Download Full eBooks in PDF
Computational Approaches To Understand Molecular Mechanisms Of Sars Cov 2 Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Computational Approaches To Understand Molecular Mechanisms Of Sars Cov 2 book. This book definitely worth reading, it is an incredibly well-written.
Author : Arvind Ramanathan,S. Chakra Chennubhotla,Nadine Kabbani,James Leland Olds,Shantenu Jha
Publisher : Frontiers Media SA
Page : 138 pages
File Size : 40,5 Mb
Release : 2022-02-28
Category : Science
ISBN : 9782889745456
Author : Stefan Canzar,Francisca Rojas Ringeling
Publisher : Humana
Page : 286 pages
File Size : 42,6 Mb
Release : 2020-10-18
Category : Science
ISBN : 1493998757
This volume explores techniques that study interactions between proteins in different species, and combines them with context-specific data, analysis of omics datasets, and assembles individual interactions into higher-order semantic units, i.e., protein complexes and functional modules. The chapters in this book cover computational methods that solve diverse tasks such as the prediction of functional protein-protein interactions; the alignment-based comparison of interaction networks by SANA; using the RaptorX-ComplexContact webserver to predict inter-protein residue-residue contacts; the docking of alternative confirmations of proteins participating in binary interactions and the visually-guided selection of a docking model using COZOID; the detection of novel functional units by KeyPathwayMiner and how PathClass can use such de novo pathways to classify breast cancer subtypes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary hardware- and software, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Protein-Protein Interaction Networks: Methods and Protocols is a valuable resource for both novice and expert researchers who are interested in learning more about this evolving field.
Author : Vladimir Uversky,Sonia Longhi
Publisher : John Wiley & Sons
Page : 532 pages
File Size : 53,8 Mb
Release : 2012-02-07
Category : Science
ISBN : 9780470618318
This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.
Author : Manja Marz,Bashar Ibrahim,Franziska Hufsky,David L. Robertson
Publisher : MDPI
Page : 330 pages
File Size : 53,9 Mb
Release : 2020-02-21
Category : Science
ISBN : 9783039218820
Virus bioinformatics is evolving and succeeding as an area of research in its own right, representing the interface of virology and computer science. Bioinformatic approaches to investigate viral infections and outbreaks have become central to virology research, and have been successfully used to detect, control, and treat infections of humans and animals. As part of the Third Annual Meeting of the European Virus Bioinformatics Center (EVBC), we have published this Special Issue on Virus Bioinformatics.
Author : Pragya Dhruv Yadav,Éric Bergeron,Sanjay Kumar,Sergio E Rodriguez,Deepak Y Patil
Publisher : Frontiers Media SA
Page : 299 pages
File Size : 48,9 Mb
Release : 2023-07-20
Category : Medical
ISBN : 9782832529829
Author : Ashutosh Kumar,Alok Dhawan
Publisher : Royal Society of Chemistry
Page : 310 pages
File Size : 54,5 Mb
Release : 2019-07-26
Category : Science
ISBN : 9781788018531
Nanoparticles have numerous biomedical applications including drug delivery, bone implants and imaging. A protein corona is formed when proteins existing in a biological system cover the nanoparticle surface. The formation of a nanoparticle–protein corona, changes the behaviour of the nanoparticle, resulting in new biological characteristics and influencing the circulation lifetime, accumulation, toxicity, cellular uptake and agglomeration. This book provides a detailed understanding of nanoparticle–protein corona formation, its biological significance and the factors that govern the formation of coronas. It also explains the impact of nanoparticle–protein interactions on biological assays, ecotoxicity studies and proteomics research. It will be of interest to researchers studying the application of nanoparticles as well as toxicologists and pharmaceutical chemists.
