Computational Vaccine Design

Author : Pedro A. Reche
Publisher : Springer Nature
Page : 513 pages
File Size : 43,6 Mb
Release : 2023-05-31
Category : Science
ISBN : 9781071632390

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Computational Vaccine Design by Pedro A. Reche Pdf

This volume explores computational vaccine design and the technologies that support it. Chapters have been divided into four parts detailing immunonics and system immunology, databases, prediction of antigenicity and immunogenicity, and computational vaccinology. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Computational Vaccine Design: Methods and Protocols aims to reflect on the rigorous and imaginative use of computational technologies to help catalyze future efforts and to improve global public health through the development of a broad range of novel vaccines.

Author : Joo Chuan Tong,Shoba Ranganathan
Publisher : Elsevier
Page : 164 pages
File Size : 55,6 Mb
Release : 2013-07-31
Category : Medical
ISBN : 9781908818416

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Computer-Aided Vaccine Design by Joo Chuan Tong,Shoba Ranganathan Pdf

Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates. Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics. Essential reading for any biologist who wants to understand methods of computer-aided vaccine design Description of available data sources and publicly available software, with detailed analysis of strengths and weaknesses Theoretical concepts and practical examples of database design and development for a virtual screening campaign

Author : Darren R. Flower
Publisher : John Wiley & Sons
Page : 302 pages
File Size : 46,8 Mb
Release : 2008-10-13
Category : Medical
ISBN : 9780470699829

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Bioinformatics for Vaccinology by Darren R. Flower Pdf

“... this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues—making the book enticing and useful, all at once...” Human Vaccines, 2010 "... This book has several strong points. Although there are many textbooks that deal with vaccinology, few attempts have been made to bring together descriptions of vaccines in history, basic bioinformatics, various computational solutions and challenges in vaccinology, detailed experimental methodologies, and cutting-edge technologies... This book may well serve as a first line of reference for all biologists and computer scientists..." –Virology Journal, 2009 Vaccines have probably saved more lives and reduced suffering in a greater number of people than any other medical intervention in human history, succeeding in eradicating smallpox and significantly reducing the mortality and incidence of other diseases. However, with the emergence of diseases such as SARS and the threat of biological warfare, vaccination has once again become a topic of major interest in public health. Vaccinology now has at its disposal an array of post-genomic approaches of great power. None has a more persuasive potential impact than the application of computational informatics to vaccine discovery; the recent expansion in genome data and the parallel increase in cheap computing power have placed the bioinformatics exploration of pathogen genomes centre stage for vaccine researchers. This is the first book to address the area of bioinformatics as applied to rational vaccine design, discussing the ways in which bioinformatics can contribute to improved vaccine development by introducing the subject of harnessing the mathematical and computing power inherent in bioinformatics to the study of vaccinology putting it into a historical and societal context, and exploring the scope of its methods and applications. Bioinformatics for Vaccinology is a one-stop introduction to computational vaccinology. It will be of particular interest to bioinformaticians with an interest in immunology, as well as to immunologists, and other biologists who need to understand how advances in theoretical and computational immunobiology can transform their working practices.

Author : Sunil Thomas
Publisher : Springer Nature
Page : 702 pages
File Size : 43,6 Mb
Release : 2021-12-16
Category : Science
ISBN : 9781071618844

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Vaccine Design by Sunil Thomas Pdf

This volume provides a practical guide providing step-by-step protocol to design and develop vaccines for human diseases. Divided into three volumes, Volume 1: Vaccines for Human Diseases guides readers through an introductory section on future challenges for vaccinologists and the immunological mechanism of vaccines. Chapters focus on design of human vaccines for viral, bacterial, fungal, and parasitic diseases as well as tumor vaccines. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Vaccine Design: Methods and Protocols, Second Edition, Volume 1: Vaccines for Human Diseases aims to be a useful practical guide to researchers to help further their study in this field.

