Cilia And Nervous System Development And Function

Author : Kerry L. Tucker,Tamara Caspary
Publisher : Springer Science & Business Media
Page : 286 pages
File Size : 46,7 Mb
Release : 2013-01-19
Category : Medical
ISBN : 9789400758087

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Cilia and Nervous System Development and Function by Kerry L. Tucker,Tamara Caspary Pdf

Cilia are tiny microtubule-based organelles projecting from the plasma membrane of practically all cells in the body. In the past 10 years a flurry of research has indicated a crucial role of this long-neglected organelle in the development and function of the central nervous system. A common theme of these studies is the critical dependency of signal transduction of the Sonic hedgehog, and more recently, Wnt signaling pathways upon cilia to regulate fate decisions and morphogenesis. Both primary and motile cilia also play crucial roles in the function of the nervous system, including the primary processing of sensory information, the control of body mass, and higher functions such as behavior and cognition, serving as "antennae" for neurons to sense and process their environment. In this book we describe the structure and function of cilia and the various tissues throughout the brain and spinal cord that are dependent upon cilia for their proper development and function.

Author : Anonim
Publisher : Academic Press
Page : 408 pages
File Size : 49,5 Mb
Release : 2009-11-30
Category : Science
ISBN : 0080962823

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Primary Cilia by Anonim Pdf

In recent years, the role of cilia in the study of health, development and disease has been increasingly clear, and new discoveries have made this an exciting and important field of research. This comprehensive volume, a complement to the new three-volume treatment of cilia and flagella by King and Pazour, presents easy-to-follow protocols and detailed background information for researchers working with cilia and flagella. *Covers protocols for primary cilia across several systems and species * Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time * Relevant to clinicians and scientists working in a wide range of fields

Author : Anonim
Publisher : Academic Press
Page : 546 pages
File Size : 53,5 Mb
Release : 2021-03-09
Category : Science
ISBN : 9780128152829

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Molecular Mechanisms of Neural Development and Insights into Disease by Anonim Pdf

Neural Development and Disease, Volume 142 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters by one or more members of an international board of authors. Sections in this new release cover The role of primary cilia in neural development and disease, Mechanisms of axon guidance receptor regulation and signaling, Synaptic recognition molecules in development and disease, The regulation of cortical neurogenesis, Axon guidance in the developing spinal cord, The role of astrocytes in synapse formation and maturation, Development of motor circuits, Molecular mechanisms that mediate dendrite morphogenesis, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series

Author : Paraskevi Goggolidou
Publisher : CRC Press
Page : 269 pages
File Size : 54,9 Mb
Release : 2018-02-28
Category : Science
ISBN : 9781351645690

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Cilia by Paraskevi Goggolidou Pdf

The scope of the book is to highlight the diverse roles of cilia in human development and disease. Almost all cell types form cilia and although they were first detected about 200 years ago, their significance was unclear. In the past ten years, it has become obvious that cilia have got sensory functions, as well as roles in motility and their mis-formation or the deregulation of the signaling pathways they control has been associated with defective development and human disease. Although research has concentrated on the role of the cilium in each organ, no effort has been made so far to bring all this information together and relate it to the various human diseases. This book aims to gather all the expertise that has been acquired on primary cilia and translate it into a medical and research context that will be of interest to postgraduate students, researchers, medics and scientists.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 43,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Vito Mennella
Publisher : Springer Nature
Page : 283 pages
File Size : 44,9 Mb
Release : 2023-11-20
Category : Science
ISBN : 9781071635070

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Cilia by Vito Mennella Pdf

This volume covers the latest advancements in the study of ciliary complexity. Protocols cover genomic, proteomic, imaging, and functional analysis of different ciliated tissues and their wide applicability in cilia biology. Chapters in this book primarily focus on methods to study multiciliated cells, and discuss topics such as SARS-CoV-2 infections of human primary nasal multiciliated epithelial cells; expansion microscopy of ciliary proteins; live-imaging centriole amplification in mouse brain multiciliated cells; biophysical properties of cilia motility; and mucociliary transport device construction. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Cilia: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this developing field.

