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Cellular Signal Processing by Friedrich Marks,Ursula Klingmüller,Karin Müller-Decker Pdf
Cellular Signal Processing offers a unifying view of cell signaling based on the concept that protein interactions act as sophisticated data processing networks that govern intracellular and extracellular communication. It is intended for use in signal transduction courses for undergraduate and graduate students working in biology, biochemistry, bioinformatics, and pharmacology, as well as medical students. The text is organized by three key topics central to signal transduction: the protein network, its energy supply, and its evolution. It covers all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling, and also highlights the clinical aspects of cell signaling in health and disease. This new edition includes expanded coverage of prokaryotes, as well as content on new developments in systems biology, epigenetics, redox signaling, and small, non-coding RNA signaling.
Signal Processing Aspects of Cell-Free Massive MIMO by Giovanni Interdonato Pdf
The fifth generation of mobile communication systems (5G) promises unprecedented levels of connectivity and quality of service (QoS) to satisfy the incessant growth in the number of mobile smart devices and the huge increase in data demand. One of the primary ways 5G network technology will be accomplished is through network densification, namely increasing the number of antennas per site and deploying smaller and smaller cells. Massive MIMO, where MIMO stands for multiple-input multiple-output, is widely expected to be a key enabler of 5G. This technology leverages an aggressive spatial multiplexing, from using a large number of transmitting/receiving antennas, to multiply the capacity of a wireless channel. A massive MIMO base station (BS) is equipped with a large number of antennas, much larger than the number of active users. The users are coherently served by all the antennas, in the same time-frequency resources but separated in the spatial domain by receiving very directive signals. By supporting such a highly spatially-focused transmission (precoding), massive MIMO provides higher spectral and energy efficiency, and reduces the inter-cell interference compared to existing mobile systems. The inter-cell interference is however becoming the major bottleneck as we densify the networks. It cannot be removed as long as we rely on a network-centric implementation, since the inter-cell interference concept is inherent to the cellular paradigm. Cell-free massive MIMO refers to a massive MIMO system where the BS antennas, herein referred to as access points (APs), are geographically spread out. The APs are connected, through a fronthaul network, to a central processing unit (CPU) which is responsible for coordinating the coherent joint transmission. Such a distributed architecture provides additional macro-diversity, and the co-processing at multiple APs entirely suppresses the inter-cell interference. Each user is surrounded by serving APs and experiences no cell boundaries. This user-centric approach, combined with the system scalability that characterizes the massive MIMO design, constitutes a paradigm shift compared to the conventional centralized and distributed wireless communication systems. On the other hand, such a distributed system requires higher capacity of back/front-haul connections, and the signal co-processing increases the signaling overhead. In this thesis, we focus on some signal processing aspects of cell-free massive MIMO. More specifically, we firstly investigate if the downlink channel estimation, via downlink pilots, brings gains to cell-free massive MIMO or the statistical channel state information (CSI) knowledge at the users is enough to reliably perform data decoding, as in conventional co-located massive MIMO. Allocating downlink pilots is costly resource-wise, thus we also propose resource saving-oriented strategies for downlink pilot assignment. Secondly, we study further fully distributed and scalable precoding schemes in order to outperform cell-free massive MIMO in its canonical form, which consists in single-antenna APs implementing conjugate beamforming (also known as maximum ratio transmission).
