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Central Sensitization and Sensitivity Syndromes by Amy Titani Pdf
Millions of people experience symptoms of central sensitization (CS) and central sensitivity syndromes (CSS) such as chronic fatigue syndrome, fibromyalgia and multiple chemical sensitivities. Yet many lack diagnoses, education and resources. Without proper support, some patients may become withdrawn, suffering needlessly and possibly developing mental illness. Covering the syndromes within the context of central sensitization (CS), this book provides candid personal experience, strategies for symptom management, and suggested methods for coping and long-term healing, with easy-to-understand science.
Early Arthritis by Karen Torralba,Francisco P. Quismorio,Richard S. Panush Pdf
To ensure the best possible clinical outcomes for arthritis patients, it is essential that they be seen early and treated appropriately at the earliest opportunity. Early therapy has proven much more effective than that given late. This issue of Rheumatic Disease Clinics of North America brings the rheumatologist up to date on the latest treatments and interventions in evolving arthritis and established early arthritis. Topics covered include early rheumatoid arthritis, psoriatic arthritis, undifferentiated arthritis, oligoarthritis, osteoarthritis, and others. Imaging modalities are addressed as well as various contemporary treatments including biologics.
FIBROMYALGIA by MARÍA DEL PILAR COVARRUBIAS MONTAÑO Pdf
Pilar’s Fibropedia is a compendium of knowledge that refers to fibromyalgia and the detonating factors of cells, as well as a compilation of strategies and treatments that can include diseases and possibilities that both patients and family members have to treat this condition. The book is dedicated to people living with fibromyalgia, their relatives and doctors who are unaware of their existence and who are interested in the treatment. The book consists of ten chapters that deal with the brief history of the condition, how it is diagnosed, the types of fibromyalgia and the factors that influence its development. There is also a section that deals with the relationship between fibromyalgia, food and sleep, to conclude with allopathic treatments, alternative therapies and psychological therapies that help improve the quality of life of those with fibromyalgia. Through the pages of this book, the author shares her vision of life with fibromyalgia, the challenges that everyone faces and how she has overcome those challenges; always looking to give incentive to those who believe they have lost the battle to an entity so unknown and disconcerting. It is important to emphasize that the author seeks to give voice to those who have remained in the dark, providing a light of hope and how it can help a society of social support so that with knowledge, love, education and affection. This work was made by the efforts of the Mexican Foundation for Fibromyalgia (FIBRO), which started work in 1999 and its Founder María del Pilar Covarrubias Montaño who is the author. The Mexican Foundation for Fibromyalgia is a non-profit civil association whose purpose is to research, update and disseminate information about fibromyalgia, as well as comprehensive care for those who suffer.
Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
Fibromyalgia and Other Central Pain Syndromes by Daniel Jeffrey Wallace,Daniel J. Clauw, M.D. Pdf
This volume is the first comprehensive text devoted to fibromyalgia and other centrally mediated chronic pain syndromes. Leading experts examine the latest research findings on these syndromes and present evidence-based reviews of current controversies. Chapters discuss the definition, epidemiology, and pathophysiology of chronic pain and fibromyalgia, the clinical presentations of fibromyalgia syndrome, and central sensitization syndromes associated with chronic neuromuscular pain. The contributors thoroughly examine various approaches to evaluation and management of patients with fibromyalgia and chronic pain. Other chapters focus on disability issues, prognosis, and future research directions. A critically reviewed listing of Websites and other resources is included.
Within the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Additionally, peripheral infection/inflammation leads to de novo synthesis and release of cytokines within the brain and spinal cord. Thus, cytokines effect neural activation both peripherally and centrally. Through this communication pathway, cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor markedly alter brain function, physiology and behavior. One important but underrecognized aspect of this communication is the dramatic impact that immune activation has on pain modulation. The purpose of this book is to examine, for the first time, immune-to-brain communication from the viewpoint of its effect on pain processing. It is aimed both at the basic scientist and health care providers, in order to clarify the major role that substances released by immune cells play in pain modulation. This book contains chapters contributed by all of the major laboratories focused on understanding how cytokines modulate pain. These chapters provide a unique vantage point from which to examine this question, as the summarized work ranges from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans.