Author : Tarun Kumar Bhatt,Surendra Nimesh
Publisher : Academic Press
Page : 310 pages
File Size : 45,7 Mb
Release : 2021-01-21
Category : Business & Economics
ISBN : 9780128214756

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The Design and Development of Novel Drugs and Vaccines by Tarun Kumar Bhatt,Surendra Nimesh Pdf

The Design and Development of Novel Drugs and Vaccines: Principles and Protocols presents both in silico methods and experimental protocols for vaccine and drug design and development, critically reviewing the most current research and emphasizing approaches and technologies that accelerate and lower the cost of product development. Sections review the technologies and approaches used to identify, characterize and establish a protein as a new drug and vaccine target, cover several molecular methods for in vitro studies of the desired target, and present various physiological parameters for in vivo studies. The book includes preclinical trials and research, along with information on FDA approval. Covers both in silico methods and experimental protocols for vaccine and drug development in a single, accessible volume Offers a holistic accounting of how developments in bioinformatics and large experimental datasets can be used in the development of vaccines and drugs Shows researchers the entire gamut of current therapies, ranging from computational inputs to animal studies Reviews the most current, cutting-edge research available on vaccine and drug design and development

Author : Gregory Gregoriadis,Brenda McCormack,Anthony C. Allison
Publisher : Springer Science & Business Media
Page : 228 pages
File Size : 50,5 Mb
Release : 1997
Category : Medical
ISBN : 0306458187

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Vaccine Design by Gregory Gregoriadis,Brenda McCormack,Anthony C. Allison Pdf

During the last decade or so vaccine development has been facilitated by rapid ad­ vances in the molecular and cell biology ofthe immune system. This has laid the foundations of a new generation of vaccines exemplified by subunit vaccines produced through gene cloning and by synthetic peptides mimicking small regions ofproteins on the outer coat ofvi­ ruses. However, as subunit and peptide vaccines are only weakly or non-immunogenic, there is areal need for strategies to improve their potency. This book contains the proceedings of the 5th NATO Advanced Studies Institute (ASI), "Vaccine Design: The Role of Cytokine Networks," held at Cape Sounion Beach, Greece, during 24 June-5 July 1996 and deals in depth with the role ofbasic immunology in the regulation of immunity and vaccine design. Special emphasis is given to the use of cyto­ kines in conjuction with vaccines with the aim ofimproving their potency or the use ofvac­ cines designed to improve cytokine production. We express our appreciation to Dr. J.-L. Virelizier and Dr. G. Kollias for their cooperation in planning the ASI and to Mrs. Concha Perring for her excellent production ofthe manuscripts. The ASI was held under the sponsor­ ship of NATO Scientific Affairs Division and generously co-sponsored by SmithKline Beecham Pharmaceuticals (Philadelphia). Financial assistance was also provided by Connaught Laboratories Ltd. (Ontario), Pasteur Merieux (Marcy I 'Etoile), Biochine (Siena), Help SA (Athens), and Avanti Polar Lipids Inc. (Birmingham, USA).

Author : W. John W. Morrow,Nadeem A. Sheikh,Clint S. Schmidt,D. Huw Davies
Publisher : John Wiley & Sons
Page : 552 pages
File Size : 50,9 Mb
Release : 2012-06-12
Category : Medical
ISBN : 9781118345344

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Vaccinology by W. John W. Morrow,Nadeem A. Sheikh,Clint S. Schmidt,D. Huw Davies Pdf

Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe. Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application Includes evaluation of vaccine efficacy and safety Details clinical trial design, including regulatory requirements Discusses the emerging field of active cellular immunotherapy Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.

Author : Vijay Kumar Prajapati
Publisher : Academic Press
Page : 438 pages
File Size : 47,9 Mb
Release : 2022-08-20
Category : Medical
ISBN : 9780323897860

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System Vaccinology by Vijay Kumar Prajapati Pdf

