Chemical Biology Of Sterols Triterpenoids And Other Natural Products

Author : Wenxu Zhou,De-an Guo
Publisher : MDPI
Page : 256 pages
File Size : 47,5 Mb
Release : 2019-06-05
Category : Science
ISBN : 9783038974161

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Chemical Biology of Sterols, Triterpenoids and Other Natural Products by Wenxu Zhou,De-an Guo Pdf

Sterols and other isoprenoids are of great interest for their molecular structure and function in cell architecture and evolution, as well as for their importance in medicine and agriculture. Molecules’ 2019 Festschrift Special Issue in honor of the 65th birthday of Prof. W. David Nes, an internationally recognized chemical biologist and recipient of the George Schroepher medal for sterol research, focuses on recent developments in the chemistry, biosynthesis, and function of these polycyclic natural products. This volume of Molecules contains 16 leading-edge review articles and original research contributions from an international cast of scientists. This volume is grouped into three sections: (i) isoprenoid metabolome and diversity, (ii) clinical evaluation of sterol and triterpene structures and biosynthesis, and (iii) methods and synthesis of steroids and other compounds. The volume will be a valuable reference tool for those who study medicinal chemistry, protein chemistry, and biochemistry of isoprenoid lipids.

Author : Wenxu Zhou,De-an Guo
Publisher : Unknown
Page : 256 pages
File Size : 44,5 Mb
Release : 2019
Category : Biochemistry
ISBN : 303897417X

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Chemical Biology of Sterols, Triterpenoids and Other Natural Products: A Themed Issue in Honor of Professor W. David Nes on the Occasion of His 65th Birthday by Wenxu Zhou,De-an Guo Pdf

Sterols and other isoprenoids are of great interest for their molecular structure and function in cell architecture and evolution, as well as for their importance in medicine and agriculture. Molecules' 2019 Festschrift Special Issue in honor of the 65th birthday of Prof. W. David Nes, an internationally recognized chemical biologist and recipient of the George Schroepher medal for sterol research, focuses on recent developments in the chemistry, biosynthesis, and function of these polycyclic natural products. This volume of Molecules contains 16 leading-edge review articles and original research contributions from an international cast of scientists. This volume is grouped into three sections: (i) isoprenoid metabolome and diversity, (ii) clinical evaluation of sterol and triterpene structures and biosynthesis, and (iii) methods and synthesis of steroids and other compounds. The volume will be a valuable reference tool for those who study medicinal chemistry, protein chemistry, and biochemistry of isoprenoid lipids.

Author : Thomas J. Bach,Michel Rohmer
Publisher : Springer Science & Business Media
Page : 507 pages
File Size : 54,6 Mb
Release : 2012-09-19
Category : Science
ISBN : 9781461440628

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Isoprenoid Synthesis in Plants and Microorganisms by Thomas J. Bach,Michel Rohmer Pdf

Isoprenoids are important in primary and secondary metabolism. They have implications in a myriad of physiological processes notably in plants, microorganisms and parasites, and biological activities at the cellular, organism, and ecosystem levels. The importance of isoprenoids in various areas of the scientific world has spurred intense research worldwide. Also their role in "nutraceuticals" has stimulated scientific curiosity. Literature on isoprenoids is widely scattered in journals with quite differing readerships and geographic distribution. A comprehensive book on isoprenoids does not exist. Isoprenoid Synthesis in Plants and Microorganisms: New Concepts and Experimental Approaches fills this gap by presenting the latest and the most applicable information on isoprenoids. The most recent TERPNET conference serves as the backdrop and provides much of the inspiration for the topics covered in the book. Additional topics of interest are covered as well, making Isoprenoid Synthesis in Plants and Microorganisms: New Concepts and Experimental Approaches the most comprehensive review of isoprenoid synthesis to date.

Author : J. Goad,T. Akihisa
Publisher : Springer Science & Business Media
Page : 453 pages
File Size : 52,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789400914476

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Analysis of Sterols by J. Goad,T. Akihisa Pdf

Knowledge is of two kinds. We know a subject ourselves, or we know where we can find information on it Samuel Johnson, 18 April, 1775* Sterols are among the most studied groups of natural products with interest commencing in the 19th century and running to the present. Investigations have embraced the refinement of separation procedures, the development of new analytical techniques and instrumentation for structure elucidation, the unravelling of biosynthetic mechanisms, the determination of the physiological functions of sterols, and the role they play in health and disease. In the past 20-30 years interest in the medical implications of sterol biochemistry, studies on the sterols of plants, algae and fungi, and the identification of the many unusual sterols from marine organisms have proceeded in parallel and somewhat independently. Although the motiva tion and goals for the various lines of investigation have differed widely the researchers working in each of these areas have contributed a wealth of knowledge to the literature relating to the analysis of sterols and many diverse new sterols have been discovered. We conceived this book as a modest attempt to bring together some of this literature in the hope that it may be helpful to newcomers to sterol research. We had originally intended to produce a 'handbook' outlining in detail the protocols to be followed for sterol extraction, chromatography, NMR analysis, etc. in order to identify the components of a sterol mixture.

