Immunoinformatics

Author : Gregory R. Bock,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 272 pages
File Size : 52,8 Mb
Release : 2004-03-05
Category : Medical
ISBN : 9780470090756

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Immunoinformatics by Gregory R. Bock,Jamie A. Goode Pdf

The astounding diversity of the immune system and the complexity of its regulatory pathways makes immunology a combinatorial science. Computational analysis has therefore become an essential element of immunology research and this has led to the creation of the emerging field of immunoinformatics. This book is the first to feature thorough coverage of this new field. Immunoinformatics facilitates the understanding of immune function by modelling the interactions among immunological components. Biological research provides ever deeper insights into the complexity of living organisms while computer science provides an effective means to store and analyse large volumes of complex data. Combining the two fields increases the efficiency of biological research and offers the potential for major advances in the study of biological systems. This book encompasses key developments in immunoinformatics, including immunological databases, sequence analysis, structure modelling, mathematical modelling of the immune system, simulation of laboratory experiments, statistical support for immunological experimentation and immunogenomics. The difficulties in effective application of bioinformatic tools in immunology arise at both ends of the spectrum: most immunologists have only a limited comprehension of sophisticated data analysis and applicability and limitations, while the average computer scientist lacks knowledge of the depth and complexity of biological data. The purpose of this book, therefore, is to present contributions from a multidisciplinary team of biologists and computer scientists to explore the issues related to better understanding of immune function and, in particular, to help apply new computer science methods to immunological research. Related Novartis Foundation symposia: 247 In Silico Simulation of Biological Processes Chair: Denis Noble 252 Generation and effector functions of regulatory lymphocytes Chair: Jean-François Bach

Author : Namrata Tomar
Publisher : Humana
Page : 409 pages
File Size : 42,6 Mb
Release : 2021-03-26
Category : Medical
ISBN : 1071603914

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Immunoinformatics by Namrata Tomar Pdf

This book covers a wide range of diverse immunoinformatics research topics, involving tools and databases of potential epitope prediction, HLA gene analysis, MHC characterizing, in silico vaccine design, mathematical modeling of host-pathogen interactions, and network analysis of immune system data. In that way, this fully updated volume explores the enormous value of computational tools and models in immunology research. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of key insights and detailed implementation advice to encourage successful results in the lab. Authoritative and practical, Immunoinformatics, Third Edition serves as an ideal guide for scientists working at the intersection of bioinformatics, mathematical modelling, and statistics for the study of immune systems biology.

Author : Christian Schönbach,Shoba Ranganathan,Vladimir Brusic
Publisher : Springer Science & Business Media
Page : 216 pages
File Size : 41,7 Mb
Release : 2007-11-21
Category : Medical
ISBN : 9780387729688

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Immunoinformatics by Christian Schönbach,Shoba Ranganathan,Vladimir Brusic Pdf

In contrast to existing books on immunoinformatics, this volume presents a cross-section of immunoinformatics research. The contributions highlight the interdisciplinary nature of the field and how collaborative efforts among bioinformaticians and bench scientists result in innovative strategies for understanding the immune system. Immunoinformatics is ideal for scientists and students in immunology, bioinformatics, microbiology, and many other disciplines.

Author : Darren R. Flower
Publisher : Springer Science & Business Media
Page : 436 pages
File Size : 45,5 Mb
Release : 2008-02-07
Category : Science
ISBN : 9781603271189

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Immunoinformatics by Darren R. Flower Pdf

This volume both engages the reader and provides a sound foundation for the use of immunoinformatics techniques in immunology and vaccinology. It addresses databases, HLA supertypes, MCH binding, and other properties of immune systems. The book contains chapters written by leaders in the field and provides a firm background for anyone working in immunoinformatics in one easy-to-use, insightful volume.