Author : Arpana Parihar,Raju Khan,Ashok Kumar,Ajeet Kumar Kaushik,Hardik Gohel
Publisher : Academic Press
Page : 620 pages
File Size : 45,6 Mb
Release : 2022-07-13
Category : Medical
ISBN : 9780323998000
Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV2 Infection: Revolutionary Strategies to Combat Pandemics compiles information about various computational bioinformatic approaches that can help combat viral infection. The book includes working knowledge of various molecular docking and molecular dynamic simulation approaches that have been exploited for drug repurposing and drug designing purpose. In addition, it sheds light on reverse vaccinomics and immunoinformatic approaches for vaccine designing against SARS-CoV2 infection. This book is an essential resource for researchers, bioinformaticians, computational biologists, computational chemists and pharmaceutical companies who are working on the development of effective and specific therapeutic interventions and point-of-care diagnostic devices using various computational approaches. Covers computational based approaches for designing and repurposing drugs Discusses immunoinformatic and reverse vaccinomic approaches for effective vaccine design Categorizes information about artificial intelligence-based drug screening and diagnostic tools
Author : Sunil K. Lal
Publisher : Springer Science & Business Media
Page : 328 pages
File Size : 43,6 Mb
Release : 2010-03-10
Category : Science
ISBN : 9783642036835
SARS was the ?rst new plague of the twenty-?rst century. Within months, it spread worldwide from its “birthplace” in Guangdong Province, China, affecting over 8,000 people in 25 countries and territories across ?ve continents. SARS exposed the vulnerability of our modern globalised world to the spread of a new emerging infection. SARS (or a similar new emerging disease) could neither have spread so rapidly nor had such a great global impact even 50 years ago, and arguably, it was itself a product of our global inter-connectedness. Increasing af?uence and a demand for wild-game as exotic food led to the development of large trade of live animal and game animal markets where many species of wild and domestic animals were co-housed, providing the ideal opportunities for inter-species tra- mission of viruses and other microbes. Once such a virus jumped species and attacked humans, the increased human mobility allowed the virus the opportunity for rapid spread. An infected patient from Guangdong who stayed for one day at a hotel in Hong Kong led to the transmission of the disease to 16 other guests who travelled on to seed outbreaks of the disease in Toronto, Singapore, and Vietnam, as well as within Hong Kong itself. The virus exploited the practices used in modern intensive care of patients with severe respiratory disease and the weakness in infection control practices within our health care systems to cause outbreaks within hospitals, further amplifying the spread of the disease. Health-care itself has become a two-edged sword.
Author : Satya Prakash Gupta
Publisher : Academic Press
Page : 516 pages
File Size : 49,5 Mb
Release : 2017-07-03
Category : Science
ISBN : 9780128096826
Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents. Provides comprehensive, state-of-the-art coverage of virus infections, the virus lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of each viral protease Presents an in-depth view of the structure and function of viral proteases
Author : Dmitrij Frishman,Manja Marz
Publisher : CRC Press
Page : 296 pages
File Size : 54,5 Mb
Release : 2021-08-18
Category : Computers
ISBN : 9781000426540
Viruses are the most numerous and deadliest biological entities on the planet, infecting all types of living organisms—from bacteria to human beings. The constantly expanding repertoire of experimental approaches available to study viruses includes both low-throughput techniques, such as imaging and 3D structure determination, and modern OMICS technologies, such as genome sequencing, ribosomal profiling, and RNA structure probing. Bioinformatics of viruses faces significant challenges due to their seemingly unlimited diversity, unusual lifestyle, great variety of replication strategies, compact genome organization, and rapid rate of evolution. At the same time, it also has the potential to deliver decisive clues for developing vaccines and medications against dangerous viral outbreaks, such as the recent coronavirus pandemics. Virus Bioinformatics reviews state-of-the-art bioinformatics algorithms and recent advances in data analysis in virology. FEATURES Contributions from leading international experts in the field Discusses open questions and urgent needs Covers a broad spectrum of topics, including evolution, structure, and function of viruses, including coronaviruses The book will be of great interest to computational biologists wishing to venture into the rapidly advancing field of virus bioinformatics as well as to virologists interested in acquiring basic bioinformatics skills to support their wet lab work.
