Channelopathies

Author : Dierk Thomas,Carol Ann Remme
Publisher : Springer
Page : 0 pages
File Size : 40,5 Mb
Release : 2018-12-26
Category : Medical
ISBN : 3030085481

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Channelopathies in Heart Disease by Dierk Thomas,Carol Ann Remme Pdf

This book provides an expert overview on ion channel-related arrhythmia mechanisms, and describes important advances in our understanding of how ion channel dysfunction causes cardiac disease. Both, scientific findings and clinical implications are presented and discussed by scientists who have considerably contributed to the field. The book is organized in three parts: part I treats the molecular and electrophysiological mechanisms of function and dysfunction of ion channels, part II focuses on genetics and clinical findings, whereas part III describes novel research techniques, the use of stem cells and animal models and provides an outlook on future investigations and applications. The book is written for scientists in Cardiovascular Biology and Neuroscience and will be of general interest to Medical Doctors in Cardiology, Cardiac Electrophysiology and related disciplines.

Author : F. Lehmann-Horn,K. Jurkat-Rott
Publisher : Elsevier
Page : 384 pages
File Size : 46,5 Mb
Release : 2000-11-16
Category : Medical
ISBN : 0080528856

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Channelopathies by F. Lehmann-Horn,K. Jurkat-Rott Pdf

This book describes human hereditary ion channel diseases of voltage- and ligand-gated ion channels covering the diverse fields of medicine myology, neurology, cardiology, and nephrology requiring a wide and interdisciplinary readership. Interesting parallels in pathogenetic mechanisms of disease are especially emphasized to interest even highly specialized readers in entities outside of their fields. Each author has written an objective overview of his or her particular subject in a way that should allow the reader within a short period of time to obtain a comprehensive picture of the present state of art.

Author : Mohamed Chahine
Publisher : Springer
Page : 450 pages
File Size : 46,5 Mb
Release : 2018-06-04
Category : Medical
ISBN : 9783319902845

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Voltage-gated Sodium Channels: Structure, Function and Channelopathies by Mohamed Chahine Pdf

This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.

Author : Nicholas Wood
Publisher : Cambridge University Press
Page : 251 pages
File Size : 50,8 Mb
Release : 2012-04-12
Category : Medical
ISBN : 9780521543729

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Neurogenetics by Nicholas Wood Pdf

A coherent, up-to-date overview of the rapidly advancing field of neurogenetics for neurologists of any level.

Author : Dierk Thomas,Carol Ann Remme
Publisher : Springer
Page : 436 pages
File Size : 53,6 Mb
Release : 2018-09-10
Category : Medical
ISBN : 9783319778129

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Channelopathies in Heart Disease by Dierk Thomas,Carol Ann Remme Pdf

This book provides an expert overview on ion channel-related arrhythmia mechanisms, and describes important advances in our understanding of how ion channel dysfunction causes cardiac disease. Both, scientific findings and clinical implications are presented and discussed by scientists who have considerably contributed to the field. The book is organized in three parts: part I treats the molecular and electrophysiological mechanisms of function and dysfunction of ion channels, part II focuses on genetics and clinical findings, whereas part III describes novel research techniques, the use of stem cells and animal models and provides an outlook on future investigations and applications. The book is written for scientists in Cardiovascular Biology and Neuroscience and will be of general interest to Medical Doctors in Cardiology, Cardiac Electrophysiology and related disciplines.

Author : Giannis G. Baltogiannis,Giulio Conte,Pedro Brugada,Juan Sieira,Gaetano M. De Ferrari
Publisher : Frontiers Media SA
Page : 135 pages
File Size : 40,5 Mb
Release : 2021-01-11
Category : Medical
ISBN : 9782889663705

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Sudden Cardiac Death and Channelopathies by Giannis G. Baltogiannis,Giulio Conte,Pedro Brugada,Juan Sieira,Gaetano M. De Ferrari Pdf

Author : Lorenzo Maggi,Emma Matthews,Jean-François Desaphy
Publisher : Frontiers Media SA
Page : 119 pages
File Size : 41,5 Mb
Release : 2021-02-04
Category : Medical
ISBN : 9782889664511

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New Insights in Skeletal Muscle Channelopathies - A Rapidly Expanding Field by Lorenzo Maggi,Emma Matthews,Jean-François Desaphy Pdf

Jean-François Desaphy is a co-inventor, with no personal financial interest, of a European patent assigned to a pharmaceutical company regarding the use of a company drug in myotonic syndromes.

Author : Frances M. Ashcroft
Publisher : Academic Press
Page : 505 pages
File Size : 46,6 Mb
Release : 1999-10-20
Category : Science
ISBN : 9780080535210

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Ion Channels and Disease by Frances M. Ashcroft Pdf

Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Introduces the relevant aspects of molecular biology and biophysics Describes the principal methods used to study channelopathies Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype

Author : George Karpati,David Hilton-Jones,Robert C. Griggs
Publisher : Cambridge University Press
Page : 800 pages
File Size : 42,7 Mb
Release : 2001-07-12
Category : Medical
ISBN : 0521650623

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Disorders of Voluntary Muscle by George Karpati,David Hilton-Jones,Robert C. Griggs Pdf

Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.

