Clinical Trials In Rheumatology

Author : David M. Reid,Colin G. Miller
Publisher : Springer Science & Business Media
Page : 323 pages
File Size : 50,8 Mb
Release : 2008-03-20
Category : Medical
ISBN : 9781846287428

Get Book

Clinical Trials in Rheumatoid Arthritis and Osteoarthritis by David M. Reid,Colin G. Miller Pdf

Designed to be a practical handbook on clinical trial management in these key therapeutic areas, 'Clinical Trials in Rheumatoid Arthritis and Osteoarthritis' is aimed at principal investigators pharmaceutical physicians and other pharmaceutical staff involved in the design, conduct and monitoring of these increasingly complex diseases. In the last several years a new classes of biologic agents have emerged and changed the treatment paradigm for patients, not only with classically defined rheumatoid arthritis, but also with other related diseases such as ankylosing spondylitis and psoriatic arthritis. Furthermore, osteoarthritis is a major disease state that is often treated by the rheumatologist, but is one where patient management programs are currently limited with a need for new therapeutic approaches. In both inflammatory and non-inflammatory arthritic conditions, clinical trials have become both large and complex due to the nature of the diseases, with ever-challenging new surrogate end-points being employed. Topics covered in this title will therefore include study design, clinical endpoints, technical issues, data collection, use of centralized medical image reading facilities and biochemical marker laboratories, as well as data analysis and future therapies. This book takes the user through the process step-by-step from start to finish, also providing a background on the regulatory guidelines, ethical implications, endpoints, and current therapies.

Author : Ruediger Mueller,Johannes von Kempis
Publisher : Springer Science & Business Media
Page : 765 pages
File Size : 40,5 Mb
Release : 2010-12-01
Category : Medical
ISBN : 9781849963848

Get Book

Clinical Trials in Rheumatology by Ruediger Mueller,Johannes von Kempis Pdf

A huge number of therapeutic studies has been published in rheumatology and clinical immunology. This number grows substantially by the year. As such, it becomes increasingly difficult to keep track of this multitude of studies and the ensuing therapeutic trends. Further to this, a particular study can be referred to in a variety of ways, either as a shortened version of the title or an acronym, adding to the confusion. The book Clinical Trials in Rheumatology provides a summary of the important studies in the field for easy reference. Every study is shown with name, acronym (if in existence), authors, complete citation, study design, results, and summary. An acronym finder is supplied at the beginning of the book. This book is a valuable reference tool for rheumatologists and other clinical specialties, as well as for research scientists interested in immunomodulatory and selected other drug therapies in rheumatologic diseases.

Author : Hasan Yazici,Yusuf Yazici,Emmanuel Lesaffre
Publisher : Springer
Page : 285 pages
File Size : 49,7 Mb
Release : 2014-10-29
Category : Medical
ISBN : 9783319083742

Get Book

Understanding Evidence-Based Rheumatology by Hasan Yazici,Yusuf Yazici,Emmanuel Lesaffre Pdf

It is imperative that health professionals caring for patients with rheumatic diseases understand how to correctly interpret evidence in their field, taking into account the merits and shortcomings of available data. Understanding Evidence-Based Rheumatology offers a practical assessment of criteria, drugs, trials, and registries and provides useful tools for successfully interpreting this data. The book introduces readers to basic analysis of trial design, statistics and application of data through no-nonsense, easy-to-follow insights. Using numerous examples, chapters outline the difficulties physicians encounter when measuring disease activity in rheumatology and offer strategies for systematically approaching these situations. Ethical issues in study design and reporting are examined and the book closes with a summary of future directions for scientific and clinical studies in rheumatology. Understanding Evidence-Based Rheumatology is an invaluable resource for trainees, clinicians and scientists, preparing them with the necessary tools to correctly gather evidence and shed light on the difficult practice of rheumatology.

Author : Daniel J. Wallace,Swamy Venuturupalli
Publisher : Elsevier Health Sciences
Page : 128 pages
File Size : 50,8 Mb
Release : 2018-11-21
Category : Medical
ISBN : 9780323655415

Get Book

Best Practices and Challenges to the Practice of Rheumatology, An Issue of Rheumatic Disease Clinics of North America by Daniel J. Wallace,Swamy Venuturupalli Pdf

Guest edited by Drs. Daniel J. Wallace and R. Swamy Venuturupalli, this issue of Rheumatic Disease Clinics will cover several key areas of interest related to Best Practices and Challenges to the Practice of Rheumatology. This issue is one of four selected each year by our series Consulting Editor, Dr. Michael Weisman of Cedars-Sinai. Articles in this issue include, but are not limited to: The Economics of Rheumatology Practice in the United States, Manpower trends in rheumatology, Challenges to practicing rheumatology in an academic center, Challenges in practicing rheumatology in a government setting, Challenges to practicing rheumatology in a small private practice setting, Challenges to working in a large multispecialty organization, Challenges to practicing pediatric rheumatology, Clinical trials in rheumatology, Challenges in having an infusion center, Implementing treatment to target in the clinic, Future directions: implementing new technologies in clinical practice, Possible Challenges in Optimizing Medical Education for Rheumatologists, and the challenges of approaching and managing gout.

