Chemokines

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The Chemokine Factsbook

Krishna Vaddi,Margaret Keller,Matthew Newton
The Chemokine Factsbook Book PDF

Author : Krishna Vaddi,Margaret Keller,Matthew Newton
Publisher : Elsevier
Page : 205 pages
File Size : 50,7 Mb
Release : 1997-04-01
Category : Medical
ISBN : 0080529089

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The Chemokine Factsbook by Krishna Vaddi,Margaret Keller,Matthew Newton Pdf

How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact? The Academic Press FactsBook series will satisfy scientists and clinical researchers suffering from information overload. Each volume provides a catalog of the essential properties of families of molecules. Gene organization, amino acid sequences, physicochemical properties, and biological activity are presented using a common, easy-to-follow format. Taken together they compile everything you want to know about proteins but are too busy to look for. The Chemokine FactsBook contains more than 40 entries on chemokines, and chemokine receptors from human or other origin, including IL-8, MCP-1, C5-a, RANTES, Lymphotactin, and CC CKR-1. The text provides information on tissue sources, target cells, physicochemical properties, transcription factors, regulation of expression in disease, receptor-binding characteristics, gene structure and location, amino acid sequences, and accession numbers and references. Contains over 40 entries on chemokines and chemokine receptors from human or other origin, including: IL-8 MCP-1 C5-a RANTES Lymphotactin CC CKR-1 Entries provide information on: Tissue sources Target cells Physicochemical properties Transcription factors Regulation of expression Expression in disease Receptor-binding characteristics Gene structure and location Amino acid sequences Database accession numbers References

Chemokines and Viral Infection

Thomas E. Lane
Chemokines and Viral Infection Book PDF

Author : Thomas E. Lane
Publisher : Springer Science & Business Media
Page : 163 pages
File Size : 50,7 Mb
Release : 2007-05-30
Category : Medical
ISBN : 9783540333975

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Chemokines and Viral Infection by Thomas E. Lane Pdf

Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. Within a relatively short period of time, early participants within the field determined that these proteins displayed distinct and conserved structural features and exerted potent chemotactic effects on defined lymphocyte subsets. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection.

Progress in Chemokine Research

W. P. Linkes
Progress in Chemokine Research Book PDF

Author : W. P. Linkes
Publisher : Nova Publishers
Page : 236 pages
File Size : 51,5 Mb
Release : 2007
Category : Medical
ISBN : 1600216412

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Progress in Chemokine Research by W. P. Linkes Pdf

Chemokines are the cytokines that may activate or chemoattract leukocytes. Each chemokine contains 65 ~ 120 amino acids, with molecular weight of 8-10 kD. Their receptors belong to G-protein-coupled receptors. Inflammatory chemokines are released from a wide variety of cells in response to bacterial infection, viruses and agents that cause physical damage such as silica or the urate crystals that occur in gout. They function mainly as chemoattractants for leukocytes, recruiting monocytes, neutrophils and other effector cells from the blood to sites of infection or damage. They can be released by many different cell types and serve to guide cells involved in innate immunity and also the lymphocytes of the adaptive immune system. The cells that are attracted by chemokines follow a signal of increasing chemokine concentration to the site of infection or tissue injury. Some chemokines also have roles in the development of lymphocytes, migration and angiogenesis (the growth of new blood vessels).Since the entry of HIV into host cells requires chemokine receptors, their antagonists are being developed to treat AIDS. This book presents leading research from around the globe in this field.

Fundamentals of Inflammation

Charles N. Serhan,Peter A. Ward,Derek W. Gilroy
Fundamentals of Inflammation Book PDF

Author : Charles N. Serhan,Peter A. Ward,Derek W. Gilroy
Publisher : Cambridge University Press
Page : 489 pages
File Size : 49,5 Mb
Release : 2010-04-26
Category : Medical
ISBN : 9780521887298

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Fundamentals of Inflammation by Charles N. Serhan,Peter A. Ward,Derek W. Gilroy Pdf

The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion.

Chemokines in Viral Infections

Surendran Mahalingam
Chemokines in Viral Infections Book PDF

Author : Surendran Mahalingam
Publisher : Springer Science & Business Media
Page : 140 pages
File Size : 51,8 Mb
Release : 2004-10-14
Category : Medical
ISBN : 0306482347

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Chemokines in Viral Infections by Surendran Mahalingam Pdf

In the past five years, a large number of new chemokines and chemokine receptors have been identified. Alarming progress in the areas of bioinformatics and expressed sequence tag (EST) databases attributed to this development. Recent discoveries provide compelling evidences supporting the roles of these messengers and their receptors in the control of viral infection as well as in aiding virus survival. Chemokines in Viral Infections is the first to provide a comprehensive write up on the various evidences available to date on the interactions between host chemokine system and viral chemokines. This book intends to unravel the chemokine constellation in the context of viral infections, a versatility that was not fully understood five years ago. This book is excellent reading material and will be of interest to research scientists, clinicians and postgraduate students.

