Computer Aided Design Of Microfluidic Very Large Scale Integration Mvlsi Biochips

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Computer-Aided Design of Microfluidic Very Large Scale Integration (mVLSI) Biochips

Kai Hu,Krishnendu Chakrabarty,Tsung-Yi Ho
Computer Aided Design of Microfluidic Very Large Scale Integration mVLSI Biochips Book PDF

Author : Kai Hu,Krishnendu Chakrabarty,Tsung-Yi Ho
Publisher : Springer
Page : 142 pages
File Size : 47,6 Mb
Release : 2017-04-05
Category : Technology & Engineering
ISBN : 9783319562551

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Computer-Aided Design of Microfluidic Very Large Scale Integration (mVLSI) Biochips by Kai Hu,Krishnendu Chakrabarty,Tsung-Yi Ho Pdf

This book provides a comprehensive overview of flow-based, microfluidic VLSI. The authors describe and solve in a comprehensive and holistic manner practical challenges such as control synthesis, wash optimization, design for testability, and diagnosis of modern flow-based microfluidic biochips. They introduce practical solutions, based on rigorous optimization and formal models. The technical contributions presented in this book will not only shorten the product development cycle, but also accelerate the adoption and further development of modern flow-based microfluidic biochips, by facilitating the full exploitation of design complexities that are possible with current fabrication techniques.

Microfluidic Very Large Scale Integration (VLSI)

Paul Pop,Wajid Hassan Minhass,Jan Madsen
Microfluidic Very Large Scale Integration VLSI Book PDF

Author : Paul Pop,Wajid Hassan Minhass,Jan Madsen
Publisher : Springer
Page : 270 pages
File Size : 44,7 Mb
Release : 2016-02-08
Category : Technology & Engineering
ISBN : 9783319295992

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Microfluidic Very Large Scale Integration (VLSI) by Paul Pop,Wajid Hassan Minhass,Jan Madsen Pdf

This book presents the state-of-the-art techniques for the modeling, simulation, testing, compilation and physical synthesis of mVLSI biochips. The authors describe a top-down modeling and synthesis methodology for the mVLSI biochips, inspired by microelectronics VLSI methodologies. They introduce a modeling framework for the components and the biochip architecture, and a high-level microfluidic protocol language. Coverage includes a topology graph-based model for the biochip architecture, and a sequencing graph to model for biochemical application, showing how the application model can be obtained from the protocol language. The techniques described facilitate programmability and automation, enabling developers in the emerging, large biochip market.

Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber-Physical Microfluidic Platforms

Mohamed Ibrahim,Krishnendu Chakrabarty
Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber Physical Microfluidic Platforms Book PDF

Author : Mohamed Ibrahim,Krishnendu Chakrabarty
Publisher : CRC Press
Page : 349 pages
File Size : 51,9 Mb
Release : 2020-05-31
Category : Technology & Engineering
ISBN : 9781000082661

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Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber-Physical Microfluidic Platforms by Mohamed Ibrahim,Krishnendu Chakrabarty Pdf

A microfluidic biochip is an engineered fluidic device that controls the flow of analytes, thereby enabling a variety of useful applications. According to recent studies, the fields that are best set to benefit from the microfluidics technology, also known as lab-on-chip technology, include forensic identification, clinical chemistry, point-of-care (PoC) diagnostics, and drug discovery. The growth in such fields has significantly amplified the impact of microfluidics technology, whose market value is forecast to grow from $4 billion in 2017 to $13.2 billion by 2023. The rapid evolution of lab-on-chip technologies opens up opportunities for new biological or chemical science areas that can be directly facilitated by sensor-based microfluidics control. For example, the digital microfluidics-based ePlex system from GenMarkDx enables automated disease diagnosis and can bring syndromic testing near patients everywhere. However, as the applications of molecular biology grow, the adoption of microfluidics in many applications has not grown at the same pace, despite the concerted effort of microfluidic systems engineers. Recent studies suggest that state-of-the-art design techniques for microfluidics have two major drawbacks that need to be addressed appropriately: (1) current lab-on-chip systems were only optimized as auxiliary components and are only suitable for sample-limited analyses; therefore, their capabilities may not cope with the requirements of contemporary molecular biology applications; (2) the integrity of these automated lab-on-chip systems and their biochemical operations are still an open question since no protection schemes were developed against adversarial contamination or result-manipulation attacks. Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber-Physical Microfluidic Platforms provides solutions to these challenges by introducing a new design flow based on the realistic modeling of contemporary molecular biology protocols. It also presents a microfluidic security flow that provides a high-level of confidence in the integrity of such protocols. In summary, this book creates a new research field as it bridges the technical skills gap between microfluidic systems and molecular biology protocols but it is viewed from the perspective of an electronic/systems engineer.

