Chromatin Structure And Gene Expression

Author : Sarah C. R. Elgin,Jerry L. Workman
Publisher : Frontiers in Molecular Biology
Page : 372 pages
File Size : 47,8 Mb
Release : 2000
Category : Chromatin
ISBN : 019963890X

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Chromatin Structure and Gene Expression by Sarah C. R. Elgin,Jerry L. Workman Pdf

Since publication of the first edition in 1995, there have been significant advances and understanding of chromatin structure and its relation to gene expression. These include a high-resolution structure of the nucleosome core, discovery of the enzymes and complexes that mediate histone acetylation and deacetylation, discovery of novel ATP-dependent chromatin remodeling complexes, new insights into nuclear organization and epigenetic silencing mechanisms. In light of these advances, Chromatin Structure and Gene Expression (2ed.) includes updated chapters and additional material that introduce new concepts in the process of gene regulation in chromatin.

Author : Jerry L. Workman,Susan M. Abmayr
Publisher : Springer Science & Business Media
Page : 587 pages
File Size : 54,8 Mb
Release : 2013-12-04
Category : Medical
ISBN : 9781461486244

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Fundamentals of Chromatin by Jerry L. Workman,Susan M. Abmayr Pdf

​​​​​​​​​​​​​While there has been an increasing number of books on various aspects of epigenetics, there has been a gap over the years in books that provide a comprehensive understanding of the fundamentals of chromatin. ​Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. Its primary function is to package DNA to fit into the cell, to strengthen the DNA to prevent damage, to allow mitosis and meiosis, and to control the expression of genes and DNA replication. The audience for this book is mainly newly established scientists ​and graduate students. Rather than going into the more specific areas of recent research on chromatin the chapters in this book give a strong, updated groundwork about the topic. Some the fundamentals that this book will cover include the structure of chromatin and biochemistry and the enzyme complexes that manage it.

Author : Anita Göndör
Publisher : Academic Press
Page : 496 pages
File Size : 53,8 Mb
Release : 2016-10-25
Category : Science
ISBN : 9780128034026

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Chromatin Regulation and Dynamics by Anita Göndör Pdf

Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases. Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation. Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspective Promotes crosstalk between basic sciences and their applications in medicine Provides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principles Integrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes

Author : Alan P. Wolffe
Publisher : Academic Press
Page : 447 pages
File Size : 42,7 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780080926605

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Chromatin by Alan P. Wolffe Pdf

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the remarkable progress in chromatin research over the past three years. It has been extensively rewritten to cover new material on chromatin remodeling, histone modification, nuclear compartmentalization, DNA methylation, and transcriptional co-activators and co-repressors. The book is written in a clear and concise fashion, with 60 new illustrations. Chromatin: Structure and Function provides the reader with a concise and coherent account of the nature, structure, and assembly of chromatin and its active involvement in the processes of DNA transcription, replication and repair. This book consistently interrelates the structure of eukaryotic DNA with the nuclear processes it undergoes, and will be essential reading for students and molecular biologists who want to really understand how DNA works. Written in a clear and concise fashion Includes 60 new illustrations Extensively rewritten Brings the reader up-to-date with the remarkable progress in chromatin research over the past three years.

Author : Philippe Jeanteur
Publisher : Springer Science & Business Media
Page : 284 pages
File Size : 43,6 Mb
Release : 2008-09-10
Category : Science
ISBN : 3540852360

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Epigenetics and Chromatin by Philippe Jeanteur Pdf

Epigenetics refers to heritable patterns of gene expression which do not depend on alterations of genomic DNA sequence. This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility. The other one deals with parental genomic imprinting, a process which allows to express a few selected genes from only one of the parental allele while extinguishing the other.

Author : Brian F. C. Clark,Hans Klenow,Jesper Zeuthen
Publisher : Elsevier
Page : 310 pages
File Size : 49,9 Mb
Release : 2014-05-18
Category : Science
ISBN : 9781483154060

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Gene Expression by Brian F. C. Clark,Hans Klenow,Jesper Zeuthen Pdf

Gene Expression provides research papers on selected topics in gene expression, presented at the 11th meeting of the Federation of European Biochemical Societies, held at Copenhagen in August 1977. The book presents research knowledge provided by eminent researchers in the field of biochemistry. Each chapter contains material that is important to other researchers, such as on initiation mechanism of protein synthesis in prokaryotes; translocation mechanism of the ribosome; and analysis of ribosomal translocation by drugs. Mechanisms for the intracellular compartmentation of newly synthesized proteins; RNA synthesis and control; the sub-structure of nucleosome core particles; and future prospects on chromosome structure and function are detailed as well. The text will be of use to researchers and workers in the field of medicine, pharmacology, gene therapy, and biochemistry.

Author : Roeland van Driel,Arie P. Otte
Publisher : Unknown
Page : 0 pages
File Size : 52,9 Mb
Release : 2023
Category : Cell nuclei
ISBN : 1383028087

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Nuclear Organization, Chromatin Structure, and Gene Expression by Roeland van Driel,Arie P. Otte Pdf

Author : Ralf Blossey
Publisher : CRC Press
Page : 182 pages
File Size : 42,5 Mb
Release : 2017-08-04
Category : Computers
ISBN : 9781351646819

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Chromatin by Ralf Blossey Pdf

An invaluable resource for computational biologists and researchers from other fields seeking an introduction to the topic, Chromatin: Structure, Dynamics, Regulation offers comprehensive coverage of this dynamic interdisciplinary field, from the basics to the latest research. Computational methods from statistical physics and bioinformatics are detailed whenever possible without lengthy recourse to specialized techniques.

