Clinical Trials In Psychiatry

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Clinical Trials in Psychiatry

Brian S. Everitt,Simon Wessely
Clinical Trials in Psychiatry Book PDF

Author : Brian S. Everitt,Simon Wessely
Publisher : John Wiley & Sons
Page : 248 pages
File Size : 42,8 Mb
Release : 2008-04-15
Category : Medical
ISBN : 047072384X

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Clinical Trials in Psychiatry by Brian S. Everitt,Simon Wessely Pdf

At last – a new edition of the highly acclaimed book Clinical Trials in Psychiatry This book provides a concise but thorough overview of clinical trials in psychiatry, invaluable to those seeking solutions to numerous problems relating to design, methodology and analysis of such trials. Practical examples and applications are used to ground theory whenever possible. The Second Edition includes new information regarding: Recent important psychiatric trials More specific discussion of psychiatry in the USA and the particular problems of trials in the USA, including comments about the FDA (U.S. Food and Drug Administration) An extended chapter on meta-analysis Further discussion of sub-group analysis Special features include appendices outlining how to design and report clinical trials, what websites and software programs are appropriate and an extensive reference section. From the reviews of the First Edition: “Everitt & Wessely are to be congratulated on producing an excellent guide to help overcome the snags in clinical trial research. Clearly written and in an engrossing style, the book is likely to become a classic textbook on clinical trials, and not just in psychiatry. The authors’ enthusiasm and grasp of clinical trial research make for a gripping and insightful read...it is one of the very best books that has been written on clinical trials.” THE BRITISH JOURNAL OF PSYCHIATRY "The experience of both authors in this area gives the book a very pragmatic approach grounded in reality, with theoretical overviews invariably being followed by practical examples and applications... an invaluable companion to anyone involved in, or contemplating undertaking, clinical trials research.” PSYCHOLOGICAL MEDICINE

Clinical Trials in Psychiatry

Brian Everitt,Simon Wessely
Clinical Trials in Psychiatry Book PDF

Author : Brian Everitt,Simon Wessely
Publisher : Unknown
Page : 0 pages
File Size : 55,7 Mb
Release : 2023
Category : Clinical trials
ISBN : 1383024421

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Clinical Trials in Psychiatry by Brian Everitt,Simon Wessely Pdf

'Clinical Trials in Psychiatry' explains RCTs for mental health professionals. It starts by discussing why we need trials and why they are the best way of deciding if a treatment works. It then describes the different types of trial, how to analyze the results, and how to conduct a trial.

50 Studies Every Psychiatrist Should Know

Ish P. Bhalla,Rajesh R. Tampi,Vinod H. Srihari
50 Studies Every Psychiatrist Should Know Book PDF

Author : Ish P. Bhalla,Rajesh R. Tampi,Vinod H. Srihari
Publisher : Oxford University Press
Page : 377 pages
File Size : 49,6 Mb
Release : 2018
Category : Medical
ISBN : 9780190625085

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50 Studies Every Psychiatrist Should Know by Ish P. Bhalla,Rajesh R. Tampi,Vinod H. Srihari Pdf

50 Studies Every Psychiatrist Should Know presents key studies that have shaped the practice of psychiatry. Selected using a rigorous methodology, the studies cover topics including: psychotic disorders, depressive disorders, women's mental health, child and adolescent disorders, and epidemiological studies. For each study, a concise summary is presented with an emphasis on the results and limitations of the study, and its implications for practice. An illustrative clinical case concludes each review, followed by brief information on other relevant studies. This book is a must-read for health care professionals and anyone who wants to learn more about the data behind clinical practice.

Neuroscience Trials of the Future

National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Neuroscience Trials of the Future Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 111 pages
File Size : 40,9 Mb
Release : 2016-11-07
Category : Medical
ISBN : 9780309442589

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Neuroscience Trials of the Future by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

On March 3-4, 2016, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop in Washington, DC, bringing together key stakeholders to discuss opportunities for improving the integrity, efficiency, and validity of clinical trials for nervous system disorders. Participants in the workshop represented a range of diverse perspectives, including individuals not normally associated with traditional clinical trials. The purpose of this workshop was to generate discussion about not only what is feasible now, but what may be possible with the implementation of cutting-edge technologies in the future.