Author : Saif Hameed,Zeeshan Fatima
Publisher : Springer Nature
Page : 538 pages
File Size : 42,6 Mb
Release : 2021-07-18
Category : Medical
ISBN : 9789811606915
This book examines applications of multi-omics approaches for understanding disease etiology, pathogenesis, host-pathogen interactions. It also analyzes the genetics, immunological and metabolic mechanisms underlying the infections. The book also explores genomics, transcriptomics, translational-omics, and metabolomics approaches to understand the pathogenesis and identify potential drug targets. It reviews the role of epigenetic reprogramming in shaping the host-pathogen interactions and presents bioinformatics application in the identification of drug targets. Further, it examines the potential applications of RNA sequencing and non-coding RNA profiling to identify the pathogenesis. Lastly, it offers the current challenges, technological advances, and prospects of using multi-omics technologies in infectious biology.
Author : Luis Enjuanes
Publisher : Springer Science & Business Media
Page : 278 pages
File Size : 52,7 Mb
Release : 2004-10-05
Category : Medical
ISBN : 3540214941
Human coronaviruses caused the SARS epidemic that infected more than 8000 people, killing about ten percent of them in 32 countries. This book provides essential information on these viruses and the development of vaccines to control coronavirus infections.
Author : A. Suresh,S. Vimal,Y. Harold Robinson,Dhinesh Kumar Ramaswami,R. Udendhran
Publisher : John Wiley & Sons
Page : 356 pages
File Size : 47,7 Mb
Release : 2022-04-12
Category : Computers
ISBN : 9781119791836
BIOINFORMATICS AND MEDICAL APPLICATIONS The main topics addressed in this book are big data analytics problems in bioinformatics research such as microarray data analysis, sequence analysis, genomics-based analytics, disease network analysis, techniques for big data analytics, and health information technology. Bioinformatics and Medical Applications: Big Data Using Deep Learning Algorithms analyses massive biological datasets using computational approaches and the latest cutting-edge technologies to capture and interpret biological data. The book delivers various bioinformatics computational methods used to identify diseases at an early stage by assembling cutting-edge resources into a single collection designed to enlighten the reader on topics focusing on computer science, mathematics, and biology. In modern biology and medicine, bioinformatics is critical for data management. This book explains the bioinformatician’s important tools and examines how they are used to evaluate biological data and advance disease knowledge. The editors have curated a distinguished group of perceptive and concise chapters that presents the current state of medical treatments and systems and offers emerging solutions for a more personalized approach to healthcare. Applying deep learning techniques for data-driven solutions in health information allows automated analysis whose method can be more advantageous in supporting the problems arising from medical and health-related information. Audience The primary audience for the book includes specialists, researchers, postgraduates, designers, experts, and engineers, who are occupied with biometric research and security-related issues.
Author : Valentina Tozzini,Giulia Palermo,Matteo Dal Peraro,Alexandre M. J. J. Bonvin,Rommie E. Amaro
Publisher : Frontiers Media SA
Page : 235 pages
File Size : 52,9 Mb
Release : 2020-10-27
Category : Science
ISBN : 9782889661091
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author : Rajani Sharma,A. V. Senthil Kumar,Kunal Kumar
Publisher : CRC Press
Page : 478 pages
File Size : 44,7 Mb
Release : 2024-08-16
Category : Medical
ISBN : 9781000988703
This new book takes an in-depth look at the emerging and prospective field of computational biology and bioinformatics, which possesses the ability to analyze large accumulated biological data collected from sequence analysis of proteins and genes and cell population with an aim to make new predictions pertaining to drug discovery and new biology. The book explains the basic methodology associated with a bioinformatics and computational approach in drug designing. It then goes on to cover the implementation of computational programming, bioinformatics, pharmacophore modeling, biotechnological techniques, and pharmaceutical chemistry in designing drugs. The major advantage of intervention of computer language or programming is to cut down the number of steps and costs in the field of drug designing, reducing the repeating steps and saving time in screening the potent component for drug or vaccine designing. The book describes algorithms used for drug designing and the use of machine learning and AI in drug delivery and disease diagnosis, which are valuable in clinical decision-making. The implementation of robotics in different diseases like stroke, cancer, COVID-19, etc. is also addressed. Topics include machine learning, AI, databases in drug design, molecular docking, bioinformatics tools, target-based drug design, and immunoinformatics, chemoinformatics, and nanoinformatics in drug design. Drug repurposing in drug design in general as well as for specific diseases, including cancer, Alzheimer’s disease, tuberculosis, COVID-19, etc., is also addressed in depth.