Circular Dichroism And The Conformational Analysis Of Biomolecules

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Circular Dichroism and the Conformational Analysis of Biomolecules

G.D. Fasman
Circular Dichroism and the Conformational Analysis of Biomolecules Book PDF

Author : G.D. Fasman
Publisher : Springer Science & Business Media
Page : 739 pages
File Size : 52,7 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781475725087

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Circular Dichroism and the Conformational Analysis of Biomolecules by G.D. Fasman Pdf

''Excellent and very timely....It will undoubtedly become a standard reference for the application of circular dichroism (CD) to biomolecules.'' --- Quarterly Review of Biology, March 1997 ''[T]estament to the book's utility is the fact that during the course of my review I had to 'rescue' it from the desks of graduate students on an almost daily basis. In summary, this is a great book.'' --- American Scientist ''Well documented chapters provide a very good insight into the problems surrounding the conformation of biomacromolecules...An indispensible source of information.'' --- Nahrung, 42(2), 1998 Renowned experts present the first state-of-the-art description of circular dichroism spectroscopy (CD). Chapters present in-depth discussions of the history of the field, the theory of CD for application to globular proteins, membrane proteins, peptides, nucleic acids and their interactions, carbohydrates, and instrumentation. Discussions also feature new techniques using synchrotron radiation, vibrational Raman optical activity, and vibrational CD. More than 250 illustrations supplement the text.

Circular Dichroism

Nina Berova,Koji Nakanishi,Robert W. Woody
Circular Dichroism Book PDF

Author : Nina Berova,Koji Nakanishi,Robert W. Woody
Publisher : John Wiley & Sons
Page : 916 pages
File Size : 41,8 Mb
Release : 2000-05-03
Category : Science
ISBN : 0471330035

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Circular Dichroism by Nina Berova,Koji Nakanishi,Robert W. Woody Pdf

Unter Zirkulardichroismus (CD) versteht man die spezifisch unterschiedliche Absorption von links- und rechtszirkular polarisiertem Licht durch bestimmte Moleküle. CD-Effekte lassen sich in Abhängigkeit von der Wellenlänge messen und spektroskopisch auswerten. Dieser Band erläutert Theorie und Anwendung der CD-Spektroskopie insbesondere für Biomoleküle. Ausführlich behandelt werden Anwendungen auf den Gebieten der organischen Stereochemie und der Biopolymere. Geschrieben von anerkannten Spezialisten! (06/00)

The Next Generation in Membrane Protein Structure Determination

Isabel Moraes
The Next Generation in Membrane Protein Structure Determination Book PDF

Author : Isabel Moraes
Publisher : Springer
Page : 184 pages
File Size : 44,5 Mb
Release : 2016-08-23
Category : Science
ISBN : 9783319350721

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The Next Generation in Membrane Protein Structure Determination by Isabel Moraes Pdf

This book reviews current techniques used in membrane protein structural biology, with a strong focus on practical issues. The study of membrane protein structures not only provides a basic understanding of life at the molecular level but also helps in the rational and targeted design of new drugs with reduced side effects. Today, about 60% of the commercially available drugs target membrane proteins and it is estimated that nearly 30% of proteins encoded in the human genome are membrane proteins. In recent years much effort has been put towards innovative developments to overcome the numerous obstacles associated with the structure determination of membrane proteins. This book reviews a variety of recent techniques that are essential to any modern researcher in the field of membrane protein structural biology. The topics that are discussed are not commonly found in textbooks. The scope of this book includes: Expression screening using fluorescent proteins The use of detergents in membrane protein research The use of NMR Synchrotron developments in membrane protein structural biology Visualisation and X-ray data collection of microcrystals X-ray diffraction data analysis from multiple crystals Serial millisecond crystallography Serial femtosecond crystallography Membrane protein structures in drug discovery The information provided in this book should be of interest to anyone working in the area of structural biology. Students will find carefully prepared overviews of basic ideas and advanced protein scientists will find the level of detail required to apply the material directly to their day to day work. Chapters 4, 5, 6, 8 and 9 of this book are published open access under a CC BY 4.0 license at link.springer.com.

