Molecular Biology Of The Sars Coronavirus

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Molecular Biology of the SARS-Coronavirus

Sunil K. Lal
Molecular Biology of the SARS Coronavirus Book PDF

Author : Sunil K. Lal
Publisher : Springer Science & Business Media
Page : 328 pages
File Size : 54,7 Mb
Release : 2010-03-10
Category : Science
ISBN : 9783642036835

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Molecular Biology of the SARS-Coronavirus by Sunil K. Lal Pdf

SARS was the ?rst new plague of the twenty-?rst century. Within months, it spread worldwide from its “birthplace” in Guangdong Province, China, affecting over 8,000 people in 25 countries and territories across ?ve continents. SARS exposed the vulnerability of our modern globalised world to the spread of a new emerging infection. SARS (or a similar new emerging disease) could neither have spread so rapidly nor had such a great global impact even 50 years ago, and arguably, it was itself a product of our global inter-connectedness. Increasing af?uence and a demand for wild-game as exotic food led to the development of large trade of live animal and game animal markets where many species of wild and domestic animals were co-housed, providing the ideal opportunities for inter-species tra- mission of viruses and other microbes. Once such a virus jumped species and attacked humans, the increased human mobility allowed the virus the opportunity for rapid spread. An infected patient from Guangdong who stayed for one day at a hotel in Hong Kong led to the transmission of the disease to 16 other guests who travelled on to seed outbreaks of the disease in Toronto, Singapore, and Vietnam, as well as within Hong Kong itself. The virus exploited the practices used in modern intensive care of patients with severe respiratory disease and the weakness in infection control practices within our health care systems to cause outbreaks within hospitals, further amplifying the spread of the disease. Health-care itself has become a two-edged sword.

The COVID-19 Pandemic: Epidemiology, Molecular Biology and Therapy

Shama Parveen
The COVID 19 Pandemic Epidemiology Molecular Biology and Therapy Book PDF

Author : Shama Parveen
Publisher : Bentham Science Publishers
Page : 276 pages
File Size : 46,8 Mb
Release : 2021-02-01
Category : Medical
ISBN : 9789811481857

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The COVID-19 Pandemic: Epidemiology, Molecular Biology and Therapy by Shama Parveen Pdf

The Coronavirus Disease 2019 (COVID-19) pandemic has affected almost every part of the globe with millions of cases and over a million deaths. The pandemic has had a significant global economic impact and addressing it systematically requires significant efforts from researchers, healthcare workers and governments. The COVID-19 Pandemic covers relevant aspects of this viral pandemic including information about the SARS-CoV-2 pathogen (morphology, genome, proteins, structural protein genes, replication), global epidemiology, transmission, risk factors, clinical manifestation, management, host immune response, pathogenesis, diagnosis and therapeutic agents (antivirals, natural compounds and vaccines). Readers will find basic and advanced knowledge about the disease organized into simple and easy-to-read chapters about the disease, making this book a handy and comprehensive reference for general readers, academics and biology students, alike.

Coronaviruses

Volker Thiel
Coronaviruses Book PDF

Author : Volker Thiel
Publisher : Caister Academic Press Limited
Page : 0 pages
File Size : 42,9 Mb
Release : 2007
Category : Science
ISBN : 1904455166

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Coronaviruses by Volker Thiel Pdf

In this timely book, internationally renowned experts review literally every aspect of cutting edge coronavirus research, providing the first coherent picture of this molecular and cellular biology since the outbreak of SARS in 2003. The book is divided into two sections. Part I focuses on the molecular biology of the virus itself and includes topics such as coronavirus binding and entry, replicase gene function, cis-acting RNA elements, coronavirus discontinuous transcription, reverse genetics, genome packaging, and molecular evolution. In Part II of the book, the focus is on molecular and cellular pathogenesis and infection control. This section includes reviews of the three prototype viruses, namely avian infectious bronchitis virus, feline coronavirus, and mouse hepatitis virus. Other topics include SARS-CoV virus pathogenesis, SARS-CoV interaction with the host INF and antiviral cytokines, the newly recognized bat coronaviruses and human coronavirus NL63, and strategies for coronavirus vaccine development and the development of novel antiviral coronavirus agents.

