Membrane Transporter Diseases

Author : Stefan Bröer,Carsten A. Wagner
Publisher : Springer Science & Business Media
Page : 382 pages
File Size : 53,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781441990235

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Membrane Transporter Diseases by Stefan Bröer,Carsten A. Wagner Pdf

Every cell and organism faces the problem of spaces, made up of the two leaflets of the lipid generating a confined space in which metabolic bilayer. The importance of traffic and signaling across membranes is reflected by the estimate and anabolic reactions take place and at the same time allowing entry and exit of metabo that 20% of all genes in the human genome encode membrane proteins. A failure of any of lites, ions, proteins, and signals across its bor der. Evolution has solved the problem by these proteins may have dramatic con se generating lipid membranes that contain trans quences for ceH function. In recent years much porters, ion channels, and receptors. In eukary attention has been paid to diseases resulting otic cells, this problem is exacerbated by the from nonfunctional ion channels ("chan presence of multiple organelles, which are con nelopathies"). Not surprisingly, many of these fined spaces in their own right. Even the lipid diseases affect the excitability of cells. membrane consists of two relatively separate Transporter diseases (perhaps coined "carrier vi PREFACE diseases") are more related to metabolic dis Each chapter is concluded by a summary, and eases, Transporters are frequently found at the most chapters also contain an overview of the beginning or the end of metabolic pathways clinical features of a particular transporter and as a result can have similar effects to disease. a missing enzyme.

Author : Thomas E. Andreoli,A.M. Brown,D.M. Fambrough,Joseph F. Hoffman,Stanley G. Schultz,Michael J. Welsh
Publisher : Springer Science & Business Media
Page : 687 pages
File Size : 40,6 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781461311430

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Molecular Biology of Membrane Transport Disorders by Thomas E. Andreoli,A.M. Brown,D.M. Fambrough,Joseph F. Hoffman,Stanley G. Schultz,Michael J. Welsh Pdf

When the six of us gathered to start planning for what was to be the Third Edition of Physiology of Membrane Disorders, it was clear that since 1986, when the Second Edition appeared, the field had experienced the dawning of a new era dominated by a change in focus from phenomenology to underlying mechanisms propelled by the power of molecular biology. In 1985, detailed molecular information was available for only three membrane transporters: the lac permease, bacterial rhodopsin, and the acetylcholine receptor. During the decade that has since elapsed, almost all of the major ion channels and transport proteins have been cloned, sequenced, mutagenized, and expressed in homologous as well as heterologous cells. Few, if any, of the transporters that were identified during the previous era have escaped the probings of the new molecular technologies and, in many instances, considerable insight has been gained into their mechanisms of function in health and disease. Indeed, in some instances novel, unexpected transporters have emerged that have yet to have their functions identified. The decision to adopt the new title Molecular Biology of Membrane Transport Disorders was a natural outgrowth of these considerations.

Author : Graça Soveral,Cesare Indiveri
Publisher : Frontiers Media SA
Page : 333 pages
File Size : 53,8 Mb
Release : 2020-01-03
Category : Electronic
ISBN : 9782889633579

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Membrane Transporters and Channels as Targets for Drugs by Graça Soveral,Cesare Indiveri Pdf

Transporters and channels are membrane proteins that mediate the traffic of metabolites, water and ions across biological membranes. Membrane transport proteins are crucial to maintain homeostasis and assure cell survival upon intracellular or environmental stress. A failure of any of these transport systems may have dramatic consequences for cell function. There is increasing evidence that membrane transport proteins play important functions in healthy conditions and that their absence or dysfunction may cause diseases. In recent years much attention has been paid to diseases resulting from defective transporters (“carrier diseases”) and ion channels (“channelopathies”). Very interestingly, altered expression of transporters has been described in several human pathologies. On this basis, many transport proteins are well acknowledged targets for drugs. Many others are involved in drug delivery and disposition and/or are considered potential targets. Others are off-targets for drugs and then, are responsible for side effects. Thus, membrane protein drug discovery is now an emerging field where the search for physiological mechanisms of regulation and for chemical compounds as modulators of transport activity, present new opportunities for drug development and for new therapies. This Research Topic addresses the latest research advances in membrane transport proteins, stimulating future research on these important protein families.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 50,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Ingolf Bernhardt,J. Clive Ellory
Publisher : Springer Science & Business Media
Page : 761 pages
File Size : 44,9 Mb
Release : 2013-04-17
Category : Science
ISBN : 9783662051818

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Red Cell Membrane Transport in Health and Disease by Ingolf Bernhardt,J. Clive Ellory Pdf

51 worldwide leading experts in the field of erythrocyte research contributed to this first book on transport processes in red blood cells. It explains the latest findings on the basis of well-established principles, in an accessibly structured and carefully organized compilation.