Conformation in Biology and Drug Design

Sidney Udenfriend,Johannes Meienhofer,Victor J. Hruby
Conformation in Biology and Drug Design Book PDF

Author : Sidney Udenfriend,Johannes Meienhofer,Victor J. Hruby
Publisher : Elsevier
Page : 516 pages
File Size : 55,8 Mb
Release : 2014-05-10
Category : Science
ISBN : 9781483218007

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Conformation in Biology and Drug Design by Sidney Udenfriend,Johannes Meienhofer,Victor J. Hruby Pdf

The Peptides: Analysis, Synthesis, Biology, Volume 7: Conformation in Biology and Drug Design focuses on the analysis of peptides, emphasizing the use of physical methods in peptide conformational analysis and the relationship of conformational properties of peptides to biological properties. This book consists of nine chapters. Chapter 1 provides a brief overview of the perspective on the application of physical methods to peptide conformational analysis. The use of circular dichroism (CD) spectroscopy to examine the conformational properties of peptides in solution is elaborated in Chapter 2, while the use of fluorescence spectroscopy to examine the special relationships of aromatic side-chain groups to one another is discussed in Chapter 3. In Chapter 4, the use of various theoretical methods to calculate the conformations of peptides is described. The methods used to stimulate peptide conformations and dynamics are outlined in Chapter 5. The last four chapters examine various aspects of the use of nuclear magnetic resonance (NMR) in peptide conformational analysis. This volume is suitable for biologists, specialists, and researchers interested in peptides and proteins.

Calcium-Binding Protein Protocols

Hans J. Vogel
Calcium Binding Protein Protocols Book PDF

Author : Hans J. Vogel
Publisher : Springer Science & Business Media
Page : 346 pages
File Size : 45,8 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781592591831

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Calcium-Binding Protein Protocols by Hans J. Vogel Pdf

Calcium plays an important role in a wide variety of biological processes. This divalent metal ion can bind to a large number of proteins; by doing so it modifies their biological activity or their stability. Because of its distinct che- cal properties calcium is uniquely suited to act as an on–off switch or as a light dimmer of biological activities. The two books entitled Calcium-Binding Protein Protocols (Volumes I and II) focus on modern experimental analyses and methodologies for the study of calcium-binding proteins. Both extracel- lar and intracellular calcium-binding proteins are discussed in detail. H- ever, proteins involved in calcium handling (e. g. , calcium pumps and calcium channels), fall outside of the scope of these two volumes. Also, calcium-bi- ing proteins involved in bone deposition will not be discussed, as this specific topic has been addressed previously. The focus of these two books is on studies of the calcium-binding proteins and their behavior in vitro and in vivo. The primary emphasis is on protein chemistry and biophysical methods. Many of the methods described will also be applicable to proteins that do not bind calcium. Calcium-Binding Protein Protocols is divided into three main sections. The section entitled Introduction and Reviews provides information on the role of calcium in intracellular secondary messenger activation mechanisms. Mo- over, unique aspects of calcium chemistry and the utilization of calcium in dairy proteins, as well as calcium-binding proteins involved in blood clotting, are addressed.

Biophysical Analysis of Membrane Proteins

Eva Pebay-Peyroula
Biophysical Analysis of Membrane Proteins Book PDF

Author : Eva Pebay-Peyroula
Publisher : John Wiley & Sons
Page : 368 pages
File Size : 54,5 Mb
Release : 2008-06-25
Category : Science
ISBN : 9783527621231

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Biophysical Analysis of Membrane Proteins by Eva Pebay-Peyroula Pdf

Meeting the need for a book on developing and using new methods to investigate membrane proteins, this is the first of its kind to present the full range of novel techniques in one resource. Top researchers from around the world focus on the physical principles exploited in the different techniques, and provide examples of how these can bring about important new insights. Following an introduction, further sections discuss structural approaches, molecular interaction and large assemblies, dynamics and spectroscopies, finishing off with an exploration of structure-function relationships in whole cells.