Author : Scott Brady,George Siegel,R. Wayne Albers,Donald Price
Publisher : Academic Press
Page : 1120 pages
File Size : 41,5 Mb
Release : 2011-11-02
Category : Science
ISBN : 9780080959016

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Basic Neurochemistry by Scott Brady,George Siegel,R. Wayne Albers,Donald Price Pdf

Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, the outstanding and comprehensive classic text on neurochemistry, is now newly updated and revised in its Eighth Edition. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. It is also an excellent source of current information on basic biochemical and cellular processes in brain function and neurological diseases for continuing medical education and qualifying examinations. This text continues to be the standard reference and textbook for exploring the translational nature of neuroscience, bringing basic and clinical neuroscience together in one authoritative volume. Our book title reflects the expanded attention to these links between neurochemistry and neurologic disease. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from: Intracellular trafficking; Stem cells, adult neurogenesis, regeneration; Lipid messengers; Expanded coverage of all major neurodegenerative and psychiatric disorders; Neurochemistry of addiction; Neurochemistry of pain; Neurochemistry of hearing and balance; Neurobiology of learning and memory; Sleep; Myelin structure, development, and disease; Autism; and Neuroimmunology. Completely updated text with new authors and material, and many entirely new chapters Over 400 fully revised figures in splendid color 61 chapters covering the range of cellular, molecular and medical neuroscience Translational science boxes emphasizing the connections between basic and clinical neuroscience Companion website at http://elsevierdirect.com/companions/9780123749475

Author : Anonim
Publisher : Academic Press
Page : 603 pages
File Size : 46,6 Mb
Release : 1995-08-31
Category : Science
ISBN : 0080859453

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Cilia and Flagella by Anonim Pdf

Cilia and Flagella presents protocols accessible to all individuals working with eukaryotic cilia and flagella. These recipes delineate laboratory methods and reagents, as well as critical steps and pitfalls of the procedures. The volume covers the roles of cilia and flagella in cell assembly and motility, the cell cycle, cell-cell recognition and other sensory functions, as well as human diseases and disorders. Students, researchers, professors, and clinicians should find the book's combination of "classic" and innovative techniques essential to the study of cilia and flagella. Key Features * A complete guide containing more than 80 concise technical chapters friendly to both the novice and experienced researcher * Covers protocols for cilia and flagella across systems and species from Chlamydomonas and Euglena to mammals * Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time, including microscopy, electrophoresis, and PCR * Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes, who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures

Author : Bradley Yoder
Publisher : Academic Press
Page : 488 pages
File Size : 41,8 Mb
Release : 2011-09-06
Category : Science
ISBN : 0080922473

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Ciliary Function in Mammalian Development by Bradley Yoder Pdf

Cilia--the tiny hairlike structures on the surface of cells—-have recently been identified as playing a role in a variety of disease and developmental disorders. Absent or defective cilia in certain cells can cause infertility, blindness, kidney disease, and lung disease. This volume presents recent findings in cilia research and current thought on the role of cilia in disease and developmental abnormalities.

Author : J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young
Publisher : Unknown
Page : 0 pages
File Size : 52,8 Mb
Release : 2013-04-25
Category : Electronic
ISBN : 1947172808

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Anatomy and Physiology by J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young Pdf

Author : Vinay Kumar,Abul K. Abbas,Jon C. Aster
Publisher : Elsevier Health Sciences
Page : 924 pages
File Size : 41,6 Mb
Release : 2012-05-01
Category : Medical
ISBN : 9781455737871

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Robbins Basic Pathology E-Book by Vinay Kumar,Abul K. Abbas,Jon C. Aster Pdf