Institute of Medicine,Board on the Health of Select Populations,Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Author : Institute of Medicine,Board on the Health of Select Populations,Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Publisher : National Academies Press Page : 304 pages File Size : 49,5 Mb Release : 2015-03-16 Category : Medical ISBN : 9780309316927
Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome by Institute of Medicine,Board on the Health of Select Populations,Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Pdf
Myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) are serious, debilitating conditions that affect millions of people in the United States and around the world. ME/CFS can cause significant impairment and disability. Despite substantial efforts by researchers to better understand ME/CFS, there is no known cause or effective treatment. Diagnosing the disease remains a challenge, and patients often struggle with their illness for years before an identification is made. Some health care providers have been skeptical about the serious physiological - rather than psychological - nature of the illness. Once diagnosed, patients often complain of receiving hostility from their health care provider as well as being subjected to treatment strategies that exacerbate their symptoms. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome proposes new diagnostic clinical criteria for ME/CFS and a new term for the illness - systemic exertion intolerance disease(SEID). According to this report, the term myalgic encephalomyelitis does not accurately describe this illness, and the term chronic fatigue syndrome can result in trivialization and stigmatization for patients afflicted with this illness. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome stresses that SEID is a medical - not a psychiatric or psychological - illness. This report lists the major symptoms of SEID and recommends a diagnostic process.One of the report's most important conclusions is that a thorough history, physical examination, and targeted work-up are necessary and often sufficient for diagnosis. The new criteria will allow a large percentage of undiagnosed patients to receive an accurate diagnosis and appropriate care. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome will be a valuable resource to promote the prompt diagnosis of patients with this complex, multisystem, and often devastating disorder; enhance public understanding; and provide a firm foundation for future improvements in diagnosis and treatment.
Functional Pain Syndromes by Emeran A. Mayer,M. Catherine Bushnell Pdf
This book explores the connection of functional pain syndromes (e.g., irritable bowel syndrome and fibromyalgia) with anxiety, depression, chronic fatigue syndrome, and posttraumatic stress disorder. The authors address possible common pathophysiologies and review a range of treatment options, from antidepressants to cognitive-behavioral therapy. Who should buy this book? Whether you are a general practitioner, specialist, or scientist, this book is essential reading. It sheds new light on the complex links between various painful syndromes and disorders.
Magnesium in the Central Nervous System by Robert Vink,Mihai Nechifor Pdf
The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Sensitive Skin Syndrome by Golara Honari,Rosa Andersen,Howard L. Maibach Pdf
Sensitive skin is a widely reported condition where there is subjective cutaneous hyper-reactivity to environmental factors. Progress has been made in many aspects of the background science that will help clinicians in their management of patients presenting with the condition. This new text sums up the advances in thinking on pathophysiology, classification, methods of investigation, and the different susceptibilities of different types of skin.
Neuropathic Pain by Cory Toth,Dwight E. Moulin Pdf
Central or peripheral neuropathic pain can be caused by a wide range of injuries, infections and diseases such as: spinal cord injury, multiple sclerosis, stroke, herpes zoster, diabetes and cancer. Many of these pain syndromes are difficult to treat, representing a challenge for many neurologists not routinely trained in pain management. Written by an international team of experts in the field, Neuropathic Pain: Causes, Management and Understanding gives readers an in-depth understanding of the multitude of conditions causing neuropathic pain. Epidemiology, clinical diagnosis, pathophysiology, outcome measurement and the best evidence-based management of individual and general neuropathic pain conditions are also described in depth. A unique chapter, written from a patient's viewpoint, gives new insight into how chronic neuropathic pain affects the lives of those patients with the condition. This book is essential reading for all pain specialists, neurologists, psychiatrists and anesthesiologists who wish to better understand their patients' neuropathic pain.