Landmark Papers in Psychiatry

Elizabeth Ryznar,Aderonke B. Pederson,John G. Csernansky,Mark A. Reinecke
Landmark Papers in Psychiatry Book PDF

Author : Elizabeth Ryznar,Aderonke B. Pederson,John G. Csernansky,Mark A. Reinecke
Publisher : Oxford University Press, USA
Page : 449 pages
File Size : 41,6 Mb
Release : 2020-01-23
Category : Medical
ISBN : 9780198836506

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Landmark Papers in Psychiatry by Elizabeth Ryznar,Aderonke B. Pederson,John G. Csernansky,Mark A. Reinecke Pdf

Advances in the practice of psychiatry have occurred in "fits and starts" over the last several decades. These advances are evident to anyone long affiliated with the field and are best appreciated through direct experience of living through the times. These advances can also be gleaned from historical overviews in textbooks or the recollections of one's teachers and mentors. Returning to the original papers that have ushered in these changes is rarely done for various, mostly practical, reasons. Filtering through thousands of articles in psychiatry may prove daunting, access to the manuscripts may be limited (especially for papers not available electronically), and understanding their impact requires a broader context. Moreover, with so much active research currently occurring in various branches of psychiatry, current practitioners or trainees may find their attention focused on the present, and this is reinforced by electronic search algorithms, which return articles in reverse chronological order. Not surprisingly, citations for articles in virtually all fields decline precipitously for articles over five years old. As scholars and professionals, we are losing touch with our academic heritage. Yet navigating the future of psychiatry requires a firm understanding of its past. This resource serves as a guide for anyone seeking to understand the evolution of psychiatry as a scientific discipline. It does so by summarizing over 100 landmark papers in psychiatry and placing their scientific contributions within a historical context. An introductory section sets the stage for the major theoretical constructs within the field, with chapters devoted to ontology and nosology. Subsequent sections examine major facets of the theory and practice of psychiatry, such as pathogenesis of psychiatric illness, pharmacotherapy, psychotherapy, and somatic treatments. These sections are divided logically into chapters addressing important contributions to the understanding and treatment of specific disorders. A final section explores ethical considerations within each field. This framework echoes the complexity of psychiatry, which cannot be reduced to a single set of diagnoses or subspecialty categories. Highlighting the research trajectory of psychiatry, this resource will appeal to academics, trainees, and practitioners who desire a comprehensive, easy-to-read, up-to-date collection of psychiatry's pivotal moments. By understanding the challenges, inspirations, and insights from the past, readers will be better poised to address new and ongoing challenges within the field.

Global Mental Health Trials

Graham Thornicroft,Vikram Patel
Global Mental Health Trials Book PDF

Author : Graham Thornicroft,Vikram Patel
Publisher : OUP Oxford
Page : 320 pages
File Size : 42,8 Mb
Release : 2014-06-19
Category : Medical
ISBN : 9780191501647

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Global Mental Health Trials by Graham Thornicroft,Vikram Patel Pdf

Global mental health is a dynamic field of global health; a core aspect of the story which has led to its emergence has been the conduct of randomised controlled trials (RCTs) evaluating innovative delivery systems of packages of care for mental disorders in low-resource settings. Global Mental Health Trials brings together many of the world's leading researchers active in the fields of RCTs in low- and medium-resource countries and settings related to improving mental health care. It presents clear and practical information about how to conduct such trials in these settings, along with critical methodological and ethical issues related to such trials, learning from the positive and negative experiences of expert scientists in many countries worldwide who have completed such trials. This book serves as a valuable resource for practitioners in mental health - psychiatrists, psychiatric nurses nursing, psychologists, social workers, and occupational therapists - as well as researchers in the areas of psycho-social treatments in mental health, mental health services research, and programme and systems evaluation.

Transforming Clinical Research in the United States

Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
Transforming Clinical Research in the United States Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
Publisher : National Academies Press
Page : 151 pages
File Size : 41,7 Mb
Release : 2010-10-22
Category : Medical
ISBN : 9780309163354

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Transforming Clinical Research in the United States by Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation Pdf

