Clinical Trials In The Rheumatic Diseases

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Clinical Trials in the Rheumatic Diseases

David Rosenbloom,Peter Brooks,Nicholas Bellamy,W. Watson Buchanan
Clinical Trials in the Rheumatic Diseases Book PDF

Author : David Rosenbloom,Peter Brooks,Nicholas Bellamy,W. Watson Buchanan
Publisher : Praeger Publishers
Page : 386 pages
File Size : 52,6 Mb
Release : 1985-03-01
Category : Medical
ISBN : 0275913236

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Clinical Trials in the Rheumatic Diseases by David Rosenbloom,Peter Brooks,Nicholas Bellamy,W. Watson Buchanan Pdf

This book reviews the design, measurement, and analytic components of randomized clinical trials conducted in the rheumatic diseases and evaluates the studies on which decisions are based for treating patients. The underlying evidence for effective drug therapies is presented along with insight into the following areas: clarity of reportage of clinical trials; identification of potential sources of error and their effect on efficiency and quality of future trials. The chapters are organized according to disease and structured so as to provide basic information, methodologic considerations, description of clinical trials, and recommendations for special consideration in future trials.

Clinical Trials in Rheumatoid Arthritis and Osteoarthritis

David M. Reid,Colin G. Miller
Clinical Trials in Rheumatoid Arthritis and Osteoarthritis Book PDF

Author : David M. Reid,Colin G. Miller
Publisher : Springer Science & Business Media
Page : 323 pages
File Size : 40,8 Mb
Release : 2008-03-20
Category : Medical
ISBN : 9781846287428

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Clinical Trials in Rheumatoid Arthritis and Osteoarthritis by David M. Reid,Colin G. Miller Pdf

Designed to be a practical handbook on clinical trial management in these key therapeutic areas, 'Clinical Trials in Rheumatoid Arthritis and Osteoarthritis' is aimed at principal investigators pharmaceutical physicians and other pharmaceutical staff involved in the design, conduct and monitoring of these increasingly complex diseases. In the last several years a new classes of biologic agents have emerged and changed the treatment paradigm for patients, not only with classically defined rheumatoid arthritis, but also with other related diseases such as ankylosing spondylitis and psoriatic arthritis. Furthermore, osteoarthritis is a major disease state that is often treated by the rheumatologist, but is one where patient management programs are currently limited with a need for new therapeutic approaches. In both inflammatory and non-inflammatory arthritic conditions, clinical trials have become both large and complex due to the nature of the diseases, with ever-challenging new surrogate end-points being employed. Topics covered in this title will therefore include study design, clinical endpoints, technical issues, data collection, use of centralized medical image reading facilities and biochemical marker laboratories, as well as data analysis and future therapies. This book takes the user through the process step-by-step from start to finish, also providing a background on the regulatory guidelines, ethical implications, endpoints, and current therapies.

Understanding Evidence-Based Rheumatology

Hasan Yazici,Yusuf Yazici,Emmanuel Lesaffre
Understanding Evidence Based Rheumatology Book PDF

Author : Hasan Yazici,Yusuf Yazici,Emmanuel Lesaffre
Publisher : Springer
Page : 285 pages
File Size : 49,7 Mb
Release : 2014-10-29
Category : Medical
ISBN : 9783319083742

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Understanding Evidence-Based Rheumatology by Hasan Yazici,Yusuf Yazici,Emmanuel Lesaffre Pdf

It is imperative that health professionals caring for patients with rheumatic diseases understand how to correctly interpret evidence in their field, taking into account the merits and shortcomings of available data. Understanding Evidence-Based Rheumatology offers a practical assessment of criteria, drugs, trials, and registries and provides useful tools for successfully interpreting this data. The book introduces readers to basic analysis of trial design, statistics and application of data through no-nonsense, easy-to-follow insights. Using numerous examples, chapters outline the difficulties physicians encounter when measuring disease activity in rheumatology and offer strategies for systematically approaching these situations. Ethical issues in study design and reporting are examined and the book closes with a summary of future directions for scientific and clinical studies in rheumatology. Understanding Evidence-Based Rheumatology is an invaluable resource for trainees, clinicians and scientists, preparing them with the necessary tools to correctly gather evidence and shed light on the difficult practice of rheumatology.