Chemokines, Chemokine Receptors and Disease

Lisa M. Schwiebert
Chemokines Chemokine Receptors and Disease Book PDF

Author : Lisa M. Schwiebert
Publisher : Gulf Professional Publishing
Page : 418 pages
File Size : 47,6 Mb
Release : 2005-09-02
Category : Medical
ISBN : 0121533557

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Chemokines, Chemokine Receptors and Disease by Lisa M. Schwiebert Pdf

This volume in the Current Topics in Membranes series discusses the biology of chemokines and their binding partners, chemokine receptors, in normal and disease-related states. Chemokines are small proteins that are important in normal immune responses. Recent research demonstrates a role for these proteins in a variety of diseases such as heart disease, allergy, asthma, and cancer. As a result of the discovery of this link to disease, the topic of chemokines and drugs that block their actions has become an intense are of study. This book presents the topics of chemokines, chemokine receptors, and related pathologies in an integrated manner that provides the reader with a comprehensive and up-to-date knowledge of these topics. Provides a comprehensive overview of the history, molecular biology, cell biology, pharmacology, physiology, and pathophysiology of chemokines and their receptors Each chapter discusses "future directions and unanswered questions" of chemokine biology Serves as a road map for future research

Chemokine Research Trends

Leah R. Grinwald
Chemokine Research Trends Book PDF

Author : Leah R. Grinwald
Publisher : Nova Publishers
Page : 226 pages
File Size : 45,9 Mb
Release : 2007
Category : Chemokines
ISBN : 1600215882

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Chemokine Research Trends by Leah R. Grinwald Pdf

Chemokines are the cytokines that may activate or chemoattract leukocytes. Each chemokine contains 65-120 amino acids, with molecular weight of 8-10 kD. Their receptors belong to G-protein-coupled receptors. Inflammatory chemokines are released from a wide variety of cells in response to bacterial infection, viruses and agents that cause physical damage such as silica or the urate crystals that occur in gout. They function mainly as chemoattractants for leukocytes, recruiting monocytes, neutrophils and other effector cells from the blood to sites of infection or damage. They can be released by many different cell types and serve to guide cells involved in innate immunity and also the lymphocytes of the adaptive immune system. The cells that are attracted by chemokines follow a signal of increasing chemokine concentration to the site of infection or tissue injury. Some chemokines also have roles in the development of lymphocytes, migration and angiogenesis (the growth of new blood vessels).Since the entry of HIV into host cells requires chemokine receptors, their antagonists are being developed to treat AIDS.

The Chemokine System in Experimental and Clinical Hematology

Oystein Bruserud
The Chemokine System in Experimental and Clinical Hematology Book PDF

Author : Oystein Bruserud
Publisher : Springer Science & Business Media
Page : 208 pages
File Size : 50,9 Mb
Release : 2010-09-30
Category : Medical
ISBN : 9783642126390

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The Chemokine System in Experimental and Clinical Hematology by Oystein Bruserud Pdf

The aim of the issue is to describe and explain the importance of the chemokine system in hematology. The chemokine system is probably important for many aspects of normal as well as malignant hematopoiesis. A major focus is the development and treatment of hematologic malignancies, including the immunobiology of stem cell transplantation. The present reviews illustrate that chemokines can be involved in leukemogenesis. The chemokine system is also important both for the crosstalk between malignant cells and their neighbouring nonmalignant stromal cells (including endothelial cells) as well as for immunoregulation in patients treated with allogeneic stem cell transplantation. Thus, chemokines are important both for the pathogenesis and treatment of hematological diseases.

Arrest chemokines

Klaus Ley
Arrest chemokines Book PDF

Author : Klaus Ley
Publisher : Frontiers Media SA
Page : 109 pages
File Size : 53,6 Mb
Release : 2015-05-20
Category : Chemokines
ISBN : 9782889194308

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Arrest chemokines by Klaus Ley Pdf

Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve lymphocytes and effector memory T cells. Most arrest chemokines are immobilized on the endothelial surface by binding to heparin sulfate proteoglycans. Whether soluble chemokines can promote integrin activation and arrest is controversial (Alon-Gerszten). Many aspects of the signaling pathway from the GPCR chemokine receptor to integrin activation are the subject of active investigation. Leukocyte adhesion deficiency III is a human disease in which chemokine-triggered integrin activation is defective because of a mutation in the cytoskeletal protein kindlin-3. About 10 different such mutations have been described. The defects seen in patients with LAD-III elucidate the importance of rapid integrin activation for host defense in humans. We welcome reports that help clarifying this crucial first step in the process of leukocyte transendothelial migration.

