Cilia

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Cilia and Nervous System Development and Function

Kerry L. Tucker,Tamara Caspary
Cilia and Nervous System Development and Function Book PDF

Author : Kerry L. Tucker,Tamara Caspary
Publisher : Springer Science & Business Media
Page : 286 pages
File Size : 45,7 Mb
Release : 2013-01-19
Category : Medical
ISBN : 9789400758087

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Cilia and Nervous System Development and Function by Kerry L. Tucker,Tamara Caspary Pdf

Cilia are tiny microtubule-based organelles projecting from the plasma membrane of practically all cells in the body. In the past 10 years a flurry of research has indicated a crucial role of this long-neglected organelle in the development and function of the central nervous system. A common theme of these studies is the critical dependency of signal transduction of the Sonic hedgehog, and more recently, Wnt signaling pathways upon cilia to regulate fate decisions and morphogenesis. Both primary and motile cilia also play crucial roles in the function of the nervous system, including the primary processing of sensory information, the control of body mass, and higher functions such as behavior and cognition, serving as "antennae" for neurons to sense and process their environment. In this book we describe the structure and function of cilia and the various tissues throughout the brain and spinal cord that are dependent upon cilia for their proper development and function.

Primary Cilia

Anonim
Primary Cilia Book PDF

Author : Anonim
Publisher : Academic Press
Page : 408 pages
File Size : 54,6 Mb
Release : 2009-11-30
Category : Science
ISBN : 0080962823

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Primary Cilia by Anonim Pdf

In recent years, the role of cilia in the study of health, development and disease has been increasingly clear, and new discoveries have made this an exciting and important field of research. This comprehensive volume, a complement to the new three-volume treatment of cilia and flagella by King and Pazour, presents easy-to-follow protocols and detailed background information for researchers working with cilia and flagella. *Covers protocols for primary cilia across several systems and species * Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time * Relevant to clinicians and scientists working in a wide range of fields

The Biology of Cilia and Flagella

M. A. Sleigh
The Biology of Cilia and Flagella Book PDF

Author : M. A. Sleigh
Publisher : Elsevier
Page : 256 pages
File Size : 53,6 Mb
Release : 2016-01-11
Category : Science
ISBN : 9781483222752

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The Biology of Cilia and Flagella by M. A. Sleigh Pdf

The Biology of Cilia and Flagella reviews advances in the study of cilia and flagella since 1928. This book focuses on four main topics—structure of cilia, factors that affect ciliary activity, movement of cilia and flagella, and coordination of beat of cilia. In these topics, this compilation specifically discusses the intracellular structures associated with ciliary bases; viscosity of the medium and ciliary activity, and energy relationships of cilia and flagella. The compounding of synchronously beating cilia, variations in shaft structure, and control of ciliary activity by the organism are also elaborated. This text likewise covers the determination of the rate of beat of cilia and root-fiber systems and coordination of ciliary beat. This publication is suitable for biologists and clinicians of other disciplines researching on the structure and physiology of cilia and flagella.

Cilia

Paraskevi Goggolidou
Cilia Book PDF

Author : Paraskevi Goggolidou
Publisher : CRC Press
Page : 269 pages
File Size : 46,5 Mb
Release : 2018-02-28
Category : Science
ISBN : 9781351645690

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Cilia by Paraskevi Goggolidou Pdf

The scope of the book is to highlight the diverse roles of cilia in human development and disease. Almost all cell types form cilia and although they were first detected about 200 years ago, their significance was unclear. In the past ten years, it has become obvious that cilia have got sensory functions, as well as roles in motility and their mis-formation or the deregulation of the signaling pathways they control has been associated with defective development and human disease. Although research has concentrated on the role of the cilium in each organ, no effort has been made so far to bring all this information together and relate it to the various human diseases. This book aims to gather all the expertise that has been acquired on primary cilia and translate it into a medical and research context that will be of interest to postgraduate students, researchers, medics and scientists.

