Circadian Clocks

Author : Michelle L. Gumz
Publisher : Springer
Page : 378 pages
File Size : 52,8 Mb
Release : 2016-02-29
Category : Medical
ISBN : 9781493934508

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Circadian Clocks: Role in Health and Disease by Michelle L. Gumz Pdf

This book sheds new light on the molecular mechanisms that generate circadian rhythms. It examines how biological rhythms influence physiological processes such as sleep, hormone synthesis and secretion, immunity, kidney function, the cardiovascular system, blood pressure, and the digestive system. Clinical implications are considered while exploring the impact of rhythms on neuropsychiatric disorders and chronotherapy’s potential for reducing cardiovascular risk. Offering a cross-section of expertise in both basic and translational (bench-to-bedside) research, this book serves as a guide for physicians and scientists who wish to learn more about the impact of circadian rhythms on physiological processes in health and disease.

Author : Steven A. Brown
Publisher : Humana
Page : 342 pages
File Size : 40,7 Mb
Release : 2021-12-22
Category : Electronic
ISBN : 1071603833

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Circadian Clocks by Steven A. Brown Pdf

Author : D. S. Minors,J. M. Waterhouse
Publisher : Butterworth-Heinemann
Page : 348 pages
File Size : 55,7 Mb
Release : 2013-11-06
Category : Science
ISBN : 9781483193427

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Circadian Rhythms and the Human by D. S. Minors,J. M. Waterhouse Pdf

Circadian Rhythms and the Human covers the basic principles behind the human circadian rhythms. This book is composed of 12 chapters that discuss the detection, analysis, and definition of rhythms, specifically exogenous and endogenous rhythms. This book also demonstrates the mechanism of metabolic and gastrointestinal rhythms. The opening chapters deal with the rhythms in living organism; establishing the endogeneity of rhythms; definition of nychthemeral rhythm; methods of measuring the frequency of rhythms; exogenous effects upon the temperature rhythm; interaction between exogenous and endogenous influences; and possible origins of renal rhythmicity. The succeeding chapters consider the effect of exercise at different times of day and the concept of sleep-wakefulness rhythm. The discussion then shifts to the effects of repeated time-zone transitions and the effects of time on drug administration. The closing chapters are devoted to the assessment of work performance during shift work. The book can provide useful information to doctors, students, researchers, and the general reader.

Author : Carl Hirschie Johnson,Michael Joseph Rust
Publisher : Springer Nature
Page : 424 pages
File Size : 44,8 Mb
Release : 2021-06-21
Category : Science
ISBN : 9783030721589

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Circadian Rhythms in Bacteria and Microbiomes by Carl Hirschie Johnson,Michael Joseph Rust Pdf

This book addresses multiple aspects of biological clocks in prokaryotes. The first part of the book deals with the circadian clock system in cyanobacteria, i.e. the pioneer of bacterial clocks. Starting with the history and background of cyanobacteria and circadian rhythms in microorganisms, the topics range from the molecular basis, structure and evolution of the circadian clock to modelling approaches, Kai systems in cyanobacteria and biotechnological applications. In the second part, emergent timekeeping properties of bacteria in microbiomes and bacteria other than cyanobacteria are discussed. Since the discovery of circadian rhythms in cyanobacteria in the late 1980s, the field has exploded with new information. The cyanobacterial model system for studying circadian rhythms (Synechococcus elongatus), has allowed a detailed genetic dissection of the bacterial clock due to state-of-the-art methods in molecular, structural, and evolutionary biology. Cutting-edge research spanning from cyanobacteria and circadian phenomena in other kinds of bacteria, to microbiomes has now given the field another major boost. This book is aimed at junior and senior researchers alike. Students or researchers new to the field of biological clocks in prokaryotes will get a comprehensive overview, while more experienced researchers will get an update on the latest developments.

Author : Christopher S. Colwell
Publisher : John Wiley & Sons
Page : 405 pages
File Size : 43,8 Mb
Release : 2015-07-07
Category : Medical
ISBN : 9781118467787

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Circadian Medicine by Christopher S. Colwell Pdf

Circadian rhythms, the biological oscillations based around our 24-hour clock, have a profound effect on human physiology and healthy cellular function. Circadian Rhythms: Health and Disease is a wide-ranging foundational text that provides students and researchers with valuable information on the molecular and genetic underpinnings of circadian rhythms and looks at the impacts of disruption in our biological clocks in health and disease. Circadian Rhythms opens with chapters that lay the fundamental groundwork on circadian rhythm biology. Section II looks at the impact of circadian rhythms on major organ systems. Section III then turns its focus to the central nervous system. The book then closes with a look at the role of biological rhythms in aging and neurodegeneration. Written in an accessible and informative style, Circadian Rhythms: Health and Disease,will be an invaluable resource and entry point into this fascinating interdisciplinary field that brings together aspects of neuroscience, cell and molecular biology, and physiology.