Author : Thomas E. Andreoli,Darrell D. Fanestil,Joseph F. Hoffman,Stanley G. Schultz
Publisher : Springer Science & Business Media
Page : 283 pages
File Size : 44,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468412864

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Clinical Disorders of Membrane Transport Processes by Thomas E. Andreoli,Darrell D. Fanestil,Joseph F. Hoffman,Stanley G. Schultz Pdf

Clinical Disorders of Membrane Transport Processes is a softcover book containing a portion of Physiology of Membrane Disorders (Second Edition). The parent volume contains six major sections that deal with general aspects of the physiology of transport processes and specific aspects of transport processes in cells and in organized cellular systems, namely epithelia. This text contains the last section, which deals with the application of the physiology of transport processes to the understanding of clinical disorders. We hope that this smaller volume will be helpful to individuals particularly interested in clinical derangements of membrane transport processes. THOMAS E. ANDREOLI JOSEPH F. HOFFMAN DARRELL D. FANESTIL STANLEY G. SCHULTZ Vll Preface to the Second Edition The second edition of Physiology of Membrane Disorders represents an extensive revision and a considerable expansion of the fIrst edition. Yet the purpose of the second edition is identical to that of its predecessor, namely, to provide a rational analysis of membrane transport processes in individual membranes, cells, tissues, and organs, which in tum serves as a frame of reference for rationalizing disorders in which derangements of membrane transport processes playa cardinal role in the clinical expression of disease. As in the fIrst edition, this book is divided into a number of individual, but closely related, sections. Part V represents a new section where the problem of transport across epithelia is treated in some detail. Finally, Part VI, which analyzes clinical derangements, has been enlarged appreciably.

Author : Thomas E. Andreoli,Darrell D. Fanestil,Joseph F. Hoffman,Stanley G. Schultz
Publisher : Springer Science & Business Media
Page : 1062 pages
File Size : 40,6 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781461320975

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Physiology of Membrane Disorders by Thomas E. Andreoli,Darrell D. Fanestil,Joseph F. Hoffman,Stanley G. Schultz Pdf

The second edition of Physiology of Membrane Disorders represents an extensive revision and a considerable expansion of the first edition . Yet the purpose ofthe second edition is identical to that of its predecessor, namely, to provide a rational analysis of membrane transport processes in individual membranes, cells, tissues, and organs, which in tum serves as a frame of reference for rationalizing disorders in which derangements of membrane transport processes playa cardinal role in the clinical expression of disease. As in the first edition, this book is divided into a number of individual, but closely related, sections. Part V represents a new section where the problem of transport across epithelia is treated in some detail. Finally, Part VI, which analyzes clinical derangements, has been enlarged appreciably. THE EDITORS xi Preface to the First Edition The purpose of this book is to provide the reader with a rational frame of reference for assessing the pa thophysiology of those disorders in which derangements of membrane transport processes are a major factor responsible for the clinical manifestations of disease. In the present context, we use the term "membrane transport to refer to those molecular processes whose cardinal function, broadly speaking, is processes" in a catholic sense, the vectorial transfer of molecules-either individually or as ensembles-across biological interfaces, the latter including those interfaces which separate different intracellular compartments, the cellular and extracellular com partments, and secreted fluids-such as glomerular filtrate-and extracellular fluids.

