Download Full eBooks in PDF
Cells Membranes And Disease Including Renal Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Cells Membranes And Disease Including Renal book. This book definitely worth reading, it is an incredibly well-written.
Author : E. Reid,G.M.W. Cooke,J.P. Luzio
Publisher : Springer Science & Business Media
Page : 484 pages
File Size : 48,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468412833
Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 41,9 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Author : Jong Hoon Park,Curie Ahn
Publisher : Springer
Page : 126 pages
File Size : 45,5 Mb
Release : 2016-10-12
Category : Medical
ISBN : 9789811020414
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Author : Angelo Azzi,Zdenek Drahota,Sergio Papa
Publisher : Springer Science & Business Media
Page : 437 pages
File Size : 53,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642744150
Biological membranes are often effected by diseases. Molecular events leading to or arising from pathological changes in the course of different diseases are as yet not clearly understood. This competent study by leading experts covers changes of the cellular environment, membranes and the metabolic functions during tissue growth and differentiation as well as aspects of abnormal organelle function in lysosomal storage diseases, peroxisomal and mitochondrial disorders, enzyme defects and regulatory defects of receptors due to oncogenes.
Author : Z.-H. Liui,J.C. He
Publisher : Karger Medical and Scientific Publishers
Page : 277 pages
File Size : 48,6 Mb
Release : 2014-05-16
Category : Medical
ISBN : 9783318026511
The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.
Author : Shaul Massry
Publisher : Springer Science & Business Media
Page : 611 pages
File Size : 45,6 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9781461342175
We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or ganizing Committee, therefore, decided to continue with the tradi tion to hold additional Workshops annually or every other year.
Author : J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young
Publisher : Unknown
Page : 0 pages
File Size : 45,7 Mb
Release : 2013-04-25
Category : Electronic
ISBN : 1947172808
Author : National Collaborating Centre for Chronic Conditions (Great Britain)
Publisher : Royal College of Physicians
Page : 238 pages
File Size : 52,9 Mb
Release : 2008
Category : Medical
ISBN : 9781860163401
This guideline presents clear criteria for testing of chronic kidney disease, for suspecting progressive CKD and referring people for specialist assessment.
Author : J. Charles Jennette
Publisher : Lippincott Williams & Wilkins
Page : 930 pages
File Size : 49,5 Mb
Release : 2007
Category : Medical
ISBN : 0781747503
Experts in the field of renal disease offer careful pathologic descriptions, appropriate clinical correlations, and extensive discussions on causes and pathogenesis to clarify the clinicians understanding and help facilitate easy, accurate diagnosis. This updated edition features hundreds of razor-sharp illustrations along with more international contributors than before.
Author : Severin Ringoir,Raymond Vanholder,Shaul G. Massry
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 44,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468454451
The present book contains the Proceedings of a two day Symposium on Uremic Toxins organized at the University of Ghent in Belgium. A series of guest lectures, free communications and posters have been presented. An international audience of 163 scientists from 16 nationalities listened to and discussed extensively a spectrum of topics brought forward by colleagues and researchers who worked for many years in the field of Uremic Toxins. There is a striking contrast between all the new dialysis strategies available in the work to "clean" the uremic patients and the almost non-progression of our knowledge on uremic toxins in the past decade. In this sense the symposium was felt by all participants as a new start for the research in the biochemical field of the definition of uremia. If the present volume would stimulate new work in this field in order to define uremia, or identify the uremic toxins, the purpose of the organizers would be maximally fulfilled.