Hardware/Software Co-Design and Optimization for Cyberphysical Integration in Digital Microfluidic Biochips

Yan Luo,Krishnendu Chakrabarty,Tsung-Yi Ho
Hardware Software Co Design and Optimization for Cyberphysical Integration in Digital Microfluidic Biochips Book PDF

Author : Yan Luo,Krishnendu Chakrabarty,Tsung-Yi Ho
Publisher : Springer
Page : 197 pages
File Size : 52,9 Mb
Release : 2014-08-06
Category : Technology & Engineering
ISBN : 9783319090061

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Hardware/Software Co-Design and Optimization for Cyberphysical Integration in Digital Microfluidic Biochips by Yan Luo,Krishnendu Chakrabarty,Tsung-Yi Ho Pdf

This book describes a comprehensive framework for hardware/software co-design, optimization, and use of robust, low-cost, and cyberphysical digital microfluidic systems. Readers with a background in electronic design automation will find this book to be a valuable reference for leveraging conventional VLSI CAD techniques for emerging technologies, e.g., biochips or bioMEMS. Readers from the circuit/system design community will benefit from methods presented to extend design and testing techniques from microelectronics to mixed-technology microsystems. For readers from the microfluidics domain, this book presents a new design and development strategy for cyberphysical microfluidics-based biochips suitable for large-scale bioassay applications. • Takes a transformative, “cyberphysical” approach towards achieving closed-loop and sensor feedback-driven biochip operation under program control; • Presents a “physically-aware” system reconfiguration technique that uses sensor data at intermediate checkpoints to dynamically reconfigure biochips; • Enables readers to simplify the structure of biochips, while facilitating the “general-purpose” use of digital microfluidic biochips for a wider range of applications.

Design Automation Methods and Tools for Microfluidics-Based Biochips

Jun Zeng
Design Automation Methods and Tools for Microfluidics Based Biochips Book PDF

Author : Jun Zeng
Publisher : Springer Science & Business Media
Page : 407 pages
File Size : 40,6 Mb
Release : 2006-11-08
Category : Technology & Engineering
ISBN : 9781402051234

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Design Automation Methods and Tools for Microfluidics-Based Biochips by Jun Zeng Pdf

Design Automation Methods and Tools for Microfluidics-Based Biochips deals with all aspects of design automation for microfluidics-based biochips. Experts have contributed chapters on many aspects of biochip design automation. Topics covered include: device modeling; adaptation of bioassays for on-chip implementations; numerical methods and simulation tools; architectural synthesis, scheduling and binding of assay operations; physical design and module placement; fault modeling and testing; and reconfiguration methods.