Biophysical Tools for Biologists

John J. Correia,H. William Detrich, III
Biophysical Tools for Biologists Book PDF

Author : John J. Correia,H. William Detrich, III
Publisher : Academic Press
Page : 1014 pages
File Size : 47,6 Mb
Release : 2011-09-21
Category : Science
ISBN : 0080554946

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Biophysical Tools for Biologists by John J. Correia,H. William Detrich, III Pdf

Driven in part by the development of genomics, proteomics, and bioinformatics as new disciplines, there has been a tremendous resurgence of interest in physical methods to investigate macromolecular structure and function in the context of living cells. This volume in Methods in Cell Biology is devoted to biophysical techniques in vitro and their applications to cellular biology. Biophysical Tools for Biologists covers methods-oriented chapters on fundamental as well as cutting-edge techniques in molecular and cellular biophysics. This book is directed toward the broad audience of cell biologists, biophysicists, pharmacologists, and molecular biologists who employ classical and modern biophysical technologies or wish to expand their expertise to include such approaches. It will also interest the biomedical and biotechnology communities for biophysical characterization of drug formulations prior to FDA approval. Describes techniques in the context of important biological problems Delineates critical steps and potential pitfalls for each method Includes full-color plates to illustrate techniques

Encyclopedia of Spectroscopy and Spectrometry

Anonim
Encyclopedia of Spectroscopy and Spectrometry Book PDF

Author : Anonim
Publisher : Academic Press
Page : 3716 pages
File Size : 45,7 Mb
Release : 2016-09-22
Category : Science
ISBN : 9780128032251

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Encyclopedia of Spectroscopy and Spectrometry by Anonim Pdf

This third edition of the Encyclopedia of Spectroscopy and Spectrometry, Three Volume Set provides authoritative and comprehensive coverage of all aspects of spectroscopy and closely related subjects that use the same fundamental principles, including mass spectrometry, imaging techniques and applications. It includes the history, theoretical background, details of instrumentation and technology, and current applications of the key areas of spectroscopy. The new edition will include over 80 new articles across the field. These will complement those from the previous edition, which have been brought up-to-date to reflect the latest trends in the field. Coverage in the third edition includes: Atomic spectroscopy Electronic spectroscopy Fundamentals in spectroscopy High-Energy spectroscopy Magnetic resonance Mass spectrometry Spatially-resolved spectroscopic analysis Vibrational, rotational and Raman spectroscopies The new edition is aimed at professional scientists seeking to familiarize themselves with particular topics quickly and easily. This major reference work continues to be clear and accessible and focus on the fundamental principles, techniques and applications of spectroscopy and spectrometry. Incorporates more than 150 color figures, 5,000 references, and 300 articles for a thorough examination of the field Highlights new research and promotes innovation in applied areas ranging from food science and forensics to biomedicine and health Presents a one-stop resource for quick access to answers and an in-depth examination of topics in the spectroscopy and spectrometry arenas

ß-barrel Channel Proteins as Tools in Nanotechnology

Marco Fioroni,Tamara Dworeck,Francisco Rodriguez-Ropero
barrel Channel Proteins as Tools in Nanotechnology Book PDF

Author : Marco Fioroni,Tamara Dworeck,Francisco Rodriguez-Ropero
Publisher : Springer Science & Business Media
Page : 168 pages
File Size : 47,7 Mb
Release : 2013-11-04
Category : Science
ISBN : 9789400774292

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ß-barrel Channel Proteins as Tools in Nanotechnology by Marco Fioroni,Tamara Dworeck,Francisco Rodriguez-Ropero Pdf

ß-barrel outer membrane channel proteins (OMP) are useful as robust and flexible models or components in nanotechnology. Over the last decade biotechnological techniques allowed to expand the natural characteristics of OMPs by modifying their geometry and properties. The present book is oriented towards a broad group of readers including graduate students and advanced researchers. It gives a general introduction to the field of OMP based nano-component development as well as the state of the art of the involved research. On the example of the E. coli FhuA the transformation of an OMP into a tailored nano-channel will be outlined. An exhaustive description of the scientific strategy, including protein selection, analytical methods and “in-silico” tools to support the planning of protein modifications for a targeted application, consideration on the production of a custom made OMP, and an overview on technological applications including membrane/polymersome technology, will be provided.