Author : Achim Kramer,Martha Merrow
Publisher : Springer Science & Business Media
Page : 414 pages
File Size : 50,7 Mb
Release : 2013-04-18
Category : Medical
ISBN : 9783642259500

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Circadian Clocks by Achim Kramer,Martha Merrow Pdf

This book provides the reader with a contemporary and comprehensive overview about the molecular, cellular and system-wide principles of circadian clock regulation. Emphasis is placed on the importance of circadian clocks for the timing of therapeutic interventions.

Author : Olivia Engmann,Marco Brancaccio
Publisher : Springer Nature
Page : 193 pages
File Size : 49,6 Mb
Release : 2021-11-13
Category : Medical
ISBN : 9783030811471

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Circadian Clock in Brain Health and Disease by Olivia Engmann,Marco Brancaccio Pdf

In this book, leading experts in the field review how circadian rhythms impact the brain. An essential function of mammalian life is the exploitation of the regularities provided by the 24-hour cycle of day and night. The development and evolution of circadian clock mechanisms have allowed us to optimally adapt our behavior and physiology to the external world. Not surprisingly, a growing body of evidence links the disruption of circadian rhythms by genetic, lifestyle and environmental factors to illnesses of the brain. In the first section of the book, readers will learn about the molecular and anatomic architecture of circadian function in mammals. The ways in which environmental disruptions and misalignments can influence such mechanisms and therefore impair brain function and health status are also addressed. In the second part, the focus shifts to those brain regions responsible for brain function and the body-wide regulation of circadian function. Amongst others, special attention is paid to the role of astrocytes and the brain’s reward and hyprocretin / orexin systems. The book concludes with an extensive discussion on the consequences of circadian rhythm dysfunction. Several chapters present the latest findings on Attention Deficit Hyperactivity Disorder, schizophrenia, autism spectrum disorder, drug abuse and mood disorders. Written by auhorities in the field, the book provides a state-of-the-art review of the latest findings on circadian clocks in the brain and highlights their potentially far-reaching impacts on our health and well-being. As such, it is essential reading for all neuroscientists and clinicians seeking to understand the intricate connections between circadian rhythms and brain health and illness.

Author : Urs Albrecht
Publisher : Springer Science & Business Media
Page : 300 pages
File Size : 49,7 Mb
Release : 2010-01-23
Category : Science
ISBN : 9781441912626

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The Circadian Clock by Urs Albrecht Pdf

With the invitation to edit this volume, I wanted to take the opportunity to assemble reviews on different aspects of circadian clocks and rhythms. Although most c- tributions in this volume focus on mammalian circadian clocks, the historical int- duction and comparative clocks section illustrate the importance of various other organisms in deciphering the mechanisms and principles of circadian biology. Circadian rhythms have been studied for centuries, but only recently, a mole- lar understanding of this process has emerged. This has taken research on circadian clocks from mystic phenomenology to a mechanistic level; chains of molecular events can describe phenomena with remarkable accuracy. Nevertheless, current models of the functioning of circadian clocks are still rudimentary. This is not due to the faultiness of discovered mechanisms, but due to the lack of undiscovered processes involved in contributing to circadian rhythmicity. We know for example, that the general circadian mechanism is not regulated equally in all tissues of m- mals. Hence, a lot still needs to be discovered to get a full understanding of cir- dian rhythms at the systems level. In this respect, technology has advanced at high speed in the last years and provided us with data illustrating the sheer complexity of regulation of physiological processes in organisms. To handle this information, computer aided integration of the results is of utmost importance in order to d- cover novel concepts that ultimately need to be tested experimentally.

Author : D.L. Denlinger,J. Giebultowicz,D.S. Saunders
Publisher : Gulf Professional Publishing
Page : 245 pages
File Size : 43,5 Mb
Release : 2001-06-19
Category : Science
ISBN : 9780444506085

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Insect Timing by D.L. Denlinger,J. Giebultowicz,D.S. Saunders Pdf

Now that many of the clock genes have been identified it is possible to track daily patterns of clock-related mRNAs and proteins to link the entraining light cycles with molecular oscillations within the cell. Insect experiments have led the way in demonstrating that the concept of a "master clock" can no longer be used to explain the temporal organization within an animal. Insects have a multitude of cellular clocks that can function independently and retain their function under organ culture conditions, and they thus offer a premier system for studying how the hierarchical organization of clocks results in the overall temporal organization of the animal. Photoperiodism, and its most obvious manifestation, diapause, does not yet have the molecular underpinning that has been established for circadian rhythms, but recent studies are beginning to identify genes that appear to be involved in the regulation of diapause.