Handbook of Cell Signaling by Ralph A. Bradshaw,Edward A. Dennis Pdf
Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field
Cell-Free Massive MIMO by Giovanni Interdonato Pdf
The fifth generation of mobile communication systems (5G) is nowadays a reality. 5G networks are been deployed all over the world, and the first 5G-capable devices (e.g., smartphones, tablets, wearable, etc.) are already commercially available. 5G systems provide unprecedented levels of connectivity and quality of service (QoS) to cope with the incessant growth in the number of connected devices and the huge increase in data-rate demand. Massive MIMO (multiple-input multiple-output) technology plays a key role in 5G systems. The underlying principle of this technology is the use of a large number of co-located antennas at the base station, which coherently transmit/receive signals to/from multiple users. This signal co-processing at multiple antennas leads to manifold benefits: array gain, spatial diversity and spatial user multiplexing. These elements enable to meet the QoS requirements established for the 5G systems. The major bottleneck of massive MIMO systems as well as of any cellular network is the inter-cell interference, which affects significantly the cell-edge users, whose performance is already degraded by the path attenuation. To overcome these limitations and provide uniformly excellent service to all the users we need a more radical approach: we need to challenge the cellular paradigm. In this regard, cell-free massive MIMO constitutes the paradigm shift. In the cell-free paradigm, it is not the base station surrounded by the users, but rather it is each user being surrounded by smaller, simpler, serving base stations referred to as access points (APs). In such a system, each user experiences being in the cell-center, and it does not experience any cell boundaries. Hence, the terminology cell-free. As a result, users are not affected by inter-cell interference, and the path attenuation is significantly reduced due to the presence of many APs in their proximity. This leads to impressive performance. Although appealing from the performance viewpoint, the designing and implementation of such a distributed massive MIMO system is a challenging task, and it is the object of this thesis. More specifically, in this thesis we study: Paper A) The large potential of this promising technology in realistic indoor/outdoor scenarios while also addressing practical deployment issues, such as clock synchronization among APs, and cost-efficient implementations. We provide an extensive description of a cell-free massive MIMO system, emphasizing strengths and weaknesses, and pointing out differences and similarities with existing distributed multiple antenna systems, such as Coordinated MultiPoint (CoMP). Paper B) How to preserve the scalability of the system, by proposing a solution related to data processing, network topology and power control. We consider a realistic scenario where multiple central processing units serve disjoint subsets of APs, and compare the spectral efficiency provided by the proposed scalable framework with the canonical cell-free massive MIMO and CoMP. Paper C) How to improve the spectral efficiency (SE) in the downlink (DL), by devising two distributed precoding schemes, referred to as local partial zero-forcing (ZF) and local protective partial ZF, that provide an adaptable trade-off between interference cancelation and boosting of the desired signal, with no additional front-haul overhead, and that are implementable by APs with very few antennas. We derive closed-form expressions for the achievable SE under the assumption of independent Rayleigh fading channel, channel estimation error and pilot contamination. These closed-form expressions are then used to devise optimal max-min fairness power control. Paper D) How to further improve the SE by letting the user estimate the DL channel from DL pilots, instead of relying solely on the knowledge of the channel statistics. We derive an approximate closed-form expression of the DL SE for conjugate beamforming (CB), and assuming independent Rayleigh fading. This expression accounts for beamformed DL pilots, estimation errors and pilot contamination at both the AP and the user side. We devise a sequential convex approximation algorithm to globally solve the max-min fairness power control optimization problem, and a greedy algorithm for uplink (UL) and DL pilot assignment. The latter consists in jointly selecting the UL and DL pilot pair, for each user, that maximizes the smallest SE in the network. Paper E) A precoding scheme that is more suitable when only the channel statistics are available at the users, referred to as enhanced normalized CB. It consists in normalizing the precoding vector by its squared norm in order to reduce the fluctuations of the effective channel seen at the user, and thereby to boost the channel hardening. The