Design and Testing of Digital Microfluidic Biochips

Yang Zhao,Krishnendu Chakrabarty
Design and Testing of Digital Microfluidic Biochips Book PDF

Author : Yang Zhao,Krishnendu Chakrabarty
Publisher : Springer Science & Business Media
Page : 207 pages
File Size : 46,9 Mb
Release : 2012-07-25
Category : Technology & Engineering
ISBN : 9781461403708

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Design and Testing of Digital Microfluidic Biochips by Yang Zhao,Krishnendu Chakrabarty Pdf

This book provides a comprehensive methodology for automated design, test and diagnosis, and use of robust, low-cost, and manufacturable digital microfluidic systems. It focuses on the development of a comprehensive CAD optimization framework for digital microfluidic biochips that unifies different design problems. With the increase in system complexity and integration levels, biochip designers can utilize the design methods described in this book to evaluate different design alternatives, and carry out design-space exploration to obtain the best design point.

Digital Microfluidic Biochips

Krishnendu Chakrabarty,Tao Xu
Digital Microfluidic Biochips Book PDF

Author : Krishnendu Chakrabarty,Tao Xu
Publisher : CRC Press
Page : 377 pages
File Size : 50,7 Mb
Release : 2010-05-03
Category : Medical
ISBN : 9781439858738

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Digital Microfluidic Biochips by Krishnendu Chakrabarty,Tao Xu Pdf

Microfluidics-based biochips combine electronics with biochemistry, providing access to new application areas in a wide variety of fields. Continued technological innovations are essential to assuring the future role of these chips in functional diversification in biotech, pharmaceuticals, and other industries.Revolutionary guidance on design, opti

Digital Microfluidic Biochips

Krishnendu Chakrabarty,Fei Su
Digital Microfluidic Biochips Book PDF

Author : Krishnendu Chakrabarty,Fei Su
Publisher : CRC Press
Page : 216 pages
File Size : 47,9 Mb
Release : 2018-10-03
Category : Technology & Engineering
ISBN : 9781351837538

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Digital Microfluidic Biochips by Krishnendu Chakrabarty,Fei Su Pdf

Digital Microfluidic Biochips focuses on the automated design and production of microfluidic-based biochips for large-scale bioassays and safety-critical applications. Bridging areas of electronic design automation with microfluidic biochip research, the authors present a system-level design automation framework that addresses key issues in the design, analysis, and testing of digital microfluidic biochips. The book describes a new generation of microfluidic biochips with more complex designs that offer dynamic reconfigurability, system scalability, system integration, and defect tolerance. Part I describes a unified design methodology that targets design optimization under resource constraints. Part II investigates cost-effective testing techniques for digital microfluidic biochips that include test resource optimization and fault detection while running normal bioassays. Part III focuses on different reconfiguration-based defect tolerance techniques designed to increase the yield and dependability of digital microfluidic biochips. Expanding upon results from ongoing research on CAD for biochips at Duke University, this book presents new design methodologies that address some of the limitations in current full-custom design techniques. Digital Microfluidic Biochips is an essential resource for achieving the integration of microfluidic components in the next generation of system-on-chip and system-in-package designs.

Design Automation for Digital Microfluidic Biochips

Tsung-Yi Ho
Design Automation for Digital Microfluidic Biochips Book PDF

Author : Tsung-Yi Ho
Publisher : CRC Press
Page : 240 pages
File Size : 51,5 Mb
Release : 2016-02-15
Category : Technology & Engineering
ISBN : 1482250861

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Design Automation for Digital Microfluidic Biochips by Tsung-Yi Ho Pdf

This book demonstrates the use of computer-aided design (CAD) tools to automate and optimize the design and synthesis of digital microfluidicbiochips (DMFBs) in fluidic and chip/hardware domains. It describes several associative combinatorial and geometric optimization problems; considers new constraints in low-cost, large-scale biochip design; and includes real-life bioassays as evaluation examples (e.g., DNA sample preparation, multiplexed in-vitro human physiological fluids diagnostics, PCR, and protein crystallization). The CAD techniques presented address real manufacturing issues and can be applied directly to industrial product development.