Clinical Trials in Rheumatology

Ruediger Mueller,Johannes von Kempis
Clinical Trials in Rheumatology Book PDF

Author : Ruediger Mueller,Johannes von Kempis
Publisher : Springer Science & Business Media
Page : 1239 pages
File Size : 48,8 Mb
Release : 2012-12-22
Category : Medical
ISBN : 9781447128700

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Clinical Trials in Rheumatology by Ruediger Mueller,Johannes von Kempis Pdf

A huge number of therapeutic studies has been published in rheumatology and clinical immunology. This number grows substantially by the year. As such, it becomes increasingly difficult to keep track of this multitude of studies and the ensuing therapeutic trends. Further to this, a particular study can be referred to in a variety of ways, either as a shortened version of the title or an acronym, adding to the confusion. The book Clinical Trials in Rheumatology, Second Edition, provides an updated summary of the important studies in the field for easy reference. Every study is shown with name, acronym (if in existence), authors, complete citation, study design, and a short overview of the trial's data and main conclusions. An acronym finder is supplied at the beginning of the book. This book is a valuable reference tool for rheumatologists and other clinical specialties, as well as for research scientists interested in immunomodulatory and selected other drug therapies in rheumatologic diseases.

Best Practices and Challenges to the Practice of Rheumatology, An Issue of Rheumatic Disease Clinics of North America

Daniel J. Wallace,Swamy Venuturupalli
Best Practices and Challenges to the Practice of Rheumatology An Issue of Rheumatic Disease Clinics of North America Book PDF

Author : Daniel J. Wallace,Swamy Venuturupalli
Publisher : Elsevier Health Sciences
Page : 128 pages
File Size : 51,6 Mb
Release : 2018-11-21
Category : Medical
ISBN : 9780323655415

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Best Practices and Challenges to the Practice of Rheumatology, An Issue of Rheumatic Disease Clinics of North America by Daniel J. Wallace,Swamy Venuturupalli Pdf

Guest edited by Drs. Daniel J. Wallace and R. Swamy Venuturupalli, this issue of Rheumatic Disease Clinics will cover several key areas of interest related to Best Practices and Challenges to the Practice of Rheumatology. This issue is one of four selected each year by our series Consulting Editor, Dr. Michael Weisman of Cedars-Sinai. Articles in this issue include, but are not limited to: The Economics of Rheumatology Practice in the United States, Manpower trends in rheumatology, Challenges to practicing rheumatology in an academic center, Challenges in practicing rheumatology in a government setting, Challenges to practicing rheumatology in a small private practice setting, Challenges to working in a large multispecialty organization, Challenges to practicing pediatric rheumatology, Clinical trials in rheumatology, Challenges in having an infusion center, Implementing treatment to target in the clinic, Future directions: implementing new technologies in clinical practice, Possible Challenges in Optimizing Medical Education for Rheumatologists, and the challenges of approaching and managing gout.

Modern Therapeutics in Rheumatic Diseases

George C. Tsokos,Larry W. Moreland,Gary M. Kammer,Jean-Pierre Pelletier,Johanne Martel-Pelletier
Modern Therapeutics in Rheumatic Diseases Book PDF

Author : George C. Tsokos,Larry W. Moreland,Gary M. Kammer,Jean-Pierre Pelletier,Johanne Martel-Pelletier
Publisher : Springer Science & Business Media
Page : 648 pages
File Size : 53,7 Mb
Release : 2001-11-08
Category : Medical
ISBN : 9781592592395

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Modern Therapeutics in Rheumatic Diseases by George C. Tsokos,Larry W. Moreland,Gary M. Kammer,Jean-Pierre Pelletier,Johanne Martel-Pelletier Pdf

Leading clinicians and clinical researchers discuss in practical detail the newest treatments used in rheumatic diseases, emphasizing-without neglecting current standard treatments-those experimental therapies now undergoing clinical trials and poised for early introduction into the rheumatology armamentarium. The diseases and therapeutic regimes examined here range from rheumatoid arthritis and its treatment by gene therapy, to osteoarthritis and systemic autoimune diseases. Each chapter is organized so that the busy clinician can quickly obtain all the information needed optimal patient treatment. This includes an analysis of the pathogenic mechanisms that explain the molecular basis of the newer therapeutics, reviews of animal data and the results of clinical trials, and recommendations concerning use, side effects, and precautions.

