Chromatin Architecture

Author : Kirti Prakash
Publisher : Springer
Page : 152 pages
File Size : 48,6 Mb
Release : 2017-02-20
Category : Science
ISBN : 9783319521831

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Chromatin Architecture by Kirti Prakash Pdf

This book sheds new light on the current state of knowledge concerning chromatin organization. Particular emphasis is given to the new imaging potential offered by super-resolution microscopy, which allows DNA imaging with a very high labeling density. From the early work on chromosomes by Walther Flemming in the nineteenth century to recent advances in genomics, the history of chromatin research now spans more than a century. The various milestones, such as the discovery of the double helix structure, the sequencing of the human genome, and the recent description of the genome in 3D space, show that understanding chromatin and chromosome function requires a clear understanding of its structure. Presenting cutting-edge data from super-resolution single molecule microscopy, the book demonstrates that chromatin manifests several levels of folding, from nucleosomes to chromosomes. Chromatin domains emerge as a new fundamental building block of chromatin architecture, with functions possibly related to gene regulation. A detailed description of chromatin folding in the pachytene stage of meiosis serves as a model for exploring this functionality, showing the apparent interplay between structure, function, and epigenetic regulation. Lastly, the book discusses possible new avenues of innovation to describe chromatin’s organization and functions. Gathering essential insights on chromatin architecture, the book offers students an introduction to microscopy and its application to chromatin organization, while also providing advanced readers with new ideas for future research.

Author : Sérgio Fernandes de Almeida,Pablo Huertas,Gaelle Legube
Publisher : Frontiers Media SA
Page : 117 pages
File Size : 47,5 Mb
Release : 2020-09-02
Category : Science
ISBN : 9782889639687

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Regulation of DNA Double Strand Break Repair by Local Chromatin Architecture by Sérgio Fernandes de Almeida,Pablo Huertas,Gaelle Legube Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Sarah C. R. Elgin,Jerry L. Workman
Publisher : Frontiers in Molecular Biology
Page : 372 pages
File Size : 54,6 Mb
Release : 2000
Category : Chromatin
ISBN : 019963890X

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Chromatin Structure and Gene Expression by Sarah C. R. Elgin,Jerry L. Workman Pdf

Since publication of the first edition in 1995, there have been significant advances and understanding of chromatin structure and its relation to gene expression. These include a high-resolution structure of the nucleosome core, discovery of the enzymes and complexes that mediate histone acetylation and deacetylation, discovery of novel ATP-dependent chromatin remodeling complexes, new insights into nuclear organization and epigenetic silencing mechanisms. In light of these advances, Chromatin Structure and Gene Expression (2ed.) includes updated chapters and additional material that introduce new concepts in the process of gene regulation in chromatin.

Author : J. Zlatanova,S. H. Leuba
Publisher : Gulf Professional Publishing
Page : 546 pages
File Size : 50,5 Mb
Release : 2004
Category : Medical
ISBN : 0444515941

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Chromatin Structure and Dynamics by J. Zlatanova,S. H. Leuba Pdf

Biological processes that replicate, preserve and use the genetic information encoded in DNA must operate in the context of chromatin, a highly organized complex of DNA and proteins. These proteins do not merely package the DNA in the tiny volume of the nucleus, but impart the structure the ability to change according to the requirements of the specific process the DNA is involved in. Moreover, chromatin structure is used by the cell to control the activity of DNA. In this volume the basics of chromatin structure and dynamics are presented by established experts in the field.

Author : Christophe Lavelle,Jean-Marc Victor
Publisher : Academic Press
Page : 618 pages
File Size : 41,8 Mb
Release : 2017-10-27
Category : Medical
ISBN : 9780128035030

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Nuclear Architecture and Dynamics by Christophe Lavelle,Jean-Marc Victor Pdf

Nuclear Architecture and Dynamics provides a definitive resource for (bio)physicists and molecular and cellular biologists whose research involves an understanding of the organization of the genome and the mechanisms of its proper reading, maintenance, and replication by the cell. This book brings together the biochemical and physical characteristics of genome organization, providing a relevant framework in which to interpret the control of gene expression and cell differentiation. It includes work from a group of international experts, including biologists, physicists, mathematicians, and bioinformaticians who have come together for a comprehensive presentation of the current developments in the nuclear dynamics and architecture field. The book provides the uninitiated with an entry point to a highly dynamic, but complex issue, and the expert with an opportunity to have a fresh look at the viewpoints advocated by researchers from different disciplines. Highlights the link between the (bio)chemistry and the (bio)physics of chromatin Deciphers the complex interplay between numerous biochemical factors at task in the nucleus and the physical state of chromatin Provides a collective view of the field by a large, diverse group of authors with both physics and biology backgrounds

