Complement In Nervous System Disease

Author : Iliana Michailidou,Frank Baas,Kees Fluiter,Nikolaos Grigoriadis,Marina Boziki
Publisher : Frontiers Media SA
Page : 147 pages
File Size : 47,6 Mb
Release : 2023-09-01
Category : Science
ISBN : 9782832532867

Get Book

Complement in Nervous System Disease by Iliana Michailidou,Frank Baas,Kees Fluiter,Nikolaos Grigoriadis,Marina Boziki Pdf

Neuroinflammation is associated with a wide spectrum of acute and chronic diseases of the central and peripheral nervous system. It causes secondary damage, which is a major determinant for progression and outcome. Activated complement is suspected to be a key player to neuroinflammation. Complement is an important evolutionary ancient system for host anti-microbial aid. It serves the innate immunity and interfaces with the adaptive immunity. Complement recognizes non-cognate or altered-self antigens and devours 'unwanted' cells or cell compartments. Activation of complement leads to opsonisation of a target, inflammation by the release of anaphylatoxins, and damage of the target by the assembled membrane attack complex. Because complement can harm self-tissue, activation is tightly controlled by regulators. However, complement activation might be excessive and uncontrolled at sites of damage contributing to neuroinflammation leading to neurodegeneration.

Author : Thomas E. Lane,Monica Carson,Conni Bergmann,Tony Wyss-Coray
Publisher : Springer Science & Business Media
Page : 321 pages
File Size : 44,8 Mb
Release : 2007-12-24
Category : Medical
ISBN : 9780387738949

Get Book

Central Nervous System Diseases and Inflammation by Thomas E. Lane,Monica Carson,Conni Bergmann,Tony Wyss-Coray Pdf

Edited and authored by top names in the field, this book provides a succinct reference on inflammatory central nervous system disease. It focuses on current areas of investigation in the fields of neuroimmunology, virology, pharmacology, and disease. Sections focus on specific categories of diseases, examining the pharmacological, virological, and immunological effects of and on the disease. This book’s unique organization provides a concise overview of inflammatory CNS disease.

Author : Jeffrey Kordower,Mark H. Tuszynski
Publisher : Elsevier
Page : 526 pages
File Size : 52,5 Mb
Release : 2011-04-28
Category : Science
ISBN : 0080556981

Get Book

CNS Regeneration by Jeffrey Kordower,Mark H. Tuszynski Pdf

This second edition of CNS Regeneration updates the burgeoning field of regeneration in the Central Nervous System (CNS) from molecular, systems, and disease-based perspective. While the book covers numerous areas in detail, special emphasis is given to discussions of movement disorders such as Parkinson’s disease, Alzheimer’s disease, and spinal cord injury. Incorporates information gained from cutting-edge photomicroscopy techniques Includes current information on clinical trials Presents chapters on stem cells and other novel treatments for diseases of the CNS

Author : Anonim
Publisher : ScholarlyEditions
Page : 448 pages
File Size : 49,7 Mb
Release : 2012-12-26
Category : Medical
ISBN : 9781464993312

Get Book

Nervous System Diseases—Advances in Research and Treatment: 2012 Edition by Anonim Pdf

Nervous System Diseases—Advances in Research and Treatment: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Nervous System Diseases. The editors have built Nervous System Diseases—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nervous System Diseases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Nervous System Diseases—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Mihály Józsi,Paul Nigel Barlow,Seppo Meri
Publisher : Frontiers Media SA
Page : 175 pages
File Size : 43,8 Mb
Release : 2022-02-21
Category : Medical
ISBN : 9782889744442

Get Book

Function and Dysfunction of Complement Factor H by Mihály Józsi,Paul Nigel Barlow,Seppo Meri Pdf

Author : Anonim
Publisher : Unknown
Page : 1520 pages
File Size : 55,8 Mb
Release : 1978
Category : Medicine
ISBN : MINN:30000008789962

Get Book

Research Awards Index by Anonim Pdf

Author : National Institutes of Health (U.S.). Division of Research Grants
Publisher : Unknown
Page : 1116 pages
File Size : 43,6 Mb
Release : 1973
Category : Medicine
ISBN : UOM:39015072175097

Get Book

Research Grants Index by National Institutes of Health (U.S.). Division of Research Grants Pdf

Author : Chukwuebuka Egbuna,Mithun Rudrapal
Publisher : John Wiley & Sons
Page : 468 pages
File Size : 43,5 Mb
Release : 2023-06-23
Category : Medical
ISBN : 9781119794110

Get Book

Phytochemical Drug Discovery for Central Nervous System Disorders by Chukwuebuka Egbuna,Mithun Rudrapal Pdf

PHYTOCHEMICAL DRUG DISCOVERY FOR CENTRAL NERVOUS SYSTEM DISORDERS Understand herbal and plant-based treatments for chronic disorders with this groundbreaking work Due in part to the aging of the global population, disorders of the central nervous system have become an increasingly grave public health concern in recent years. Demand for pharmaceutical treatments has been correspondingly high, but there are many barriers to the successful development of effective synthetic drugs. Phytomedicines, or plant-based and herbal medicines, have proven to be an effective alternative, boasting lower toxicity and cost and higher efficacy, and one that demands greater research and broader-based practitioner knowledge. Phytochemical Drug Discovery for Central Nervous System Disorders meets this demand with a timely, clearly-structured guide. It thorough coverage presents a wide range of phytochemicals with potential as candidates for drug discovery, describing their sources, properties, and therapeutic efficacy. The result is a vital contribution to the ongoing fight against central nervous system (CNS) disorders. Phytochemical Drug Discovery for Central Nervous System Disorders readers will also find: Detailed treatment of CNS-active plant products, neuroprotective chemicals, plant-based nutraceutical products, and more Up-to-date information on FDA-approved drugs and existing plant-based products used to treat CNS disorders An authorial team featuring experts from across the globe Phytochemical Drug Discovery for Central Nervous System Disorders is essential for drug discovery scientists, drug developers, medicinal chemists, biochemists, and any researchers and professionals in the health care or pharmaceutical industries.