Cilia and Flagella

Anonim
Cilia and Flagella Book PDF

Author : Anonim
Publisher : Academic Press
Page : 603 pages
File Size : 41,8 Mb
Release : 1995-08-31
Category : Science
ISBN : 0080859453

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Cilia and Flagella by Anonim Pdf

Cilia and Flagella presents protocols accessible to all individuals working with eukaryotic cilia and flagella. These recipes delineate laboratory methods and reagents, as well as critical steps and pitfalls of the procedures. The volume covers the roles of cilia and flagella in cell assembly and motility, the cell cycle, cell-cell recognition and other sensory functions, as well as human diseases and disorders. Students, researchers, professors, and clinicians should find the book's combination of "classic" and innovative techniques essential to the study of cilia and flagella. Key Features * A complete guide containing more than 80 concise technical chapters friendly to both the novice and experienced researcher * Covers protocols for cilia and flagella across systems and species from Chlamydomonas and Euglena to mammals * Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time, including microscopy, electrophoresis, and PCR * Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes, who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures

Cilia

Wallace F. Marshall,Renata Basto
Cilia Book PDF

Author : Wallace F. Marshall,Renata Basto
Publisher : Unknown
Page : 0 pages
File Size : 44,6 Mb
Release : 2016-11-30
Category : Science
ISBN : 1621821412

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Cilia by Wallace F. Marshall,Renata Basto Pdf

Nearly every cell in the human body has one or more protrusive structures called cilia or flagella. These power cell movement and fluid flow, sense the extracellular environment, coordinate cell signaling, and establish left-right asymmetry during development. Mutations in genes that encode cilia can lead to disorders known as ciliopathies. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines key aspects of ciliary biology-from the molecular to the organismal level-in normal physiology and disease. The contributors dissect the complex structures of motile and nonmotile (primary) cilia, discuss how the intraflagellar transport machinery moves cargo across the central axoneme, and review how the ciliary gate controls the composition of cilia and flagella. The roles of cilia in coordinating cellular responses to environmental stimuli via cell signaling pathways (e.g., Hedgehog) are also covered, as are physiological functions in processes such as fertilization, mucociliary clearance, and vision. The authors also survey the wide spectrum of ciliopathies, describing their genetic bases, pathogenic mechanisms, and clinical manifestations. This volume is therefore an indispensable reference for all cell and developmental biologists, as well as medical geneticists and clinical scientists wishing to understand and treat disorders involving ciliary dysfunction.

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

M. A. Hayat
Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging Book PDF

Author : M. A. Hayat
Publisher : Academic Press
Page : 430 pages
File Size : 53,7 Mb
Release : 2016-12-28
Category : Medical
ISBN : 9780128094273

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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by M. A. Hayat Pdf

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

The Ciliated Protozoa

Denis Lynn
The Ciliated Protozoa Book PDF

Author : Denis Lynn
Publisher : Springer Science & Business Media
Page : 627 pages
File Size : 40,9 Mb
Release : 2008-06-24
Category : Science
ISBN : 9781402082399

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The Ciliated Protozoa by Denis Lynn Pdf

distances between groups of ciliates were as vast as significant hurdles to obtain copyright permissions the genetic distances between plants and animals for the over 1,000 required illustrations, and I put – THE major eukaryotic kingdoms at that time! the publication schedule ahead of this element. I continued to collaborate with Mitch, and in There are a number of significant illustrated guides 1991 my first “molecular” Magisterial student, to genera and species that have recently been pub- Spencer Greenwood, published an article estab- lished. References are made to these throughout lishing 1990 or thereabouts as the beginning of the book as sources that readers can consult for this the “Age of Refinement” – the period when gene aspect of ciliate diversity. A future project that I am sequencing techniques would deepen our under- contemplating is an illustrated guide to all the valid standing of the major lines of evolution within ciliate genera.

Etiology and Morphogenesis of Congenital Heart Disease

Toshio Nakanishi,Roger R. Markwald,H.Scott Baldwin,Bradley B. Keller,Deepak Srivastava,Hiroyuki Yamagishi
Etiology and Morphogenesis of Congenital Heart Disease Book PDF

Author : Toshio Nakanishi,Roger R. Markwald,H.Scott Baldwin,Bradley B. Keller,Deepak Srivastava,Hiroyuki Yamagishi
Publisher : Springer
Page : 0 pages
File Size : 52,5 Mb
Release : 2018-06-07
Category : Medical
ISBN : 4431566333

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Etiology and Morphogenesis of Congenital Heart Disease by Toshio Nakanishi,Roger R. Markwald,H.Scott Baldwin,Bradley B. Keller,Deepak Srivastava,Hiroyuki Yamagishi Pdf

This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration. This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.

