Co Crystals

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Pharmaceutical Salts and Co-crystals

Author : Johan Wouters,Luc Quéré
Publisher : Royal Society of Chemistry
Page : 406 pages
File Size : 41,7 Mb
Release : 2011-11-04
Category : Medical
ISBN : 9781849733502

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Pharmaceutical Salts and Co-crystals by Johan Wouters,Luc Quéré Pdf

From crystal structure prediction to totally empirical screening, the quest for new crystal forms has become one of the most challenging issues in the solid state science and particularly in the pharmaceutical world. In this context, multi-component crystalline materials like co-crystals have received renewed interest as they offer the prospect of optimized physical properties. As illustrated in this first book_ entirely dedicated to this emerging class of pharmaceutical compounds_ the outcome of such endeavours into crystal engineering have demonstrated clear impacts on production, marketing and intellectual property protection of active pharmaceutical ingredients (APIs). Indeed, co-crystallization influences relevant physico-chemical parameters (such as solubility, dissolution rate, chemical stability, melting point, hygroscopicity, à) and often offers solids with properties superior to those of the free drug. Combining both reports of the latest research and comprehensive overviews of basic principles, with contributions from selected experts in both academia and industry, this unique book is an essential reference, ideal for pharmaceutical development scientists and graduate students in pharmaceutical science.

Co-crystals

Author : Christer B Aakeröy,Abhijeet S Sinha
Publisher : Royal Society of Chemistry
Page : 342 pages
File Size : 55,8 Mb
Release : 2018-07-16
Category : SCIENCE
ISBN : 9781788011150

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Co-crystals by Christer B Aakeröy,Abhijeet S Sinha Pdf

Multi-component crystalline systems or co-crystals have received tremendous attention from academia and industry alike in the past decade. Applications of co-crystals are varied and are likely to positively impact a wide range of industries dealing with molecular solids. Co-crystallization has been used to improve the properties and performance of materials from pharmaceuticals to energetic materials, as well as for separation of compounds. This book combines co-crystal applications of commercial and practical interest from diverse fields in to a single volume. It also examines effective structural design of co-crystals, and provides insights into practical synthesis and characterization techniques. Providing a useful resource for postgraduate students new to applied co-crystal research and crystal engineering, it will also be of interest to established researchers in academia or industry.

Annual Reports in Medicinal Chemistry

Author : Anonim
Publisher : Academic Press
Page : 585 pages
File Size : 42,6 Mb
Release : 2008-12-17
Category : Science
ISBN : 9780080921877

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Annual Reports in Medicinal Chemistry by Anonim Pdf

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Covers findings related to cardiovascular, inflammation, and pulmonary diseases Examines issues in oncology, from mTor inhibitors to drug targets Incorporates up-to-date information on drug design and discovery, including delivery to market

Multi-Component Crystals

Author : Edward Tiekink,Julio Zukerman-Schpector
Publisher : Walter de Gruyter GmbH & Co KG
Page : 362 pages
File Size : 48,5 Mb
Release : 2017-11-20
Category : Science
ISBN : 9783110464955

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Multi-Component Crystals by Edward Tiekink,Julio Zukerman-Schpector Pdf

In this volume, contributions covering the theoretical and practical aspects of multicomponent crystals provide a timely and contemporary overview of the state-of-the art of this vital aspect of crystal engineering/materials science. With a solid foundation in fundamentals, multi-component crystals can be formed, for example, to enhance pharmaceutical properties of drugs, for the specific control of optical responses to external stimuli and to assemble molecules to allow chemical reactions that are generally intractable following conventional methods. Contents Pharmaceutical co-crystals: crystal engineering and applications Pharmaceutical multi-component crystals: improving the efficacy of anti-tuberculous agents Qualitative and quantitative crystal engineering of multi-functional co-crystals Control of photochromism in N-salicylideneaniline by crystal engineering Quinoline derivatives for multi-component crystals: principles and applications N-oxides in multi-component crystals and in bottom-up synthesis and applications Multi-component crystals and non-ambient conditions Co-crystals for solid-state reactivity and thermal expansion Solution co-crystallisation and its applications The salt-co-crystal continuum in halogen-bonded systems Large horizontal displacements of benzene-benzene stacking interactions in co-crystals Simultaneous halogen and hydrogen bonding to carbonyl and thiocarbonylfunctionality Crystal chemistry of the isomeric N,N’-bis(pyridin-n-ylmethyl)-ethanediamides, n = 2, 3 or 4 Solute・solvent interactions mediated by main group element (lone-pair)・・・π(aryl) interactions