Author : Anonim
Publisher : Unknown
Page : 281 pages
File Size : 45,5 Mb
Release : 1987
Category : Membrane disorders
ISBN : OCLC:641069153

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Clinical Disorders of Membrane Transport Processes by Anonim Pdf

Author : Qing Yan
Publisher : Springer Science & Business Media
Page : 374 pages
File Size : 40,5 Mb
Release : 2008-02-02
Category : Science
ISBN : 9781592593873

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Membrane Transporters by Qing Yan Pdf

Studies of membrane transporters have had great impact on our und- standing human diseases and the design of effective drugs. About 30% of current clinically marketed drugs are targeting membrane transporters or channels. Membrane Transporters: Methods and Protocols provides various practical methodologies for the ongoing research on membrane transporters. To provide readers the most up-to-date information, several emerging fields and methodologies are embraced in this book, including pharmacogenomics, bioin-formatics, and microarray technology. Pharmacogenomics studies of membrane transporters are useful in drug discovery and in predicting drug responses in the clinic. In this volume, the current status of pharma- genomics studies of transporters is reviewed and research methodologies in this field are described. Transporter classification is important in studying the structure and function of membrane transporters and has thus triggered intensive interest in recent years. Membrane Transporters: Methods and Protocols provides a systematic classification of all transmembrane transport proteins found in living org- isms on Earth. This classification system will be helpful for further studies on various aspects of membrane transporters, especially for such large-scale gene expression studies as those employing microarray technologies. Bioinformatics is frequently used in transporter studies and has become indispensable for all kinds of research methods. Commonly used bio- formatics methods, such as databases and tools for sequence analysis and - tif studies, are explained in order to facilitate membrane transporters research. Because of heterogeneous sources and tremendous amounts of data, data in- gration has become one of the most important issues in transporter studies.

Author : Thomas E. Andreoli,Darrell D. Fanestil,Joseph F. Hoffman,Stanley G. Schultz
Publisher : Springer Science & Business Media
Page : 399 pages
File Size : 47,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468454048

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Membrane Transport Processes in Organized Systems by Thomas E. Andreoli,Darrell D. Fanestil,Joseph F. Hoffman,Stanley G. Schultz Pdf

Membrane Transport Processes in Organized Systems is a softcover book containing portions of Physiology of Membrane Disorders (Second Edition). The parent volume contains six major sections. This text encompasses the fourth and fifth sections: Transport Events in Single Cells and Transport in Epithelia: Vectorial Transport through Parallel Arrays. We hope that this smaller volume, which deals with transport processes in single cells and in organized epithelia, will be helpful to individuals interested in general physiology, transport in single cells and epithelia, and the methods for studying those transport processes. THOMAS E. ANDREOLI JOSEPH F. HOFFMAN DARRELL D. FANESTIL STANLEY G. SCHULTZ Vll Preface to the Second Edition The second edition of Physiology of Membrane Disorders represents an extensive revision and a considerable expansion ofthe first edition . Yet the purpose of the second edition is identical to that of its predecessor, namely, to provide a rational analysis of membrane transport processes in individual membranes, cells, tissues, and organs, which in tum serves as a frame of reference for rationalizing disorders in which derangements of membrane transport processes play a cardinal role in the clinical expression of disease. As in the first edition, this book is divided into a number of individual, but closely related, sections. Part V represents a new section where the problem of transport across epithelia is treated in some detail. Finally, Part VI, which analyzes clinical derangements, has been enlarged appreciably.

Author : Rashmi Wardhan,Padmshree Mudgal
Publisher : Springer
Page : 368 pages
File Size : 55,8 Mb
Release : 2018-01-10
Category : Science
ISBN : 9789811071010

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Textbook of Membrane Biology by Rashmi Wardhan,Padmshree Mudgal Pdf

This book provides a comprehensive overview of the basic principles, concepts, techniques and latest advances in the field of biomembranes and membrane-associated processes. With new emerging technologies and bioinformatics tools, this is a promising area for future study and research. The book discusses the composition, fluidity and dynamic nature of phospholipid bilayers, which vary with cell/organelle type and function. It describes the various types of transport proteins that facilitate the transport of polar and nonpolar molecules across the membrane actively or passively via ion-channels or through porins. It also explores the many cellular functions membranes participate in: (1) energy transduction, which includes the electron transport chain in inner membrane of mitochondria and bacterial cytoplasmic membrane and photosynthetic electron transport in thylakoid membranes in chloroplast and photosynthetic bacterial membranes; (2) cell–cell communication involving various signal transduction pathways triggered by activated membrane receptors; (3) cell–cell interactions involving various types of adhesion and receptor proteins; (4) nerve transmission involving opening and closing of voltage gated ionic channels; and (5) intracellular transport involving the processes of endocytosis, exocytosis, vesicular transport of solutes between intracellular compartments, membrane fusion and membrane biogenesis.