Author : Ralf Blossey
Publisher : CRC Press
Page : 182 pages
File Size : 41,6 Mb
Release : 2017-08-04
Category : Computers
ISBN : 9781351646819

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Chromatin by Ralf Blossey Pdf

An invaluable resource for computational biologists and researchers from other fields seeking an introduction to the topic, Chromatin: Structure, Dynamics, Regulation offers comprehensive coverage of this dynamic interdisciplinary field, from the basics to the latest research. Computational methods from statistical physics and bioinformatics are detailed whenever possible without lengthy recourse to specialized techniques.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 52,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Jerry L. Workman,Susan M. Abmayr
Publisher : Springer Science & Business Media
Page : 594 pages
File Size : 42,8 Mb
Release : 2013-12-04
Category : Medical
ISBN : 9781461486244

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Fundamentals of Chromatin by Jerry L. Workman,Susan M. Abmayr Pdf

​​​​​​​​​​​​​While there has been an increasing number of books on various aspects of epigenetics, there has been a gap over the years in books that provide a comprehensive understanding of the fundamentals of chromatin. ​Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. Its primary function is to package DNA to fit into the cell, to strengthen the DNA to prevent damage, to allow mitosis and meiosis, and to control the expression of genes and DNA replication. The audience for this book is mainly newly established scientists ​and graduate students. Rather than going into the more specific areas of recent research on chromatin the chapters in this book give a strong, updated groundwork about the topic. Some the fundamentals that this book will cover include the structure of chromatin and biochemistry and the enzyme complexes that manage it.

Author : Alexey V. Pindyurin,Veniamin Fishman
Publisher : Frontiers Media SA
Page : 248 pages
File Size : 46,9 Mb
Release : 2022-11-11
Category : Science
ISBN : 9782832505298

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The Role of High-Order Chromatin Organization in Gene Regulation by Alexey V. Pindyurin,Veniamin Fishman Pdf

Author : Sarah Baatout
Publisher : Springer Nature
Page : 687 pages
File Size : 55,7 Mb
Release : 2023-09-23
Category : Science
ISBN : 9783031188107

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Radiobiology Textbook by Sarah Baatout Pdf

This open access textbook focuses on the various aspects of radiobiology. The goal of radiobiological research is to better understand the effects of radiation exposure at the cellular and molecular levels in order to determine the impact on health. This book offers a unique perspective, by covering not only radiation biology but also radiation physics, radiation oncology, radiotherapy, radiochemistry, radiopharmacy, nuclear medicine, space radiation biology & physics, environmental and human radiation protection, nuclear emergency planning, molecular biology and bioinformatics, as well as the ethical, legal and social considerations related to radiobiology. This range of disciplines contributes to making radiobiology a broad and rather complex topic. This textbook is intended to provide a solid foundation to those interested in the basics and practice of radiobiological science. It is a learning resource, meeting the needs of students, scientists and medical staff with an interest in this rapidly evolving discipline, as well as a teaching tool, with accompanying teaching material to help educators.

Author : Alan P. Wolffe
Publisher : Academic Press
Page : 462 pages
File Size : 55,9 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780080926605

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Chromatin by Alan P. Wolffe Pdf

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the remarkable progress in chromatin research over the past three years. It has been extensively rewritten to cover new material on chromatin remodeling, histone modification, nuclear compartmentalization, DNA methylation, and transcriptional co-activators and co-repressors. The book is written in a clear and concise fashion, with 60 new illustrations. Chromatin: Structure and Function provides the reader with a concise and coherent account of the nature, structure, and assembly of chromatin and its active involvement in the processes of DNA transcription, replication and repair. This book consistently interrelates the structure of eukaryotic DNA with the nuclear processes it undergoes, and will be essential reading for students and molecular biologists who want to really understand how DNA works. Written in a clear and concise fashion Includes 60 new illustrations Extensively rewritten Brings the reader up-to-date with the remarkable progress in chromatin research over the past three years.