Author : Héctor M. Hernández,Carlos Gómez-Hinostrosa
Publisher : Unknown
Page : 128 pages
File Size : 50,5 Mb
Release : 2011
Category : Cactus
ISBN : 0953813487

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Mapping the Cacti of Mexico by Héctor M. Hernández,Carlos Gómez-Hinostrosa Pdf

Author : Anne E. Osbourn,Virginia Lanzotti
Publisher : Springer Science & Business Media
Page : 588 pages
File Size : 54,7 Mb
Release : 2009-07-07
Category : Science
ISBN : 9780387854984

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Plant-derived Natural Products by Anne E. Osbourn,Virginia Lanzotti Pdf

Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.

Author : Shahid Ul-Islam,Javid Ahmad Banday
Publisher : John Wiley & Sons
Page : 434 pages
File Size : 52,6 Mb
Release : 2021-06-29
Category : Science
ISBN : 9781119640349

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Chemistry of Biologically Potent Natural Products and Synthetic Compounds by Shahid Ul-Islam,Javid Ahmad Banday Pdf

In view of their promising biological and pharmaceutical activities, natural product inspired and heterocyclic compounds have recently gained a reputation in the field of medicinal chemistry. Over the past decades, intensive research efforts have been ongoing to understand the synthesis, biochemistry and engineering involved in their preparation and action mechanisms. Several novel natural product derivatives, heterocyclic and other synthetic compounds, have been reported to have shown interesting biological activities including anticancer, antimicrobial, anti-inflammatory, anti-glycemic, anti-allergy and antiviral etc. Chemistry of Biologically Potent Natural Products and Synthetic Compounds provides up-to-date information on new developments and most recent medicinal applications of the natural products and derivatives, as well as the chemistry and synthesis of heterocyclic and other related compounds.

Author : Rensheng Xu,Yang Ye,Weimin Zhao
Publisher : CRC Press
Page : 381 pages
File Size : 44,6 Mb
Release : 2011-07-20
Category : Medical
ISBN : 9781439860779

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Introduction to Natural Products Chemistry by Rensheng Xu,Yang Ye,Weimin Zhao Pdf

Natural products chemistry-the chemistry of metabolite products of plants, animals and microorganisms-is involved in the investigation of biological phenomena ranging from drug mechanisms to gametophytes and receptors and drug metabolism in the human body to protein and enzyme chemistry. Introduction to Natural Products Chemistry has collected the

Author : Corrado Tringali
Publisher : CRC Press
Page : 704 pages
File Size : 47,5 Mb
Release : 2003-09-02
Category : Science
ISBN : 9780203212318

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Bioactive Compounds from Natural Sources by Corrado Tringali Pdf

Interest in obtaining biologically active compounds from natural sources has recently spiked due to their low toxicity, complete biodegradability, availability from renewable sources, and in most cases, low cost. Taking an interdisciplinary approach, Bioactive Compounds from Natural Sources: Isolation, Characterization, and Biological Properties covers general methods and main topics in the research field of bioactive natural products. The book describes general screening methods, modern HPLC hyphenated techniques, and NMR methods in the structural elucidation of compounds and devotes individual chapters to specific topics of research. Surveys on compounds displaying important pharmacological activities are presented in chapters devoted to Mexican medicinal plants, anti-tumor drugs of natural origin, cancer chemopreventive flavonoids, and metabolites displaying anti-HIV, antioxidative, antimalarial, and anti-inflammatory activity. The final chapters are devoted to representative examples of research into marine metabolites: immunomodulating marine glycolipids and surveys of bioactive compounds from marine opisthobranchs and Japanese soft corals. With its focus on modern approaches to the isolation of biologically active natural products, this book encourages interdisciplinary work among chemists, pharmacologists, biologists, botanists, and agronomists with an interest in bioactive natural products.

Author : K. E. Peters,C. C. Walters,J. M. Moldowan
Publisher : Cambridge University Press
Page : 1096 pages
File Size : 44,9 Mb
Release : 2007-08-16
Category : Science
ISBN : 9781107079373

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The Biomarker Guide: Volume 1, Biomarkers and Isotopes in the Environment and Human History by K. E. Peters,C. C. Walters,J. M. Moldowan Pdf

The second edition of The Biomarker Guide is a fully updated and expanded version of this essential reference. Now in two volumes, it provides a comprehensive account of the role that biomarker technology plays both in petroleum exploration and in understanding Earth history and processes. Biomarkers and Isotopes in the Environment and Human History details the origins of biomarkers and introduces basic chemical principles relevant to their study. It discusses analytical techniques, and applications of biomarkers to environmental and archaeological problems. The Biomarker Guide is an invaluable resource for geologists, petroleum geochemists, biogeochemists, environmental scientists and archaeologists.