Landmark Papers in Rheumatology

Richard A. Watts,David G. I. Scott
Landmark Papers in Rheumatology Book PDF

Author : Richard A. Watts,David G. I. Scott
Publisher : OUP Oxford
Page : 456 pages
File Size : 54,6 Mb
Release : 2015-06-25
Category : Medical
ISBN : 9780191512797

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Landmark Papers in Rheumatology by Richard A. Watts,David G. I. Scott Pdf

Rheumatic disease is a major cause of morbidity and disability in the Western world. There have been major developments in our understanding of the causes of rheumatic disease and in their treatment during the last half-century, and there are relatively few papers which can be regarded as truly 'landmark' in their construction and subsequent findings. Part of the Landmark Papers in series, this book provides a detailed review of the seminal papers that have paved the way for breakthroughs in the clinical management of the entire spectrum of rheumatic diseases.

Clinical Innovation in Rheumatology

Jason Liebowitz,Philip Seo
Clinical Innovation in Rheumatology Book PDF

Author : Jason Liebowitz,Philip Seo
Publisher : CRC Press
Page : 434 pages
File Size : 55,7 Mb
Release : 2022-10-04
Category : Medical
ISBN : 9781000684766

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Clinical Innovation in Rheumatology by Jason Liebowitz,Philip Seo Pdf

Tremendous advances have been made in the field of rheumatology, profoundly changing our understanding of many rheumatologic conditions and creating a new frontier for effective treatments. This book explains the most significant advances in research and care and speculates as to what will be the future of rheumatology over the next several decades, including challenges and lessons learned from past experiences in the field. It highlights landmark research articles and scientific discoveries, discusses how big data, personalized medicine, new biomarkers for disease, and other technological revolutions will shape the future, making it a must-have resource for physicians from all regions of the world. Key Features • Includes concise yet thorough description of the landmark studies and scientific breakthroughs coupled with easy-to-follow organizational structure of chapters that are accessible to readers at different levels of training. • Brings together world-leading experts to provide a fresh perspective to trainees such as residents and fellows-in-training, as well as more senior clinicians and researchers across the field of rheumatology and in specialties such as cardiology, dermatology, pulmonology, nephrology, and neurology, all of whom care for patients with rheumatologic conditions. • Allows the authors to imagine and speculate about the evolution of the field of rheumatology in the coming decades. Examples of such speculative possibilities include use of synovial biopsy to predict response to treatment in rheumatoid arthritis, replacement of renal biopsy with urinary proteomics in diagnosing and classifying lupus nephritis, use of new therapeutics to obviate the need for steroids in the treatment of ANCA-associated vasculitis, and the use of machine learning to evaluate subtle changes in imaging for management of inflammatory arthritis.

Drug Safety: Managing Innovation in Rheumatology, An Issue of Rheumatic Disease Clinics

Jack Cush,Kathryn H. Dao
Drug Safety Managing Innovation in Rheumatology An Issue of Rheumatic Disease Clinics Book PDF

Author : Jack Cush,Kathryn H. Dao
Publisher : Elsevier Health Sciences
Page : 240 pages
File Size : 53,5 Mb
Release : 2012-11-15
Category : Medical
ISBN : 9781455750597

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Drug Safety: Managing Innovation in Rheumatology, An Issue of Rheumatic Disease Clinics by Jack Cush,Kathryn H. Dao Pdf

Edited by Drs. Jack Cush and Kathryn Dao, this issue of Rheumatic Disease Clinics of North America addresses one of the most significant issues facing the rheumatologist today––drug safety in a changing world where rheumatoid arthritis (RA) severity is less, patients are being identified and treated at a very early stage, and prevention is on the horizon. Topics covered include: communicating the risk of side effects, urate-lowering therapies, biphosphonates, biologics, malignancy risks, and administering therapies to patients with co-morbidities.

