Cellular Mechanisms Of Cardiovascular Disease

Author : Tânia Martins-Marques,Gonçalo F Coutinho,Attila Kiss
Publisher : Mdpi AG
Page : 0 pages
File Size : 43,6 Mb
Release : 2023-10-10
Category : Science
ISBN : 3036589880

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Cellular Mechanisms of Cardiovascular Disease by Tânia Martins-Marques,Gonçalo F Coutinho,Attila Kiss Pdf

Cardiovascular diseases (CVD) remain the major cause of mortality and disability worldwide. Although cardiovascular outcomes have significantly improved due to early diagnosis and timely treatment, the prevalence of CVD is expected to increase in the coming years, highlighting the pressing need to identify novel biomarkers and disease-modifying treatments. In addition to classical risk factors, CVD burden is now recognized to be aggravated due to the growing population of cancer survivors treated with cardiotoxic cancer therapies or radiotherapy, which has fostered the development of a new field of research-cardio-oncology. Across the spectrum of CVD, multiple molecular pathways converge in endothelial dysfunction and myocardial remodeling, including inflammation, oxidative stress, defective calcium homeostasis, intercellular communication, and metabolic abnormalities. Therefore, a major future challenge in cardiovascular medicine lies in understanding the molecular basis of cardiac and valvular remodeling, paving the way for the identification of more efficient diagnostic and therapeutic tools. This Special Issue intended to bring together the latest findings in the field of cardiovascular biology and cardio-oncology, involving both cell-based studies and animal models of CVD, aiming to identify novel mechanisms underlying cardiac remodeling and dysfunction.

Author : Linda L. Gallo
Publisher : Springer Science & Business Media
Page : 566 pages
File Size : 40,6 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9781468452969

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Cardiovascular Disease by Linda L. Gallo Pdf

The Sixth Annual International Spring Symposium on Health Sciences, held in Washington, D. C. , in May 1986, brought together over 650 scientists from 19 countries to review and update research on cardiovascular disease. In this volume, which contains 59 chapters, an internationally recognized group of authors con tribute up-to-date accounts of molecular and cellular processes occurring in the vessel wall in atherogenesis and describe approaches to the prevention and treatment of atherosclerosis. The volume is divided into six major sections. Two sections deal with current aspects of lipoprotein metabolism. In Part I, we are alerted to the impact on li poprotein metabolism of structural heterogeneity within the four broad lipoprotein classes. Attention then turns to the components that orchestrate lipoprotein metab olism. Apolipoprotein identities, processing, and functions are described, as are the roles of lipid transfer proteins in plasma lipoprotein remodeling. Hepatic lipase synthesis and secretion are described. In Part II, Nobel Laureates Michael S. Brown and Joseph L. Goldstein describe mutations in the LDL receptor that reveal the functions of its various domains and point out how understanding the LDL receptor has provided a rational basis for its regulation. A discussion of the role of receptors in regulating cholesterol uptake by tissues follows, with emphasis on receptor-ligand interactions. Additional pathways for cholesterol delivery to cells are explored, as are pathways for cholesterol egress.

Author : Monte Willis,Jonathon W. Homeister,James R. Stone
Publisher : Academic Press
Page : 339 pages
File Size : 54,7 Mb
Release : 2013-12-23
Category : Medical
ISBN : 9780124055254

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Cellular and Molecular Pathobiology of Cardiovascular Disease by Monte Willis,Jonathon W. Homeister,James R. Stone Pdf

Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

Author : Hasso 04Scholz,Masao Endoh,Toshihiko Iijima,Martin Morad,Hasso Scholz
Publisher : Springer Science & Business Media
Page : 445 pages
File Size : 45,7 Mb
Release : 2013-12-14
Category : Medical
ISBN : 9784431659525

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Molecular and Cellular Mechanisms of Cardiovascular Regulation by Hasso 04Scholz,Masao Endoh,Toshihiko Iijima,Martin Morad,Hasso Scholz Pdf

This volume contains selected papers presented at the Sendai International Sympo sium on Molecular and Cellular Mechanisms of Cardiovascular Regulation held from May 10-12, 1995, to honor the contributions ofProfessorNorio Taira, Chairman of the Department of Pharmacology (1972-1995), Tohoku University School of Medicine, Sendai, Japan. The Department of Pharmacology at Sendai has a long tradition of significant contribution to the development of drug therapy for cardiovascular diseases. The late Professor Koroku Hashimoto, the predecessor of Professor Norio Taira, first suggested the mode of action of calcium antagonists and their potential usefulness in therapy of ischemic heart disease and hypertension at an early stage of their development. The need for greater understanding of the pathophysiology of cardiovascular dis eases is more critical now than ever before because modern advances in basic and clinical sciences have prolonged the average life expectancy. Using a wide range of molecular and electrophysiological techniques, major advances are occurring frequently in the field of cardiovascular physiology and pharmacology. Such multifaceted approaches are preferred because human cardiovascular diseases are complex, requiring multiple interventions and an in-depth understanding of molecular mechanisms underlying the disease. The first section of this book focuses on molecular mechanisms of ion channel regulation. Eight of ten chapters in this section are devoted to the recent advances in molecular characterization and regulation of various types of potassium channels in cardiac, vascular, and neuronal tissues. A discussion of the structure and function of sodium and calcium channels is also included.