BIWIC 2007

Author : Alison Lewis,Christine Olsen
Publisher : IOS Press
Page : 284 pages
File Size : 50,5 Mb
Release : 2007
Category : Science
ISBN : 9781586037901

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BIWIC 2007 by Alison Lewis,Christine Olsen Pdf

The field of crystallization holds many challenges, with the physical and chemical complexity of the crystallization process being core to the dynamic nature of the field. Exciting advances are achieved in the areas of nanoparticle formation, product and particle design and methods of particle characterization.

Intermolecular Interactions in Crystals

Author : Juan J Novoa
Publisher : Royal Society of Chemistry
Page : 782 pages
File Size : 43,9 Mb
Release : 2017-10-25
Category : Science
ISBN : 9781788013338

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Intermolecular Interactions in Crystals by Juan J Novoa Pdf

The field of crystal engineering concerns the design and synthesis of molecular crystals with desired properties. This requires an in-depth understanding of the intermolecular interactions within crystal structures. This new book brings together the latest information and theories about intermolecular bonding, providing an introductory text for graduates. The book is divided into three parts. The first part covers the nature, physical meaning and methods for identification and analysis of intermolecular bonds. The second part explains the different types of bond known to occur in molecular crystals, with each chapter written by a specialist in that specific bond type. The final part discusses the cooperativity effects of different bond types present in one solid. This comprehensive textbook will provide a valuable resource for all students and researchers in the field of crystallography, materials science and supramolecular chemistry.

Chemical Bonding in Crystals and Their Properties

Author : Anna V. Vologzhanina,Yulia V. Nelyubina
Publisher : MDPI
Page : 144 pages
File Size : 54,7 Mb
Release : 2020-06-16
Category : Science
ISBN : 9783039361700

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Chemical Bonding in Crystals and Their Properties by Anna V. Vologzhanina,Yulia V. Nelyubina Pdf

Unravelling an intricate network of interatomic interactions and their relations to different behaviors of chemical compounds is key to the successful design of new materials for both existing and novel applications, from medicine to innovative concepts of molecular electronics and spintronics. X-ray crystallography has proven to be very helpful in addressing many important chemical problems in modern materials science and biosciences. Intertwined with computational techniques, it provides insights into the nature of chemical bonding and the physicochemical properties (including optical, magnetic, electrical, mechanical, and others) of crystalline materials, otherwise accessible by experimental techniques that are not so readily available to chemists. In addition to the advanced approaches in charge density analysis made possible by X-ray diffraction, the information collected over the years through this technique (which is easily mined from huge databases) has tremendous use in the design of new materials for medicine, gas storage, and separation applications as well as for electronic devices. This Special Issue contains two reviews and five articles that cover very different aspects of ‘composition–structure’ and ‘structure–property’ relations identified by X-ray diffraction and complementary techniques (from conventional IR and Raman spectroscopies to cutting-edge quantum chemical calculations) and their use in crystal engineering and materials science.