Author : Professor Satyajit D. Sarker,Lutfun Nahar
Publisher : John Wiley & Sons
Page : 397 pages
File Size : 45,6 Mb
Release : 2013-05-28
Category : Science
ISBN : 9781118687536

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Chemistry for Pharmacy Students by Professor Satyajit D. Sarker,Lutfun Nahar Pdf

"This book has succeeded in covering the basic chemistry essentials required by the pharmaceutical science student... the undergraduate reader, be they chemist, biologist or pharmacist will find this an interesting and valuable read." –Journal of Chemical Biology, May 2009 Chemistry for Pharmacy Students is a student-friendly introduction to the key areas of chemistry required by all pharmacy and pharmaceutical science students. The book provides a comprehensive overview of the various areas of general, organic and natural products chemistry (in relation to drug molecules). Clearly structured to enhance student understanding, the book is divided into six clear sections. The book opens with an overview of general aspects of chemistry and their importance to modern life, with particular emphasis on medicinal applications. The text then moves on to a discussion of the concepts of atomic structure and bonding and the fundamentals of stereochemistry and their significance to pharmacy- in relation to drug action and toxicity. Various aspects of aliphatic, aromatic and heterocyclic chemistry and their pharmaceutical importance are then covered with final chapters looking at organic reactions and their applications to drug discovery and development and natural products chemistry. accessible introduction to the key areas of chemistry required for all pharmacy degree courses student-friendly and written at a level suitable for non-chemistry students includes learning objectives at the beginning of each chapter focuses on the physical properties and actions of drug molecules

Author : Paul M. Dewick
Publisher : John Wiley & Sons
Page : 524 pages
File Size : 42,5 Mb
Release : 2002-01-03
Category : Medical
ISBN : 0471496413

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Medicinal Natural Products by Paul M. Dewick Pdf

This guide covers classes of natural products in medicine, whether derived from plants, micro-organisms or animals. Structured according to biosynthetic pathway, it is written from a chemistry-based approach.

Author : Sunil Kumar Talapatra,Bani Talapatra
Publisher : Springer
Page : 1180 pages
File Size : 49,6 Mb
Release : 2015-03-05
Category : Science
ISBN : 9783642454103

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Chemistry of Plant Natural Products by Sunil Kumar Talapatra,Bani Talapatra Pdf

Aimed at advanced undergraduate and graduate students and researchers working with natural products, Professors Sunil and Bani Talapatra provide a highly accessible compilation describing all aspects of plant natural products. Beginning with a general introduction to set the context, the authors then go on to carefully detail nomenclature, occurrence, isolation, detection, structure elucidation (by both degradation and spectroscopic techniques) stereochemistry, conformation, synthesis, biosynthesis, biological activity and commercial applications of the most important natural products of plant origin. Each chapter also includes detailed references (with titles) and a list of recommended books for additional study making this outstanding treatise a useful resource for teachers of chemistry and researchers working in universities, research institutes and industry.

Author : Shagufta Perveen,Areej Al-Taweel
Publisher : BoD – Books on Demand
Page : 154 pages
File Size : 54,5 Mb
Release : 2018-12-19
Category : Science
ISBN : 9781789847765

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Terpenes and Terpenoids by Shagufta Perveen,Areej Al-Taweel Pdf

Terpenes belong to the diverse class of chemical constituents isolated from materials found in nature (plants, fungi, insects, marine organisms, plant pathogens, animals and endophytes). These metabolites have simple to complex structures derived from Isopentyl diphosphate (IPP), dimethyl allyl diphosphate (DMAPP), mevalonate and deoxyxylulose biosynthetic pathways. Terpenes play a very important role in human health and have significant biological activities (anticancer, antimicrobial, anti-inflammatory, antioxidant, antiallergic, skin permeation enhancer, anti-diabetic, immunomodulatory, anti-insecticidal). This book gives an overview and highlights recent research in the phytochemical and biological understanding of terpenes and terpenoid and explains the most essential functions of these kinds of secondary metabolites isolated from natural sources.

Author : José L. Medina-Franco
Publisher : MDPI
Page : 158 pages
File Size : 52,8 Mb
Release : 2019-07-01
Category : Medical
ISBN : 9783039211043

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New Approaches for the Discovery of Pharmacologically-Active Natural Compounds by José L. Medina-Franco Pdf

A major source of active compounds, natural products from different sources supply a large variety of molecules that have been approved for clinical use or used as the starting points of optimization programs. This book features nine papers (eight full articles and one review paper) written by more than 45 scientists from around the world. These papers illustrate the development and application of a broad range of computational and experimental techniques applied to natural product research. On behalf of the contributors to the book, our hope is that the research presented here contributes to advancements in the field, and encourages multidisciplinary teams, young scientists, and students to further advance in the discovery of pharmacologically-active natural compounds