Author : Kenneth Scott Campbell,Amy Li,Sean Lal
Publisher : Frontiers Media SA
Page : 187 pages
File Size : 54,8 Mb
Release : 2023-09-06
Category : Medical
ISBN : 9782832533185

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Molecular and Cellular Mechanisms of Heart Failure: Pathophysiology, pathogenesis and therapeutics by Kenneth Scott Campbell,Amy Li,Sean Lal Pdf

Author : Linda L. Gallo
Publisher : Springer
Page : 608 pages
File Size : 53,6 Mb
Release : 1987-11-30
Category : Medical
ISBN : 0306425378

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Cardiovascular Disease by Linda L. Gallo Pdf

The Sixth Annual International Spring Symposium on Health Sciences, held in Washington, D. C. , in May 1986, brought together over 650 scientists from 19 countries to review and update research on cardiovascular disease. In this volume, which contains 59 chapters, an internationally recognized group of authors con tribute up-to-date accounts of molecular and cellular processes occurring in the vessel wall in atherogenesis and describe approaches to the prevention and treatment of atherosclerosis. The volume is divided into six major sections. Two sections deal with current aspects of lipoprotein metabolism. In Part I, we are alerted to the impact on li poprotein metabolism of structural heterogeneity within the four broad lipoprotein classes. Attention then turns to the components that orchestrate lipoprotein metab olism. Apolipoprotein identities, processing, and functions are described, as are the roles of lipid transfer proteins in plasma lipoprotein remodeling. Hepatic lipase synthesis and secretion are described. In Part II, Nobel Laureates Michael S. Brown and Joseph L. Goldstein describe mutations in the LDL receptor that reveal the functions of its various domains and point out how understanding the LDL receptor has provided a rational basis for its regulation. A discussion of the role of receptors in regulating cholesterol uptake by tissues follows, with emphasis on receptor-ligand interactions. Additional pathways for cholesterol delivery to cells are explored, as are pathways for cholesterol egress.

Author : Linda L. Gallo
Publisher : Springer Science & Business Media
Page : 352 pages
File Size : 52,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461519591

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Cardiovascular Disease by Linda L. Gallo Pdf

The Fourteenth Washington International Spring Symposium, held in Washington, D.C., in June 1994, brought together over 400 leading scientists from 21 countries to review and update research on cardiovascular disease. This group satisfied the symposium goals of formulating a more comprehensive and integrated picture of the events contributing to atherosclerosis and of exploring modified gene expression as an to understanding the causes of atherosclerosis and providing clues to the approach prevention and treatment. This volume contains most of the papers presented at the eight plenary sessions together with selected contributions from the special sessions. The multidisciplinary nature of the chapters and their authors should stimulate the interests of biochemists, cell and molecular biologists, pathologists, pharmacologists, epidemiologists, nutritionists, and clinicians. The volume is divided into eight sections which reflect the focus of the plenary sessions. Part I focuses on the pathophysiology of atherosclerotic plaques and predicts that the nature of the fibrous cap of atheroma determines plaque disruption and clinical events. Papers in Part II deal with atherogenic lipoproteins. The introductory paper reviews the current view of the role of plasma lipoproteins in atherosclerosis. With respect to the newer members on the list,: [oxidized LDL, Lp(a)] evidence is provided that suggests the involvement of one major gene in the development of oxidized LDL lipids. the expression of inflammatory genes, and the development of aortic fatty streaks.

Author : Gowraganahalli Jagadeesh,Pitchai Balakumar,Khin Maung-U
Publisher : Springer
Page : 1342 pages
File Size : 43,6 Mb
Release : 2015-05-06
Category : Medical
ISBN : 9783319159614

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Pathophysiology and Pharmacotherapy of Cardiovascular Disease by Gowraganahalli Jagadeesh,Pitchai Balakumar,Khin Maung-U Pdf

The present book covers the basic principles of cardiovascular physiology, pathophysiology and advanced pharmacology with particular emphasis on cellular mechanisms of drug action. It provides an update on the progress made in several aspects of cardiovascular diseases so that it might kindle scientists and clinicians alike in furthering basic and translational research. In addition, the book is expected to fill imperative gaps in understanding and optimally treating cardiovascular disease.

Author : Sarah Jane George,Jason Johnson
Publisher : John Wiley & Sons
Page : 420 pages
File Size : 51,5 Mb
Release : 2010-01-07
Category : Science
ISBN : 3527629599

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Atherosclerosis by Sarah Jane George,Jason Johnson Pdf

With atherosclerosis being the number one cause of death in the western world, this handbook and ready reference provides a comprehensive account of the different stages and factors in the development of the atherosclerotic plaque. Each chapter is written by experts in the field and highlights the role of specific mediators of atherosclerotic plaque development, as well as potential therapeutic targets. A large amount of this up-to-date information is conveyed by way of tables and schematic figures, in a readily comprehensible manner. A must-have for master and PhD students, researchers, MDs and lecturers in vascular biology and cardiology, as well as for academics and scientists in the pharmaceutical industry.