Targeted Treatment of the Rheumatic Diseases

Michael H. Weisman
Targeted Treatment of the Rheumatic Diseases Book PDF

Author : Michael H. Weisman
Publisher : Elsevier Health Sciences
Page : 503 pages
File Size : 43,8 Mb
Release : 2010-01-01
Category : Medical
ISBN : 9781416099932

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Targeted Treatment of the Rheumatic Diseases by Michael H. Weisman Pdf

Michael H. Weisman, Michael Weinblatt, James S Louie, and Ronald Van Vollenhoven offer their unique insights into choosing the correct pharmacological and non-pharmacological therapies for your patients. Chapters cover the full breadth of rheumatic diseases, rheumatoid arthritis, lupus, connective tissue diseases, osteoporosis, regional pain disorders, and fibromyalgia. The full-color design presents detailed clinical photographs and treatment algorithms for visual guidance and easy reference. Covers the treatment of pediatric patients as well as adults so that you can properly address the particular needs of any patient you see. Features the guidance and specific recommendations of experts from United States and Europe for a state-of-the-art approach to the variety of treatments currently in use. Displays the clinical manifestations of rheumatic diseases in full color, along with treatment algorithms for easy at-a-glance reference.

Patient Reported Outcomes in Rheumatic Diseases, An Issue of Rheumatic Disease Clinics of North America, E-Book

Jennifer L. Barton,Patti Katz
Patient Reported Outcomes in Rheumatic Diseases An Issue of Rheumatic Disease Clinics of North America E Book Book PDF

Author : Jennifer L. Barton,Patti Katz
Publisher : Elsevier Health Sciences
Page : 225 pages
File Size : 43,8 Mb
Release : 2016-05-27
Category : Medical
ISBN : 9780323445245

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Patient Reported Outcomes in Rheumatic Diseases, An Issue of Rheumatic Disease Clinics of North America, E-Book by Jennifer L. Barton,Patti Katz Pdf

This issue is devoted to patient reported outcomes and their impact in the study of rheumatic diseases and the authors will also discuss PROs and vulnerable populations with rheumatic disease; technology, electronic health records and PROs: past, present and future; the promise of PROMIS – a uniform approach to PROs across rheumatic diseases, quality measures and PROs and how they relate and the importance of PROs in delivering quality care in the rheumatic diseases, and many more exciting articles.

Health disparities in rheumatic diseases: Part II, An Issue of Rheumatic Disease Clinics of North America, E-Book

Candace H Feldman
Health disparities in rheumatic diseases Part II An Issue of Rheumatic Disease Clinics of North America E Book Book PDF

Author : Candace H Feldman
Publisher : Elsevier Health Sciences
Page : 153 pages
File Size : 43,7 Mb
Release : 2020-11-20
Category : Medical
ISBN : 9780323813648

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Health disparities in rheumatic diseases: Part II, An Issue of Rheumatic Disease Clinics of North America, E-Book by Candace H Feldman Pdf

This issue of Rheumatic Disease Clinics, guest edited by Dr. Candace Feldman, is Part II of a two-part issue covering Health Disparities in Rheumatic Diseases. This issue is one of four selected each year by series Consulting Editor, Dr. Michael Weisman. Topics discussed in this issue include, but are not limited to: Disparities in Lupus Care and Outcomes among U.S. Medicaid Beneficiaries, Understanding Risk Factors for Poor Outcomes in a Multiethnic Longitudinal Cohort, Impact of Psychosocial Factors on RA and Lupus Health Disparities, Racial/ethnic and geographic disparities in knee and hip osteoarthritis, Racial/ethnic Disparities in Osteoarthritis Management, Challenges and Strategies to Achieve Equitable Rheumatologic Care Across the World, Strategies to Reduce Disparities, Understanding and Addressing the Provider Biases and the Lack of Diversity in Lupus Clinical Trials, Community-engaged Research: Lupus Conversations, Leveraging Telemedicine as an Approach to Address Rheumatic Disease Health Disparities, and Understanding the Role and Challenges of Patient Preferences in Disparities in Rheumatic Disease Care.