Chemokines

Anonim
Chemokines Book PDF

Author : Anonim
Publisher : Academic Press
Page : 400 pages
File Size : 48,5 Mb
Release : 2009-05-16
Category : Science
ISBN : 0080956971

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Chemokines by Anonim Pdf

The understanding of chemokines, the proteins that control the migration of cells, and their receptors, is critical to the study of causes and therapies for a wide range of human diseases and infections, including certain types of cancer, inflammatory diseases, HIV, and malaria. This volume, focusing on chemokines as potential targets for disease intervention, and its companion volume (Methods in Enzymology volume 462, focusing on chemokine structure and function, as well as signaling) provide a comprehensive overview and time-tested protocols in this field, making it an essential reference for researchers in the area. Along with its companion volume, provides a comprehensive overview of chemokine methods, specifically as related to potential disease therapy Gathers tried, tested, and trusted methods and techniques from top players in chemokine research Provides an essential reference for researchers in the field

Chemokines and Chemokine Receptors in Brain Homeostasis

Flavia Trettel,Richard M. Ransohoff
Chemokines and Chemokine Receptors in Brain Homeostasis Book PDF

Author : Flavia Trettel,Richard M. Ransohoff
Publisher : Frontiers Media SA
Page : 126 pages
File Size : 54,9 Mb
Release : 2015-08-17
Category : Brain
ISBN : 9782889196166

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Chemokines and Chemokine Receptors in Brain Homeostasis by Flavia Trettel,Richard M. Ransohoff Pdf

Virtually involved in all pathologies that present an inflammatory component, it is now evident that, in the central nervous system, chemokines and chemokine receptors possess pleiotropic properties beyond chemotaxis: costitutive brain expression of chemokines and their receptors on endothelial cells, but also on neurons and glia, suggests a role for such molecules in mediating homeostatic cross-talk between cells of the brain perenchyma. Cross-talk between neurons and glia is determinant to the establishment and maintenance of a brain enviroment that ensure normal function, and in particular glial cells are active players that respond to enviromental changes and act for the survival, growth, differentiation and repair of the nervous tissue: in this regard brain endogenous chemokines represent key molecules that play a role in brain development, neurogenesis, neurotransmission and neuroprotection. As important regulators of peripheral immune response, chemokines are molecules of the immune system that play a central role in coordinating communication between the nervous and the immune systems, in the context of infections and brain injury. Indeed, in phatological processes resulting from infections, brain trauma, ischemia and chronic neurodegenerative diseases, chemokines represent important neuroinflammatory mediators that drive leucocytes trafficking into the central nervous system, facilitating an immune response by targeting cells of the innate and adaptive immune system. The third edition of the international conference "Chemokines and Chemokine Receptors in the Nervous System", hold in Rome in October 2013, represented an exciting platform to promote discussion among researchers in different disciplines to understand the role of chemokines in brain homoestasis. This Frontiers Research Topic arises from this conference, and wants to be an opportunity to further discuss and highlight the importance of brain chemokines as key molecules that, not only grant the interplay between the immune and the nervous systems, but in addition drive modulatory functions on brain homeoastasis orchestrating neurons, microglia, and astrocytes communication.

Universes in Delicate Balance: Chemokines and the Nervous System

R.M. Ransohoff,K. Suzuki,A.E.I. Proudfoot,W.F. Hickey,J.K. Harrison
Universes in Delicate Balance Chemokines and the Nervous System Book PDF

Author : R.M. Ransohoff,K. Suzuki,A.E.I. Proudfoot,W.F. Hickey,J.K. Harrison
Publisher : Elsevier
Page : 404 pages
File Size : 44,5 Mb
Release : 2002-04-29
Category : Medical
ISBN : 0080520197

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Universes in Delicate Balance: Chemokines and the Nervous System by R.M. Ransohoff,K. Suzuki,A.E.I. Proudfoot,W.F. Hickey,J.K. Harrison Pdf