Author : Enrico Drioli,Lidietta Giorno
Publisher : Newnes
Page : 1528 pages
File Size : 55,6 Mb
Release : 2010-07-09
Category : Technology & Engineering
ISBN : 9780080932507
Comprehensive Membrane Science and Engineering, Four Volume Set covers all aspects of membrane science and technology - from basic phenomena to the most advanced applications and future perspectives. Modern membrane engineering is critical to the development of process-intensification strategies and to the stimulation of industrial growth. The work presents researchers and industrial managers with an indispensable tool toward achieving these aims. Covers membrane science theory and economics, as well as applications ranging from chemical purification and natural gas enrichment to potable water Includes contributions and case studies from internationally recognized experts and from up-and-coming researchers working in this multi-billion dollar field Takes a unique, multidisciplinary approach that stimulates research in hybrid technologies for current (and future) life-saving applications (artificial organs, drug delivery)
Author : Stefan Bröer,Carsten A. Wagner
Publisher : Springer Science & Business Media
Page : 382 pages
File Size : 49,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781441990235
Every cell and organism faces the problem of spaces, made up of the two leaflets of the lipid generating a confined space in which metabolic bilayer. The importance of traffic and signaling across membranes is reflected by the estimate and anabolic reactions take place and at the same time allowing entry and exit of metabo that 20% of all genes in the human genome encode membrane proteins. A failure of any of lites, ions, proteins, and signals across its bor der. Evolution has solved the problem by these proteins may have dramatic con se generating lipid membranes that contain trans quences for ceH function. In recent years much porters, ion channels, and receptors. In eukary attention has been paid to diseases resulting otic cells, this problem is exacerbated by the from nonfunctional ion channels ("chan presence of multiple organelles, which are con nelopathies"). Not surprisingly, many of these fined spaces in their own right. Even the lipid diseases affect the excitability of cells. membrane consists of two relatively separate Transporter diseases (perhaps coined "carrier vi PREFACE diseases") are more related to metabolic dis Each chapter is concluded by a summary, and eases, Transporters are frequently found at the most chapters also contain an overview of the beginning or the end of metabolic pathways clinical features of a particular transporter and as a result can have similar effects to disease. a missing enzyme.
Author : S. Tsuyoshi Ohnishi,Tomoko Ohnishi
Publisher : CRC Press
Page : 440 pages
File Size : 51,7 Mb
Release : 1992-09-29
Category : Science
ISBN : 084938091X
Cellular Membrane: A Key to Disease Processes focuses on cellular membranes as a key to unlocking important new information about the pathological processes of strokes, heart attacks, diabetes, cancer, and other major diseases. The clinical relevance of basic research is particularly emphasized. Topics include calcium ions and calcium channel blockers, membrane ion channels and diabetes, membrane perturbation by asbestos fibers and disease, membrane receptors and signal transduction in tumor cells, anti-HIV compounds with membrane oriented specificity, and neuroleptic malignant syndrome. Cellular Membrane: A Key to Disease Processes is filled with illustrations, schemes, exciting ideas, and provocative hypotheses that are bound to lead to the development of new pharmacological techniques. It will prove to be an excellent reference guide for cell biologists and pathologists.
Author : Anonim
Publisher : Elsevier
Page : 392 pages
File Size : 43,5 Mb
Release : 2011-09-22
Category : Science
ISBN : 0080475345
All living cells are surrounded by a lipidic membrane that isolates them from the often harsh environment. However, to take up nutrients, to excrete waste, and to communicate among each other, Nature has invented an incredibly diverse set of transmembrane transport proteins. Specialized transporters exist to shuttle electrically charged ions, positive cations like sodium or negative anions like chloride, across the membrane. In the recent years, tremendous progress has been made in the field of chloride transport. The present book presents the state of the art of this rapidly expanding and interest-gaining field of membrane transport. It is addressed at a broad medically, physiologically, biologically, and biophysically interested readership. Describes the state-of-the-art in anion transport research Written by leaders in the field Presents a timely discussion of this rapidly emerging and expanding field
Author : Nicholas Kefalides,Jacques Borel
Publisher : Gulf Professional Publishing
Page : 460 pages
File Size : 43,8 Mb
Release : 2005-10-24
Category : Medical
ISBN : 0121533565
Basement Membranes: Cell and Molecular Biology brings together the most important research developments of the past 45 years that have enriched our knowledge and contributed to a better understanding of the biochemistry and cell and molecular biology of basement membranes. It describes the studies that shed light on the ultrastructural organization, the biosynthesis of the macromolecular components, their functions in embryonic development and differentiation, and in the mature state. A major portion of the book is devoted to the description of the genes that regulate the expression of the various structural macromolecules. Reviews the early years of research and the discovery of type IV collagen Presents the diversity of basement membrane morphology Discusses gene structure