Author : Sajal Chakraborti,Naranjan S. Dhalla,Madhu Dikshit,Nirmal K. Ganguly
Publisher : Springer Nature
Page : 686 pages
File Size : 53,8 Mb
Release : 2019-11-10
Category : Science
ISBN : 9789811389467

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Modulation of Oxidative Stress in Heart Disease by Sajal Chakraborti,Naranjan S. Dhalla,Madhu Dikshit,Nirmal K. Ganguly Pdf

This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease. The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions.

Author : Jennifer E. Van Eyk,Michael J. Dunn
Publisher : John Wiley & Sons
Page : 423 pages
File Size : 46,7 Mb
Release : 2006-03-06
Category : Science
ISBN : 9783527605453

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Proteomic and Genomic Analysis of Cardiovascular Disease by Jennifer E. Van Eyk,Michael J. Dunn Pdf

This is the very first book to focus on this new approach that will eventually aid in developing new diagnostic markers and therapies for controlling and treating heart disease - the number-one killer in the industrialized world. Divided into two parts, the book describes not only the potentials, but also the limitations of these technologies. The editors, both well known within the scientific community, provide new insights into the biochemical and cellular mechanisms of cardiovascular disease, as well as covering the transition into clinical applications. In so doing, they highlight the various strategies and technical aspects so as to assist the growing number of researchers intending to utilize these approaches. The result is an excellent way of educating and informing graduate students, post-doctoral fellows as well as researchers in academia and industry about the latest developments in this area.

Author : José Marín-García
Publisher : Springer Science & Business Media
Page : 495 pages
File Size : 49,8 Mb
Release : 2012-11-19
Category : Medical
ISBN : 9781461445999

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Mitochondria and Their Role in Cardiovascular Disease by José Marín-García Pdf

Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.

Author : Heinz-Peter Schultheiss,Peter Schwimmbeck
Publisher : Springer Science & Business Media
Page : 496 pages
File Size : 43,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642604638

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The Role of Immune Mechanisms in Cardiovascular Disease by Heinz-Peter Schultheiss,Peter Schwimmbeck Pdf

An involvement of the immune system is suspected in various cardiovascular diseases. Recent advances in the fields of molecular biology, genetics, cell biology, and immunology have made it possible to identify several pathomechanisms. However, still more questions arise with regard to the pathophysiology, diagnosis, and treatment of immunologically mediated cardiovascular diseases. In this book, leading scientists and clinicians from different areas of cardiology present the state-of-the-art knowledge on the involve ment of the immune system in myocardial and vascular diseases. In the field of myocarditis, both the virological and the immunological findings are presented, and the interactions between the virus and the immune system are discussed. Since the cellular immune system and its mediators play an important role in the inflammation by bacteria that cause endocarditis and septic shock, studies investigating the underlying pathomechanisms are de scribed. Another major topic in this volume is the involvement of the immune system in arteriosclerosis and coronary heart disease, which represents an important problem in clinical cardiology. The final chapter addresses the question of therapeutic options, presenting new approaches for a specific and effective therapy based on the current knowledge of immunologically mediated cardiovascular diseases.

Author : Robert H. Cox
Publisher : Springer Science & Business Media
Page : 245 pages
File Size : 44,6 Mb
Release : 2013-03-08
Category : Medical
ISBN : 9781468460155

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Cellular and Molecular Mechanisms in Hypertension by Robert H. Cox Pdf

Hypertension is recognized to be one of the major risk factors for the development of peripheral vascular disease. The last decade has witnessed several major advances in therapy for hypertension, including the development of angiotensin-converting enzyme inhibitors and calcium channel blockers. These compounds have greatly improved the ability to control blood pressure and to reduce the impact of this risk factor on morbidity and mortality. In spite of these advances, cardiovascular disease remains a major health problem in most modern industrialized countries with related deaths exceeding those from all other causes combined. In contrast to these advances in therapy, our understanding of the basic mechanisms responsible for the pathogenesis of hypertension remains incomplete. Recent studies have produced new insights into the nature of the regulation of muscle contraction in both heart and blood vessels as well as the changes in muscle function that occur in hypertension. However, the effects of antihypertensive therapy, both in terms of restoring normal function and in producing reversal of hypertension-associated changes, has not been as thoroughly studied, especially in the vasculature. Studies in the heart suggest that the efficacy of different therapeutic agents in restoring normal function and reversing hypertensive changes vary substantially with the mechanism of action of the therapeutic agent. It has also been recently determined that some therapeutic agents produce adverse effects on plasma lipid profiles, which could lead to the secondary acceleration of the atherosclerotic process, while at the same time normalizing blood pressure.

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 47,8 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.