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Author : Curtis L. Meinert
Publisher : Curtis L. Meinert
Page : 490 pages
File Size : 54,7 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015038565050
Explanatory notes - Usage practice, cautions, and recommendations - Glossary of abbreviations and designations - Listing of entries References - Index
Author : Curtis L. Meinert
Publisher : John Wiley & Sons
Page : 449 pages
File Size : 52,9 Mb
Release : 2012-08-15
Category : Reference
ISBN : 9781118315286
A thoroughly updated new edition of the essential reference on the design, practice, and analysis of clinical trials Clinical Trials Dictionary: Terminology and Usage Recommendations, Second Edition presents clear, precise, meticulously detailed entries on all aspects of modern-day clinical trials. Written and compiled by one of the world’s leading clinical trialists, this comprehensive volume incorporates areas of medicine, statistics, epidemiology, computer science, and bioethics—providing a treasure trove of key terms and ideas. This new edition continues to supply readers with the A–Z terminology needed to design, conduct, and analyze trials, introducing a vocabulary for the characterization and description of related features and activities. More than 300 new entries are now included, reflecting the current usage practices and conventions in the field, along with usage notes with recommendations on when to use the term in question. Detailed biographical notes highlight prominent historical figures and institutions in the field, and an extensive bibliography has been updated to provide readers with additional resources for further study. The most up-to-date work of its kind, Clinical Trials Dictionary, Second Edition is an essential reference for anyone who needs to report on, index, analyze, or assess the scientific strength and validity of clinical trials.
Author : Simon Day
Publisher : John Wiley & Sons
Page : 262 pages
File Size : 44,9 Mb
Release : 2007-04-30
Category : Medical
ISBN : 9780470319161
As a result of the expansion in the area of pharmaceutical medicine there is an ever-increasing need for educational resources. The Dictionary of Clinical Trials, Second Edition comprehensively explains the 3000 words and short phrases commonly used when designing, running, analysing and reporting clinical trials. This book is a quick, pocket reference tool to understand the common and less well-used terms within the discipline of clinical trials, and provides an alternative to the textbooks available. Terms are heavily cross-referenced, which helps the reader to understand how terms fit into the broad picture of clinical trials. Wide ranging, brief, pragmatic explanations of clinical trial terminology Scope includes medical, statistical, epidemiological, ethical, regulatory and data management terminology Thoroughly revised and expanded - increase of 280 terms from First Edition, reference to Cochrane included From the reviews of the First Edition: "This invaluable text explains the majority of clinical trial terms, in alphabetical order, that are likely to be found in clinical trial protocols, reports, regulatory guidelines, and published manuscripts... Fully comprehensive - provides definitions of clinical trial terms in one complete volume... Includes extensive use of graphs throughout." LA DOC STI "...covers a range of subject matter, with emphasis on medical, statistical, epidemiological and ethical terms... a useful adjunct to standard clinical trial texts... a reference source to keep within easy reach." TALANTA The Dictionary of Clinical Trials, Second Edition is a ‘must-have’ for all pharmaceutical companies who conduct a lot of clinical trials, in all or one therapeutic area. The book is also of interest for public health and health science workers, and for contract research organisations and departments of medicine, where medics are involved with clinical trials.
Author : Gerhard Nahler
Publisher : Springer Science & Business Media
Page : 186 pages
File Size : 52,7 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9783709140161
This dictionary is aimed primarily at the beginners entering the new discipline of Pharmaceutical Medicine, an area comprising aspects of toxicology, pharmacology, pharmaceutics, epidemiology, statistics, drug regulatory and legal affairs, medicine and marketing. But also more experienced colleagues in departments engaged in clinical development as well as researchers and marketing experts in the pharmaceutical industry will find concise and up-to-date information. The book is completed by a list of a about 1000 abbreviations encountered in pharmaceutical medicine and a compilation of important addresses of national and international health authorities.
Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Strategies for Small-Number-Participant Clinical Research Trials
Publisher : National Academies Press
Page : 222 pages
File Size : 41,7 Mb
Release : 2001-01-01
Category : Medical
ISBN : 0309171148
Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
Author : David R. Hutchinson,Jeffrey Winslade
Publisher : Unknown
Page : 108 pages
File Size : 54,7 Mb
Release : 1998-04-01
Category : Clinical medicine
ISBN : 1874409145
Author : B. S. Everitt
Publisher : Cambridge University Press
Page : 250 pages
File Size : 55,8 Mb
Release : 2006-12-21
Category : Medical
ISBN : 9781139460958
From 'Abcissa' to 'Zygosity determination' - this accessible introduction to the terminology of medical statistics describes more than 1500 terms all clearly explained, illustrated and defined in non-technical language, without any mathematical formulae! With the majority of terms revised and updated and the addition of more than 100 brand new definitions, this new edition will enable medical students to quickly grasp the meaning of any of the statistical terms they encounter when reading the medical literature. Furthermore, annotated comments are used judiciously to warn the unwary of some of the common pitfalls that accompany some cherished biomedical statistical techniques. Wherever possible, the definitions are supplemented with a reference to further reading where the reader may gain a deeper insight, so whilst the definitions are easily disgestible, they also provide a stepping stone to a more sophisticated comprehension. Statistical terminology can be quite bewildering for clinicians: this guide will be a lifesaver.
Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Clinical Research Involving Children
Publisher : National Academies Press
Page : 445 pages
File Size : 48,8 Mb
Release : 2004-07-09
Category : Medical
ISBN : 9780309133388
In recent decades, advances in biomedical research have helped save or lengthen the lives of children around the world. With improved therapies, child and adolescent mortality rates have decreased significantly in the last half century. Despite these advances, pediatricians and others argue that children have not shared equally with adults in biomedical advances. Even though we want children to benefit from the dramatic and accelerating rate of progress in medical care that has been fueled by scientific research, we do not want to place children at risk of being harmed by participating in clinical studies. Ethical Conduct of Clinical Research Involving Children considers the necessities and challenges of this type of research and reviews the ethical and legal standards for conducting it. It also considers problems with the interpretation and application of these standards and conduct, concluding that while children should not be excluded from potentially beneficial clinical studies, some research that is ethically permissible for adults is not acceptable for children, who usually do not have the legal capacity or maturity to make informed decisions about research participation. The book looks at the need for appropriate pediatric expertise at all stages of the design, review, and conduct of a research project to effectively implement policies to protect children. It argues persuasively that a robust system for protecting human research participants in general is a necessary foundation for protecting child research participants in particular.
Author : Curtis L. Meinert
Publisher : John Wiley & Sons
Page : 469 pages
File Size : 54,9 Mb
Release : 2012-10-10
Category : Reference
ISBN : 9781118422793
A systematic approach to all aspects of designing and conducting clinical trials The success or failure of clinical trials hinges on hundreds of details that need to be developed, often under less than ideal conditions. Written by one of the world's leading trialists, Clinical Trials Handbook: Design and Conduct provides clinicians with a complete guide to designing, conducting, and evaluating clinical trials—teaching them how to simplify the process and avoid costly mistakes. The author draws on his extensive clinical trials experience to outline all steps employed in setting up and running clinical trials, from budgeting and fundraising to publishing the results. Along the way, practical advice is offered while also addressing a mix of logistical, ethical, psychological, behavioral, and administrative issues inherent to clinical trials. Topics of coverage include: Protocols for drug masking, controls, and treatment randomization Consent, enrollment, eligibility, and follow-up procedures Different types of sample size design and data collection and processing Working with study centers, research staff, and various committees Monitoring treatment effects and performance, and ensuring quality control Data analysis and access policies for study data and documents Clinical Trials Handbook is invaluable for practicing clinicians and trialists who would like to learn more about or improve their understanding of the design and execution of clinical trials. The book is also an excellent supplement for courses on clinical trials at the graduate level.
Author : Prison de Clichy (Paris, France)
Publisher : Unknown
Page : 128 pages
File Size : 45,5 Mb
Release : 1863
Category : Manuscripts, French
ISBN : OCLC:318649513
(1) requests that Le Petit Journal reprint a letter sent to him from the prison; (2) enclosed copies of letter he sent to Michel Lévy, George Sand and Albert Millaud on behalf of the prison's prospective library. Correspondents: Le Petit Journal and the inmates of the debtors' prison at rue de Clichy.
Author : Institute of Medicine,Roundtable on Research and Development of Drugs, Biologics, and Medical Devices
Publisher : National Academies Press
Page : 88 pages
File Size : 40,7 Mb
Release : 1999-07-27
Category : Medical
ISBN : 9780309172806
In an effort to increase knowledge and understanding of the process of assuring data quality and validity in clinical trials, the IOM hosted a workshop to open a dialogue on the process to identify and discuss issues of mutual concern among industry, regulators, payers, and consumers. The presenters and panelists together developed strategies that could be used to address the issues that were identified. This IOM report of the workshop summarizes the present status and highlights possible strategies for making improvements to the education of interested and affected parties as well as facilitating future planning.
Author : Curtis L. Meinert
Publisher : OUP USA
Page : 702 pages
File Size : 44,9 Mb
Release : 2012-03-27
Category : Medical
ISBN : 9780195387889
The classic, definitive guide to the design, conduct, and analysis of randomized clinical trials.
Author : Lisa Marie Sullivan,Joseph Massaro
Publisher : Wiley-Interscience
Page : 578 pages
File Size : 54,6 Mb
Release : 2008
Category : Biomedical engineering
ISBN : UCLA:L0099757734
Here you'll find more than 500 entries from the world's leading experts in the field on the basic concepts, methodologies, and applications in clinical trials. The range of topics includes: basic statistical concepts, design and analysis of clinical trials, ethics, regulatory issues, and methodologies for clinical data management and analysis
Author : Alain Wan Po Li
Publisher : Radcliffe Publishing
Page : 180 pages
File Size : 54,8 Mb
Release : 1998
Category : Medical
ISBN : 1857753054
Draws on terminology used in biostatistics, epidemiology, health economics, philosophy, ethics, logic and the social sciences.
Author : Carol K. Redmond,Theodore Colton
Publisher : John Wiley & Sons
Page : 530 pages
File Size : 49,9 Mb
Release : 2001-04-25
Category : Medical
ISBN : 0471822116
The second volume in the Wiley reference series in Biostatistics. Featuring articles from the prestigious Encyclopedia of Biostatistics, many of which have been fully revised and updated to include recent developments, Biostatistics in Clinical Trials also includes up to 25% newly commissioned material reflecting the latest thinking in: Bayesian methods Benefit/risk assessment Cost-effectiveness Ethics Fraud With exceptional contributions from leading experts in academia, government and industry, Biostatistics in Clinical Trials has been designed to complement existing texts by providing extensive, up-to-date coverage and introducing the reader to the research literature. Offering comprehensive coverage of all aspects of clinical trials Biostatistics in Clinical Trials: Includes concise definitions and introductions to numerous concepts found in current literature Discusses the software and textbooks available Uses extensive cross-references helping to facilitate further research and enabling the reader to locate definitions and related concepts Biostatistics in Clinical Trials offers both academics and practitioners from various disciplines and settings, such as universities, the pharmaceutical industry and clinical research organisations, up-to-date information as well as references to assist professionals involved in the design and conduct of clinical trials.