Author : David Rosenbloom
Publisher : Greenwood
Page : 408 pages
File Size : 47,6 Mb
Release : 1985
Category : Medical
ISBN : UOM:39015007132353

Get Book

Clinical Trials in the Rheumatic Diseases by David Rosenbloom Pdf

Author : David G. I. Scott,Richard A. Watts
Publisher : Landmark Papers in
Page : 379 pages
File Size : 49,8 Mb
Release : 2015
Category : Medical
ISBN : 9780199688371

Get Book

Landmark Papers in Rheumatology by David G. I. Scott,Richard A. Watts Pdf

There have been major developments in our understanding of the causes of rheumatic disease and in their treatment during the last half-century. This book provides a detailed review of the seminal papers that have paved the way for breakthroughs in the clinical management of the entire spectrum of rheumatic disease.

Author : Jason Liebowitz,Philip Seo
Publisher : CRC Press
Page : 434 pages
File Size : 51,8 Mb
Release : 2022-10-04
Category : Medical
ISBN : 9781000684766

Get Book

Clinical Innovation in Rheumatology by Jason Liebowitz,Philip Seo Pdf

Tremendous advances have been made in the field of rheumatology, profoundly changing our understanding of many rheumatologic conditions and creating a new frontier for effective treatments. This book explains the most significant advances in research and care and speculates as to what will be the future of rheumatology over the next several decades, including challenges and lessons learned from past experiences in the field. It highlights landmark research articles and scientific discoveries, discusses how big data, personalized medicine, new biomarkers for disease, and other technological revolutions will shape the future, making it a must-have resource for physicians from all regions of the world. Key Features • Includes concise yet thorough description of the landmark studies and scientific breakthroughs coupled with easy-to-follow organizational structure of chapters that are accessible to readers at different levels of training. • Brings together world-leading experts to provide a fresh perspective to trainees such as residents and fellows-in-training, as well as more senior clinicians and researchers across the field of rheumatology and in specialties such as cardiology, dermatology, pulmonology, nephrology, and neurology, all of whom care for patients with rheumatologic conditions. • Allows the authors to imagine and speculate about the evolution of the field of rheumatology in the coming decades. Examples of such speculative possibilities include use of synovial biopsy to predict response to treatment in rheumatoid arthritis, replacement of renal biopsy with urinary proteomics in diagnosing and classifying lupus nephritis, use of new therapeutics to obviate the need for steroids in the treatment of ANCA-associated vasculitis, and the use of machine learning to evaluate subtle changes in imaging for management of inflammatory arthritis.

Author : George C. Tsokos,Larry W. Moreland,Gary M. Kammer,Jean-Pierre Pelletier,Johanne Martel-Pelletier
Publisher : Springer Science & Business Media
Page : 648 pages
File Size : 54,6 Mb
Release : 2001-11-08
Category : Medical
ISBN : 9781592592395

Get Book

Modern Therapeutics in Rheumatic Diseases by George C. Tsokos,Larry W. Moreland,Gary M. Kammer,Jean-Pierre Pelletier,Johanne Martel-Pelletier Pdf

Leading clinicians and clinical researchers discuss in practical detail the newest treatments used in rheumatic diseases, emphasizing-without neglecting current standard treatments-those experimental therapies now undergoing clinical trials and poised for early introduction into the rheumatology armamentarium. The diseases and therapeutic regimes examined here range from rheumatoid arthritis and its treatment by gene therapy, to osteoarthritis and systemic autoimune diseases. Each chapter is organized so that the busy clinician can quickly obtain all the information needed optimal patient treatment. This includes an analysis of the pathogenic mechanisms that explain the molecular basis of the newer therapeutics, reviews of animal data and the results of clinical trials, and recommendations concerning use, side effects, and precautions.

Author : Jack Cush,Kathryn H. Dao
Publisher : Elsevier Health Sciences
Page : 240 pages
File Size : 52,9 Mb
Release : 2012-11-15
Category : Medical
ISBN : 9781455750597

Get Book

Drug Safety: Managing Innovation in Rheumatology, An Issue of Rheumatic Disease Clinics by Jack Cush,Kathryn H. Dao Pdf

Edited by Drs. Jack Cush and Kathryn Dao, this issue of Rheumatic Disease Clinics of North America addresses one of the most significant issues facing the rheumatologist today––drug safety in a changing world where rheumatoid arthritis (RA) severity is less, patients are being identified and treated at a very early stage, and prevention is on the horizon. Topics covered include: communicating the risk of side effects, urate-lowering therapies, biphosphonates, biologics, malignancy risks, and administering therapies to patients with co-morbidities.