performance achieved by this scheme is compared with the CB scheme with DL training (described in Paper D). Paper F) A maximum-likelihood-based method to estimate the channel statistics in the UL, along with an accompanying pilot transmission scheme, that is particularly useful in line-of-sight operation and in scenarios with resource constraints. Pilots are structurally phase-rotated over different coherence blocks to create an effective statistical distribution of the received pilot signal that can be efficiently exploited by the AP when performing the proposed estimation method. The overall conclusion is that cell-free massive MIMO is not a utopia, and a practical, distributed, scalable, high-performance system can be implemented. Today it represents a hot research topic, but tomorrow it might represent a key enabler for beyond-5G technology, as massive MIMO has been for 5G. La quinta generazione dei sistemi radiomobili cellulari (5G) è oggi una realtà. Le reti 5G si stanno diffondendo in tutto il mondo e i dispositivi 5G (ad esempio smartphones, tablets, indossabili, ecc.) sono già disponibili sul mercato. I sistemi 5G garantiscono livelli di connettività e di qualità di servizio senza precedenti, per fronteggiare l’incessante crescita del numero di dispositivi connessi alla rete e della domanda di dati ad alta velocità. La tecnologia Massive MIMO (multiple-input multiple-output) riveste un ruolo fondamentale nei sistemi 5G. Il principio alla base di questa tecnologia è l’impiego di un elevato numero di antenne collocate nella base station (stazione radio base) le quali trasmettono/ricevono segnali, in maniere coerente, a/da più terminali utente. Questo co-processamento del segnale da parte di più antenne apporta molteplici benefici: guadagno di array, diversità spaziale e multiplazione degli utenti nel dominio spaziale. Questi elementi consentono di raggiungere i requisiti di servizio stabiliti per i sistemi 5G. Tuttavia, il limite principale dei sistemi massive MIMO, così come di ogni rete cellulare, è rappresentato dalla interferenza inter-cella (ovvero l’interferenza tra aree di copertura gestite da diverse base stations), la quale riduce in modo significativo le performance degli utenti a bordo cella, già degradate dalle attenuazioni del segnale dovute alla considerevole distanza dalla base station. Per superare queste limitazioni e fornire una qualità del servizio uniformemente eccellente a tutti gli utenti, è necessario un approccio più radicale e guardare oltre il classico paradigma cellulare che caratterizza le attuali architetture di rete. A tal proposito, cell-free massive MIMO (massive MIMO senza celle) costituisce un cambio di paradigma: ogni utente è circondato e servito contemporaneamente da numerose, semplici e di dimensioni ridotte base stations, denominate access points (punti di accesso alla rete). Gli access points cooperano per servire tutti gli utenti nella loro area di copertura congiunta, eliminando l’interferenza inter-cella e il concetto stesso di cella. Non risentendo più dell’effetto “bordo-cella”, gli utenti possono usufruire di qualità di servizio e velocità dati eccellenti. Sebbene attraente dal punto di vista delle performance, l’implementazione di un tale sistema distribuito è una operazione impegnativa ed è oggetto di questa tesi. Piu specificatamente, questa tesi di dottorato tratta: Articolo A) L’enorme potenziale di questa promettente tecnologia in scenari realistici sia indoor che outdoor, proponendo anche delle soluzioni di implementazione flessibili ed a basso costo. Articolo B) Come preservare la scalabilità del sistema, proponendo soluzioni distribuite riguardanti il processamento e la condivisione dei dati, l’architettura di rete e l’allocazione di potenza, ovvero come ottimizzare i livelli di potenza trasmessa dagli access points per ridurre l’interferenza tra utenti e migliorare le performance. Articolo C) Come migliorare l’efficienza spettrale in downlink (da access point verso utente) proponendo due schemi di pre-codifica dei dati di trasmissione, denominati local partial zero-forcing (ZF) e local protective partial ZF, che forniscono un perfetto compromesso tra cancellazione dell’interferenza tra utenti ed amplificazione del segnale desiderato. Articolo D) Come migliorare l’efficienza spettrale in downlink permettendo al terminale utente di stimare le informazioni sulle condizioni istantanee del canale da sequenze pilota, piuttosto che basarsi su informazioni statistiche ed a lungo termine, come convenzionalmente previsto. Articolo E) In alternativa alla soluzione precedente, uno schema di pre-codifica che è più adatto al caso in cui gli utenti hanno a disposizione esclusivamente informazioni statistiche sul canale per poter effettuare la decodifica dei dati. Articolo F) Un metodo per permettere agli access points di stimare, in maniera rapida, le condizioni di canale su base statistica, favorito da uno schema di trasmissione delle sequenze pilota basato su rotazione di fase. Realizzare un sistema cell-free massive MIMO pratico, distribuito, scalabile e performante non è una utopia. Oggi questo concept rappresenta un argomento di ricerca interessante, attraente e stimolante ma in futuro potrebbe costituire un fattore chiave per le tecnologie post-5G, proprio come massive MIMO lo è stato per il 5G. Den femte generationens mobilkommunikationssystem (5G) är numera en verklighet. 