An ideal health care system relies on efficiently generating timely, accurate evidence to deliver on its promise of diminishing the divide between clinical practice and research. There are growing indications, however, that the current health care system and the clinical research that guides medical decisions in the United States falls far short of this vision. The process of generating medical evidence through clinical trials in the United States is expensive and lengthy, includes a number of regulatory hurdles, and is based on a limited infrastructure. The link between clinical research and medical progress is also frequently misunderstood or unsupported by both patients and providers. The focus of clinical research changes as diseases emerge and new treatments create cures for old conditions. As diseases evolve, the ultimate goal remains to speed new and improved medical treatments to patients throughout the world. To keep pace with rapidly changing health care demands, clinical research resources need to be organized and on hand to address the numerous health care questions that continually emerge. Improving the overall capacity of the clinical research enterprise will depend on ensuring that there is an adequate infrastructure in place to support the investigators who conduct research, the patients with real diseases who volunteer to participate in experimental research, and the institutions that organize and carry out the trials. To address these issues and better understand the current state of clinical research in the United States, the Institute of Medicine's (IOM) Forum on Drug Discovery, Development, and Translation held a 2-day workshop entitled Transforming Clinical Research in the United States. The workshop, summarized in this volume, laid the foundation for a broader initiative of the Forum addressing different aspects of clinical research. Future Forum plans include further examining regulatory, administrative, and structural barriers to the effective conduct of clinical research; developing a vision for a stable, continuously funded clinical research infrastructure in the United States; and considering strategies and collaborative activities to facilitate more robust public engagement in the clinical research enterprise.

Clinical Trials in Psychopharmacology

Marc Hertzman,Lawrence Adler
Clinical Trials in Psychopharmacology Book PDF

Author : Marc Hertzman,Lawrence Adler
Publisher : John Wiley & Sons
Page : 406 pages
File Size : 45,8 Mb
Release : 2010-03-16
Category : Medical
ISBN : 0470749172

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Clinical Trials in Psychopharmacology by Marc Hertzman,Lawrence Adler Pdf

Although clinical trials were virtually unheard of in psychiatry for many years, they are now the gold standard for judging whether drugs are safe and useful. But should they be? What is the true status of clinical trials? Even when they ostensibly demonstrate a benefit of a certain treatment, the strict patient selection criteria, poor compliance and high drop-out rate leave the conclusions open to question. Are the new treatments really better or more cost-effective than the old? Do they have fewer side effects? In this book the authors take a critical look at recent developments and present a series of trenchant and challenging observations. Section I examines the significant changes in law and the regulatory environment that have occurred during the past ten years. Has fossilization handicapped the US Food and Drug Administration in promoting treatment advances? How can the plethora of findings be regulated? This is particularly pertinent in genomic studies and there are two chapters addressing the impact of genomics on psychiatric research. This section also addresses the role of women in drug trials – a group long excluded but now demanding a part, for without testing how can optimal treatments be devised? The next two Sections highlight clinical trials in the major areas of psychiatric pharmacological treatment, including Mood Disorders, especially Bipolar, Anxiety Disorders, and addictions. Chapters on pharmacological treatments for Eating Disorders, Attention Deficit Disorder, Autism and Asperger’s Syndrome, and Impulse Control Disorder represent the latest thinking on these subjects. The final Section contains a consummate example of out-of-the [Western]- box thinking, namely consideration of herbal medicines – used by a large number of patients, with or without medical supervision. We conclude with a close look at the problem of side effects, then selected thoughts about methodology. Clearly written, the text provides immediate access to new developments across the spectrum of drug testing. Clinical Trials in Psychopharmacology: A Better Brain is provocative reading for psychiatrists, pharmacologists and all those interested in improved drug treatments for patients with mental illness. Raises questions about the conduct of trials and the credibility of their outcomes that are relevant not just in psychiatry but all areas of medicine Discusses the ethical problems in assessing outcomes in humans, including children

Clinical Trials of Antidepressants

Martin M. Katz
Clinical Trials of Antidepressants Book PDF

Author : Martin M. Katz
Publisher : Springer
Page : 66 pages
File Size : 54,5 Mb
Release : 2016-02-08
Category : Psychology
ISBN : 9783319264646

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Clinical Trials of Antidepressants by Martin M. Katz Pdf

This brief guide takes current clinical trial protocols to task and replaces them with a contemporary framework for improving next-generation antidepressants and their underlying science. Innovative models are based on a nuanced, neurologically-informed understanding of drug mechanisms and the component cognitive, mood, and behavioral aspects of depression. The book reconceptualizes not only the clinical trial process but the clinical concept of depression itself as essential to bringing pharmaceutical research and development up to date, boosting efficiency and effectiveness, finding new molecules, and reducing waste. Case studies and a review of salient depression scales illustrate the potential benefits of such wide-scale change. Included in the coverage: Why now the need for a new clinical trials model for antidepressants? Aims and basic requirements of clinical trials: conventional and component-specific models. Methods for measuring the components and the profile of drug actions: the multivantaged approach. Achieving the ideal clinical trial: an example of the merged componential and established models. Prediction and shortening the clinical trial. The video clinical trial. Clinical Trials of Antidepressants will interest a varied audience, including clinical investigators, academic and pharmaceutical company scientists, clinical trial organizations, psychiatrists, outpatient physicians, psychotherapists, clinical psychologists, psychology graduate students, medical students, and government agencies such as the FDA.