Author : D. S. Saunders
Publisher : Elsevier
Page : 288 pages
File Size : 44,5 Mb
Release : 2014-05-19
Category : Science
ISBN : 9781483182186

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Insect Clocks by D. S. Saunders Pdf

Insect Clocks is mainly concerned with the phenomena in which ""environmental time"" has a practical implication for the life of insects for them to perform behavioral or physiological episodes at the ""right time"" and season. This text first discusses the concept of rhythms and clocks, along with the seasonal changes in the environment that affect a particular group of organisms. This book then explains circadian rhythms of insects. Photoperiodism and seasonal cycles of development; photoperiodic response, clock, and counter; and other types of insect clock are also tackled. This text concludes by explaining the anatomical location of photoreceptors and clocks. This publication will be invaluable to those interested in studying insects and their development affected by circles of influences.

Author : Charles A. Czeisler
Publisher : Unknown
Page : 692 pages
File Size : 52,8 Mb
Release : 1978
Category : Human physiology
ISBN : OCLC:84039346

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Human Circadian Physiology by Charles A. Czeisler Pdf

Author : Daniel B. Forger
Publisher : MIT Press
Page : 369 pages
File Size : 43,9 Mb
Release : 2017-11-16
Category : Science
ISBN : 9780262036771

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Biological Clocks, Rhythms, and Oscillations by Daniel B. Forger Pdf

An introduction to the mathematical, computational, and analytical techniques used for modeling biological rhythms, presenting tools from many disciplines and example applications. All areas of biology and medicine contain rhythms, and these behaviors are best understood through mathematical tools and techniques. This book offers a survey of mathematical, computational, and analytical techniques used for modeling biological rhythms, gathering these methods for the first time in one volume. Drawing on material from such disciplines as mathematical biology, nonlinear dynamics, physics, statistics, and engineering, it presents practical advice and techniques for studying biological rhythms, with a common language. The chapters proceed with increasing mathematical abstraction. Part I, on models, highlights the implicit assumptions and common pitfalls of modeling, and is accessible to readers with basic knowledge of differential equations and linear algebra. Part II, on behaviors, focuses on simpler models, describing common properties of biological rhythms that range from the firing properties of squid giant axon to human circadian rhythms. Part III, on mathematical techniques, guides readers who have specific models or goals in mind. Sections on “frontiers” present the latest research; “theory” sections present interesting mathematical results using more accessible approaches than can be found elsewhere. Each chapter offers exercises. Commented MATLAB code is provided to help readers get practical experience. The book, by an expert in the field, can be used as a textbook for undergraduate courses in mathematical biology or graduate courses in modeling biological rhythms and as a reference for researchers.

Author : Satchin Panda, PhD
Publisher : Rodale Books
Page : 290 pages
File Size : 42,8 Mb
Release : 2020-02-11
Category : Health & Fitness
ISBN : 9780593135907

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The Circadian Code by Satchin Panda, PhD Pdf

When we eat may be as important as what we eat. Like most people, you probably wake up, get hungry for meals and doze off in bed around the same time every day. If you’ve ever experienced jet lag or pulled an all-nighter, you know that this schedule can easily be thrown off kilter. But for some people, that imbalance—difficulty sleeping at night, hunger at odd times, or sudden fatigue at noon—is a constant. If you're one of those people, Dr. Satchin Panda, one of the leading researchers on circadian rhythms, has a plan to reset your body clock. Beginning with an in-depth explanation of the circadian clock—why it’s important, how it works, and how to know it isn’t working—The Circadian Code outlines lifestyle changes to make to get back on track. It's a concrete plan to enhance weight loss, improve sleep, optimize exercise, and manage technology so that it doesn’t interfere with your body’s natural rhythm. Dr. Panda’s life changing methods show you how to prevent and reverse ailments like diabetes, cancer, and dementia, as well as microbiome conditions like acid reflux, heartburn, and irritable bowel disease.

Author : Paolo Sassone-Corsi,Yves Christen
Publisher : Springer
Page : 132 pages
File Size : 43,6 Mb
Release : 2016-04-04
Category : Medical
ISBN : 9783319270692

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A Time for Metabolism and Hormones by Paolo Sassone-Corsi,Yves Christen Pdf

Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.

Author : Joseph S. Takahashi,Fred W. Turek,Robert Y. Moore
Publisher : Springer Science & Business Media
Page : 820 pages
File Size : 45,9 Mb
Release : 2001-09-30
Category : Medical
ISBN : 0306465043

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Circadian Clocks by Joseph S. Takahashi,Fred W. Turek,Robert Y. Moore Pdf

The nature of the circadian clocks is described at the molecular, cellular, tissue, and system levels of organization in diverse organisms. The central role of the circadian clock in the regulation of the sleep-wake cycle as well as seasonal rhythms and other cyclical processes is also discussed. The importance of the circadian clock system for human health, safety, performance, and productivity is also reviewed in this volume."--BOOK JACKET.