Emergence of new and deadly infectious diseases is significantly deteriorating the human health. Development of vaccine by the scientist has become an important weapon to control the spread of infectious diseases as well as to improve the life expectancy at global level in 20th-21st Century. This book will provide the in-depth knowledge of vaccine history, and development of new strategies to design efficacious and safe vaccine molecule. This book will cover the development of system vaccinology and their applications revolutionize the vaccine discovery. This will provide a resource for the basic and clinical researcher working to human life expectancy by their vaccine experiments and clinical trials. My purpose to write this book to educate the students and researchers with modern development in the field of vaccinology and empowering the researcher with new tools and methodology for developing potential and immunogenic vaccines. This book will be helpful to solve the curiosity of science and medical background students related with vaccinology and will be helpful to devise a new vaccine molecule to control the spread of new and emerging pathogens. Systems biology is a rapidly expanding research discipline aiming to integrate multifaceted datasets generated using state-of-the-art high- throughput technologies such as arrays and next-generation sequencing. Combined with sophisticated computational analysis we are able to interrogate host responses to infections and vaccination on a systems level, thus generating important new hypotheses and discovering unknown associations between immunological parameters. Provides in-depth knowledge of vaccine history Covers the development of system vaccinology and their applications revolutionize the vaccine discovery Gives insights to the development of new strategies to design efficacious and safe vaccine molecule Provides a resource for the basic and clinical researcher working to human life expectancy by their vaccine experiments and clinical trials Highlights the importance of differential miRNA expression, microbiome after vaccination for human health Serves the need of students and researcher for applying computational tools and quick designing of potential molecule which may be proposed for vaccine trial Take the decisions to perform the kind of experiments for assessment of vaccine immunogenicity Aims to understand disease pathogenesis and host responses to infection and vaccination Offers a seamless continuum of scientific discovery and vaccine invention

Author : Namrata Tomar
Publisher : Humana
Page : 409 pages
File Size : 50,9 Mb
Release : 2021-03-26
Category : Medical
ISBN : 1071603914

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Immunoinformatics by Namrata Tomar Pdf

This book covers a wide range of diverse immunoinformatics research topics, involving tools and databases of potential epitope prediction, HLA gene analysis, MHC characterizing, in silico vaccine design, mathematical modeling of host-pathogen interactions, and network analysis of immune system data. In that way, this fully updated volume explores the enormous value of computational tools and models in immunology research. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of key insights and detailed implementation advice to encourage successful results in the lab. Authoritative and practical, Immunoinformatics, Third Edition serves as an ideal guide for scientists working at the intersection of bioinformatics, mathematical modelling, and statistics for the study of immune systems biology.

Author : Christian Schönbach,Shoba Ranganathan,Vladimir Brusic
Publisher : Springer Science & Business Media
Page : 216 pages
File Size : 40,5 Mb
Release : 2007-11-21
Category : Medical
ISBN : 9780387729688

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Immunoinformatics by Christian Schönbach,Shoba Ranganathan,Vladimir Brusic Pdf

In contrast to existing books on immunoinformatics, this volume presents a cross-section of immunoinformatics research. The contributions highlight the interdisciplinary nature of the field and how collaborative efforts among bioinformaticians and bench scientists result in innovative strategies for understanding the immune system. Immunoinformatics is ideal for scientists and students in immunology, bioinformatics, microbiology, and many other disciplines.

Author : Darren R. Flower,Yvonne Perrie
Publisher : Springer Science & Business Media
Page : 316 pages
File Size : 41,6 Mb
Release : 2012-12-09
Category : Medical
ISBN : 9781461450702

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Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines by Darren R. Flower,Yvonne Perrie Pdf

This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.

Author : Jessica R. Burdman
Publisher : Plenum Publishing Corporation
Page : 1008 pages
File Size : 43,6 Mb
Release : 1995
Category : Drugs
ISBN : UOM:39015034444953

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Vaccine Design by Jessica R. Burdman Pdf