Robbins Basic Pathology delivers the pathology knowledge you need, the way you need it, from the name you can trust! This medical textbook’s unbeatable author team helps you efficiently master the core concepts you need to know for your courses and USMLE exams. Get a rich understanding of all essential pathology concepts with expert guidance from an all-star editorial team. Grasp the connections between basic science and clinical medicine with clinicopathologic correlations throughout. Learn core concepts quickly and efficiently with a highly templated design that highlights pathogenesis and morphology. Artwork revised and updated for a more modern look and more three-dimensional feel Targeted Therapy boxes – provides clinical information on appropriate therapy related to the disease under discussion All photomicrographs and gross photos reviewed and improved to ensure excellent quality

Author : Andreas Oksche,Esteban M. Rodriguez,Pedro Fernandez-Llebrez
Publisher : Springer Science & Business Media
Page : 322 pages
File Size : 40,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642780134

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The Subcommissural Organ by Andreas Oksche,Esteban M. Rodriguez,Pedro Fernandez-Llebrez Pdf

The subcommissural organ is a secretory ependymo-glial structure of the brain. It secretes glycoproteins into the crebrospinal fluid. The chemical nature of this material is only partly known, and the functional role of theentire circumventricular complex has remained enigmatic. New experimental models include transplantation, immunological blockade,and experimental and clinical hydrocephalus. This first book in the field containing provocative ideas will most likely stimulate further investigations into molecular and systemic aspects of the problem.

Author : Michael Hippler
Publisher : Springer
Page : 217 pages
File Size : 52,5 Mb
Release : 2017-12-30
Category : Science
ISBN : 9783319663609

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Chlamydomonas: Biotechnology and Biomedicine by Michael Hippler Pdf

This Microbiology Monographs volume covers the current and most recent advances in genomics and genetics, biochemistry, physiology, and molecular biology of C. reinhardtii. Expert international scientists contribute with reviews on the genome, post-genomic techniques, the genetic toolbox development as well as new insights in regulation of photosynthesis and acclimation strategies towards environmental stresses and other structural and genetic aspects, including applicable aspects in biotechnology and biomedicine. Advancement in Chlamydomonas biology allowed new understandings in biotechnological and biomedical related aspects.

Author : Hitoshi Sawada,Naokazu Inoue,Megumi Iwano
Publisher : Springer
Page : 463 pages
File Size : 40,9 Mb
Release : 2014-02-07
Category : Science
ISBN : 9784431545897

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Sexual Reproduction in Animals and Plants by Hitoshi Sawada,Naokazu Inoue,Megumi Iwano Pdf

This book contains the proceedings of the International Symposium on the Mechanisms of Sexual Reproduction in Animals and Plants, where many plant and animal reproductive biologists gathered to discuss their recent progress in investigating the shared mechanisms and factors involved in sexual reproduction. This now is the first book that reviews recent progress in almost all fields of plant and animal fertilization. It was recently reported that the self-sterile mechanism of a hermaphroditic marine invertebrate (ascidian) is very similar to the self-incompatibility system in flowering plants. It was also found that a male factor expressed in the sperm cells of flowering plants is involved in gamete fusion not only of plants but also of animals and parasites. These discoveries have led to the consideration that the core mechanisms or factors involved in sexual reproduction may be shared by animals, plants and unicellular organisms. This valuable book is highly useful for reproductive biologists as well as for biological scientists outside this field in understanding the current progress of reproductive biology.

Author : Richard A. Kahn
Publisher : Springer Science & Business Media
Page : 368 pages
File Size : 43,8 Mb
Release : 2004-02-29
Category : Science
ISBN : 9781402017193

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ARF Family GTPases by Richard A. Kahn Pdf

For the first time experts in the area of signalling research with a focus on the ARF family have contributed to the production of a title devoted to ARF biology. A comprehensive phylogenetic analysis of the ARF family, tables of the ARF GEFs and ARF GAPs, and more than a dozen chapters describing them in detail are provided. The impact of the ARF proteins on widely diverse aspects of cell biology and cell signalling can be clearly seen from the activities described; including membrane traffic, lipid metabolism, receptor desensitization, mouse development, microtubule dynamics, and bacterial pathogenesis. Anyone interested in understanding the complexities of cell signalling and the integration of signalling networks will benefit from this volume.