5G-nätverk är utplacerade på ett flertal platser världen över och de första 5G-kapabla terminalerna (såsom smarta telefoner, surfplattor, kroppsburna apparater, etc.) är redan kommersiellt tillgängliga. 5G-systemen kan tillhandahålla tidigare oöverträffade nivåer av uppkoppling och servicekvalitet och är designade för en fortsatt oavbruten tillväxt i antalet uppkopplade apparater och ökande datataktskrav. Massiv MIMO-teknologi (eng: multiple-input multiple-output) spelar en nyckelroll i dagens 5G-system. Principen bakom denna teknik är användningen av ett stort antal samlokaliserade antenner vid basstationen, där alla antennerna sänder och tar emot signaler faskoherent till och från flera användare. Gemensam signalbehandling av många antennsignaler ger ett flertal fördelar, såsom hög riktverkan via lobformning, vilket leder till högre datatakter samt möjliggör att flera användare utnyttjar samma radioresurser via rumslig användarmultiplexering. Eftersom en signal kan gå genom flera olika, möjligen oberoende kanaler, så utsätts den för flera olika förändringar samtidigt. Denna mångfald ökar kvaliteten på signalen vid mottagaren och förbättrar radiolänkens robusthet och tillförlitlighet. Detta gör det möjligt att uppfylla de höga kraven på servicekvalitet som fastställts för 5G-systemen. Den största begränsningen för massiva MIMO-system såväl som för alla cellulära mobilnätverk, är störningar från andra celler som påverkar användare på cellkanten väsentligt, vars prestanda redan begränsas av sträckdämpningen på radiokanalen. För att övervinna dessa begränsningar och för att kunna tillhandahålla samma utmärkta servicekvalitet till alla användare behöver vi ett mer radikalt angreppssätt: vi måste utmana cellparadigmet. I detta avseende utgör cellfri massiv-MIMO teknik ett paradigmskifte. I cellfri massive-MIMO är utgångspunkten inte att basstationen är omgiven av användare som den betjänar, utan snarare att varje användare omges av basstationer som de betjänas av. Dessa basstationer, ofta mindre och enklare, kallas accesspunkter (AP). I ett sådant system upplever varje användare att den befinner sig i centrum av systemet och ingen användare upplever några cellgränser. Därav terminologin cellfri. Som ett resultat av detta påverkas inte användarna av inter-cellstörningar och sträckdämpningen reduceras kraftigt på grund av närvaron av många accesspunkter i varje användares närhet. Detta leder till imponerande prestanda. Även om det är tilltalande ur ett prestandaperspektiv så är utformningen och implementeringen av ett sådant distribuerat massivt MIMO-system en utmanande uppgift, och det är syftet med denna avhandling att studera detta. Mer specifikt studerar vi i denna avhandling: A) den mycket stora potentialen med denna teknik i realistiska inomhus- såväl som utomhusscenarier, samt hur man hanterar praktiska implementeringsproblem, såsom klocksynkronisering bland accesspunkter och kostnadseffektiva implementeringar; B) hur man ska uppnå skalbarhet i systemet genom att föreslå lösningar relaterade till databehandling, nätverkstopologi och effektkontroll; C) hur man ökar datahastigheten i nedlänken med hjälp av två nyutvecklade distribuerade överföringsmetoder som tillhandahåller en avvägning mellan störningsundertryckning och förstärkning av önskade signaler, utan att öka mängden intern signalering till de distribuerade accesspunkterna, och som kan implementeras i accesspunkter med mycket få antenner; D) hur man kan förbättra prestandan ytterligare genom att låta användaren estimera nedlänkskanalen med hjälp av nedlänkspiloter, istället för att bara förlita sig på kunskap om kanalstatistik; E) en överföringsmetod för nedlänk som är mer lämpligt när endast kanalstatistiken är tillgänglig för användarna. Prestandan som uppnås genom detta schema jämförs med en utökad variant av den nedlänk-pilotbaserade metoden (beskrivet i föregående punkt); F) en metod för att uppskatta kanalstatistiken i upplänken, samt en åtföljande pilotsändningsmetod, som är särskilt användbart vid direktvägsutbredning (line-of-sight) och i scenarier med resursbegränsningar. Den övergripande slutsatsen är att cellfri massiv MIMO inte är en utopi, och att ett distribuerat, skalbart, samt högpresterande system kan implementeras praktiskt. Idag representerar detta ett hett forskningsämne, men snart kan det visa sig vara en viktig möjliggörare för teknik bortom dagens system, på samma sätt som centraliserad massiv MIMO har varit för de nya 5G-systemen.