Author : Nima Rezaei,Parnian Jabbari
Publisher : Academic Press
Page : 284 pages
File Size : 44,5 Mb
Release : 2022-04-19
Category : Medical
ISBN : 9780128224304

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Immunoinformatics of Cancers by Nima Rezaei,Parnian Jabbari Pdf

Immunoinformatics of Cancers: Practical Machine Learning Approaches Using R takes a bioinformatics approach to understanding and researching the immunological aspects of malignancies. It details biological and computational principles and the current applications of bioinformatic approaches in the study of human malignancies. Three sections cover the role of immunology in cancers and bioinformatics, including databases and tools, R programming and useful packages, and present the foundations of machine learning. The book then gives practical examples to illuminate the application of immunoinformatics to cancer, along with practical details on how computational and biological approaches can best be integrated.This book provides readers with practical computational knowledge and techniques, including programming, and machine learning, enabling them to understand and pursue the immunological aspects of malignancies. Presents the knowledge researchers need to apply computational techniques to immunodeficiencies Provides the most practical material for bioinformatics approaches to the immunology of cancers Gives straightforward and efficient explanations of programming and machine learning approaches in R Includes details of the most useful databases, tools, programming packages and algorithms for immunoinformatics Illuminates clear explanations with practical examples of immunoinformatic approaches to cancer

Author : Muhammad Sarwar Khan
Publisher : Bentham Science Publishers
Page : 413 pages
File Size : 43,7 Mb
Release : 2021-12-09
Category : Science
ISBN : 9789815036671

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Frontiers in Molecular Pharming by Muhammad Sarwar Khan Pdf

The advent of large-scale production and clinical trials of drugs developed through diverse production routes - involving viruses, microbes, plants, and animals - has increased the demand for an expanded capacity for pharmaceutical manufacturing. The production and purification of expressed proteins accounts for the bulk of the manufacturing costs for new therapeutics. Several pharmaceutical proteins have been synthesized by exploiting plant genetics allowing producers to override conventional approaches used to manufacture pharmaceuticals. The process of inserting a gene into a host organism for the purpose of harvesting a bioactive molecule for therapeutic use is known as molecular pharming. Frontiers in Molecular Pharming covers an array of topics relevant to understanding the structure, function, regulation, and mechanisms of action, biochemical significance, and usage of proteins and peptides as biomarkers, therapeutics, and vaccines for animals and humans. The contributions aim to highlight current progress in three areas, including system biology (in vivo characterization of proteins and peptides), molecular pharming for animals and molecular pharming for humans. The book gives special attention to computational biology tools, production platforms and fields (such as immunoinformatics) and applications of molecular pharming (such as veterinary therapeutics). A balance of theoretical concepts and practical applications is provided through 13 chapters. Frontiers in Molecular Pharming is an invaluable resource for students and researchers of biochemistry, molecular biology, and biotechnology. The book also serves as a springboard for understanding the process of how discoveries in protein and peptide research and its applications are coming to fruition.

Author : M. Amin-ul Mannan,Gaurav Kumar
Publisher : Bentham Science Publishers
Page : 384 pages
File Size : 47,5 Mb
Release : 2023-03-08
Category : Science
ISBN : 9789815080063

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Current Trends in the Identification and Development of Antimicrobial Agents by M. Amin-ul Mannan,Gaurav Kumar Pdf

Despite an increase in life expectancy over the past 20 years, the number of novel, multidrug resistant microorganisms has also risen dramatically. To reduce the risk of reemerging infections, and limit the spread of multidrug resistant microorganisms, it is urgently necessary to develop safe and effective therapeutic countermeasures. New antimicrobial chemicals are mostly produced with the help of microorganisms, and the bulk of medications now on the market are of this type. The use of high therapeutic screening and recent developments in analytical instrumentation has allowed the researchers to identify novel antimicrobial compounds from bacteria, fungi, plants, mushrooms, algae, and other sources more quickly. The second volume of Frontiers in Antimicrobial Agents highlights the ongoing requirement for researching and creating novel antimicrobial medications. Current Trends in the Identification and Development of Antimicrobial Agents aims to bring together the expertise of notable academics to examine all facets of antimicrobial research while keeping recent advancements in perspective. Antibiotic discovery, sources of novel antimicrobial chemicals, developing and reemerging microbial infections, various elements of drug resistance, and the need for antimicrobial medications in the future are all covered in this book. It is a timely reference for anyone involved in the discovery and development of new drugs, including microbiologists, biotechnologists, pharmacologists, doctors, and researchers.