Author : Anonim
Publisher : Academic Press
Page : 168 pages
File Size : 41,5 Mb
Release : 2011-09-06
Category : Science
ISBN : 0080923100

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Ion Channel Diseases by Anonim Pdf

Ion channel dysfunction in humans leads to impairment of the excitable processes necessary for the normal function of several tissues, such as muscle and brain. It follows that an increasing number of human diseases have been associated with malfunctioning ion channels, many of which have a genetic component. This volume of Advances in Genetics presents a broad and comprehensive overview of the inherited channelopathies in humans, including clinical, genetic and molecular aspects of these conditions. Keeping true to the scope of the serial, novel genomic and modeling research approaches and a review of potential therapeutic approaches for each of these conditions are also incorporated.

Author : Jeffrey L. Noebels,Massimo Avoli
Publisher : OUP USA
Page : 1258 pages
File Size : 53,7 Mb
Release : 2012-06-29
Category : Medical
ISBN : 9780199746545

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Jasper's Basic Mechanisms of the Epilepsies by Jeffrey L. Noebels,Massimo Avoli Pdf

Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

Author : Michael Rose,Robert C. Griggs
Publisher : Butterworth-Heinemann
Page : 376 pages
File Size : 41,5 Mb
Release : 2001
Category : Ion channels
ISBN : UOM:39015050821365

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Channelopathies of the Nervous System by Michael Rose,Robert C. Griggs Pdf

* A unique reference focusing on the rapidly developing field of channelopathies of common neurological disorders * Written specifically for the clinical neurologist and neuroscientist * It reviews the underlying scientific principles of ion channel function and the current research and its clinical applications

Author : Suzanne K. W. Mankowitz
Publisher : Springer
Page : 628 pages
File Size : 52,6 Mb
Release : 2018-11-15
Category : Medical
ISBN : 9783319596808

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Consults in Obstetric Anesthesiology by Suzanne K. W. Mankowitz Pdf

This text addresses the need for a book specifically aimed at obstetric anesthesia and covers topics such as pulmonary, cardiac renal, hepatic, hematologic, neurologic, endocrine and other diseases. The real anesthetic challenge arises when patients present to Labor and Delivery with unusual or complicated medical problems and, in recent years, a few of the larger institutions have developed an Obstetric Anesthesiology Consultation Service to prepare for the management of these patients. While most pregnant women who present to Labor and Delivery require anesthetic intervention, they typically meet the anesthesiologist for the first time in labor. Since the majority of laboring women are healthy without significant comorbidities, this does not present much of a challenge to the anesthesiologist and the anesthetic management tends to be straight-forward with favorable outcomes. However, using this new model, the anesthesiologist has the opportunity to discuss the various treatment modalities and potentially suggest diagnostic testing to be performed prior to delivery, similar to the pre-operative testing that is done in other surgical environments.

Author : A. John Camm
Publisher : Unknown
Page : 3198 pages
File Size : 47,6 Mb
Release : 2019
Category : Cardiology
ISBN : 0198824874

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The ESC Textbook of Cardiovascular Medicine by A. John Camm Pdf

Author : Osama O. Zaidat,Alan J. Lerner,J.Douglas Miles
Publisher : Elsevier Health Sciences
Page : 640 pages
File Size : 40,8 Mb
Release : 2019-04-30
Category : Medical
ISBN : 9780323550727

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The Little Black Book of Neurology E-Book by Osama O. Zaidat,Alan J. Lerner,J.Douglas Miles Pdf

Widely known and well-respected, The Little Black Book of Neurology has been a thorough yet portable reference in this complex field for more than 30 years, presenting definitions, classifications, and guidance on diagnosis and management for a wide range of neurological disorders. The 6th Edition offers updated and expanded coverage of neuropharmacology and neuroimaging – plus a new, more user-friendly, fast-access format that makes the book ideal for quick clinical consultation or as a refresher for the Boards. Presents a comprehensive, yet concise, "all-in-one" introduction to neurology in a portable, alphabetical format – now newly structured to make reference faster and easier than ever. Enables you to access critical guidance at a glance with new tables of differential diagnosis, patient evaluation, and treatment options. Covers many new topics including significantly expanded sections on sleep, neuromuscular disorders, and critical care. Includes four new appendices: Neurocritical Emergencies • Therapeutic Care • AAN Guideline Summaries • and Scales – highlighting evidence-based guidelines when available, enabling you to make more informed clinical judgments. Offers updated and expanded coverage of neuropharmacology and neuroimaging.