Author : Institute of Medicine,Board on Neuroscience and Behavioral Health,Committee on Multiple Sclerosis: Current Status and Strategies for the Future
Publisher : National Academies Press
Page : 457 pages
File Size : 45,7 Mb
Release : 2001-08-10
Category : Medical
ISBN : 9780309072854

Get Book

Multiple Sclerosis by Institute of Medicine,Board on Neuroscience and Behavioral Health,Committee on Multiple Sclerosis: Current Status and Strategies for the Future Pdf

Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.

Author : K. Whaley,M. Loos,J. Weiler
Publisher : Springer Science & Business Media
Page : 385 pages
File Size : 45,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401122146

Get Book

Complement in Health and Disease by K. Whaley,M. Loos,J. Weiler Pdf

Since the first edition of Complement in Health and Disease was published in 1986, significant advances have been made. The cDNAs for all of the components and some of the receptors have been cloned and sequenced. The chromosomal localization and the structural organization of a number of these genes have now been determined. These advances are now facilitating research into the structure of the complement proteins, the nature of the complement deficiency syndromes, the regulation of complement gene expression and the role of complement in different diseases. This edition contains contributions from both basic and clinical scientists in a format which we hope will appeal to both immunologists and physicians who wish to know more about this fascinating and important host defence system. The introductory chapter by John Weiler presents a historical background to research on the complement system and describes the biochemical events occurring during activation of the system. In Chapter 2 Alastair Dodds and Tony Day discuss the phylogeny and evolution of the complement system. The techniques of protein chemistry and molecular biology have provided powerful insights into the modular structure of complement proteins and the evolution of the complement system. The structure and organisation of the complement genes is described in Chapter 3 by Ken Reid and Duncan Campbell. This chapter describes the modular structure of the complement proteins and some of the mutations which are responsible for deficiencies of individual components.

Author : Joost Verhaagen,Elly M. Hol,Inge Huitinga,Jan Wijnholds,Arthur B. Bergen,Gerard J. Boer,Dick F. Swaab
Publisher : Elsevier
Page : 414 pages
File Size : 47,7 Mb
Release : 2009-09-14
Category : Medical
ISBN : 0080922961

Get Book

Neurotherapy by Joost Verhaagen,Elly M. Hol,Inge Huitinga,Jan Wijnholds,Arthur B. Bergen,Gerard J. Boer,Dick F. Swaab Pdf

This book focuses on the exciting recent progress in restorative neurology and neuroscience. The book includes chapters on major neurodegenerative disorders of the brain and the visual system, including Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, macular degeneration, retinitis pigmentosa, glaucoma, spinal cord trauma, and multiple sclerosis. The primary goal of the book is to give an overview of new developments in translational research and in potential therapeutic strategies, including stem cell therapy, immunotherapy, gene therapy, pharmacotherapy, neuroprostheses and deep brain stimulation. * Provides the reader with a unique overview over all aspects of new advances in the therapy of neurological and psychiatric disorders * Covers all levels of biological organization including novel molecular and cellular targets, electrophysiological, anatomical and behavioural substrates of neurodegeneration and the application of whole brain in vivo imaging * Broad focus with contributions by the top scientists worldwide in the respective disciplines

Author : Anonim
Publisher : Unknown
Page : 1422 pages
File Size : 52,7 Mb
Release : 1989
Category : Medicine
ISBN : MINN:31951D001728682

Get Book

Cumulated Index Medicus by Anonim Pdf

Author : Guanhu Yang,Cunzhi Liu ,Xiang-Hong Jing,Weixing Pan ,Qinhong Zhang
Publisher : Frontiers Media SA
Page : 276 pages
File Size : 55,5 Mb
Release : 2024-05-07
Category : Science
ISBN : 9782832548745

Get Book

Neural Mechanism and Effect of Acupuncture for Central Nervous System Diseases by Guanhu Yang,Cunzhi Liu ,Xiang-Hong Jing,Weixing Pan ,Qinhong Zhang Pdf

Central nervous system (CNS) diseases, such as stroke, Parkinson’s disease, vascular dementia, Alzheimer’s disease, multiple sclerosis, bulbar palsy, spinal cord injury, traumatic brain injury, brain tumor, cerebral palsy, headache, migraine, epilepsy, depression, anxiety, etc., involve complex neural mechanism, and seriously affect quality of life and threaten life safety in patients with these disorders. Multiple neural techniques, such as functional magnetic resonance imaging, positron emission tomography, electroencephalography, etc., provide powerful tools for uncovering complex networks of neural mechanism and exploring key potential biomarkers to reveal the underlying neural feature of those disorders.

Author : National Academy of Sciences,Institute of Medicine,Sandra Ackerman
Publisher : National Academies Press
Page : 195 pages
File Size : 48,5 Mb
Release : 1992-01-01
Category : Medical
ISBN : 9780309045292

Get Book

Discovering the Brain by National Academy of Sciences,Institute of Medicine,Sandra Ackerman Pdf

The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

Author : Maciej Cedzyński,Nicole M. Thielens,Tom Eirik Mollnes,Thomas Vorup-Jensen
Publisher : Frontiers Media SA
Page : 631 pages
File Size : 50,7 Mb
Release : 2019-11-18
Category : Electronic
ISBN : 9782889631599

Get Book

The Role of Complement in Health and Disease by Maciej Cedzyński,Nicole M. Thielens,Tom Eirik Mollnes,Thomas Vorup-Jensen Pdf