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The Gene Makeover by Vincent C. Giampapa,Ohan Karatoprak,Frederick F. Buechel Pdf
This book shows readers how they can personally direct and monitor their own health and become proactive in optimizing their quality of life. Thanks to the latest advances in genetic science, one no longer has to be a victim of genetic inheritance.
Your source of beauty is at the cellular level. "Cellular Makeover" deals with much more than just appearance, as appearance as well as the elements and gravity are what pay their toll over time. But we will be dealing with the actions and emotions that in turn have caused a certain amount of havoc within the body, deep within the systems and their harmonious function one with the other. Rejuvenation is at the cellular level and mirrors itself into one's face. The body's tissue, much more evident in the facial features, is a holographic image of the general state of health of the body. With the latest Scientific knowledge from the West and the ancient wisdom from the East, this book guides you through the latest knowledge on how to evaluate, how to prevent and how to nurture your cells to give you that absolute Cellular Makeover" which is your true source of beauty.
Autophagy of the Nervous System by Zhenyu Yue,Charleen T Chu Pdf
What is autophagy? Why would neurons digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as an accomplice to cell death in others? By what mechanisms are autophagy-related processes dysregulated in neurological diseases, and are there therapeutic strategies to correct or compensate for their dysfunction? This book provides an expert view of major concepts in autophagy research with a focus on autophagy in neurons. Experimental evidence for evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented, including recent data on braking mechanisms. Areas of intersection with cell death, the ubiquitin-proteasome system, chaperone-mediated autophagy, and the endocytic pathway will be reviewed, along with emerging areas of mitochondrial autophagy (mitophagy) and the autophagic regulation of neuritic/synaptic processes. Advances in delineating mechanisms by which autophagy is involved in the pathophysiology of neurological disorders, including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, ischemia/hypoxia and lysosomal storage diseases, will be discussed along with current drug development strategies targeting autophagy. Contents:Neuronal Autophagy: Cellular Process and Regulation:The Cellular Process of Autophagy and Control of Autophagy in Neurons (Nicole C McKnight, Noboru Mizushima and Zhenyu Yue)Autophagosome Maturation, Endocytosis and Neurodegenerative Disease (Ai Yamamoto and Anne Simonsen)Cross-Talk Between the Ubiquitin-Proteasome System and Macroautophagy (Serhiy Pankiv and Terje Johansen)Chaperone-Mediated Autophagy (CMA) in Neurons (Maria Xilouri, Hsiao-Yu Peng and Leonidas Stefanis)Maintaining Autophagic Balance: A Role for Brakes (Salvatore J Cherra, III and Charleen T Chu)Autophagy and Neurological Diseases:Autophagy and Its Cross-Talk with Cell Death in Neural Development (Sabrina Di Bartolomeo and Francesco Cecconi)Autophagy in the Retina: Development, Physiology and Pathology (Patricia Boya)Genetic Mouse Models for Elucidation of Autophagy-Lysosomal Systems in Neurons Under Physiologic and Pathologic Conditions (Masaaki Komatsu, Masato Koike, Yoshinobu Ichimura and Yasuo Uchiyama)Autophagy in Amyotrophic Lateral Sclerosis (Jozsef Gal and Haining Zhu)Autophagy Failure in Alzheimer's Disease and Lysosomal Storage Disorders: A Common Pathway to Neurodegeneration? (Devin M Wolfe and Ralph Nixon)Autophagy in Huntington's and Parkinson's Diseases: Pathogenic Mechanism and Therapeutic Potentials (Junghyun Lim, Lauren G Friedman, Nicole C McKnight and Zhenyu Yue)Metabolism, Autophagy and Neurodegeneration (W Haung Yu and Karen E Duff)The Potential of Autophagy Regulation in the Treatment of Neurodegenerative Diseases (Ashley R Winslow, Zeyn W Green-Thompson and David C Rubinsztein)Lysosome Storage Disorders on the Brain: The Autophagy-Lysosome Pathway Contributes to Disease Pathophysiology and May be Utilized for Therapeutic Benefit (John J Shacka)Specialized Autophagy: The New Frontier:Autophagy — Roles in Synaptic Structure and Function (Daniela Hernandez and David Sulzer)Neuronal Mitochondrial Transport and Turnover via Mitophagy (Zu-Hang Sheng and Charleen T Chu)Role of Autophagy in Neurite Degeneration In Vitro (Yi Yang, Xiaoxiang Zheng and Tatsuro Koike) Readership: Neurologists (clinical), molecular biologists (scientists), and college students. Keywords:Autophagy;Neurons;Neurodegeneration;Cell Death;Disease;Neuropathology;Neurological Disorders;Autophagosomes;Lysosomes;Degradation;Axons;Mitochondria;Chaperone Proteins;Alzheimer's Disease;Parkinson's Disease;Huntington's Disease;Protein AggregationKey Features:Collates the most recent research on autophagy regulation and critically examines the relevance of specific mechanisms to disease in light of unique aspects of neuronal cell biologyCovers newer knowledge of general autophagy processes, reviews the state of the art on specific aspects of autophagy regulation in neurons, and discusses the role of autophagy in neurodegenerative diseaseThe co-editors and contributing authors for each of the chapters are all experts, including some of the most influential figures in autophagy research and neurodegeneration