Coronaviruses

Hubert Laude,Jean-Francois Vautherot
Coronaviruses Book PDF

Author : Hubert Laude,Jean-Francois Vautherot
Publisher : Springer Science & Business Media
Page : 462 pages
File Size : 44,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461529965

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Coronaviruses by Hubert Laude,Jean-Francois Vautherot Pdf

Coronaviruses represent a major group of viruses of both molecular biological interest and clinical significance in animals and humans. During the past two decades, coronavirus research has been an expanding field and, since 1980, an international symposium was held every 3 years. We organized the yth symposium for providing an opportunity to assess important progresses made since the last symposium in Cambridge (U. K. ) and to suggest areas for future investigations. The symposium, held in September 1992, in Chantilly, France, was attended by 120 participants representing the majOlity of the laboratories engaged in the field. The present volume collects 75 papers which were presented during the yth symposium, thus providing a comprehensive view of the state of the art ofCoronavirology. The book is divided into 7 chapters. The first chapters gather reports dealing with genome organization, gene expression and structure-function relationships of the viral polypeptides. New sequence data about as yet poorly studied coronaviruses - canine coronavirus CCY and porcine epidemic diarrhoea virus PEDY - are presented. Increasing efforts appear to be devoted to the characterization of products of unknown function, encoded by various open reading frames present in the coronavirus genomes or delived from the processing of the large polymerase polyprotein. Due to the extreme size of their genome, the genetic engineering ofcoronavi\'uses through the production of full length cDNA clones is presently viewed as an unachievahle task.

Clinical, Biological and Molecular Aspects of COVID-19

Paul C. Guest
Clinical Biological and Molecular Aspects of COVID 19 Book PDF

Author : Paul C. Guest
Publisher : Springer Nature
Page : 356 pages
File Size : 48,7 Mb
Release : 2021-03-03
Category : Medical
ISBN : 9783030592615

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Clinical, Biological and Molecular Aspects of COVID-19 by Paul C. Guest Pdf

The novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just eight months. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the virus are profound, and has required extreme social distancing measures across the globe in order to prevent overwhelming the healthcare services and hospitals. COVID-19 appears to have the greatest effects on elderly individuals and those who have co-morbid diseases, such as heart disease, asthma, and diabetes. As the peak begins to slow in many countries, the death rates remain high amidst justified fears of a second wave. A rapid worldwide mobilization has begun to identify effective treatments and develop vaccines. This new volume will increase readers’ understanding of the ongoing COVID-19 pandemic through a series of chapters that address these concerns. Leading experts will discuss the effects of the virus in cases of co-morbidities, new treatment approaches, mental health aspects of the pandemic, and convey the results of survey studies. The book will be an excellent resource for researchers studying virology, metabolic diseases, respiratory disorders, and clinical scientists, physicians, drug companies, and healthcare services and workers.

Molecular Biology and Pathogenesis of Coronaviruses

P. J. Rottier
Molecular Biology and Pathogenesis of Coronaviruses Book PDF

Author : P. J. Rottier
Publisher : Springer Science & Business Media
Page : 408 pages
File Size : 54,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461593737

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Molecular Biology and Pathogenesis of Coronaviruses by P. J. Rottier Pdf