Artificial Cilia

Jaap MJ den Toonder,Patrick R Onck
Artificial Cilia Book PDF

Author : Jaap MJ den Toonder,Patrick R Onck
Publisher : Royal Society of Chemistry
Page : 300 pages
File Size : 55,6 Mb
Release : 2013-05-31
Category : Technology & Engineering
ISBN : 9781849737098

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Artificial Cilia by Jaap MJ den Toonder,Patrick R Onck Pdf

Cilia are tiny hairs covering biological cells to generate and sense fluid flow. Millions of years of evolution have inspired a novel technology which is barely a decade old. Artificial cilia have been developed to control and sense fluid flow in microscopic systems, presenting new and interesting options for flow control in lab-on-a-chip devices. This appealing link between nature and technology has seen rapid development in the last few years, and this book presents a review of the state-of-the-art in the form of a professional reference book. The editors have pioneered the field, having initiated a major European project on this topic soon after its inception. Active researchers in academia and industry will benefit from the comprehensive nature of this book, while postgraduates and those new to the field will gain a clear understanding of the theory, techniques and applications of artificial cilia.

Cilia: From Mechanisms to Disease–Part A

Anonim
Cilia From Mechanisms to Disease Part A Book PDF

Author : Anonim
Publisher : Elsevier
Page : 270 pages
File Size : 55,8 Mb
Release : 2023-03-24
Category : Science
ISBN : 9780443185878

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Cilia: From Mechanisms to Disease–Part A by Anonim Pdf

Cilia: From Mechanisms to Disease, Part A, Volume 175 in the Methods in Cell Biology series, offers a range of techniques and protocols that can be used to study aspects of this interesting cellular organelle both in vitro and in vivo. Sections in this new release include Protocols to induce and study ciliogenesis, Flow Cytometry-Based Approach for the study of primary Cilia, Microscopic observation of human airway ciliary movement using wheat germ agglutinin, Time-lapse imaging of primary cilia behavior with physiological expression of fluorescent ciliary proteins, Evaluation of ciliary-GPCR dynamics using a validated organotypic brain slice culture method, and much more. Other sections cover Studying the morphology, composition and function of the photoreceptor primary cilium in zebrafish, Visualizing Multiciliated Cells in the Zebrafish, Isolation of Ciliary Ectosomes and Analysis of Peptide-mediated Chemotaxis in Chlamydomonas, Using Paramecium as a Model for Ciliopathies, Using organoids to study cilia, Using in vivo cerebellar electroporation to study neuronal cell proliferation and differentiation in a Joubert syndrome mouse model, and more. Offers a detailed overview of the protocols used to study cilia structure and various aspects of ciliary function Provides an approach to the study of some diseases related to ciliary dysfunction, also known as ciliopathies Written in an accessible style by renowned experts in the field

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades

Wolfgang B. Liedtke, MD, PH.D.
TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades Book PDF

Author : Wolfgang B. Liedtke, MD, PH.D.
Publisher : CRC Press
Page : 467 pages
File Size : 50,5 Mb
Release : 2006-09-29
Category : Science
ISBN : 9781420005844

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TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades by Wolfgang B. Liedtke, MD, PH.D. Pdf

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell body. How we sense heat and cold, how we taste food, how eggs are fertilized, how the heart expands and contracts is each dependent on the function of these channels. While no single book could possibly cover all the research being undertaken, TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades presents the most advanced compilation of work in this area to date. All 31 chapters are written by international pioneers working at the vanguard of TRP ion channel research. They explain much about the pivotal function and behavior of these channels, which are most exquisitely tuned to their specific tasks, and delve into how researchers are putting this knowledge to use in the development of novel pharmaceuticals, which may well prove effective in ameliorating treatment-resistant conditions including cancer, heart disease, inflammation, and immune system dysfunctions. Individual chapters shed light on selected topics of interest in the TRP arena, such as signal transduction in axonal path-finding, and in vascular, renal, and auditory functions, as well as pain. The text also covers subjects as diverse as mating and fertilization, inflammatory pain, and mechanisms of pheromone detection in mammals. While the book presents much new insight and explores findings that will be of interest to those involved with advanced research, it also includes significant background material for those looking to familiarize themselves with this exceptionally promising path of inquiry.

