Chemistry Of Metalloproteins

Author : Joseph J. Stephanos,Anthony W. Addison
Publisher : John Wiley & Sons
Page : 448 pages
File Size : 41,7 Mb
Release : 2014-07-22
Category : Science
ISBN : 9781118801529

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Chemistry of Metalloproteins by Joseph J. Stephanos,Anthony W. Addison Pdf

Addresses the full gamut of questions in metalloprotein science Formatted as a question-and-answer guide, this book examines all major families of metal binding proteins, presenting our most current understanding of their structural, physicochemical, and functional properties. Moreover, it introduces new and emerging medical applications of metalloproteins. Readers will discover both the underlying chemistry and biology of this important area of research in bioinorganic chemistry. Chemistry of Metalloproteins features a building block approach that enables readers to master the basics and then advance to more sophisticated topics. The book begins with a general introduction to bioinorganic chemistry and metalloproteins. Next, it covers: Alkali and alkaline earth cations Metalloenzymes Copper proteins Iron proteins Vitamin B12 Chlorophyll Chapters are richly illustrated to help readers fully grasp all the chemical concepts that govern the biological action of metalloproteins. In addition, each chapter ends with a list of suggested original research articles and reviews for further investigation of individual topics. Presenting our most current understanding of metalloproteins, Chemistry of Metalloproteins is recommended for students and researchers in coordination chemistry, biology, and medicine. Each volume of the Wiley Series in Protein and Peptide Science addresses a specific facet of the field, reviewing the latest findings and presenting a broad range of perspectives. The volumes in this series constitute essential reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, and physiologists as well as researchers in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.

Author : Ivano Bertini,Astrid Sigel
Publisher : CRC Press
Page : 1382 pages
File Size : 52,9 Mb
Release : 2001-06-29
Category : Medical
ISBN : 0824705203

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Handbook on Metalloproteins by Ivano Bertini,Astrid Sigel Pdf

This Handbook on Metalloproteins focuses on the available structural information of proteins and their metal ion coordination spheres. It centers on the metal ions indispensable for life but also considers metal ions used as substitution probes in studies of metalloproteins. Emphasizing the structure-function relationship, the book covers the common and distinct characterstics of metallo- enzymes, proteins, and amino acids bonded to copper, zinc, iron, and more.

Author : Art E. Cho,William A. Goddard III
Publisher : CRC Press
Page : 294 pages
File Size : 40,9 Mb
Release : 2015-04-17
Category : Science
ISBN : 9781498759922

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Metalloproteins by Art E. Cho,William A. Goddard III Pdf

Numerous essential biological functions involve metalloproteins; therefore, understanding metalloproteins and how to manipulate them is significant in the biological and medical fields. An examination of current research, Metalloproteins: Theory, Calculations, and Experiments explores the interplay between theory and experiment, detailing the role

Author : Michael K. Johnson,Robert A. Scott
Publisher : John Wiley & Sons
Page : 424 pages
File Size : 55,9 Mb
Release : 2017-08-14
Category : Science
ISBN : 9781119159858

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Metalloprotein Active Site Assembly by Michael K. Johnson,Robert A. Scott Pdf

Summarizes the essential biosynthetic pathways for assembly of metal cofactor sites in functional metalloproteins Metalloprotein Active Site Assembly focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding of the processes involved. An excellent companion to the earlier book in this series Metals in Cells—which discussed both the positive and negative effects of cellular interactions with metals—this comprehensive book provides a diverse sampling of what is known about metalloprotein active site assembly processes. It covers all major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components, metal-binding organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin), and post-translationally modified metal binding sites that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since it is a relatively new, fast-developing area of research. Metalloprotein Active Site Assembly is an ideal text for practitioners of inorganic biochemistry who are studying the biosynthetic pathways and gene clusters involved in active site assembly, and for inorganic chemists who want to apply the concepts learned to potential synthetic pathways to active site mimics.

Author : Albrecht Messerschmidt
Publisher : Wiley-Blackwell
Page : 816 pages
File Size : 47,8 Mb
Release : 2001
Category : Science
ISBN : WISC:89082989401

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Handbook of Metalloproteins, Handbook of Metalloproteins by Albrecht Messerschmidt Pdf

The first two volumes of the "Handbook of Metalloproteins", published in 2001, focused on a number of metals, including iron, nickel, manganese, cobalt, copper and vanadium. Now we are delighted to present volume three which extends the wealth of knowledge and focuses on proteins found in the redox-inactive ions of zinc and calcium. (Midwest).