The present volume contains the Proceedings of an EMBO Workshop organized in June 1983 by the Institute of Virology, Veterinary Faculty, State University of Utrecht, The Netherlands. Some 70 scientists from 11 countries followed the invitation to present and discuss their recent data on the structure, replication, genetics and pathogenesis of coronaviruses. It was the second international meeting on these viruses; the Workshop, which was held in Zeist near Utrecht followed the example of the Wuerzburg symposium of October 1980. At that time it became clear that coronaviruses are unique in many respects. Once a group of viruses that were defined merely on the basis of their characteristic peplomer morphology, Coronaviridae family members are known today - to be constructed from essentially three polypeptides - to use a "nested set" of 5-6 subgenomic mRNAs in the expression of their large, positive and single stranded RNA genome, - to generate these subgenomic RNAs through specific fusion of non contiguous sequences, - to mature by budding from intracellular membranes, - to cause persistent infection with neurological involvement and sometimes immunopathological conditons. These and many other findings have been established only very recently. The articles collected in this book reveal and/or further detail these findings. Since these Proceedings contain the combined scientific presentations of representatives from virtually all laboratories engaged in the field, they provide a fairly comprehensive review of the state of the art in corona virology.

SARS- and Other Coronaviruses

Dave Cavanagh
SARS and Other Coronaviruses Book PDF

Author : Dave Cavanagh
Publisher : Springer Science & Business Media
Page : 368 pages
File Size : 40,9 Mb
Release : 2008-09-02
Category : Medical
ISBN : 1588298671

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SARS- and Other Coronaviruses by Dave Cavanagh Pdf

In 2003, the word "coronavirus" spread across the globe, somewhat further than the virus that sparked the panic. In this book, expert researchers examine these devastating viruses through 23 state-of-the-art, widely applicable protocols with minute detail. Comprehensive and cutting-edge, the book serves as an ideal guide for all virologists and especially for those working with coronaviruses. Written by international experts, this book is relevant to a wide array of professions.

Learning from SARS

Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Learning from SARS Book PDF

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 376 pages
File Size : 52,9 Mb
Release : 2004-04-26
Category : Medical
ISBN : 9780309182157

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Learning from SARS by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

The emergence of severe acute respiratory syndrome (SARS) in late 2002 and 2003 challenged the global public health community to confront a novel epidemic that spread rapidly from its origins in southern China until it had reached more than 25 other countries within a matter of months. In addition to the number of patients infected with the SARS virus, the disease had profound economic and political repercussions in many of the affected regions. Recent reports of isolated new SARS cases and a fear that the disease could reemerge and spread have put public health officials on high alert for any indications of possible new outbreaks. This report examines the response to SARS by public health systems in individual countries, the biology of the SARS coronavirus and related coronaviruses in animals, the economic and political fallout of the SARS epidemic, quarantine law and other public health measures that apply to combating infectious diseases, and the role of international organizations and scientific cooperation in halting the spread of SARS. The report provides an illuminating survey of findings from the epidemic, along with an assessment of what might be needed in order to contain any future outbreaks of SARS or other emerging infections.

Corona- and Related Viruses

Gary A. Levy,Pierre J. Talbot
Corona and Related Viruses Book PDF

Author : Gary A. Levy,Pierre J. Talbot
Publisher : Springer Science & Business Media
Page : 592 pages
File Size : 52,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461518990

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Corona- and Related Viruses by Gary A. Levy,Pierre J. Talbot Pdf

Corona- and related viruses are important human and animal pathogens that also serve as models for other viral-mediated diseases. Interest in these pathogens has grown tremendously since the First International Symposium was held at the Institute of Virology and Immunobiology of the University of Wiirzburg, Germany. The Sixth International Symposium was held in Quebec City from August 27 to September I, 1994, and provided further understanding of the molecular biology, immunology, and pathogenesis of corona-, toro-, and arterivirus infections. Lectures were given on the molecular biology, pathogenesis, immune responses, and development of vaccines. Studies on the pathogenesis of coronavirus infections have been focused mainly on murine coronavirus, and mouse hepatitis virus. Neurotropic strains ofMHV (e.g., JHM, A59) cause a demyelinating disease that has served as an animal model for human multiple sclerosis. Dr. Samuel Dales, of the University of Western Ontario, London, Canada, gave a state-of-the-art lecture on our current under standing of the pathogenesis of JHM-induced disease.