Systems Biology of Cell Signaling by James Ferrell Pdf
How can we understand the complexity of genes, RNAs, and proteins and the associated regulatory networks? One approach is to look for recurring types of dynamical behavior. Mathematical models prove to be useful, especially models coming from theories of biochemical reactions such as ordinary differential equation models. Clever, careful experiments test these models and their basis in specific theories. This textbook aims to provide advanced students with the tools and insights needed to carry out studies of signal transduction drawing on modeling, theory, and experimentation. Early chapters summarize the basic building blocks of signaling systems: binding/dissociation, synthesis/destruction, and activation/inactivation. Subsequent chapters introduce various basic circuit devices: amplifiers, stabilizers, pulse generators, switches, stochastic spike generators, and oscillators. All chapters consistently use approaches and concepts from chemical kinetics and nonlinear dynamics, including rate-balance analysis, phase plane analysis, nullclines, linear stability analysis, stable nodes, saddles, unstable nodes, stable and unstable spirals, and bifurcations. This textbook seeks to provide quantitatively inclined biologists and biologically inclined physicists with the tools and insights needed to apply modeling and theory to interesting biological processes. Key Features: Full-color illustration program with diagrams to help illuminate the concepts Enables the reader to apply modeling and theory to the biological processes Further Reading for each chapter High-quality figures available for instructors to download
Cellular Signal Transduction in Toxicology and Pharmacology by Jonathan W. Boyd,Richard R. Neubig Pdf
Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets. Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug studies and translational research Includes detailed presentations of study methodology and data collection, analysis, and interpretation Discusses tools like experimental design, sample handling, analytical measurement techniques
Signal Processing for 5G by Fa-Long Luo,Charlie Jianzhong Zhang Pdf
A comprehensive and invaluable guide to 5G technology, implementation and practice in one single volume. For all things 5G, this book is a must-read. Signal processing techniques have played the most important role in wireless communications since the second generation of cellular systems. It is anticipated that new techniques employed in 5G wireless networks will not only improve peak service rates significantly, but also enhance capacity, coverage, reliability , low-latency, efficiency, flexibility, compatibility and convergence to meet the increasing demands imposed by applications such as big data, cloud service, machine-to-machine (M2M) and mission-critical communications. This book is a comprehensive and detailed guide to all signal processing techniques employed in 5G wireless networks. Uniquely organized into four categories, New Modulation and Coding, New Spatial Processing, New Spectrum Opportunities and New System-level Enabling Technologies, it covers everything from network architecture, physical-layer (down-link and up-link), protocols and air interface, to cell acquisition, scheduling and rate adaption, access procedures and relaying to spectrum allocations. All technology aspects and major roadmaps of global 5G standard development and deployments are included in the book. Key Features: Offers step-by-step guidance on bringing 5G technology into practice, by applying algorithms and design methodology to real-time circuit implementation, taking into account rapidly growing applications that have multi-standards and multi-systems. Addresses spatial signal processing for 5G, in particular massive multiple-input multiple-output (massive-MIMO), FD-MIMO and 3D-MIMO along with orbital angular momentum multiplexing, 3D beamforming and diversity. Provides detailed algorithms and implementations, and compares all multicarrier modulation and multiple access schemes that offer superior data transmission performance including FBMC, GFDM, F-OFDM, UFMC, SEFDM, FTN, MUSA, SCMA and NOMA. Demonstrates the translation of signal processing theories into practical solutions for new spectrum opportunities in terms of millimeter wave, full-duplex transmission and license assisted access. Presents well-designed implementation examples, from individual function block to system level for effective and accurate learning. Covers signal processing aspects of emerging system and network architectures, including ultra-dense networks (UDN), software-defined networks (SDN), device-to-device (D2D) communications and cloud radio access network (C-RAN).