Author : A. Wolffe
Publisher : R. G. Landes
Page : 152 pages
File Size : 42,9 Mb
Release : 1994
Category : Science
ISBN : STANFORD:36105009757555

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Regulation of Chromatin Structure and Function by A. Wolffe Pdf

Author : Ajit Kumar
Publisher : Springer Science & Business Media
Page : 238 pages
File Size : 52,9 Mb
Release : 2013-03-09
Category : Science
ISBN : 9781468474596

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Eukaryotic Gene Expression by Ajit Kumar Pdf

The recent surge of interest in recombinant DNA research is understandable considering that biologists from all disciplines, using recently developed mo lecular techniques, can now study with great precision the structure and regulation of specific genes. As a discipline, molecular biology is no longer a mere subspeciality of biology or biochemistry: it is the new biology. Current approaches to the outstanding problems in virtually all the traditional disci plines in biology are now being explored using the recombinant DNA tech nology. In this atmosphere of rapid progress, the role of information exchange and swift publication becomes quite crucial. Consequently, there has been an equally rapid proliferation of symposia volumes and review articles, apart from the explosion in popular science magazines and news media, which are always ready to simplify and sensationalize the implications of recent dis coveries, often before the scientific community has had the opportunity to fully scrutinize the developments. Since many of the recent findings in this field have practical implications, quite often the symposia in molecular biology are sponsored by private industry and are of specialized interest and in any case quite expensive for students to participate in. Given that George Wash ington University is a teaching institution, our aim in sponsoring these Annual Spring Symposia is to provide, at cost, a forum for students and experts to discuss the latest developments in selected areas of great significance in biology. Additionally, since the University is located in Washington, D. C.

Author : Esteban Ballestar
Publisher : Springer Science & Business Media
Page : 182 pages
File Size : 46,9 Mb
Release : 2011-02-16
Category : Medical
ISBN : 9781441982162

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Epigenetic Contributions in Autoimmune Disease by Esteban Ballestar Pdf

This volume focuses on the relevance of epigenetic mechanisms in autoimmune disease. It provides new directions for future research in autoimmune disease.

Author : A. Wolffe
Publisher : Unknown
Page : 320 pages
File Size : 48,8 Mb
Release : 1995
Category : Medical
ISBN : UOM:39015035021255

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Chromatin by A. Wolffe Pdf

Chromatin: Structure and Function provides the reader with a concise and coherent account of the nature, structure and assembly of chromatin and its involvement in the processes of DNA transcription, replication and repair. Constantly interrelating the structure of eukaryotic DNA with the nuclear processes it undergoes, CHROMATIN: Structure and Function is essential reading for students and molecular biologists who want to really understand how DNA works.

Author : Danuta Radzioch
Publisher : BoD – Books on Demand
Page : 237 pages
File Size : 42,5 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9789535110873

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Chromatin Remodelling by Danuta Radzioch Pdf

The term "chromatin remodelling" is widely used to describe changes in chromatin structure which is controlled by histone-modifying enzymes, chromatin remodelling complexes, non-histone DNA-binding proteins and noncoding RNAs. Many human diseases such as cancer, various genetic syndromes, autism and infectious disease have been linked to the disruption of these control processes by genetic, environmental or microbial factors. Therefore, to unravel the mechanisms by which they operate is one of the most exciting and rapid developing fields of modern biology and will contribute to new ways in treatment of these diseases. The chapters in this book will focus on recent advances in our understanding of the mechanisms that govern the dynamic structural of chromatin, thereby providing important insights into gene regulation, DNA repair, and human diseases.

Author : Bryan M. Turner
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 47,8 Mb
Release : 2008-04-15
Category : Science
ISBN : 9780470751671

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Chromatin and Gene Regulation by Bryan M. Turner Pdf

Written in an informal and accessible style, Chromatin and Gene Regulation enables the reader to understand the science of this rapidly moving field. Chromatin is a fundamental component in the network of controls that regulates gene expression. Many human diseases have been linked to disruption of these control processes by genetic or environmental factors, and unravelling the mechanisms by which they operate is one of the most exciting and rapidly developing areas of modern biology. Chromatin is central both to the rapid changes in gene transcription by which cells respond to changes in their environment and also to the maintenance of gene expression patterns from one cell generation to the next. This book will be an invaluable guide to undergraduate and postgraduate students in the biological sciences and all those with an interest in the medical implications of aberrant gene expression.

Author : R. Curtis Bird,Wilfred D. Stein,Jane B. Lian,Janet L. Stein
Publisher : Elsevier
Page : 304 pages
File Size : 47,7 Mb
Release : 1996-11-28
Category : Science
ISBN : 0080537812

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Nuclear Structure and Gene Expression by R. Curtis Bird,Wilfred D. Stein,Jane B. Lian,Janet L. Stein Pdf

Nuclear Structure and Gene Expression assimilates the contributions of genome organization and of the components of the nuclear matrix to the control of DNA and RNA synthesis. Nuclear domains which accommodate DNA replication and gene expression are considered in relation to short-term developmental and homeostatic requirements as well as to long-term commitments to phenotypic gene expression in differentiated cells. Consideration is given to the involvement of nuclear structure in gene localization as well as to the targeting and concentration of transcription factors. Aberrations in nuclear architecture associated with and potentially functionally related to pathologies are evaluated. Tumor cells are described from the perspective of the striking modifications in both the composition and organization of nuclear components. Nuclear Structure and Gene Expression presents concepts as well as experimental approaches, which define functionality of nuclear morphology. * Mechanisms of interaction between nuclear structure and genes * Gene expression regulation by elements of the nuclear matrix * How nuclear structure exerts a regulatory effect on other aspects of cell function/physiology