Health disparities in rheumatic diseases: Part I, An Issue of Rheumatic Disease Clinics of North America, E-Book

Candace H Feldman
Health disparities in rheumatic diseases Part I An Issue of Rheumatic Disease Clinics of North America E Book Book PDF

Author : Candace H Feldman
Publisher : Elsevier Health Sciences
Page : 161 pages
File Size : 44,5 Mb
Release : 2020-10-15
Category : Medical
ISBN : 9780323796026

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Health disparities in rheumatic diseases: Part I, An Issue of Rheumatic Disease Clinics of North America, E-Book by Candace H Feldman Pdf

This issue of Rheumatic Disease Clinics, guest edited by Dr. Candace Feldman, will Health Disparities in Rheumatic Diseases. This issue is one of four selected each year by series Consulting Editor, Dr. Michael Weisman. Topics discussed in this issue include, but are not limited to: Disparities in Rheumatology Through the Lens of Critical Race Theory; Use of Quality Metrics to Identify Disparities in Lupus Care; The Role of Individual and Area-level Poverty on Lupus Disparities; Disparities in Lupus Care and Outcomes among U.S. Medicaid Beneficiaries; Disparities in Rheumatoid Arthritis Care; Disparities in Childhood-onset Lupus and Mental Health Care for Pediatric Lupus Patients; Disparities in Rheumatic Disease Care, Access and Outcomes in the First Nations Population; Impact of Psychosocial Factors on RA and Lupus Health Disparities; Racial and gender disparities among patients with Gout; Racial/ethnic and geographic disparities in knee and hip osteoarthritis; Racial/ethnic Disparities in Osteoarthritis Management; Racial disparities in systemic sclerosis; Community-engaged Research: Lupus Conversations; Leveraging Telemedicine as an Approach to Address Rheumatic Disease Health Disparities; Understanding the Role and Challenges of Patient Preferences in Disparities in Rheumatic Disease Care; Designing an Intervention to Improve Management and Care Coordination for High Risk Lupus Patients; Greatest Challenges and Strategies to Achieve Equitable Rheumatologic Care Across the World, among others.

Patient Reported Outcome Measures in Rheumatic Diseases

Yasser El Miedany
Patient Reported Outcome Measures in Rheumatic Diseases Book PDF

Author : Yasser El Miedany
Publisher : Springer
Page : 449 pages
File Size : 43,6 Mb
Release : 2016-09-14
Category : Medical
ISBN : 9783319328515

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Patient Reported Outcome Measures in Rheumatic Diseases by Yasser El Miedany Pdf

This book discusses the role of patient reported outcome measures (PROMs) in the diagnosis and management of rheumatic diseases and their implementation in patient-centered care. It aims to improve the quality and efficiency of patient care in standard practice by outlining the appropriate information-gathering and decision-making processes. The book highlights the evidence and advanced knowledge base of PROMs in rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus, juvenile idiopathic arthritis, osteoarthritis, and systemic sclerosis. Featuring reviews of Patient Reported Outcome tools and Physician RheuMetric Measures as well as examples of patient reported outcome questionnaires, Patient Reported Outcome Measures in Rheumatic Diseases serves as an excellent introduction and resource for implementation of PROMs in clinical rheumatology practice.

Lupus, An Issue of Rheumatic Disease Clinics of North America, E-Book

Zahi Touma,Alfred Kim
Lupus An Issue of Rheumatic Disease Clinics of North America E Book Book PDF

Author : Zahi Touma,Alfred Kim
Publisher : Elsevier Health Sciences
Page : 257 pages
File Size : 55,6 Mb
Release : 2021-07-06
Category : Medical
ISBN : 9780323835572

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Lupus, An Issue of Rheumatic Disease Clinics of North America, E-Book by Zahi Touma,Alfred Kim Pdf

This issue of Rheumatic Disease Clinics, guest edited by Dr. Alfred Kim and Zahi Touma, will discuss a number of key topics surrounding Lupus. This issue is one of four selected each year by series Consulting Editor, Dr. Michael Weisman. Topics discussed in this issue include, but are not limited to: Interferons in SLE, NETosis and neutrophils in SLE, AMP update in lupus nephritis, Patient-reported outcomes, Complement, T cells in SLE, B cells in SLE, Outcome measures for SLE clinical trials, Mitochondrial physiology in SLE, Pregnancy, Lupus cohorts, Innovative trials and new opportunities in SLE, Classification and diagnosis of SLE, and Updates on SLE Treatment.