Modulation Of Oxidative Stress In Heart Disease

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Modulation of Oxidative Stress in Heart Disease

Sajal Chakraborti,Naranjan S. Dhalla,Madhu Dikshit,Nirmal K. Ganguly
Modulation of Oxidative Stress in Heart Disease Book PDF

Author : Sajal Chakraborti,Naranjan S. Dhalla,Madhu Dikshit,Nirmal K. Ganguly
Publisher : Springer Nature
Page : 686 pages
File Size : 52,8 Mb
Release : 2019-11-10
Category : Science
ISBN : 9789811389467

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Modulation of Oxidative Stress in Heart Disease by Sajal Chakraborti,Naranjan S. Dhalla,Madhu Dikshit,Nirmal K. Ganguly Pdf

This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease. The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions.

Oxidative Stress in Heart Diseases

Sajal Chakraborti,Naranjan S Dhalla,Nirmal K Ganguly,Madhu Dikshit
Oxidative Stress in Heart Diseases Book PDF

Author : Sajal Chakraborti,Naranjan S Dhalla,Nirmal K Ganguly,Madhu Dikshit
Publisher : Springer Nature
Page : 596 pages
File Size : 49,5 Mb
Release : 2019-11-06
Category : Science
ISBN : 9789811382734

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Oxidative Stress in Heart Diseases by Sajal Chakraborti,Naranjan S Dhalla,Nirmal K Ganguly,Madhu Dikshit Pdf

This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.

Oxidative Stress and Vascular Disease

John F. Keaney Jr.
Oxidative Stress and Vascular Disease Book PDF

Author : John F. Keaney Jr.
Publisher : Springer Science & Business Media
Page : 373 pages
File Size : 52,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461546498

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Oxidative Stress and Vascular Disease by John F. Keaney Jr. Pdf

One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.

Mechanisms and Modulation of Oxidative Stress

Emmett Allison
Mechanisms and Modulation of Oxidative Stress Book PDF

Author : Emmett Allison
Publisher : States Academic Press
Page : 0 pages
File Size : 40,6 Mb
Release : 2023-09-26
Category : Science
ISBN : 1639897712

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Mechanisms and Modulation of Oxidative Stress by Emmett Allison Pdf

Oxidative stress refers to a condition caused by an imbalance between the systemic expression of reactive oxygen species (ROS) and the ability of a biological system to quickly detoxify the reactive intermediates or repair the harm. Strand breaks in DNA and base damage are caused by oxidative stress. It can interrupt normal mechanisms of cellular signaling and has been linked to the development of a number of diseases such as cancer, cardiovascular diseases and neurodegenerative diseases. Modulation of oxidative stress is done specifically through the regulation of gene transcription, such as the activation or inhibition of Nrf2. It is regarded as an important strategy for developing new drugs for some of the pathologies, including neoplastic and cardiovascular diseases, that are resistant to other treatments. This book provides significant information to help develop a good understanding of oxidative stress mechanisms and modulation. It presents researches and studies performed by experts across the globe. The extensive content of this book provides the readers with a thorough understanding of this subject.

Oxidative Stress in Microbial Diseases

Sajal Chakraborti,Tapati Chakraborti,Dhrubajyoti Chattopadhyay,Chandrima Shaha
Oxidative Stress in Microbial Diseases Book PDF

Author : Sajal Chakraborti,Tapati Chakraborti,Dhrubajyoti Chattopadhyay,Chandrima Shaha
Publisher : Springer
Page : 0 pages
File Size : 41,8 Mb
Release : 2019-11-12
Category : Science
ISBN : 9811387621

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Oxidative Stress in Microbial Diseases by Sajal Chakraborti,Tapati Chakraborti,Dhrubajyoti Chattopadhyay,Chandrima Shaha Pdf

This book discusses recent advances in our understanding of the role of oxidants in microbial pathophysiology, providing valuable insights into the complex role of reactive oxygen species (ROS) in host-microbial interactions. The various chapters take readers through the function of ROS in infections ranging from viral to bacterial, and describe how microorganisms have developed complex strategies to not only avoid contact with phagocyte-derived oxidants, but also protect themselves from injury when oxidants are encountered. Featuring the latest research in the field of microbial diseases, this timely book is a ready reference for scientists looking to develop new anti-microbial drugs.