Foundations of User-Centric Cell-Free Massive MIMO by Özlem Tugfe Demir,Emil Björnson,Luca Sanguinetti Pdf
Modern day cellular mobile networks use Massive MIMO technology to extend range and service multiple devices within a cell. This has brought tremendous improvements in the high peak data rates that can be handled. Nevertheless, one of the characteristics of this technology is large variations in the quality of service dependent on where the end user is located in any given cell. This becomes increasingly problematic when we are creating a society where wireless access is supposed to be ubiquitous. When payments, navigation, entertainment, and control of autonomous vehicles are all relying on wireless connectivity the primary goal for future mobile networks should not be to increase the peak rates, but the rates that can be guaranteed to the vast majority of the locations in the geographical coverage area. The cellular network architecture was not designed for high-rate data services but for low-rate voice services, thus it is time to look beyond the cellular paradigm and make a clean-slate network design that can reach the performance requirements of the future. This monograph considers the cell-free network architecture that is designed to reach the aforementioned goal of uniformly high data rates everywhere. The authors introduce the concept of a cell-free network before laying out the foundations of what is required to design and build such a network. They cover the foundations of channel estimation, signal processing, pilot assignment, dynamic cooperation cluster formation, power optimization, fronthaul signaling, and spectral efficiency evaluation in uplink and downlink under different degrees of cooperation among the access points and arbitrary linear combining and precoding. This monograph provides the reader with all the fundamental information required to design and build the next generation mobile networks without being hindered by the inherent restrictions of modern cellular-based technology.
Multimedia Signal Processing by Saeed V. Vaseghi Pdf
Multimedia Signal Processing is a comprehensive and accessible text to the theory and applications of digital signal processing (DSP). The applications of DSP are pervasive and include multimedia systems, cellular communication, adaptive network management, radar, pattern recognition, medical signal processing, financial data forecasting, artificial intelligence, decision making, control systems and search engines. This book is organised in to three major parts making it a coherent and structured presentation of the theory and applications of digital signal processing. A range of important topics are covered in basic signal processing, model-based statistical signal processing and their applications. Part 1: Basic Digital Signal Processing gives an introduction to the topic, discussing sampling and quantization, Fourier analysis and synthesis, Z-transform, and digital filters. Part 2: Model-based Signal Processing covers probability and information models, Bayesian inference, Wiener filter, adaptive filters, linear prediction hidden Markov models and independent component analysis. Part 3: Applications of Signal Processing in Speech, Music and Telecommunications explains the topics of speech and music processing, echo cancellation, deconvolution and channel equalization, and mobile communication signal processing. Covers music signal processing, explains the anatomy and psychoacoustics of hearing and the design of MP3 music coder Examines speech processing technology including speech models, speech coding for mobile phones and speech recognition Covers single-input and multiple-inputs denoising methods, bandwidth extension and the recovery of lost speech packets in applications such as voice over IP (VoIP) Illustrated throughout, including numerous solved problems, Matlab experiments and demonstrations Companion website features Matlab and C++ programs with electronic copies of all figures. This book is ideal for researchers, postgraduates and senior undergraduates in the fields of digital signal processing, telecommunications and statistical data analysis. It will also be a valuable text to professional engineers in telecommunications and audio and signal processing industries.
Cell Signaling by Wendell Lim,Bruce Mayer,Tony Pawson Pdf
Cell Signaling presents the principles and components that underlie all known signaling processes. It provides undergraduate and graduate students the conceptual tools needed to make sense of the dizzying array of pathways used by the cell to communicate. By emphasizing the common design principles, components, and logic that drives all signa
Signal Processing for Neuroscientists by Wim van Drongelen Pdf
Signal Processing for Neuroscientists introduces analysis techniques primarily aimed at neuroscientists and biomedical engineering students with a reasonable but modest background in mathematics, physics, and computer programming. The focus of this text is on what can be considered the ‘golden trio’ in the signal processing field: averaging, Fourier analysis, and filtering. Techniques such as convolution, correlation, coherence, and wavelet analysis are considered in the context of time and frequency domain analysis. The whole spectrum of signal analysis is covered, ranging from data acquisition to data processing; and from the mathematical background of the analysis to the practical application of processing algorithms. Overall, the approach to the mathematics is informal with a focus on basic understanding of the methods and their interrelationships rather than detailed proofs or derivations. One of the principle goals is to provide the reader with the background required to understand the principles of commercially available analyses software, and to allow him/her to construct his/her own analysis tools in an environment such as MATLAB®. Multiple color illustrations are integrated in the text Includes an introduction to biomedical signals, noise characteristics, and recording techniques Basics and background for more advanced topics can be found in extensive notes and appendices A Companion Website hosts the MATLAB scripts and several data files: http://www.elsevierdirect.com/companion.jsp?ISBN=9780123708670
Signal Transduction by Bastien D. Gomperts,Ijsbrand M. Kramer,Peter E.R. Tatham Pdf
Signal Transduction is a text reference on cellular signalling processes. Starting with the basics, it explains how cells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix etc), and shows how these inputs are integrated and co-ordinated. The first half of the book provides the conceptual framework, explaining the formation and action of second messengers, particularly cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. The remaining chapters deal with the formation of complex signalling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, there to regulate gene transcription. In this context, growth is an important potential outcome and this has relevance to the cellular transformations that underlie cancer. The book ends with a description at the molecular level of how signalling proteins interact with their environment and with each other through their structural domains. Each main topic is introduced with a historical essay, detailing the sources, key observations and experiments that set the scene for recent and current work.