Elements of Clinical Research in Psychiatry

James E. Mitchell,Ross D. Crosby,Stephen A. Wonderlich,David E. Adson
Elements of Clinical Research in Psychiatry Book PDF

Author : James E. Mitchell,Ross D. Crosby,Stephen A. Wonderlich,David E. Adson
Publisher : American Psychiatric Pub
Page : 219 pages
File Size : 45,8 Mb
Release : 2008-11-01
Category : Medical
ISBN : 9781585628261

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Elements of Clinical Research in Psychiatry by James E. Mitchell,Ross D. Crosby,Stephen A. Wonderlich,David E. Adson Pdf

Clinical research is often thought of as a dry and somewhat arcane pursuit. Not so, assert the editors of Elements of Clinical Research in Psychiatry. The editors, all actively engaged in clinical research, bring this topic to life by combining a boundless enthusiasm for their chosen field with a depth of knowledge rarely seen in the literature. They show that clinical research can be rewarding not only because the research results contribute to improving the welfare of psychiatric patients, but also because the research process itself is exciting. Arguably the definitive guidebook on clinical psychiatric research, this volume discusses Careers in clinical mental health research -- Describes what clinical psychiatric researchers do and how to get started on this career path. Research design, measurement, and assessment -- Covers all aspects of research design, defines and evaluates measurement types, and details various assessment methods (from interviews and questionnaires to lab tests and brain images). Descriptive and inferential statistics -- Shows how statistics are used to analyze and summarize measurement data. Research support -- Provides a roadmap for those seeking research support in the U.S. (more than 90% is funded via NIH), detailing how to write grants from the ground up. Use of human subjects (the Institutional Review Board [IRB]) and ethics and misconduct -- Demystifies the often intimidating process of seeking and receiving IRB approval, with tips on how to work with the IRB and complete its consent forms; uses a series of practical scenarios, including a highly publicized case of alleged misconduct, to illustrate complex ethics and misconduct issues. Writing journal articles, reviewing manuscripts, and giving scientific presentations -- Presents the nuts and bolts of publishing journal articles; gives step-by-step advice for reviewing manuscripts and giving oral presentations, symposia, poster sessions, and colloquia. Carefully chosen appendixes provide readers with additional information they can use right away, augmented by an index and detailed reference list for further investigation. Anyone considering clinical psychiatric research as a career option will find in this succinct and eminently practical volume the single source they need. Practicing psychiatrists interested in specific areas of clinical research, such as human subject use or biomedical ethics, will also find much of interest here. Replete with useful information, these stimulating discussions provide the building blocks for embarking upon -- and enhancing -- a successful career in clinical psychiatric research.

Research Methods in Psychiatry

Chris Freeman,Peter J. Tyrer,Peter Tyrer
Research Methods in Psychiatry Book PDF

Author : Chris Freeman,Peter J. Tyrer,Peter Tyrer
Publisher : RCPsych Publications
Page : 366 pages
File Size : 46,6 Mb
Release : 2006-12
Category : Medical
ISBN : 1904671330

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Research Methods in Psychiatry by Chris Freeman,Peter J. Tyrer,Peter Tyrer Pdf

This updated comprehensive guide to psychiatric research methods takes the reader from getting started in research through to publishing a paper, with advice on avoiding common pitfalls along the way. Systematic analysis and meta-analysis, epidemiology, qualitative research, and research focused on a few patients are discussed, together with the principles of validity and reliability in the assessment of psychological variables and statistical aspects of the design and analysis of clinical trials. Five completely new chapters cover topics such as research from the trainee's perspective and research in learning disability and child and adolescent psychiatry. A key text for psychiatric trainees embarking on research projects, this book will also be useful to psychiatrists supervising research projects, and those in the social sciences with an interest in carrying out research or critically reviewing the published evidence. Topics covered include setting up a research project, how to make a comprehensive review of the literature, choosing a rating scale, and getting research published.