Author : Alberto Martini,Francesco Dieli,Kendall A Smith,Paola Zanovello,Ronald H. Schwartz,Stefan Carl Wilhelm Meuer,Jerrold Weiss,Francesca Di Rosa,Elizabeth Anne Grice,Carlo Riccardi
Publisher : Frontiers E-books
Page : 197 pages
File Size : 50,6 Mb
Release : 2014-11-11
Category : Immunologic diseases. Allergy
ISBN : 9782889193387

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Proceedings of ICI Milan 2013 by Alberto Martini,Francesco Dieli,Kendall A Smith,Paola Zanovello,Ronald H. Schwartz,Stefan Carl Wilhelm Meuer,Jerrold Weiss,Francesca Di Rosa,Elizabeth Anne Grice,Carlo Riccardi Pdf

This Research Topic covers all of the major lectures and symposia addresses delivered by invited speakers at the 2013 International Congress in Immunology (ICI) at Milan, Italy, August 22-27, 2013.

Author : Sandeep Kautish,Sheng-Lung Peng,Ahmed J. Obaid
Publisher : Springer Nature
Page : 392 pages
File Size : 54,7 Mb
Release : 2021
Category : Biomedical engineering
ISBN : 9783030689360

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Computational Intelligence Techniques for Combating COVID-19 by Sandeep Kautish,Sheng-Lung Peng,Ahmed J. Obaid Pdf

This book presents the latest cutting edge research, theoretical methods, and novel applications in the field of computational intelligence and computational biological approaches that are aiming to combat COVID-19. The book gives the technological key drivers behind using AI to find drugs that target the virus, shedding light on the structure of COVID-19, detecting the outbreak and spread of new diseases, spotting signs of a COVID-19 infection in medical images, monitoring how the virus and lockdown is affecting mental health, and forecasting how COVID-19 cases and deaths will spread across cities and why. Further, the book helps readers understand computational intelligence techniques combating COVID-19 in a simple and systematic way. Provides a comprehensive reference covering innovations and development of theories, conceptual models and computational algorithms focused on COVID-19; Asserts all relevant research, key themes, complex adaptive systems, metrics and paradigms dedicated towards COVID-19, enabled with evolutionary methods of computational sciences; Explores how AI and computational techniques can help to predict which patients with the virus would go on to develop Acute Respiratory Distress Syndrome (ARDS).

Author : Rajani Sharma,A. V. Senthil Kumar,Kunal Kumar
Publisher : CRC Press
Page : 478 pages
File Size : 44,6 Mb
Release : 2024-08-16
Category : Medical
ISBN : 9781000988703

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Computational Biology in Drug Discovery and Repurposing by Rajani Sharma,A. V. Senthil Kumar,Kunal Kumar Pdf

This new book takes an in-depth look at the emerging and prospective field of computational biology and bioinformatics, which possesses the ability to analyze large accumulated biological data collected from sequence analysis of proteins and genes and cell population with an aim to make new predictions pertaining to drug discovery and new biology. The book explains the basic methodology associated with a bioinformatics and computational approach in drug designing. It then goes on to cover the implementation of computational programming, bioinformatics, pharmacophore modeling, biotechnological techniques, and pharmaceutical chemistry in designing drugs. The major advantage of intervention of computer language or programming is to cut down the number of steps and costs in the field of drug designing, reducing the repeating steps and saving time in screening the potent component for drug or vaccine designing. The book describes algorithms used for drug designing and the use of machine learning and AI in drug delivery and disease diagnosis, which are valuable in clinical decision-making. The implementation of robotics in different diseases like stroke, cancer, COVID-19, etc. is also addressed. Topics include machine learning, AI, databases in drug design, molecular docking, bioinformatics tools, target-based drug design, and immunoinformatics, chemoinformatics, and nanoinformatics in drug design. Drug repurposing in drug design in general as well as for specific diseases, including cancer, Alzheimer’s disease, tuberculosis, COVID-19, etc., is also addressed in depth.

