Clinical Challenges In Therapeutic Drug Monitoring

Author : Seth Kwabena Amponsah,Yashwant V. Pathak
Publisher : Springer Nature
Page : 384 pages
File Size : 55,6 Mb
Release : 2022-10-25
Category : Medical
ISBN : 9783031123986

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Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology by Seth Kwabena Amponsah,Yashwant V. Pathak Pdf

This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges

Author : William Clarke,Amitava Dasgupta
Publisher : Elsevier
Page : 376 pages
File Size : 52,9 Mb
Release : 2016-07-21
Category : Medical
ISBN : 9780128020524

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Clinical Challenges in Therapeutic Drug Monitoring by William Clarke,Amitava Dasgupta Pdf

Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring. This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations. Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoring Focuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoring Explores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interference Explains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window

Author : Daniel M. Baer,William R. Dito
Publisher : Unknown
Page : 418 pages
File Size : 52,9 Mb
Release : 1981
Category : Medical
ISBN : UOM:39015006016458

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Interpretations in Therapeutic Drug Monitoring by Daniel M. Baer,William R. Dito Pdf

Author : Amitava Dasgupta
Publisher : Academic Press
Page : 469 pages
File Size : 47,5 Mb
Release : 2012-06-07
Category : Medical
ISBN : 9780123854681

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Therapeutic Drug Monitoring by Amitava Dasgupta Pdf

Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety. Includes both the technical and clinical issues associated with therapeutic drug monitoring Discusses the utility of therapeutic drug monitoring of newer drugs such as antiretroviral agents, anticonvulsants, antidepressants etc. Provides up-to-date information on issues in pharmacogenomics and personalized medicine with emphasis on therapy with warfarin, certain anticancer drugs and antidepressants Covers important content on the limitations of commercially available immunoassays (chemical tests) for therapeutic drug monitoring and additional analytical techniques

Author : Gerald E. Schumacher
Publisher : McGraw-Hill/Appleton & Lange
Page : 712 pages
File Size : 53,7 Mb
Release : 1995
Category : Medical
ISBN : UOM:39015033266571

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Therapeutic Drug Monitoring by Gerald E. Schumacher Pdf

Author : Catherine A. Hammett-Stabler,Amitava Dasgupta
Publisher : Unknown
Page : 241 pages
File Size : 52,8 Mb
Release : 2007-01-01
Category : Drug monitoring
ISBN : 1594250758

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Therapeutic Drug Monitoring Data by Catherine A. Hammett-Stabler,Amitava Dasgupta Pdf

Author : Anonim
Publisher : Unknown
Page : 414 pages
File Size : 46,8 Mb
Release : 1982
Category : Chemotherapy
ISBN : UCLA:31158009743732

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Applied Therapeutic Drug Monitoring by Anonim Pdf

Author : Mike Hallworth,Nigel Capps
Publisher : AACC Press
Page : 0 pages
File Size : 52,6 Mb
Release : 1993
Category : Biochemistry
ISBN : 0902429051

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Therapeutic Drug Monitoring and Clinical Biochemistry by Mike Hallworth,Nigel Capps Pdf

This text considers the close inter-relationship of therapeutic drug monitoring and clinical biochemistry. It covers principles of TDM, looking at drug dosage and effect; clinical monitoring and pharmacokinetics; interpretation and response; and near-patient testing. It also includes information on methodology, dosage prediction, drug structure, sampling requirements and target range. The drugs covered include anti-convulsants; aminoglycosides; lithium; anti-arrythmics; xanthines; cyclosporine; methotrexate; and tricyclics. The work also contains case studies.

Author : William Eugene Evans,Michael Oellerich,David W. Holt
Publisher : Abbott Labs
Page : 108 pages
File Size : 42,6 Mb
Release : 1984
Category : Medical
ISBN : 3924805032

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Therapeutic Drug Monitoring Clinical Guide by William Eugene Evans,Michael Oellerich,David W. Holt Pdf

Author : Irving Sunshine
Publisher : CRC Press
Page : 807 pages
File Size : 49,6 Mb
Release : 2023-06-14
Category : Medical
ISBN : 9781000943030

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Recent Developments in Therapeutic Drug Monitoring and Clinical Toxicology by Irving Sunshine Pdf

Papers from the Second International Conference on TDM Toxicology (date and place not stated) describe research on various aspects of therapeutic monitoring pharmacology, selected high-performance liquid chromatographic methods, antiepileptics, substances subject to abuse, inorganics. Over 100 contr

Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 118 pages
File Size : 51,8 Mb
Release : 2014-02-06
Category : Medical
ISBN : 9780309292498

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Improving and Accelerating Therapeutic Development for Nervous System Disorders by Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Author : Michael E. Burton
Publisher : Lippincott Williams & Wilkins
Page : 924 pages
File Size : 54,7 Mb
Release : 2006
Category : Medical
ISBN : 0781744318

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Applied Pharmacokinetics & Pharmacodynamics by Michael E. Burton Pdf

The definitive advanced-level clinical pharmacokinetics text is now in its Fourth Edition, with new emphasis on the relationship between pharmacokinetics and pharmacodynamics. Written by 70 leading researchers and practitioners, this book is a rigorous yet practical text on the application of pharmacokinetic methods, pharmacodynamic principles, and pharmacotherapeutic data for optimal, individualized drug therapy. This edition includes case studies that apply concepts to actual patient problems. New chapters cover tacrolimus, mycophenolic acid, sirolimus, antipsychotics, and critical evaluation of therapeutic drug monitoring methods. Other new features include more drawings and reference tables and an appendix on outcome studies with therapeutic drug monitoring.

Author : Steven H.Y. Wong,Irving Sunshine
Publisher : CRC Press
Page : 367 pages
File Size : 44,7 Mb
Release : 2017-11-22
Category : Medical
ISBN : 9781351364287

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Handbook of Analytical Therapeutic Drug Monitoring and Toxicology (1996) by Steven H.Y. Wong,Irving Sunshine Pdf

Adapting modern advances in analytical techniques to daily laboratory practices challenges many toxicologists, clinical laboratories, and pharmaceutical scientists. The Handbook of Analytical Therapeutic Drug Monitoring and Toxicology helps you keep abreast of the innovative changes that can make your laboratory - and the studies undertaken in it - a success. This volume simplifies your search for appropriate techniques, describes recent contributions from leading investigators, and provides valuable evaluations and advice.

Author : Amitava Dasgupta
Publisher : Springer Science & Business Media
Page : 441 pages
File Size : 54,7 Mb
Release : 2007-10-23
Category : Medical
ISBN : 9781588297808

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Handbook of Drug Monitoring Methods by Amitava Dasgupta Pdf

Written in a handbook style with specific methods and tips on eliminating false positive and false negative results, this book is a practical guide to the detailed mechanisms of such occurrences.

Author : Irving Sunshine
Publisher : Unknown
Page : 0 pages
File Size : 48,8 Mb
Release : 2008
Category : MEDICAL
ISBN : 1003418155

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Recent Developments in Therapeutic Drug Monitoring and Clinical Toxicology by Irving Sunshine Pdf

Papers from the Second International Conference on TDM Toxicology (date and place not stated) describe research on various aspects of therapeutic monitoring pharmacology, selected high-performance liquid chromatographic methods, antiepileptics, substances subject to abuse, inorganics. Over 100 contr