Choosing Methods in Mental Health Research

Mike Slade,Stefan Priebe
Choosing Methods in Mental Health Research Book PDF

Author : Mike Slade,Stefan Priebe
Publisher : Routledge
Page : 548 pages
File Size : 42,7 Mb
Release : 2007-01-24
Category : Psychology
ISBN : 9781135446680

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Choosing Methods in Mental Health Research by Mike Slade,Stefan Priebe Pdf

Choosing Methods in Mental Health Research develops a new framework for mental health research. It is concerned with how to choose the most appropriate mental health research method, not only to address a specific question, but to maximize the potential impact on shaping mental health care. Mike Slade and Stefan Priebe focus attention on the types of audience that the researcher is seeking to influence, the types of evidence each audience accepts as valid, and the relative strengths and limitations of each type of methodology. A range of research methodologies are described and critically appraised, and the use of evidence by different groups is discussed. This produces some important findings about the interplay between research production and consumption, and highlights directions for future mental health research theory and practice. The findings presented here will be relevant to mental health service users and professionals who use research evidence to inform decision-making. It will also prove an invaluable resource for students and researchers in the field of mental health.

Clinical Trial Design Challenges in Mood Disorders

Mauricio Tohen,Charles Bowden,Andrew A. Nierenberg,John Geddes
Clinical Trial Design Challenges in Mood Disorders Book PDF

Author : Mauricio Tohen,Charles Bowden,Andrew A. Nierenberg,John Geddes
Publisher : Academic Press
Page : 192 pages
File Size : 42,6 Mb
Release : 2015-01-24
Category : Medical
ISBN : 9780124051768

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Clinical Trial Design Challenges in Mood Disorders by Mauricio Tohen,Charles Bowden,Andrew A. Nierenberg,John Geddes Pdf

Poor clinical trial designs result in failed studies wasting research funds and limiting the advancement of cures for disorders. Clinical Trial Design Challenges in Mood Disorders outlines classic problems researchers face in designing clinical trials and discusses how best to address them for the most definitive and generalizable results. Traditional trial designs are included as well as novel analytic techniques. The book examines information on high placebo response, the generalizability of studies conducted in the developing world, the duration of maintenance studies, and the application of findings into clinical practice. With representation from contributors throughout the world and from academia, industry, regulatory agencies, and advocacy groups, this book will contribute toward improved clinical trial design and valid, precise, and reliable answers about what works better and faster for patients. Summarizes common trial design problems and their solutions Encompasses funding, subject selection, regulatory issues and more Identifies best practices for definitive and generalizable results Includes traditional trial designs and novel analytic techniques Represents academia, industry, regulatory agencies, and advocacy groups

Research in Psychiatry

L.K. George Hsu,Michel Hersen
Research in Psychiatry Book PDF

Author : L.K. George Hsu,Michel Hersen
Publisher : Springer Science & Business Media
Page : 486 pages
File Size : 53,9 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781489906885

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Research in Psychiatry by L.K. George Hsu,Michel Hersen Pdf

This multiauthored textbook is directed to the psychiatric resident and other professionals who are interested in the issues, strategies, and methods of psychiatric research. Although the field of psychiatry has not attained the scientific rigor and clinical sophistication of some of its sister disciplines in the medical arena, considerable progress has been made in the last decade or two, and a full understanding of the types of articles that now appear in such publications as the American Journal of Psychiatry, the Archives of General Psychi atry, and the Journal of the American Academy of Child and Adolescent Psychiatry requires a fair amount of knowledge about research design and strategy. Whereas articles in psychiatric journals 20 years ago dealt mainly with psycho dynamic topics and utilized nonexperimental observations, today their counter parts are concerned mostly with psychobiology, clinical features, diagnosis, and treatment, and employ scientific experimental designs. The trend of applying scientific methodology to research in psychiatry is increasing and undoubtedly will continue to do so in the future.

50 Studies Every Psychiatrist Should Know

Ish P. Bhalla,Rajesh R. Tampi,Vinod H. Srihari
50 Studies Every Psychiatrist Should Know Book PDF

Author : Ish P. Bhalla,Rajesh R. Tampi,Vinod H. Srihari
Publisher : Unknown
Page : 128 pages
File Size : 47,5 Mb
Release : 2018
Category : Psychiatry
ISBN : 0190625112

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50 Studies Every Psychiatrist Should Know by Ish P. Bhalla,Rajesh R. Tampi,Vinod H. Srihari Pdf

'50 Studies Every Psychiatrist Should Know' presents key studies that have shaped the clinical practice of psychiatry. Selected using a rigorous methodology, the studies cover a broad range of topics including anxiety disorders, bipolar disorder, major depressive disorder, schizophrenia, women's mental health, child and adolescent disorders, obsessive compulsive disorder, personality disorders, psychiatry in primary care, cognitive disorders, and epidemiological studies with an emphasis on clinical trials. For each study, a concise summary is presented with an emphasis on the results and limitations of the study and its implications for practice.