Intermittent Fasting for Beginners by Emily Costa Pdf
DISCOVER THE SECRETS BEHIND QUICK AND EFFECTIVE WEIGHT LOSS WITH THIS PERFECT GUIDE ON INTERMITTENT FASTING Are you looking for an easy and effective way to lose weight? You've probably heard about intermittent fasting and how great it is for weight loss and overall health, but you're not sure where to start. That's why this book was written to help beginners get started with intermittent fasting easily and effectively. In this book, you'll learn all about autophagy, the keto diet, and meal plan hacks that will make your fasting journey easier than ever before! The secret is that intermittent fasting allows your body to go into a fasted state, which means that instead of needing food as fuel, it burns fat! With this book, you'll be handed the keys to: - A diet that's efficient and easy to stick to. - Practice self-discipline! - Meal plan hacks so you'll never go off track. - The secret to looking young and radiant! - Higher levels of energy so you can stay motivated throughout the day! - Skip the confusion about intermittent fasting and get straight into reaping its benefits. - Rapidly burn fat while still eating your favorite foods! - Lose weight without spending hours in the gym! Learn everything you need to know about intermittent fasting in order to get started today! With this easy-to-follow guide, you can't go wrong. You'll be guided every step of the way! Eat whatever you want while still losing weight. SCROLL UP, CLICK ON "BUY NOW", AND GET STARTED!
The award-winning New York Times bestselling author of the New Fat Flush series is back with a foolproof way to melt fat faster than ever Go beyond Keto and Paleo with Radical Metabolism, which reveals the secrets to reviving a sluggish over-40 metabolism -- secrets that work even faster if you're in your 20s and 30s, or you suffer from thyroid issues. No matter your age, if you're a "slow loser" who wants to speed off stubborn pounds and keep those pounds off for good, then this book is for you. Inside Radical Metabolism you'll discover which "forbidden fats," forgotten flavors, and fat-busting beverages you must eat and drink in order to supercharge your metabolism--making weight loss easier than ever before. But weight loss is just the beginning. With this easy-to-follow program you'll also enjoy greater energy, balanced mood, healthier skin, and protection against autoimmunity, gallbladder issues, type II diabetes, and other devastating health problems. A breeze to use, the Radical Metabolism program consists of: a 4-day Radical Intensive Cleanse designed to rest your digestive tract and detoxify your body a 21-Day Radical Reboot where you'll learn exactly what combinations of foods to eat for results you can feel and see a Maintenance Plan for a radically healthy life With menu plans, 50 sumptuous recipes, an extensive resource section, Radical Metabolism has everything you need to say supercharge your metabolism and transform your body into a fat-burning dynamo in just 21 days.
Ketogenic Diet and Intermittent Fasting for Beginners by Emily Costa Pdf
IF YOU’RE TIRED OF INEFFECTIVE AND RESTRICTIVE DIETS THAT DON’T EVEN WORK THEN THIS IS THE BOOK FOR YOU! Do you want to lose weight and feel better than ever before? Are you ready to take the first step towards a happier and new you? You know that you need to make a change, but it feels so overwhelming and you don't even know where to start. It's tough to know where to start when it comes to weight loss. There are so many diets and exercise programs out there, all with different promises and results. How can you possibly decide what will work for you? The ketogenic diet and intermittent fasting are two of the most effective ways to do just that – without feeling hungry or deprived! They’re both incredibly effective, and when combined they can help you achieve your goals faster than ever before! This book combines the best of both diets, to bring to you the most informative and in-depth guide so you can get started on your weight loss journey immediately. It will teach you everything you need to know about how to start losing weight today using these methods! With this guide, you can finally achieve the body you’ve always wanted – without restrictive diets or grueling workouts. You’ll learn how to create a meal plan that fits your needs, autophagy tricks for speeding up weight loss, and delicious low-carb recipes that will keep you satisfied all day long. The body you’ve always wanted is now within reach! So, what are you waiting for? SCROLL UP, CLICK ON “BUY NOW”, AND START READING!
