchillo Lopes,Alan Dardik Pdf

Vascular diseases are the leading cause of death worldwide. Distinguished clinical and surgical approaches have attempted to overcome its morbidity and mortality; still 17.9 million people die every year due to vascular affections. Stem cell therapy has emerged as a promising therapeutic strategy. Stem cells synthesize and secrete cytokines that promote cell recruitment, immunomodulation, extracellular matrix remodeling, angiogenesis, and neuroregeneration, all of which promote regeneration. Besides that, stem cells are also capable of differentiating in various cell types, being employed in tissue engineering. Preclinical and clinical investigations have reported efficacy of stem cell therapy for various vascular diseases. Even though results are encouraging, the studies demonstrate variation in stem cell type and origin, route and protocol for administration, and concomitant use of other treatment strategies, impairing easy interpretation of results and clinical application. The purpose of this book is to compile and comprise the current state of the evidence regarding stem cell therapy for each vascular disease, elucidating possible clinical applications. More than an objective guide for readers on the use of this novel treatment strategy, this publication will advocate for stem cell therapy use and development and will be of significant interest to physicians in a wide range of disciplines as well as researchers.

Author : Ranjana Patnaik,Amit Kumar Tripathi,Ashish Dwivedi
Publisher : Unknown
Page : 188 pages
File Size : 55,5 Mb
Release : 2019
Category : Cerebrovascular disease
ISBN : 9811314543

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Advancement in the Pathophysiology of Cerebral Stroke by Ranjana Patnaik,Amit Kumar Tripathi,Ashish Dwivedi Pdf

This book provides detailed and comprehensive mechanistic insights of the various risk factors that lead to the ischemic stroke and the novel therapeutic interventions against it. The first section discusses the different ischemic cerebral stroke-induced inflammatory pathways and dysfunctionality of blood-brain barrier. The later sections of the book deals with the role of endoplasmic reticulum stress and mitophagy in cerebral stroke and introduces the different neuroimaging techniques such as Computed tomography (CT), Magnetic resonance imaging (MRI), Positron emission tomography (PET) and Single-Photon emission computed tomography (SPECT) that are used to identify the arterial blockages. The final section comprises of chapters that focus on various neuroprotective strategies and emerging therapeutic interventions for combating stroke pathophysiology. The chapters cover the role of stem cell therapy, the therapeutic effect of low-frequency electromagnetic radiations (LF-EMR), and implications of non-coding RNAs such as micro-RNAs as the biomarkers for diagnosis, prognosis, and therapy in ischemic stroke.

Author : Charles S. Cox, Jr.
Publisher : Springer Science & Business Media
Page : 200 pages
File Size : 40,8 Mb
Release : 2010-11-25
Category : Science
ISBN : 9781607619659

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Progenitor Cell Therapy for Neurological Injury by Charles S. Cox, Jr. Pdf

There are currently no reparative therapies for severe neurological injury, including brain injury, spinal cord injury and stroke. Actually, most treatments are designed simply to limit secondary damage. However, pre-clinical data supports the idea that exogenous stem and progenitor cells have the potential to promote a reparative response to severe neurological injuries. Progenitor Cell Therapy for Neurological Injury is a compilation of seminal essays that explore many unique aspects of neurological injury, focusing on the critical translational issues of cell delivery. Specifically, it discusses routes of administration, types of progenitor cells (alone and/or in combinations), timing of delivery and adjuncts to promote cell engraftment, survival and effectiveness. In addition, many chapters address measuring the effects of transplanted cells and cell tracking. The paradigms of how cell-based therapeutics affect neurological injury is changing rapidly. The developments in this field may ultimately offer realistic hope for improvement in patients with severe injuries. This book is a vital key toward unlocking those future treatments.

Author : Cyndy D. Davis,Paul R. Sanberg
Publisher : Springer Science & Business Media
Page : 392 pages
File Size : 42,8 Mb
Release : 2007-11-09
Category : Medical
ISBN : 9781597451475

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Cell Therapy, Stem Cells and Brain Repair by Cyndy D. Davis,Paul R. Sanberg Pdf

As our world continues to evolve, the field of regenerative medicine f- lows suit. Although many modern day therapies focus on synthetic and na- ral medicinal treatments for brain repair, many of these treatments and prescriptions lack adequate results or only have the ability to slow the p- gression of neurological disease or injury. Cell therapy, however, remains the most compelling treatment for neurodegenerative diseases, disorders, and injuries, including Parkinson’s disease, Huntington’s disease, traumatic brain injury, and stroke, which is expanded upon in more detail in Chapter 1 by Snyder and colleagues. Cell therapy is also unique in that it is the only therapeutic strategy that strives to replace lost, damaged, or dysfunctional cells with healthy ones. This repair and replacement may be due to an administration of exogenous cells itself or the activation of the body’s own endogenous reparative cells by a trophic, immune, or inflammatory response to cell transplantation. However, the precise mechanism of how cell therapy works remains elusive and is c- tinuing to be investigated in terms of molecular and cellular responses, in particular. Moreover, Chapter 11 by Emerich and associates, discusses some of the possibilities of cell immunoisolation and the potential for treating central nervous system diseases.

Author : Haruo Shintaku,Akira Oka,Makoto Nabetani
Publisher : Springer
Page : 150 pages
File Size : 48,8 Mb
Release : 2018-03-01
Category : Medical
ISBN : 9789811014123

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Cell Therapy for Perinatal Brain Injury by Haruo Shintaku,Akira Oka,Makoto Nabetani Pdf

This book provides a wealth of insights, advances and new perspectives on cell therapy for different types of neonatal ischemic disease, such as Hypoxic-Ischemic Encephalopathy (HIE), Periventricular Leukomalacia (PVL) and neonatal infarction. These diseases pose serious challenges for neonatologists and neurologists, because the severe sequelae lead to decreasing QOL for patients and their families. Accordingly, new treatments for neonatal ischemic diseases are needed all over the world. The book develops new effective therapies combined with hypothermia therapy, an established treatment for HIE. After reviewing past approaches, it presents cutting-edge topics in cell therapy, one of the most promising candidates for treating neonatal ischemic disease. Cell Therapy for Neonatal Ischemic Disease will offer readers a better understanding of the current state of the art in this field from bench to bedside, and inspire researchers and physicians to further explore this evolving therapy.