Author : Thomas E. Andreoli,Darrell D. Fanestil,Joseph F. Hoffman,Stanley G. Schultz
Publisher : Springer Science & Business Media
Page : 397 pages
File Size : 45,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461319436

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Membrane Physiology by Thomas E. Andreoli,Darrell D. Fanestil,Joseph F. Hoffman,Stanley G. Schultz Pdf

Membrane Physiology (Second Edition) is a soft-cover book containing portions of Physiology of Membrane Disorders (Second Edition). The parent volume contains six major sections. This text encompasses the first three sections: The Nature of Biological Membranes, Methods for Studying Membranes, and General Problems in Membrane Biology. We hope that this smaller volume will be helpful to individuals interested in general physiology and the methods for studying general physiology. THOMAS E. ANDREOLI JOSEPH F. HOFFMAN DARRELL D. FANESTIL STANLEY G. SCHULTZ vii Preface to the Second Edition The second edition of Physiology of Membrane Disorders represents an extensive revision and a considerable expansion of the first edition. Yet the purpose of the second edition is identical to that of its predecessor, namely, to provide a rational analysis of membrane transport processes in individual membranes, cells, tissues, and organs, which in tum serves as a frame of reference for rationalizing disorders in which derangements of membrane transport processes playa cardinal role in the clinical expression of disease. As in the first edition, this book is divided into a number of individual, but closely related, sections. Part V represents a new section where the problem of transport across epithelia is treated in some detail. Finally, Part VI, which analyzes clinical derangements, has been enlarged appreciably.

Author : Julita Kulbacka,Saulius Satkauskas
Publisher : Springer
Page : 140 pages
File Size : 55,5 Mb
Release : 2017-10-04
Category : Medical
ISBN : 9783319568959

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Transport Across Natural and Modified Biological Membranes and its Implications in Physiology and Therapy by Julita Kulbacka,Saulius Satkauskas Pdf

This book elucidates the mechanisms involved in biological membrane functions. It describes the new modalities and characterization for basic in vitro as well as computer models of biological membranes. Biological membranes are analyzed in terms of advances in molecular dynamics. The individual chapters provide an in depth analysis of images from various biological models. The potential of membrane models in the context of treatment trials is discussed. The authors present new insights and current concepts for treatment procedures (nanocarriers, electroporation, channel blockers).

Author : Anonim
Publisher : Academic Press
Page : 414 pages
File Size : 49,9 Mb
Release : 2019-06-05
Category : Science
ISBN : 9780128177655

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Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders by Anonim Pdf

Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders, Volume 83, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this volume presenting chapters from recognized experts on topics such as cardiotonic steroids, Na+, K+ pumps and vascular fibrosis, purinergic signaling in the lung, structural models of a2-subunit N-termini and binding interfaces, ubiquitous and cell type-specific transcriptomic changes triggered by dissipation of monovalent cation gradients, the Na, K-ATPase alpha2 isoform in cardiovascular pathologies, the role of cell swelling and volume-sensitive ion channels in stroke pathology, structure-function relationships in the renal NaCl cotransporter, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Membranes series Includes the latest information on membrane ion transporters

Author : Qing Yan
Publisher : Humana Press
Page : 357 pages
File Size : 48,5 Mb
Release : 2011-08-25
Category : Medical
ISBN : 1607617153

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Membrane Transporters in Drug Discovery and Development by Qing Yan Pdf

Studies of membrane transporters have had a great impact on our understanding of human diseases and the design of effective drugs. In Membrane Transporters in Drug Discovery and Development: Methods and Protocols, expert researchers provide practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development. Chapters include new and useful fields and methodologies, including pharmacogenomics, nutrigenomics, systems biology, bioinformatics, nuclear magnetic resonance (NMR), imaging, and quantitative real-time-PCR. Transporter studies in drug discovery and development for various diseases are discussed, including neuropsychiatric disorders, cardiovascular diseases, ophthalmic diseases, cancer, and diabetes. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Wide-ranging and current, Membrane Transporters in Drug Discovery and Development: Methods and Protocols delivers a collection of practical protocols that can be used immediately in the lab, along with critical surveys of key topics by leading researchers in the field.