Coronaviruses

Helena J. Maier,Erica Bickerton
Coronaviruses Book PDF

Author : Helena J. Maier,Erica Bickerton
Publisher : Humana
Page : 278 pages
File Size : 53,9 Mb
Release : 2021-09-08
Category : Medical
ISBN : 1071609025

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Coronaviruses by Helena J. Maier,Erica Bickerton Pdf

This detailed new edition provides a comprehensive collection of protocols applicable to all members of the Coronavirinae sub-family currently and that are also transferrable to other fields of virology. Beginning with a section on detection, discovery, and evolution, the volume continues with coverage of propagation and titration of coronaviruses, genome manipulation, study of virus-host interactions, as well as imaging coronavirus infections. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Coronaviruses: Methods and Protocols, Second Edition serves as a valuable guide to researchers working to identify and control viruses with increased potential to cross the species barrier and to develop the diagnostics, vaccines, and antiviral therapeutics that are required to manage future outbreaks in both humans and animals.

SARS-CoV-2

Justin Jang Hann Chu,Bintou Ahmadou Ahidjo,Chee Keng Mok
SARS CoV 2 Book PDF

Author : Justin Jang Hann Chu,Bintou Ahmadou Ahidjo,Chee Keng Mok
Publisher : Humana
Page : 478 pages
File Size : 52,8 Mb
Release : 2022-05-12
Category : Medical
ISBN : 1071621106

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SARS-CoV-2 by Justin Jang Hann Chu,Bintou Ahmadou Ahidjo,Chee Keng Mok Pdf

This detailed volume provides the increasing number of SARS-CoV-2 researchers with a useful handbook covering multidisciplinary approaches on various aspects of SARS-CoV-2 research, brought together by leading laboratories across the globe. Topics covered include techniques in clinical and diagnostic virology, basic protocols in cell and virus culture, as well as bioinformatics and proteomics approaches in cellular response studies. This comprehensive collection also covers methods in immunology, animal models, antivirals and vaccine development strategies, as well as biorisk and mitigation measurements for SARS-CoV-2 research. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detailed implementation advice that is vital for success in the lab. Practical and timely, SARS-CoV-2: Methods and Protocols serves as an ideal guide for scientists investigating this prevalent and perilous RNA virus and the novel coronavirus disease that results from it.

Immunobiology of COVID-19

Anonim
Immunobiology of COVID 19 Book PDF

Author : Anonim
Publisher : Elsevier
Page : 262 pages
File Size : 52,9 Mb
Release : 2024-01-17
Category : Science
ISBN : 9780443132858

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Immunobiology of COVID-19 by Anonim Pdf

This volume provides a comprehensive and in-depth exploration of the SARS-CoV-2 virus and its impact on human health. Written by a team of expert contributors, the book covers various aspects of the virus, including its structure, life cycle, and genomic replication. It delves into the epidemiology of COVID-19, comparing it with other related coronaviruses and discussing the concept of herd immunity. The structural biology of SARS-CoV-2 is examined, with a focus on techniques such as electron microscopy and cryo-electron tomography. The book also explores the biology of SARS-CoV-2 variants and their immune evasion strategies. Furthermore, it delves into the pathogenesis of COVID-19, examining its multiorgan manifestations and the long-term effects of the disease. The innate and adaptive immune responses to SARS-CoV-2 are discussed in detail, along with the role of B cells and T cells in the immune response. The volume concludes with a look at future insights and potential developments in the field. Accompanied by illustrative diagrams and visuals, this volume would aid in grasping complex concepts, serving as a valuable resource for researchers, healthcare professionals, and anyone interested in understanding the intricate details of SARS-CoV-2 and its impact on global health. Comprehensive coverage of various aspects of the COVID-19 pandemic, including virus structure, variants, immune responses, disease pathogenesis including its multiorgan manifestations and long COVID Focus on in-depth analysis of innate and adaptive immune responses to SARS-CoV-2, including B cell and T cell responses, discussing the recognition and activation mechanisms, antibody production, immunological memory as well as the role of spike proteins in immunological regulation Richly illustrated with informative diagrams, providing visual aids to enhance understanding of complex concepts and structures related to COVID-19