From the author of Eat, Drink, and Be Gorgeous comes the must-have little Pink Bible for on-the-spot advice on how to be healthy while having fun. Offering up over 200 quick tips, Secrets of Gorgeous shows women how to eat and drink what they love yet maintain their youthful beauty. No diets, no gimmicks, just real solutions for gorgeous girls on the go. Esther reveals secrets she shares with her A-list clients at Dr. Perricone’s flagship Manhattan store—how to nip a hangover in the bud, choose the best dish on a date, dine out without packing on the pounds, rev up the sex drive, and much, much more. Secrets of Gorgeous proves that it’s possible to have that cosmopolitan and drink it, too. Praise for Eat, Drink, and Be Gorgeous “Blum’s complete guide to women’s health is an encouraging, smart and sisterly volume that deserves a place alongside other trusted go-to resources.” —Publishers Weekly “Filled with sound nutritional advice on what to eat and drink and how to repair the damage when our good intentions slip. A delightful book, as entertaining as it is educational.” —Nicholas Perricone, MD “A lusty, sensual ‘diet book’ for real people . . . filled with great information and user-friendly advice for people who really appreciate food; best of all, it’s written with a twinkle in the eye and a sense of glamour.” —Jonny Bowden, PhD, CNS, national bestselling coauthor of The Great Cholesterol Myth
The Unfolded Protein Response and Cellular Stress by P. Michael Conn Pdf
This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights. This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological ins.
The Unfolded Protein Response and Cellular Stress by P. Michael Conn Pdf
This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights. This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.
Quality Control of Cellular Protein in Neurodegenerative Disorders by Uddin, Md. Sahab,Ashraf, Ghulam Md. Pdf
Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of neurodegeneration. Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the role of the protein quality control in neurodegenerative disorders and potential therapeutic strategies to combat the development and propagation of neurodegeneration. Featuring coverage on a broad range of topics such as molecular chaperones, protein misfolding, and stress signaling, this book is ideally designed for neurobiologists, neuropsychologists, neurophysiologists, medical professionals, neuropathologists, researchers, academicians, students, and practitioners engaged in studies of the protein quality control system in neuronal cells.
Cellular Endocrinology in Health and Disease by Alfredo Ulloa-Aguirre,Ya-Xiong Tao Pdf
Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts Explores endocrine cells biology in normal and pathologic conditions Covers new aspects of endocrine cell function in distinct tissues Provides a view into the biological effect in local and systemic levels 15 new chapters covering the recent developments in the field
Oxford American Writer's Thesaurus by Christine A. Lindberg Pdf
Much more than a word list, the Oxford American Writer's Thesaurus is a browsable source of inspiration as well as an authoritative guide to selecting and using vocabulary. This innovative thesaurus eatures real-life example sentences, usage notes, literary quotations, and thought-provoking reflections on favorite (and not-so-favorite) words by over two dozen renowned contemporary writers. The third edition revises and updates this innovative reference, enhancing it with new features and adding hundreds of new words, senses, and phrases to the more than 300,000 synonyms and 10,000 antonyms.
From USA Today bestselling author Anthea Sharp, Steampunk with an intergalactic twist! Enter a fantastical world filled with alien spacecraft and Victorian sensibilities, formal balls and travel to the stars. From a mishap-filled wedding to a fugitive’s fresh start, experience the world of Victoria Eternal - where nanotech ball gowns are all the rage, steam power vies with alien starship technology, and the yearnings of the human heart remain unchanged… Includes: A Splendid Wedding, The Clockwork Harp, Lady Elizabeth's Betrothal Ball, One More Star, Shining, and Stowaway. KEYWORDS: Steampunk, Alternate History, British Galactic Empire, Fresh Start, Lesbian Main Character, LGBT Science Fiction, Space Opera, Space Adventure, Genetic Engineering
I found more than religion in an angel’s kiss. My studies in theology didn’t prepare me to deal with angels from outer space. They’re real. They fly. And in their elevated arrogance, they don’t think they need anyone’s help. So, imagine my surprise when the shy but hunky Zakai asks for my assistance in locating Noah’s ark. Apparently, it’s not just a religious myth. The massive ship did exist, and it looks like humanity might need it if they’re going to survive an incoming invasion. As we work to uncover the mystery, we’re stymied by opposing forces doing everything they can to stop us. I’ll admit, I never thought I’d end up fighting demons, just like I never expected to fall in love with an angel. But when given a choice, will he choose me or God? A celestial, alien romance.