Signal Processing for 5G by Fa-Long Luo,Charlie Jianzhong Zhang Pdf
A comprehensive and invaluable guide to 5G technology, implementation and practice in one single volume. For all things 5G, this book is a must-read. Signal processing techniques have played the most important role in wireless communications since the second generation of cellular systems. It is anticipated that new techniques employed in 5G wireless networks will not only improve peak service rates significantly, but also enhance capacity, coverage, reliability , low-latency, efficiency, flexibility, compatibility and convergence to meet the increasing demands imposed by applications such as big data, cloud service, machine-to-machine (M2M) and mission-critical communications. This book is a comprehensive and detailed guide to all signal processing techniques employed in 5G wireless networks. Uniquely organized into four categories, New Modulation and Coding, New Spatial Processing, New Spectrum Opportunities and New System-level Enabling Technologies, it covers everything from network architecture, physical-layer (down-link and up-link), protocols and air interface, to cell acquisition, scheduling and rate adaption, access procedures and relaying to spectrum allocations. All technology aspects and major roadmaps of global 5G standard development and deployments are included in the book. Key Features: Offers step-by-step guidance on bringing 5G technology into practice, by applying algorithms and design methodology to real-time circuit implementation, taking into account rapidly growing applications that have multi-standards and multi-systems. Addresses spatial signal processing for 5G, in particular massive multiple-input multiple-output (massive-MIMO), FD-MIMO and 3D-MIMO along with orbital angular momentum multiplexing, 3D beamforming and diversity. Provides detailed algorithms and implementations, and compares all multicarrier modulation and multiple access schemes that offer superior data transmission performance including FBMC, GFDM, F-OFDM, UFMC, SEFDM, FTN, MUSA, SCMA and NOMA. Demonstrates the translation of signal processing theories into practical solutions for new spectrum opportunities in terms of millimeter wave, full-duplex transmission and license assisted access. Presents well-designed implementation examples, from individual function block to system level for effective and accurate learning. Covers signal processing aspects of emerging system and network architectures, including ultra-dense networks (UDN), software-defined networks (SDN), device-to-device (D2D) communications and cloud radio access network (C-RAN).
Regulation of Signal Transduction in Human Cell Research by Nariyoshi Shinomiya,Hiroaki Kataoka,Qian Xie Pdf
This volume focuses on the relationship between the regulation of signal transduction and disease mechanisms, and discusses how the dysregulation of intracellular signals cause diseases, cell death, carcinogenesis, and other disorders. Growth, survival, transformation, and metabolic activities at the cellular level are regulated by various intracellular signal transduction pathways. Sources that stimulate intracellular signals include intracellular stresses and signal regulators/modulators, as well as extracellular growth factors. Recent studies on signal transduction analysis using animal and human cell lines have revealed how the intracellular signals are regulated and why their dysregulation leads to pathological states such as tumorigenesis, metabolic diseases, cell death, and so on. This book highlights several important key molecules and intracellular signaling pathways such as microRNA, the TGF-beta signaling pathway, the Wnt signaling pathway and MET signaling pathway as topical and highly relevant issues in human cell research related to signal transduction. In addition to assessing the pathogenic role of these signaling pathways, it focuses on the molecular design of small molecule regulators/inhibitors of said pathways, one of the most important approaches in this area. This book offers a valuable guide, helping not only research scientists but also clinicians to understand how the dysregulation of intracellular signals leads to diseases.
'Cell Signalling' presents a carefully structured introduction to this subject, introducing those conserved features which underlie many different extra-and intracellular signalling systems.