Modulators of Oxidative Stress

Hande Gurer-Orhan,Luciano Saso,Višnja Stepanić
Modulators of Oxidative Stress Book PDF

Author : Hande Gurer-Orhan,Luciano Saso,Višnja Stepanić
Publisher : MDPI
Page : 298 pages
File Size : 47,5 Mb
Release : 2020-11-03
Category : Science
ISBN : 3039432281

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Modulators of Oxidative Stress by Hande Gurer-Orhan,Luciano Saso,Višnja Stepanić Pdf

The book starts with the editors' preface summarizing the contributions of each of the following thirteen articles dealing with chemical and pharmacological aspects of the molecular modulators of the oxidative stress in regard to various therapeutic approaches in cardiovascular and neurodegenerative diseases, cancer, and diabetes. The seven articles present data from original research studies enlightening the roles and mechanisms of action of small molecular weight compounds (natural and synthetic; ascorbic acid/vitamin C, deferoxamine, N-acetylcysteine, MitoVitE, α-tocopherol, trolox, and ezetimibe) or proteins (SIRT3) in modulation of oxidative stress. In the six review papers, the authors present and discuss the possible therapeutic potential of novel approaches and compounds that are promising and deserve further investigation, in modulation of oxidative stress.

Modulation of Oxidative Stress

Luciano Saso,Alessandro Giuffre,Giuseppe Valacchi,Mauro Maccarrone
Modulation of Oxidative Stress Book PDF

Author : Luciano Saso,Alessandro Giuffre,Giuseppe Valacchi,Mauro Maccarrone
Publisher : Elsevier
Page : 308 pages
File Size : 46,9 Mb
Release : 2023-08-01
Category : Medical
ISBN : 9780443192487

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Modulation of Oxidative Stress by Luciano Saso,Alessandro Giuffre,Giuseppe Valacchi,Mauro Maccarrone Pdf

Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects explores the field using an interdisciplinary approach, including chemical, biological, physiological, pharmaceutical, pharmacological and physicochemical perspectives. The book is comprised of three main parts, with the first discussing the biochemical aspects of oxidative stress modulation. Other sections cover physiological and pathophysiological aspects on relevant conditions, including aging, neurological diseases, cerebral cavernous malformation, maternal and early-life malnutrition, Alzheimer’s disease, liver transplant, and cancer. Final content is dedicated to pharmacological aspects and includes chapters on phytotherapy and flavonoids. This book is a strong reference for pharma researchers in academia and industry considering leveraging modulation of oxidative stress as a strategy for the development of new drugs. Biochemists and Nutritionists may also benefit of the foundational understanding of cellular redox processes laid out. Provides the latest updates in the fast-developing field of REDOX biochemistry and pharmacology Presents content that is clear and easy to read Useful for researchers and instructors in many fields

Antioxidants in Sport Nutrition

Manfred Lamprecht
Antioxidants in Sport Nutrition Book PDF

Author : Manfred Lamprecht
Publisher : CRC Press
Page : 304 pages
File Size : 48,9 Mb
Release : 2014-09-17
Category : Medical
ISBN : 9781466567573

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Antioxidants in Sport Nutrition by Manfred Lamprecht Pdf

The use of antioxidants in sports is controversial due to existing evidence that they both support and hinder athletic performance. Antioxidants in Sport Nutrition covers antioxidant use in the athlete ́s basic nutrition and discusses the controversies surrounding the usefulness of antioxidant supplementation. The book also stresses how antioxidants may affect immunity, health, and exercise performance. The book contains scientifically based chapters explaining the basic mechanisms of exercise-induced oxidative damage. Also covered are methodological approaches to assess the effectiveness of antioxidant treatment. Biomarkers are discussed as a method to estimate the bioefficacy of dietary/supplemental antioxidants in sports. This book is useful for sport nutrition scientists, physicians, exercise physiologists, product developers, sport practitioners, coaches, top athletes, and recreational athletes. In it, they will find objective information and practical guidance.

Inflammation and Cancer

Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Inflammation and Cancer Book PDF

Author : Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Publisher : Springer
Page : 489 pages
File Size : 41,9 Mb
Release : 2014-05-12
Category : Medical
ISBN : 9783034808378

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Inflammation and Cancer by Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta Pdf

This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Molecular and Cellular Effects of Nutrition on Disease Processes

Grant N. Pierce,Heinz Rupp,Tohru Izumi,Alain Grynberg
Molecular and Cellular Effects of Nutrition on Disease Processes Book PDF

Author : Grant N. Pierce,Heinz Rupp,Tohru Izumi,Alain Grynberg
Publisher : Springer Science & Business Media
Page : 227 pages
File Size : 53,6 Mb
Release : 2013-04-17
Category : Science
ISBN : 9781461557630

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Molecular and Cellular Effects of Nutrition on Disease Processes by Grant N. Pierce,Heinz Rupp,Tohru Izumi,Alain Grynberg Pdf

This volume contains the proceedings of the 2nd World Conference of the International Society for Molecular Nutrition & Therapy. This conference was held on August 2-4, 1997, in Winnipeg, Canada. The goal of the conference was to advance our knowledge concerning the molecular events which link nutrition to various disease processes in the body. This volume represents an important compilation of unique articles addressing the molecular and cellular basis for the nutritional and therapeutic treatment of five general disease processes.