Frontiers in Crystal Engineering

Author : Edward R. T. Tiekink,Jagadese Vittal
Publisher : John Wiley & Sons
Page : 346 pages
File Size : 51,8 Mb
Release : 2006-05-01
Category : Science
ISBN : 9780470022597

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Frontiers in Crystal Engineering by Edward R. T. Tiekink,Jagadese Vittal Pdf

Crystal engineering - where the myriad of intermolecular forces operating in the solid-state are employed to design new nano- and functional materials - is a key new technology with implications for catalysis, pharmaceuticals, synthesis and materials science. Frontiers in Crystal Engineering gathers personal perspectives, from international specialists working in molecular aspects of crystal engineering, on the practical and theoretical challenges of the discipline, and future prospects. These demonstrate the approaches that are being used to tackle the problems associated with the complexity, design and functionality of crystalline molecular solids. Topics include * how intermolecular forces direct and sustain crystal structures * functional engineering and design elements * coordination polymers and network structures * applications in green and pharmaceutical chemistry Frontiers in Crystal Engineering is a useful guide to this exciting new discipline for both entrants to the field as well as established practitioners, and for those working in crystallography, medicinal and pharmaceutical sciences, solid-state chemistry, and materials and nanotechnology.

Crystal Engineering

Author : Gautam R. Desiraju,Jagadese J. Vittal,Arunachalam Ramanan
Publisher : World Scientific
Page : 232 pages
File Size : 52,7 Mb
Release : 2011
Category : Science
ISBN : 9789814338752

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Crystal Engineering by Gautam R. Desiraju,Jagadese J. Vittal,Arunachalam Ramanan Pdf

This book is important because it is the first textbook in an area that has become very popular in recent times. There are around 250 research groups in crystal engineering worldwide today. The subject has been researched for around 40 years but there is still no textbook at the level of senior undergraduates and beginning PhD students. This book is expected to fill this gap. The writing style is simple, with an adequate number of exercises and problems, and the diagrams are easy to understand. This book consists major areas of the subject, including organic crystals and co-ordination polymers, and can easily form the basis of a 30 to 40 lecture course for senior undergraduates.

Carbohydrates

Author : Chuan-Fa Chang
Publisher : BoD – Books on Demand
Page : 574 pages
File Size : 49,5 Mb
Release : 2012-11-21
Category : Science
ISBN : 9789535108641

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Carbohydrates by Chuan-Fa Chang Pdf

It is my great honor and pleasure to introduce this comprehensive book to readers who are interested in carbohydrates. This book contains 23 excellent chapters written by experts from the fields of chemistry, glycobiology, microbiology, immunology, botany, zoology, as well as biotechnology. According to the topics, methods and targets, the 23 chapters are further divided into five independent sections. In addition to the basic research, this book also offers much in the way of experiences, tools, and technologies for readers who are interested in different fields of Glycobiology. I believe that readers can obtain more than anticipated from this meaningful and useful book.

Advances in Organic Crystal Chemistry

Author : Rui Tamura,Mikiji Miyata
Publisher : Springer
Page : 706 pages
File Size : 53,8 Mb
Release : 2015-08-06
Category : Science
ISBN : 9784431555551

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Advances in Organic Crystal Chemistry by Rui Tamura,Mikiji Miyata Pdf

For the last decade, the topics of organic crystal chemistry have become diversified, and each topic has been substantially advanced in concert with the rapid development of various analytical and measurement techniques for solid-state organic materials. The aim of this book is to systematically summarize and record the recent notable advances in various topics of organic crystal chemistry involving liquid crystals and organic–inorganic hybrid materials that have been achieved mainly in the last 5 years or so. The authors are invited members of the Division of Organic Crystals, The Chemical Society of Japan (CSJ), and prominent invited experts from abroad. This edited volume is planned to be published periodically, at least every 5 years, with contributions by prominent authors in Japan and from abroad.