Author : Silvia Maria Doglia,Marina Lotti
Publisher : Wiley
Page : 288 pages
File Size : 49,9 Mb
Release : 2014-04-14
Category : Science
ISBN : 1118448529

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Protein Aggregation in Bacteria by Silvia Maria Doglia,Marina Lotti Pdf

Focuses on the aggregation of recombinant proteins in bacterial cells in the form of inclusion bodies—and on their use in biotechnological and medical applications The first book devoted specifically to the topic of aggregation in bacteria, Protein Aggregation in Bacteria: Functional and Structural Properties of Inclusion Bodies in Bacterial Cells provides a large overview of protein folding and aggregation, including cell biology and methodological aspects. It summarizes, for the first time in one book, ideas and technical approaches that pave the way for a direct use of inclusion bodies in biotechnological and medical applications. Protein Aggregation in Bacteria covers: Molecular and cellular mechanisms of protein folding, aggregation, and disaggregation in bacteria Physiological importance and consequences of aggregation for the bacterial cell Factors inherent to the protein sequence responsible for aggregation and evolutionary mechanisms to keep proteins soluble Structural properties of proteins expressed as soluble aggregates and as inclusion bodies within bacterial cells both from a methodological point of view and with regard to their similarity with amyloids Control of the structural and functional properties of aggregated proteins and use thereof in biotechnology and medicine Protein Aggregation in Bacteria is ideal for researchers in protein science, biochemistry, bioengineering, biophysics, microbiology, medicine, and biotechnology, particularly if they are related with the production of recombinant proteins and pharmaceutical science.

Author : Albrecht Messerschmidt
Publisher : Wiley
Page : 2308 pages
File Size : 53,8 Mb
Release : 2004-06-28
Category : Science
ISBN : 047086981X

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Handbook of Metalloproteins, 3 volume set by Albrecht Messerschmidt Pdf

The first two volumes of the "Handbook of Metalloproteins", published in 2001, focused on a number of metals, including iron, nickel, manganese, cobalt, copper and vanadium. Now we are delighted to present volume three which extends the wealth of knowledge and focuses on proteins found in the redox-inactive ions of zinc and calcium. * Colour illustrations throughout * 3D structures of modified metalloproteins for easier understanding of functions * International expert contributors The amazing new set will prove to be an essential reference providing comprehensive understanding and focused coverage of metalloproteins. "it is a pleasure to use ...this excellent, authoritative, and valuable text...I regard this work as essential for library purchase..." (Natural Products Report, Vol.19, No.4, 2002) "highly recommended as a resource for bioinorganic chemistry. It will have lasting value for researchers in the field" (The Alchemist - Chemweb, 2002)

Author : Robert H. Kretsinger,Vladimir N. Uversky,Eugene A. Permyakov
Publisher : Springer
Page : 0 pages
File Size : 52,9 Mb
Release : 2013-05-01
Category : Science
ISBN : 1461415322

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Encyclopedia of Metalloproteins by Robert H. Kretsinger,Vladimir N. Uversky,Eugene A. Permyakov Pdf

In biochemistry, a metalloprotein is a generic term for a protein that contains a metal cofactor. The metal may be an isolated ion or may be coordinated with a nonprotein organic compound, such as the porphyrin found in hemoproteins. In some cases, the metal is co-coordinated with a side chain of the protein and an inorganic nonmetallic ion. This kind of protein-metal-nonmetal structure is seen in iron-sulfur clusters Metalloproteins deals with all aspects related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The biological roles of metal cations and metal-binding proteins are endless. They are involved in all crucial cellular activities. Many pathological conditions are related to the problematic metal metabolism. Research in metalloprotein-related topics is therefore rapidly growing, and different aspects of metal-binding proteins progressively enter curricula at Universities and even at the High School level on occasion. However, no key resource providing basic, but comprehensible knowledge on this rapidly expanding field exists. The Encyclopedia of Metalloproteins aims to bridge this gap, and will attempt to cover various aspects of metalloprotein/metalloproteomics and will deal with the different issues related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The goal is to cover exhaustively all catalytically and biologically crucial metal ions and to find at least one interacting protein for other metal ions. The Encyclopedia of Metalloproteins will provide a key resource for advanced undergraduate and graduate students, researchers, instructors, and professors interested in protein science, biochemistry, cell biology, and genetics.

Author : Yilin Hu
Publisher : Humana Press
Page : 275 pages
File Size : 40,8 Mb
Release : 2018-10-31
Category : Science
ISBN : 1493988638

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Metalloproteins by Yilin Hu Pdf

This volume provides an up-to-date, in-depth overview of the methods that have been applied to studying the complex metalloproteins at a molecular level. Chapters cover a wide range of approaches focusing on genetic, biochemical, spectroscopic, chemical methods, and theoretical calculations. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Metalloproteins: Methods and Protocols aims to be useful for anyone who is interested in metalloprotein research and wants to address the unanswered mechanistic and biosynthetic questions of these fascinating enzyme systems.

Author : H.A.O. Hill,P.J. Sadler,A.J. Thomson
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 53,6 Mb
Release : 1999-04-01
Category : Science
ISBN : 3540655530

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Metal Sites in Proteins and Models by H.A.O. Hill,P.J. Sadler,A.J. Thomson Pdf

Biological chemistry is a major frontier of inorganic chemistry. Three special volumes devoted to Metal Sites in Proteins and Models address the questions: how unusual ("entatic") are metal sites in metalloproteins and metalloenzymes compared to those in small coordination complexes? and if they are special, how do polypeptide chains and co-factors control this? The chapters deal with iron, with metal centres acting as Lewis acids, metals in phosphate enzymes, with vanadium, and with the wide variety of transition metal ions which act as redox centres. They illustrate in particular how the combined armoury of genetics and structure determination at the molecular level are providing unprecedented new tools for molecular engineering.