Innovative Medicine

Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Innovative Medicine Book PDF

Author : Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Publisher : Springer
Page : 330 pages
File Size : 45,6 Mb
Release : 2015-10-13
Category : Science
ISBN : 9784431556510

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Innovative Medicine by Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto Pdf

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Oxidative Stress and Aging

R.C. Cutler,L. Packer,J. Bertram,A. Mori
Oxidative Stress and Aging Book PDF

Author : R.C. Cutler,L. Packer,J. Bertram,A. Mori
Publisher : Birkhäuser
Page : 393 pages
File Size : 55,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783034873376

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Oxidative Stress and Aging by R.C. Cutler,L. Packer,J. Bertram,A. Mori Pdf

Oxidative stress and aging Over the past several years there has been an extraordinarily rapid growth in our knowledge of free radical chemistry and its possible involvement in both normal essential biology and age related disease and dysfunction. Much of this growth in the traditionally separate sciences of chemistry and molecular gerontology occurred independently, with little interaction or communi cation between the scientists working in these two fields. In view of the growing maturity of the two fields and the potential importance of advancing our knowledge in the area of oxidative stress and aging, we perceived a critical need to organize an international conference the "First Inter national Conference on Oxidative Stress and Aging" in Hawaii in 1994 to bring together the world's leading scientists in the fields of reactive oxygen species and molecular gerontology. The objective of this conference was to provide a unique opportunity for scholars working in these two related and rapidly growing fields to participate in the exchange, integration, and synthesis of new concepts and ideas, to engage in constructive criticism and to initiate new collaborative research projects. The conference focused on the molecular and cellular aspects of aging as related to oxidative stress. It was one of the largest and most comprehensive international conferences held in molecular gerontology. At this conference a call was made for submission of papers to be used in the publication of a book covering the major contributions of the meeting.

Oxidative Stress and Chronic Degenerative Diseases

Jose Antonio Morales-Gonzalez
Oxidative Stress and Chronic Degenerative Diseases Book PDF

Author : Jose Antonio Morales-Gonzalez
Publisher : BoD – Books on Demand
Page : 516 pages
File Size : 42,7 Mb
Release : 2013-05-22
Category : Science
ISBN : 9789535111238

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Oxidative Stress and Chronic Degenerative Diseases by Jose Antonio Morales-Gonzalez Pdf

This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases.

Vitamin D

Adrian F. Gombart
Vitamin D Book PDF

Author : Adrian F. Gombart
Publisher : CRC Press
Page : 457 pages
File Size : 52,5 Mb
Release : 2012-11-21
Category : Medical
ISBN : 9781439850213

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Vitamin D by Adrian F. Gombart Pdf

Vitamin D insufficiency/deficiency is a worldwide, public health problem in both developed and developing countries. Rickets among infants has reemerged. Low levels of vitamin D are associated with increased risk and mortality from cancer. At the same time, the beneficial effects of vitamin D on a host of conditions have recently been discovered. F

Myocardial Protection

Tomas A. Salerno,Marco Ricci
Myocardial Protection Book PDF

Author : Tomas A. Salerno,Marco Ricci
Publisher : John Wiley & Sons
Page : 344 pages
File Size : 42,7 Mb
Release : 2008-04-15
Category : Medical
ISBN : 9781405178433

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Myocardial Protection by Tomas A. Salerno,Marco Ricci Pdf

Myocardial protection is regarded as one of the most important, yet also most controversial aspects of cardiac surgery. There has been considerable improvement in myocardial protection strategies over recent years, utilising a variety of new approaches to treat cardiac diseases, and this text is intended to embrace the state of the art in this field. The book summarises the state of knowledge on all aspects of myocardial protection, including the latest in the treatment of cardiac diseases, robotics, pediatric surgery and the treatment of cardiac failure. Robotic surgery, valvular surgery, pediatric surgery and coronary surgery are all covered by renowned experts, producing a comprehensive, forward-looking view of the field of myocardial protection. This book should function to update physicians and surgeons interested in the field of cardiac surgery on the current state of knowledge on myocardial protection.