Vibrational Spectroscopy of Biological and Polymeric Materials

Vasilis G. Gregoriou,Mark S. Braiman
Vibrational Spectroscopy of Biological and Polymeric Materials Book PDF

Author : Vasilis G. Gregoriou,Mark S. Braiman
Publisher : CRC Press
Page : 448 pages
File Size : 47,9 Mb
Release : 2005-11-14
Category : Science
ISBN : 9781420027549

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Vibrational Spectroscopy of Biological and Polymeric Materials by Vasilis G. Gregoriou,Mark S. Braiman Pdf

Used primarily for characterizing polymers and biological systems, vibrational spectroscopy continues to uncover structural information pertinent to a growing number of applications. Vibrational Spectroscopy of Biological and Polymeric Materials compiles the latest developments in advanced infrared and Raman spectroscopic techniques that are applicable to both polymeric materials and biological compounds. It also presents instrumentation and experimental details that can be used by polymer chemists and biochemists in the design of their own experiments. The text starts by describing the application of static and dynamic FT-IR spectroscopies to liquid crystalline polyurethanes, including a clear exposition of the theory behind the experiments. It discusses the measurement of static and dynamic linear dichroism and stress or strain in both single and multiple fiber composite materials. The book explains the roles of vibrational spectroscopy and the Langmuir-Blodgett technique in the study and preparation of high-quality ultrathin materials. Chapters rich in both theoretical and experimental details describe two-dimensional correlation spectroscopy and vibrational circular dichroism. Biomedically-oriented chapters describe the advances in IR imaging of tissues made possible by focal-plane arrays; as well as the use of ligand-gated FT-IR difference spectroscopy in neuropharmacology, particularly in identifying ligands and modes of action for the large number of membrane receptors recently identified in the human genome. The final chapter discusses the application of time-resolved FT-IR spectroscopy to biological materials, providing a detailed guide to the use of commercial step-scan instrumentation for examining sub-millisecond mechanistic details of photobiological processes. Written by eminent experts in these fields, Vibrational Spectroscopy of Biological and Polymeric Materials is an ideal and practical reference for the broad spectrum of researchers interested in the analysis and integration of biological and polymeric materials.

Optical Spectroscopic and Microscopic Techniques

Harekrushna Sahoo
Optical Spectroscopic and Microscopic Techniques Book PDF

Author : Harekrushna Sahoo
Publisher : Springer Nature
Page : 260 pages
File Size : 40,9 Mb
Release : 2022-02-25
Category : Science
ISBN : 9789811645501

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Optical Spectroscopic and Microscopic Techniques by Harekrushna Sahoo Pdf

This book illustrates the significance of various optical spectroscopy and microscopy techniques, including absorption spectroscopy, fluorescence spectroscopy, infrared spectroscopy, and Raman spectroscopy for deciphering the nature of biological molecules. The content of this book chiefly focuses on (1) the principle, theory, and instrumentation used in different optical spectroscopy techniques, and (2) the application of these techniques in exploring the nature of different biomolecules (e.g., proteins, nucleic acids, enzymes, and carbohydrates). It emphasizes the structural, conformational and dynamic, and kinetic including the changes in biomolecules under a range of conditions. In closing, the book summarizes recent advances in the field of optical spectroscopic and microscopic techniques.