Explain Pain by David S Butler,G Lorimer Moseley Pdf
Imagine an orchestra in your brain. It plays all kinds of harmonious melodies, then pain comes along and the different sections of the orchestra are reduced to a few pain tunes. All pain is real. And for many people it is a debilitating part of everyday life. It is now known that understanding more about why things hurt can actually help people to overcome their pain. Recent advances in fields such as neurophysiology, brain imaging, immunology, psychology and cellular biology have provided an explanatory platform from which to explore pain. In everyday language accompanied by quirky illustrations, Explain Pain discusses how pain responses are produced by the brain: how responses to injury from the autonomic motor and immune systems in your body contribute to pain, and why pain can persist after tissues have had plenty of time to heal. Explain Pain aims to give clinicians and people in pain the power to challenge pain and to consider new models for viewing what happens during pain. Once they have learnt about the processes involved they can follow a scientific route to recovery. The Authors: Dr Lorimer Moseley is Professor of Clinical Neurosciences and the Inaugural Chair in Physiotherapy at the University of South Australia, Adelaide, where he leads research groups at Body in Mind as well as with Neuroscience Research Australia in Sydney. Dr David Butler is an international freelance educator, author and director of the Neuro Orthopaedic Institute, based in Adelaide, Australia. Both authors continue to publish and present widely.
Institute of Medicine,Board on Population Health and Public Health Practice,Committee on Lyme Disease and Other Tick-Borne Diseases: The State of the Science
Author : Institute of Medicine,Board on Population Health and Public Health Practice,Committee on Lyme Disease and Other Tick-Borne Diseases: The State of the Science Publisher : National Academies Press Page : 560 pages File Size : 52,9 Mb Release : 2011-07-01 Category : Medical ISBN : 9780309211093
Critical Needs and Gaps in Understanding Prevention, Amelioration, and Resolution of Lyme and Other Tick-Borne Diseases by Institute of Medicine,Board on Population Health and Public Health Practice,Committee on Lyme Disease and Other Tick-Borne Diseases: The State of the Science Pdf
A single tick bite can have debilitating consequences. Lyme disease is the most common disease carried by ticks in the United States, and the number of those afflicted is growing steadily. If left untreated, the diseases carried by ticks-known as tick-borne diseases-can cause severe pain, fatigue, neurological problems, and other serious health problems. The Institute of Medicine held a workshop October 11-12, 2010, to examine the state of the science in Lyme disease and other tick-borne diseases.
The Fibromyalgia Syndrome by Stanley R. Pillemer Pdf
The Fibromyalgia Syndrome summarizes major advances in the understanding of fibromyalgia and helps increase readers'knowledge of the disorder, which can lead to the development of new strategies for diagnosis and treatment. Fibromyalgia is not an uncommon disorder, and can be a frustrating problem for patients and physicians alike. In this valuable reference, leading experts in the field of fibromyalgia research provide important information on fibromyalgia and offer suggestions for future research. Contributing authors begin to unravel the many unanswered questions about fibromyalgia as they explore the mechanisms underlying pain, fatigue, and sleep disturbance, the interrelationship between pain, fatigue, and sleep disturbance, and the relationship between fibromyalgia and other overlapping disorders. This book provides current knowledge, identifies research gaps and opportunities, and recommends future directions for research on the cause, pathogenesis, diagnosis, and treatment of fibromyalgia syndrome. Chapters are divided into sections which examine: the clinical spectrum and epidemiology of fibromyalgia neuroendocrine and metabolic aspects of fibromyalgia therapeutic interventions research opportunities and recommendations Readers will find themselves challenged to learn more about fibromyalgia syndrome, how to recognize and diagnose it earlier, and begin effective treatment sooner. The Fibromyalgia Syndrome is an instructive and informative resource for researchers, physicians, and knowledgeable lay people who are interested in learning more about this enigmatic disorder.