Immunological and formulation design considerations for subunit vaccines. Public health implications of emerging vaccine technologies. Preclinical safety assessment considerations in vaccine development. Regulatory considerations in vaccine design. Clinical considerations in vaccine trials with special reference to candidate HIV vaccines. Laboratory empiricism, clinical design, and social value: the rough road toward vaccine development. A compedium of vaccine adjuvants and excipients. Adjuvant properties of aluminum and calcium compounds. Structure and properties of aluminum-containing adjuvants. MF59: design and evaluation of a safe and potent adjuvant for human vaccines. Development of vaccines based on formulations containing nonionic block copolymers. Development of an emulsion-based muramyl dipeptide adjuvant formulation for vaccines. Liposomal presentation of antigens for human vaccines. Liposome design and vaccine development. Lipid matrix-based vaccines for mucosal and systemic immunization. Polymer microspheres for vaccine delivery. Vehicle for oral immunization. Design and production of single-immunization vaccines using polylactide polyglycolide microsphere systems. Nanoparticles as adjuvants for vaccines. Water-soluble phosphazene polymers for parenteral and mucosal vaccine delivery. Monophosphoryl lipid A as an adjuvant: past experiences and new directions. Structural and immunological characterization of the vaccine adjuvant QS-21. A novel generation of viral vaccines based on the ISCOM matrix. Vaccine adjuvants based on gamma inulin. A new approach to vaccine adjuvants: immunopotentiation by intracellular T-helper-like signals transmitted by loxoribine. Stearyl tyrosine: an organic equivalent of aluminum-based immunoadjuvants. Cytokines as vaccine adjuvants: current status and potential applications. Cytokines as immunological adjuvants. Cytokine-containing liposomes as adjuvants for subunit vaccines. Haemophilus influenzae type b conjugate vaccines. Pneumococcal conjugate vaccines. Lyme vaccine enhancement: N-terminal acylation of a protein antigen and inclusion of a saponin adjuvant. Vaccine research and development for the prevention of filarial nematode infections. Retrovirus and retrotransposon particles as antigen presentation and delivery systems. Rationale and approaches to constructing preerythrocytic malaria vaccines. The MAP system: a flexible and unambiguous vaccine design of branched peptides. Design of experimental synthetic peptide immunogens for prevention of HIV-1 and HTLV-I retroviral infections. Design and testing of peptide-based cytotoxic T-cell-mediated immunotherapeutics to treat infectious diseases and cancer. Development of active specific immunotherapeutic agents based on cancer-associated mucins. Synthetic peptide vaccines for schistosomiasis. Synthetic hormone/growth factor subunit vaccine with application to antifertility and cancer.

Author : Clarisa Beatriz Palatnik-de-Sousa,Irene da Silva Soares,Daniela Santoro Rosa
Publisher : Frontiers Media SA
Page : 284 pages
File Size : 47,6 Mb
Release : 2018-07-12
Category : Antigens
ISBN : 9782889455225

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Epitope Discovery and Synthetic Vaccine Design by Clarisa Beatriz Palatnik-de-Sousa,Irene da Silva Soares,Daniela Santoro Rosa Pdf

Author : Rino Rappuoli,Fabio Bagnoli
Publisher : Caister Academic Press Limited
Page : 0 pages
File Size : 48,5 Mb
Release : 2011
Category : Medical
ISBN : 1904455743

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Vaccine Design by Rino Rappuoli,Fabio Bagnoli Pdf

In this book, expert international authors critically review the current cutting-edge research in vaccine design and development. Particular emphasis is given to new approaches and technologies.

Author : Khalid Raza
Publisher : Springer Nature
Page : 436 pages
File Size : 50,8 Mb
Release : 2020-10-16
Category : Technology & Engineering
ISBN : 9789811585340

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Computational Intelligence Methods in COVID-19: Surveillance, Prevention, Prediction and Diagnosis by Khalid Raza Pdf

The novel coronavirus disease 2019 (COVID-19) pandemic has posed a major threat to human life and health. This book is beneficial for interdisciplinary students, researchers, and professionals to understand COVID-19 and how computational intelligence can be used for the purpose of surveillance, control, prevention, prediction, diagnosis, and potential treatment of the disease. The book contains different aspects of COVID-19 that includes fundamental knowledge, epidemic forecast models, surveillance and tracking systems, IoT- and IoMT-based integrated systems for COVID-19, social network analysis systems for COVID-19, radiological images (CT, X-ray) based diagnosis system, and computational intelligence and in silico drug design and drug repurposing methods against COVID-19 patients. The contributing authors of this volume are experts in their fields and they are from various reputed universities and institutions across the world. This volume is a valuable and comprehensive resource for computer and data scientists, epidemiologists, radiologists, doctors, clinicians, pharmaceutical professionals, along with graduate and research students of interdisciplinary and multidisciplinary sciences.