Author : Albrecht Messerschmidt,Robert Huber,Thomas Poulos,Karl Wieghardt
Publisher : Wiley
Page : 1500 pages
File Size : 45,8 Mb
Release : 2001-08-16
Category : Science
ISBN : 0471627437

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Handbook of Metalloproteins by Albrecht Messerschmidt,Robert Huber,Thomas Poulos,Karl Wieghardt Pdf

"it is a pleasure just to read this handsome and carefully produced work" Angewandte Chemie 2002 "...the Handbook of Metalloproteins is highly recommended as a resource for bioinorganic chemistry. It will have lasting value for researchers in the field..." The Alchemist - Chemweb In recent years, the analysis and classification of metalloproteins at the interface between chemistry and biology has accelerated. Many developments and initiatives have taken place and this two-volume handbook provides a comprehensive, yet focussed, collection of 105 major metalloproteins. Content is presented in both a large format and full colour and covers the most relevant transition metals such as Iron, Nickel, Copper, Cobalt, Molybdenum, Manganese Tungsten and Vanadium. This is the first Handbook of Metalloproteins ever published and is comprised of articles written by renowned experts in the field. It draws together contributions from over two hundred internationally renowned researchers that include: Douglas Rees and Charles Stout as well as Nobel Prize winner Robert Huber. Each contribution is presented in a similar format and shows a ribbon plot of the overall 3D Structure on their first page, a representation of the metal active site and numerous other figures and tables underpinning the remarks. Comparative information is provided on different proteins and every entry has been extensively referenced to current literature. * First comprehensive handbook to cover the major metalloproteins * Presents structural and functional data in an organised manner * Incorporates full-colour representation of molecular structures throughout * Unifies information from molecular biology, enzymology, spectroscopy, biochemistry, chemistry, biophysics, macromolecular crystallography and structural biology * Includes comprehensive sections that cover: Functional Class, Occurrence, Amino Acid Sequence Information, Protein Production, Purification and Molecular Characterisation, Metal Content and Cofactors, Activity Test, Spectroscopy, 3D Structure, Functional Aspects.

Author : Sei Otsuka,Tateo Yamanaka
Publisher : Unknown
Page : 586 pages
File Size : 45,7 Mb
Release : 1988
Category : Metalloenzymes
ISBN : STANFORD:36105033109799

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Metalloproteins by Sei Otsuka,Tateo Yamanaka Pdf

Author : Helmut Sigel,Astrid Sigel
Publisher : CRC Press
Page : 536 pages
File Size : 45,9 Mb
Release : 1994-02-08
Category : Science
ISBN : 0824790936

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Metal Ions in Biological Systems by Helmut Sigel,Astrid Sigel Pdf

This volume is devoted solely to the research area of metalloenzymes involving amino acid-residue and related radicals. Topics covered include: general considerations; structure, function and engineering of peroxidases; and ribonucleotide reductase in mammalian systems.

Author : Astrid Sigel
Publisher : CRC Press
Page : 744 pages
File Size : 50,5 Mb
Release : 2001-01-30
Category : Medical
ISBN : 9781482270150

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Metal Ions in Biological Systems by Astrid Sigel Pdf

"Focuses on the vibrant area of probing enzymes or proteins by metal ions and small complexes. Offers a summary of the basic characteristics of the amide bond, emphasizing its proton and metal ion interactions, including a quantitative analysis of its hydrolysis and formation."

Author : Albrecht Messerschmidt
Publisher : Wiley
Page : 3273 pages
File Size : 40,8 Mb
Release : 2011-05-31
Category : Science
ISBN : 1119994292

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Handbook of Metalloproteins by Albrecht Messerschmidt Pdf

Researching the structure and function of metalloproteins is one of the biggest challenges in modern biological chemistry - and several Nobel Prizes have been awarded to research in the field, including to the Co-Editor Robert Huber in 1988. This 5-Volume Set gives a representative presentation of the key enzymes [= Metalloproteins and reflect the success of the current ongoing research and includes coverage of 234 Metalloproteins. The set comprises of Volumes 1 & 2 published in 2001, Volume 3 published in 2004 and Volumes 4 & 5 published in February 2011. Praise for this publication includes: "It is a pleasure just to read this handsome and carefully produced work..." From volumes 1 & 2, Angewandte Chemie , vol. 41, 2002) "it is a pleasure to use... this excellent, authoritative, and valuable text...I regard this work as essential for library purchase..." Natural Products Report, Vol.19, No.4, 2002 "highly recommended as a resource for bioinorganic chemistry. It will have lasting value for researchers in the field" The Alchemist - Chemweb, 2002 Also available online via http://onlinelibrary.wiley.com/book/10.1002/0470028637