Advances in Protein Chemistry and Structural Biology

Anonim
Advances in Protein Chemistry and Structural Biology Book PDF

Author : Anonim
Publisher : Academic Press
Page : 296 pages
File Size : 48,8 Mb
Release : 2010-12-16
Category : Science
ISBN : 0123812658

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Advances in Protein Chemistry and Structural Biology by Anonim Pdf

Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale. Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission

Conformation of Biological Molecules and Polymers

Ernst David Bergmann,Bernard Pullman
Conformation of Biological Molecules and Polymers Book PDF

Author : Ernst David Bergmann,Bernard Pullman
Publisher : Academic Press
Page : 852 pages
File Size : 45,5 Mb
Release : 1973
Category : Science
ISBN : UOM:39015000808710

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Conformation of Biological Molecules and Polymers by Ernst David Bergmann,Bernard Pullman Pdf

Accuracy of potential functions in the analysis of biopolymer coformation; The dipeptide model-its significance and limitations; Conformational properties of peptides deduced from energy calculations; Interactions in polypertides and proteins; Experimental study of the conformation of dipeptides; Dipole moments and conformations of dipeptides in solution.

Biophysical Characterization of Proteins in Developing Biopharmaceuticals

Damian J. Houde,Steven A. Berkowitz
Biophysical Characterization of Proteins in Developing Biopharmaceuticals Book PDF

Author : Damian J. Houde,Steven A. Berkowitz
Publisher : Elsevier
Page : 586 pages
File Size : 54,8 Mb
Release : 2019-11-13
Category : Medical
ISBN : 9780444641748

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Biophysical Characterization of Proteins in Developing Biopharmaceuticals by Damian J. Houde,Steven A. Berkowitz Pdf

Biophysical Characterization of Proteins in Developing Biopharmaceuticals, Second Edition, presents the latest on the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure, this book explains the best way to achieve this goal using key methods commonly employed in the biopharmaceutical industry. This book will help today’s industrial scientists plan a career in this industry and successfully implement these biophysical methodologies. This updated edition has been fully revised, with new chapters focusing on the use of chromatography and electrophoresis and the biophysical characterization of very large biopharmaceuticals. In addition, best practices of applying statistical analysis to biophysical characterization data is included, along with practical issues associated with the concept of a biopharmaceutical’s developability and the technical decision-making process needed when dealing with biophysical characterization data. Presents basic protein characterization methods and tools applicable to (bio)pharmaceutical research and development Highlights the capabilities and limitations of each technique Discusses the underlining science of each tool Empowers industrial biophysical chemists by providing a roadmap for applying biophysical tools Outlines the needs for new characterization and analytical tools in the biopharmaceutical industry

Advances in Protein Molecular and Structural Biology Methods

Timir Tripathi,Vikash Kumar Dubey
Advances in Protein Molecular and Structural Biology Methods Book PDF

Author : Timir Tripathi,Vikash Kumar Dubey
Publisher : Academic Press
Page : 716 pages
File Size : 53,8 Mb
Release : 2022-01-14
Category : Science
ISBN : 9780323902656

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Advances in Protein Molecular and Structural Biology Methods by Timir Tripathi,Vikash Kumar Dubey Pdf

Advances in Protein Molecular and Structural Biology Methods offers a complete overview of the latest tools and methods applicable to the study of proteins at the molecular and structural level. The book begins with sections exploring tools to optimize recombinant protein expression and biophysical techniques such as fluorescence spectroscopy, NMR, mass spectrometry, cryo-electron microscopy, and X-ray crystallography. It then moves towards computational approaches, considering structural bioinformatics, molecular dynamics simulations, and deep machine learning technologies. The book also covers methods applied to intrinsically disordered proteins (IDPs)followed by chapters on protein interaction networks, protein function, and protein design and engineering. It provides researchers with an extensive toolkit of methods and techniques to draw from when conducting their own experimental work, taking them from foundational concepts to practical application. Presents a thorough overview of the latest and emerging methods and technologies for protein study Explores biophysical techniques, including nuclear magnetic resonance, X-ray crystallography, and cryo-electron microscopy Includes computational and machine learning methods Features a section dedicated to tools and techniques specific to studying intrinsically disordered proteins