Author : Zahi Touma,Alfred Kim
Publisher : Elsevier Health Sciences
Page : 257 pages
File Size : 45,6 Mb
Release : 2021-07-06
Category : Medical
ISBN : 9780323835572

Get Book

Lupus, An Issue of Rheumatic Disease Clinics of North America, E-Book by Zahi Touma,Alfred Kim Pdf

This issue of Rheumatic Disease Clinics, guest edited by Dr. Alfred Kim and Zahi Touma, will discuss a number of key topics surrounding Lupus. This issue is one of four selected each year by series Consulting Editor, Dr. Michael Weisman. Topics discussed in this issue include, but are not limited to: Interferons in SLE, NETosis and neutrophils in SLE, AMP update in lupus nephritis, Patient-reported outcomes, Complement, T cells in SLE, B cells in SLE, Outcome measures for SLE clinical trials, Mitochondrial physiology in SLE, Pregnancy, Lupus cohorts, Innovative trials and new opportunities in SLE, Classification and diagnosis of SLE, and Updates on SLE Treatment.

Author : Henry Scammell,Thomas McPherson Brown
Publisher : M Evans & Company
Page : 276 pages
File Size : 50,5 Mb
Release : 1993-01
Category : Health & Fitness
ISBN : 0871316900

Get Book

The Arthritis Breakthrough by Henry Scammell,Thomas McPherson Brown Pdf

The most important news in half a century. DSThe Midwest Book Review

Author : Paul-Peter Tak
Publisher : Springer Science & Business Media
Page : 233 pages
File Size : 41,5 Mb
Release : 2009-05-14
Category : Medical
ISBN : 9783764382384

Get Book

New Therapeutic Targets in Rheumatoid Arthritis by Paul-Peter Tak Pdf

This volume focuses on therapeutic targets that were identified after TNF blockade. All these targets have recently been registered or are currently under development for the treatment of rheumatoid arthritis. Each chapter explores the biological rationale of a distinct therapeutic target in great detail. Readers will discover the latest in vitro work, animal models, and results from clinical trials.

Author : Michael H. Weisman
Publisher : Elsevier Health Sciences
Page : 503 pages
File Size : 45,5 Mb
Release : 2010-01-01
Category : Medical
ISBN : 9781416099932

Get Book

Targeted Treatment of the Rheumatic Diseases by Michael H. Weisman Pdf

Michael H. Weisman, Michael Weinblatt, James S Louie, and Ronald Van Vollenhoven offer their unique insights into choosing the correct pharmacological and non-pharmacological therapies for your patients. Chapters cover the full breadth of rheumatic diseases, rheumatoid arthritis, lupus, connective tissue diseases, osteoporosis, regional pain disorders, and fibromyalgia. The full-color design presents detailed clinical photographs and treatment algorithms for visual guidance and easy reference. Covers the treatment of pediatric patients as well as adults so that you can properly address the particular needs of any patient you see. Features the guidance and specific recommendations of experts from United States and Europe for a state-of-the-art approach to the variety of treatments currently in use. Displays the clinical manifestations of rheumatic diseases in full color, along with treatment algorithms for easy at-a-glance reference.

Author : Jennifer L. Barton,Patti Katz
Publisher : Elsevier Health Sciences
Page : 225 pages
File Size : 50,5 Mb
Release : 2016-05-27
Category : Medical
ISBN : 9780323445245

Get Book

Patient Reported Outcomes in Rheumatic Diseases, An Issue of Rheumatic Disease Clinics of North America, E-Book by Jennifer L. Barton,Patti Katz Pdf

This issue is devoted to patient reported outcomes and their impact in the study of rheumatic diseases and the authors will also discuss PROs and vulnerable populations with rheumatic disease; technology, electronic health records and PROs: past, present and future; the promise of PROMIS – a uniform approach to PROs across rheumatic diseases, quality measures and PROs and how they relate and the importance of PROs in delivering quality care in the rheumatic diseases, and many more exciting articles.

Author : Marc C. Hochberg,Alan J. Silman,Josef S. Smolen,Michael E. Weinblatt,Michael H. Weisman
Publisher : Elsevier Health Sciences
Page : 2047 pages
File Size : 42,6 Mb
Release : 2014-06-16
Category : Medical
ISBN : 9780702063039

Get Book

Rheumatology E-Book by Marc C. Hochberg,Alan J. Silman,Josef S. Smolen,Michael E. Weinblatt,Michael H. Weisman Pdf

Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg’s Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner. Track disease progression and treat patients more effectively with the information on genetic findings, imaging outcomes, cell and biologic therapies, rheumatoid arthritis, and SLE. Incorporate recent findings about pathogenesis of disease; imaging outcomes for specific diseases like RA, osteoarthritis, and spondyloarthropathies; cell and biologic therapies; and other timely topics. Remain up to date on the latest information in rheumatology through 13 brand-new chapters covering biomedical and translation science, disease and outcome assessment, new imaging modalities, early emerging disease, clinical therapeutics, patient management, and rehabilitation. Take advantage of expanded coverage of small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies. Focus on the core knowledge needed for successful results with each chapter co-authored by an internationally-renowned specialist in the field. Easily find the information you need thanks to a consistent, user-friendly format with templated content and large-scale images.