Author : Vitali Sintchenko
Publisher : Springer Science & Business Media
Page : 435 pages
File Size : 52,9 Mb
Release : 2009-12-08
Category : Medical
ISBN : 9781441913272

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Infectious Disease Informatics by Vitali Sintchenko Pdf

There are several reasons to be interested in infectious disease informatics. First, it is of practical significance to understand how the technology revolution has been reshaping infectious disease research and management, as rapid advances in geno- associated technologies have changed the very nature of the questions we can ask. Second, the emerging evidence has confirmed that the application of information technologies in healthcare enhances our ability to deal with infectious diseases. Finally, the implementation of electronic health records has created new and exciting opportunities for secure, reliable and ethically sound clinical decision support and biosurveillance guided by the genomics of pathogens with epidemic potential. This volume addresses the growing need for the critical overview of recent developments in microbial genomics and biomedical informatics relevant to the control of infectious diseases. This field is rapidly expanding, and attracts a wide audience of clinicians, public health professionals, biomedical researchers and computer scientists who are fascinated by the complex puzzle of infectious disease. This book takes a multidisciplinary approach with a calculated move away from the traditional health informatics topics of computerized protocols for antibiotic p- scribing and pathology testing. Instead authors invite you to explore the emerging frontiers of bioinformatics-guided pathogen profiling, the system microbiolo- enabled intelligent design of new drugs and vaccines, and new ways of real-time biosurveillance and hospital infection control. Throughout the book, references are made to different products supplied by public sources and commercial vendors, but this is not an endorsement of these products or vendors.

Author : Sankhadip Bose
Publisher : Springer Nature
Page : 472 pages
File Size : 40,9 Mb
Release : 2024-06-28
Category : Electronic
ISBN : 9789819711482

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Concepts in Pharmaceutical Biotechnology and Drug Development by Sankhadip Bose Pdf

Author : Roy Jefferis,Koichi Kato,William R. (Bill) Strohl
Publisher : MDPI
Page : 440 pages
File Size : 45,8 Mb
Release : 2021-02-05
Category : Science
ISBN : 9783039438976

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Structure and Function of Antibodies by Roy Jefferis,Koichi Kato,William R. (Bill) Strohl Pdf

This book provides a detailed description of all kinds of therapeutic antibodies including IgGs, IgAs, IgEs, and IgMs, bispecific antibodies, chimeric antigen receptor antibodies, and antibody fragments. Details about how each of these antibodies interact with their ligands, the immune system, and their targets are provided. Additionally, this book delves into the details of antibody, Fc, and variable chain structures, and how subtle changes in structure, charge, flexibility, post-translational modification, and the ability to bind to natural antibody ligands can result in a significant impact on antibody activity and functionality. Finally, the book explains the critical quality attributes of modern therapeutic antibodies and how to ensure that antibodies entering development have the best possible chance of success.

Author : Anil K. Sharma
Publisher : CRC Press
Page : 153 pages
File Size : 49,7 Mb
Release : 2019-03-07
Category : Health & Fitness
ISBN : 9781351366946

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Immunology by Anil K. Sharma Pdf

Immunology has emerged as a key component of the curricula of graduate and postgraduate courses in biotechnology, microbiology, biochemistry, bioinformatics, and other interdisciplinary fields of biology, including zoology, veterinary science, and medicine. As a basic introductory textbook on one of the fastest-moving and most challenging areas of immunological science, this book contains the most recent information about immunologic mechanisms and their importance, along with various molecular techniques employed in immunology. The short and concise text helps make the structures, processes, and interactions of the immune system easily comprehensible. The book includes chapters on immunoinformatics as well as the immune system of the brain, rarely found in any of the immunology books published so far. Many diverse and interesting aspects of the advances in immunology have also been covered, including tumor immunology and immunodeficiency disorders. The easy-to-understand concepts presented in the textbook make it an ideal companion for learners preparing for competitive and other examinations. Undergraduate, postgraduate, and PhD students, people from the industry and academia, and research scholars will immensely benefit from it.

Author : Shayne Cox Gad
Publisher : John Wiley & Sons
Page : 1352 pages
File Size : 46,8 Mb
Release : 2008-03-21
Category : Medical
ISBN : 9780470249024

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Preclinical Development Handbook by Shayne Cox Gad Pdf

A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * Modeling and informatics in drug design * Bioanalytical chemistry * Absorption of drugs after oral administration * Transporter interactions in the ADME pathway of drugs * Metabolism kinetics * Mechanisms and consequences of drug-drug interactions Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.