Author : David Hollar
Publisher : Springer
Page : 386 pages
File Size : 49,5 Mb
Release : 2016-02-08
Category : Medical
ISBN : 9783319253251

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Epigenetics, the Environment, and Children’s Health Across Lifespans by David Hollar Pdf

This stimulating volume addresses vital questions about gene/environment interactions as they affect cell health from the prenatal period through later life. Beginning with a tour of epigenetic processes in the human body, the book assembles current theoretical and empirical developments across the discipline, among them transgenerational epigenetic inheritance, the effects of maternal nutrition on epigenetic change, and possible links between epigenetics and childhood obesity. Public health and policy aspects of the field are discussed in depth, with the understanding that much can be done to improve our epigenetic health as a species. And in this vein, contributors consider future possibilities, such as the reprogramming of genes to reverse cancer and other diseases. Included in the coverage: The role of environmental epigenetics in perinatal and neonatal development The epigenetic biomarker γH2AX: from bench science to clinical trials What’s the risk? Dental amalgam, mercury exposure, and human health risks throughout the lifespan Post-traumatic stress disorder: neurological, genetic, and epigenetic bases Children’s exposure to alcohol, tobacco, and drugs: long-term outcomes Ethical implications of epigenetics Epigenetics, the Environment, and Children’s Health Across Lifespans brings real-world knowledge and applications of this increasingly important field to public health practitioners, maternal and child health researchers, and environmental health experts.

Author : Randall H. Morse
Publisher : Academic Press
Page : 586 pages
File Size : 47,5 Mb
Release : 2024-06-15
Category : Science
ISBN : 9780128148105

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Chromatin by Randall H. Morse Pdf

Chromatin: Structure, Function, and History covers the basics of chromatin biology, beginning with the discoveries that culminated in the recognition of the nucleosome as the basic subunit of chromatin. Chromatin folding, nucleosome positioning, and histone variants are discussed, as well as research on chromatin modifications and remodeling, which exploded in the early to mid-1990s and led to widespread interest in epigenetics. Considerable attention is given to methods and experiments that led to key insights and recent developments such as the use of genome-wide approaches and innovations in imaging approaches are also emphasized. By providing historical background together with detailed discussion of contemporary studies, the book aims to instill in the reader an appreciation not only of our current knowledge of chromatin structure and function, but also of the remarkable path that has taken chromatin to the forefront of modern research. Provides a current, expansive, and well-documented resource on chromatin and epigenetics Addresses the role of chromatin in transcription regulation and chromatin abnormalities in disease Reviews the historical background of specific areas of chromatin research, enabling readers to understand how the field was born and to appreciate the discoveries and technical advances that have propelled it forward

Author : Anonim
Publisher : Academic Press
Page : 378 pages
File Size : 42,7 Mb
Release : 2019-05-24
Category : Medical
ISBN : 9780128137970

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Chromatin Signaling and Neurological Disorders by Anonim Pdf

Chromatin Signaling and Neurological Disorders, Volume Seven, explores our current understanding of how chromatin signaling regulates access to genetic information, and how their aberrant regulation can contribute to neurological disorders. Researchers, students and clinicians will not only gain a strong grounding on the relationship between chromatin signaling and neurological disorders, but they'll also discover approaches to better interpret and employ new diagnostic studies and epigenetic-based therapies. A diverse range of chapters from international experts speaks to the basis of chromatin and epigenetic signaling pathways and specific chromatin signaling factors that regulate a range of diseases. In addition to the basic science of chromatin signaling factors, each disease-specific chapter speaks to the translational or clinical significance of recent findings, along with important implications for the development of epigenetics-based therapeutics. Common themes of translational significance are also identified across disease types, as well as the future potential of chromatin signaling research. Examines specific chromatin signaling factors that regulate spinal muscular atrophy, ulbospinal muscular atrophy, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, multiple sclerosis, Angelman syndrome, Rader-Willi syndrome, and more Contains chapter contributions from international experts who speak to the clinical significance of recent findings and the implications for the development of epigenetics-based therapeutics Provides researchers, students and clinicians with approaches to better interpret and employ new diagnostic studies for treating neurological disorders

Author : Alasdair Steven,Wolfgang Baumeister,Louise N. Johnson,Richard N. Perham
Publisher : Garland Science
Page : 881 pages
File Size : 47,5 Mb
Release : 2016-02-18
Category : Medical
ISBN : 9781000064902

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Molecular Biology of Assemblies and Machines by Alasdair Steven,Wolfgang Baumeister,Louise N. Johnson,Richard N. Perham Pdf

Molecular Biology of Assemblies and Machines provides a comprehensive narrative of the ways in which macromolecular structures assemble and how they interact with other complexes and organelles in the cell. Richly illustrated in full color, the text is written for advanced undergraduates, graduate students, and researchers in biochemistry, molecular biology, biophysics, cell biology, chemistry, structural biology, immunology, microbiology, and medicine.