Integrated Nano-Biomechanics

Takami Yamaguchi,Takuji Ishikawa,Yohsuke Imai
Integrated Nano Biomechanics Book PDF

Author : Takami Yamaguchi,Takuji Ishikawa,Yohsuke Imai
Publisher : William Andrew
Page : 314 pages
File Size : 51,6 Mb
Release : 2018-06-27
Category : Medical
ISBN : 9780323389594

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Integrated Nano-Biomechanics by Takami Yamaguchi,Takuji Ishikawa,Yohsuke Imai Pdf

Integrated Nano-Biomechanics provides an integrated look into the rapidly evolving field of nanobiomechanics. The book demystifies the processes in living organisms at the micro- and nano-scale through mechanics, using theoretical, computational and experimental means. The book develops the concept of integrating different technologies along the hierarchical structure of biological systems and clarifies biomechanical interactions among different levels for the analysis of multi-scale pathophysiological phenomena. With a focus on nano-scale processes and biomedical applications, it is shown how knowledge obtained can be utilized in a range of areas, including diagnosis and treatment of various human diseases and alternative energy production. This book is based on collaboration of researchers from a unique combination of fields, including biomechanics, computational mechanics, GPU application, electron microscopy, biology of motile micro-organisms, entomological mechanics and clinical medicine. The book will be of great interest to scientists and researchers involved in disciplines, such as micro- and nano-engineering, bionanotechnology, biomedical engineering, micro- and nano-scale fluid-mechanics (such as in MEMS devices), nanomedicine and microbiology, as well as industries such as optical devices, computer simulation, plant based energy sources and clinical diagnosis of the gastric diseases. Provides knowledge of integrated biomechanics, focusing on nano-scale, in this rapidly growing research field Explains how the different technologies can be integrated and applied in a variety of biomedical application fields, as well as for alternative energy sources Uses a collaborative, multidisciplinary approach to provide a comprehensive coverage of nano-biomechanics

Cilia, Ciliated Epithelium and Ciliary Activity

José A. Rivera
Cilia Ciliated Epithelium and Ciliary Activity Book PDF

Author : José A. Rivera
Publisher : Pergamon
Page : 192 pages
File Size : 48,5 Mb
Release : 1962
Category : Science
ISBN : UOM:39015006908027

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Cilia, Ciliated Epithelium and Ciliary Activity by José A. Rivera Pdf

Cilia, Ciliated Epithelium, and Ciliary Activity reviews the state of knowledge of the activity of cilia and of the role these structures play in maintaining the normal physiology of the body, especially in the respiratory and genital systems. It relates the diversity of manifestations shown by cilia and ciliated epithelium in health and disease, and the effect of the physicochemical agents studied which influence the life and death of these structures. The volume is organized into five sections. Section A provides a general discussion on the history of studies on the ciliated epithelium; the ...

Artificial Cilia

Jaap M. J. den Toonder,Patrick R. Onck
Artificial Cilia Book PDF

Author : Jaap M. J. den Toonder,Patrick R. Onck
Publisher : Royal Society of Chemistry
Page : 279 pages
File Size : 48,7 Mb
Release : 2013
Category : Science
ISBN : 9781849735971

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Artificial Cilia by Jaap M. J. den Toonder,Patrick R. Onck Pdf

This book gives an overview of the research field of artificial cilia, a novel technology for controlling and sensing fluid flow at microscopic scales. This field is inspired by nature, namely by naturally occurring cilia which are tiny hairs covering biological cells and that are used already for over a billion years by nature to generate and sense fluid flow. The research field started less than a decade ago and has grown fast in recent years, since it offers very interesting options for flow control in lab-on-a-chip devices.