Covid-19: Biomedical Perspectives

Anonim
Covid 19 Biomedical Perspectives Book PDF

Author : Anonim
Publisher : Academic Press
Page : 300 pages
File Size : 42,7 Mb
Release : 2022-05-31
Category : Science
ISBN : 9780323853408

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Covid-19: Biomedical Perspectives by Anonim Pdf

Covid-19: Biomedical Perspectives, Volume 50 in the Methods in Microbiology series highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Individual chapters in this new release include Sensitive methods for detection of SARS-CoV-2 RNA, Treatment of COVID-19 using Chinese herbal medicine, Understanding how SARS-CoV-2 is evolving and its impact on COVID-19 animal models and vaccine evaluation, Methods in machine learning to identify COVID-19 literature, COVID-19 seasonal behavior and the mutational landscape of the SARS-CoV-2 virus, CRISPR use in Diagnosis and Therapy for COVID-19, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods of Microbiology serials Updated release includes the latest information on Covid-19: Biomedical Perspectives

Molecular and Cellular Biology of Viruses

Phoebe Lostroh
Molecular and Cellular Biology of Viruses Book PDF

Author : Phoebe Lostroh
Publisher : CRC Press
Page : 550 pages
File Size : 45,9 Mb
Release : 2024-03-25
Category : Science
ISBN : 9781040005330

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Molecular and Cellular Biology of Viruses by Phoebe Lostroh Pdf

This fully revised second edition of Molecular and Cellular Biology of Viruses leads students on an exploration of viruses by supporting engaging and interactive learning. All the major classes of viruses are covered, with separate chapters for their replication and expression strategies, and chapters for mechanisms such as attachment that are independent of the virus genome type. Specific cases drawn from primary literature foster student engagement. End-of-chapter questions focus on analysis and interpretation with answers being given at the back of the book. Examples come from the most-studied and medically important viruses such as SARS-CoV-2, HIV, and influenza. Plant viruses and bacteriophages are also included. There are chapters on the overall effect of viral infection on the host cell. Coverage of the immune system is focused on the interplay between host defenses and viruses, with a separate chapter on medical applications such as antiviral drugs and vaccine development. The final chapter is on virus diversity and evolution, incorporating contemporary insights from metagenomic research. The second edition has updated suggestions for primary literature to discuss along with each chapter. New to this second edition, a supplementary chapter, freely available for download, looks at how virology intersects with public health, and uses the COVID-19 pandemic as a notable example. Key Features Readable but rigorous coverage of the molecular and cellular biology of viruses Molecular mechanisms of all major groups, including plant viruses and bacteriophages, illustrated by example Host-pathogen interactions at the cellular and molecular level emphasized throughout Medical implications and consequences included Quality illustrations available to instructors New to this second edition, interactive quiz questions hosted online

Coronavirus Replication and Reverse Genetics

Luis Enjuanes
Coronavirus Replication and Reverse Genetics Book PDF

Author : Luis Enjuanes
Publisher : Springer Science & Business Media
Page : 278 pages
File Size : 43,6 Mb
Release : 2004-10-05
Category : Medical
ISBN : 3540214941

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Coronavirus Replication and Reverse Genetics by Luis Enjuanes Pdf

Human coronaviruses caused the SARS epidemic that infected more than 8000 people, killing about ten percent of them in 32 countries. This book provides essential information on these viruses and the development of vaccines to control coronavirus infections.