Molecular Networks

Author : Mir Wais Hosseini
Publisher : Springer Science & Business Media
Page : 173 pages
File Size : 42,8 Mb
Release : 2009-06-29
Category : Science
ISBN : 9783642013669

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Molecular Networks by Mir Wais Hosseini Pdf

In the future, many modern materials will be increasingly based on the assembly of preformed molecular entities. Their structural characteristics and functional prop- ties will be programmed at the molecular level and their formation as a completed entity will be achieved by self-assembly processes. This in essence is a bottom-up approach and its success will require a deep understanding not only of the chemistry of intermolecular interactions and associations but also of self-assembly processes in the condensed phase. Among various interesting innovations brought about by the development of supramolecular chemistry, supramolecular synthesis is a part- ularly powerful approach for the design and generation of molecular architectures displaying both structural and functional complexity. The combination of mol- ular synthesis (which allows chemists to design and prepare extremely sophis- cated biotic and abiotic molecules through the interconnection of atoms or group of atoms by strong covalent bonds) and supramolecular synthesis (which orch- trates the association of molecules by recognition processes through the use of weak and reversible interactions) opens up endless structural and functional possibilities. Following the perceptive observation by Dunitz that "A crystal is, in a sense, the supramolecule par excellence", molecular crystals may be seen as in'nite periodic architectures resulting from the interconnection of building blocks or tectons ca- ble of self-assembling through speci'c recognising events.

Drug Formulation Design

Author : Rahul Shukla,Aleksey Kuznetsov,Akbar Ali
Publisher : BoD – Books on Demand
Page : 330 pages
File Size : 49,7 Mb
Release : 2023-06-07
Category : Medical
ISBN : 9781837684717

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Drug Formulation Design by Rahul Shukla,Aleksey Kuznetsov,Akbar Ali Pdf

This book discusses the theoretical and practical aspects required to formulate conventional drug dosage forms and advanced technology-based therapeutics. It is organized into four sections: “Preformulation”, “Formulation Design and Approaches”, “Characterization and Analysis”, and “Cocrystal Engineering”. The approaches discussed enhance the overall quality of treatment and overcome the side effects of available therapies. The book is a collection of scholarly literature relevant to pharmaceutical technology and existing pharmaceutical technologies. It is a useful reference for industrial personnel working on developing novel pharmaceutical dosage forms.

Formulating Poorly Water Soluble Drugs

Author : Robert O. Williams III,Alan B. Watts,Dave A. Miller
Publisher : Springer
Page : 779 pages
File Size : 48,8 Mb
Release : 2016-12-16
Category : Medical
ISBN : 9783319426099

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Formulating Poorly Water Soluble Drugs by Robert O. Williams III,Alan B. Watts,Dave A. Miller Pdf

The objective of this volume is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at minimum a working knowledge of each of the abovementioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop

Solid State Development and Processing of Pharmaceutical Molecules

Author : Michael Gruss
Publisher : John Wiley & Sons
Page : 578 pages
File Size : 55,7 Mb
Release : 2021-11-15
Category : Science
ISBN : 9783527346356

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Solid State Development and Processing of Pharmaceutical Molecules by Michael Gruss Pdf

Solid State Development and Processing of Pharmaceutical Molecules A guide to the lastest industry principles for optimizing the production of solid state active pharmaceutical ingredients Solid State Development and Processing of Pharmaceutical Molecules is an authoritative guide that covers the entire pharmaceutical value chain. The authors—noted experts on the topic—examine the importance of the solid state form of chemical and biological drugs and review the development, production, quality control, formulation, and stability of medicines. The book explores the most recent trends in the digitization and automation of the pharmaceutical production processes that reflect the need for consistent high quality. It also includes information on relevant regulatory and intellectual property considerations. This resource is aimed at professionals in the pharmaceutical industry and offers an in-depth examination of the commercially relevant issues facing developers, producers and distributors of drug substances. This important book: Provides a guide for the effective development of solid drug forms Compares different characterization methods for solid state APIs Offers a resource for understanding efficient production methods for solid state forms of chemical and biological drugs Includes information on automation, process control, and machine learning as an integral part of the development and production workflows Covers in detail the regulatory and quality control aspects of drug development Written for medicinal chemists, pharmaceutical industry professionals, pharma engineers, solid state chemists, chemical engineers, Solid State Development and Processing of Pharmaceutical Molecules reviews information on the solid state of active pharmaceutical ingredients for their efficient development and production.