It is commonly acknowledged that the nervous system and the immune system, those most complex of networks, share attributes beyond their intricacy. Elements common to the two systems include memory, connectivity, flexibility and developmental selection of cellular composition by a rigorous process involving widespread programmed cell death. There is one salient difference: the cells of the immune system are predominantly in constant motion, while post-mitotic neurons and glia are largely fixed in place. Therefore, chemokines, initially characterized as leukocyte chemoattractants, have for the last one and one-half decades been intensely and productively studied in the contexts of inflammation, immunity and hematopoietic development. Only recently have the two fields, neurobiology and immunology, displayed mutual interests in chemokines. This convergence of the two tribes of investigators was catalyzed by the finding that SDF-1 (now known as CXCL12) and its receptor, CXCR4, exerted significant and similar functions in development of both nervous and immune systems. Indeed CXCL12 and CXCR4 were required, in an uncannily similar fashion, for retention of pre-B lymphocytes at sites of maturation in the bone marrow and of neuronal progenitors in the external granule cell layer of the developing cerebellum. Recent reports indicate that chemoattraction of cerebellar granule cells through CXCR4 can be suppressed by reverse signaling initiated by binding of soluble eph receptors to transmembrane ephrin B, thereby establishing a link between chemokine action and a cardinal patterning system of the developing nervous system. As may be anticipated when a dam breaks, a massive influx of correlative observations in the nervous and immune systems is likely to ensue. This volume represents the state of current knowledge. To this end, introductory material for both systems is provided. Basic and advanced 'chemokinology' are presented. The recipe for making a nervous system (both ingredients and instructions for preparation) is described, as are the roles of chemokines and their receptors in making an immune system. Given their importance and complexity, CXCL12/CXCR4 interactions are separately treated in varying contexts. The field of 'neurobiology of chemokines' has not lain fallow during the last ten years. During much of this time the principal focus has been on neuroinflammation. Linking the immune and nervous systems are explanations of the functions of chemokines and their receptors for resident brain macrophages, the microglia, the unique cerebrovascular endothelium and angiogenesis. Understanding human disease is the goal of much of this research. New discoveries are being made and reported at a gratifying rate. It is expected that this volume will promote the steady production and application of useful new knowledge in this developing field. It provides a unique single-source database for basic neurobiology highlighting the fundamental aspects of chemokines and discussing the relations of chemokine science to animal models and human disease.

Chemokine Receptors in Cancer

Amy M. Fulton
Chemokine Receptors in Cancer Book PDF

Author : Amy M. Fulton
Publisher : Springer Science & Business Media
Page : 181 pages
File Size : 53,8 Mb
Release : 2009-06-12
Category : Medical
ISBN : 9781603272674

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Chemokine Receptors in Cancer by Amy M. Fulton Pdf

Chemokines are a superfamily of low molecular weight cytokines that were initially described based on their ability to induce the directed migration of leukocytes to sites of inflammation or injury. In humans, there are approximately 45 chemokines that bind to 19 G-protein-coupled receptors. In addition to mediating cellular migration, chemokines have now been shown to affect many cellular functions including survival, adhesion, invasion, proliferation, and to regulate circulating chemokine levels. Although chemokine receptors were first described on leukocytes, it is now appreciated that chemokine receptors are also expressed by many other cells including endothelial and epithelial cells. Since the first description of chemokine receptors on malignant cells in 2001, an extensive literature has developed describing the expression and function of chemokine receptors in many malignancies. These studies support the initial hypothesis that malignant cells use chemokine receptors to migrate to distant sites of ligand expression and that expression of certain receptors is associated with a poor prognosis. It has also become apparent that malignancies of different tissues may use a diverse profile of chemokine receptors and that the same receptor may mediate metastasis to different sites in tumors of different histological origins. Receptor function may also maintain survival and expansion of the primary tumor.

Chemokine Receptors and AIDS

Thomas R. O'Brien
Chemokine Receptors and AIDS Book PDF

Author : Thomas R. O'Brien
Publisher : CRC Press
Page : 224 pages
File Size : 48,6 Mb
Release : 2019-04-23
Category : Medical
ISBN : 9780429524820

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Chemokine Receptors and AIDS by Thomas R. O'Brien Pdf

This authoritative reference presents the latest research on the role of chemokines, chemokine receptors, and genetic variability in the susceptibility, prevention, and treatment of HIV-1-exploring new therapeutic strategies for improved treatment of HIV-1 infected patients by blocking chemokine receptor expression. With contributions from s

Chemokine Biology - Basic Research and Clinical Application

Kuldeep Neote,L. Gordon Letts,Bernhard Moser
Chemokine Biology Basic Research and Clinical Application Book PDF

Author : Kuldeep Neote,L. Gordon Letts,Bernhard Moser
Publisher : Springer Science & Business Media
Page : 171 pages
File Size : 42,5 Mb
Release : 2007-08-08
Category : Medical
ISBN : 9783764374372

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Chemokine Biology - Basic Research and Clinical Application by Kuldeep Neote,L. Gordon Letts,Bernhard Moser Pdf

Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 2 of this two-volume set discusses the pathophysiology of chemokines. It is divided into two parts: a) chemokines in animal disease models, and b) chemokines as drug targets. Together with volume 1, which discusses the immunobiology of chemokines, both volumes give a comprehensive overview of chemokine biology.