Micro-Electrode-Dot-Array Digital Microfluidic Biochips

Zipeng Li,Krishnendu Chakrabarty,Tsung-Yi Ho,Chen-Yi Lee
Micro Electrode Dot Array Digital Microfluidic Biochips Book PDF

Author : Zipeng Li,Krishnendu Chakrabarty,Tsung-Yi Ho,Chen-Yi Lee
Publisher : Springer
Page : 144 pages
File Size : 42,6 Mb
Release : 2018-12-14
Category : Technology & Engineering
ISBN : 9783030029647

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Micro-Electrode-Dot-Array Digital Microfluidic Biochips by Zipeng Li,Krishnendu Chakrabarty,Tsung-Yi Ho,Chen-Yi Lee Pdf

This book provides an insightful guide to the design, testing and optimization of micro-electrode-dot-array (MEDA) digital microfluidic biochips. The authors focus on the characteristics specific for MEDA biochips, e.g., real-time sensing and advanced microfluidic operations like lamination mixing and droplet shape morphing. Readers will be enabled to enhance the automated design and use of MEDA and to develop a set of solutions to facilitate the full exploitation of design complexities that are possible with standard CMOS fabrication techniques. The book provides the first set of design automation and test techniques for MEDA biochips. The methods described in this book have been validated using fabricated MEDA biochips in the laboratory. Readers will benefit from an in-depth look at the MEDA platform and how to combine microfluidics with software, e.g., applying biomolecular protocols to software-controlled and cyberphysical microfluidic biochips.

Secure and Trustworthy Cyberphysical Microfluidic Biochips

Jack Tang,Mohamed Ibrahim,Krishnendu Chakrabarty,Ramesh Karri
Secure and Trustworthy Cyberphysical Microfluidic Biochips Book PDF

Author : Jack Tang,Mohamed Ibrahim,Krishnendu Chakrabarty,Ramesh Karri
Publisher : Springer
Page : 144 pages
File Size : 40,7 Mb
Release : 2019-05-28
Category : Technology & Engineering
ISBN : 9783030181635

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Secure and Trustworthy Cyberphysical Microfluidic Biochips by Jack Tang,Mohamed Ibrahim,Krishnendu Chakrabarty,Ramesh Karri Pdf

This book describes novel hardware security and microfluidic biochip design methodologies to protect against tampering attacks in cyberphysical microfluidic biochips (CPMBs). It also provides a general overview of this nascent area of research, which will prove to be a vital resource for practitioners in the field.This book shows how hardware-based countermeasures and design innovations can be a simple and effective last line of defense, demonstrating that it is no longer justifiable to ignore security and trust in the design phase of biochips.

Design and Testing of Digital Microfluidic Biochips

Krishnendu Chakrabarty,Springer
Design and Testing of Digital Microfluidic Biochips Book PDF

Author : Krishnendu Chakrabarty,Springer
Publisher : Unknown
Page : 216 pages
File Size : 42,6 Mb
Release : 2012-08-31
Category : Electronic
ISBN : 1461403715

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Design and Testing of Digital Microfluidic Biochips by Krishnendu Chakrabarty,Springer Pdf

This book provides a comprehensive methodology for automated design, test and diagnosis, and use of robust, low-cost, and manufacturable digital microfluidic systems. It focuses on the development of a comprehensive CAD optimization framework for digital microfluidic biochips that unifies different design problems. With the increase in system complexity and integration levels, biochip designers can utilize the design methods described in this book to evaluate different design alternatives, and carry out design-space exploration to obtain the best design point.

Introduction to VLSI Systems

Carver Mead,Lynn Conway
Introduction to VLSI Systems Book PDF

Author : Carver Mead,Lynn Conway
Publisher : Addison Wesley Publishing Company
Page : 436 pages
File Size : 55,6 Mb
Release : 1980
Category : Computers
ISBN : UOM:39015030950151

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Introduction to VLSI Systems by Carver Mead,Lynn Conway Pdf

Mos devices and circuits - Integrated system fabrication - Data and control flow in systematic structures - Implementing integrated system designs : from circuit topology to patterning geometry to wafer fabrication - Overview of an LSI computer system, and the design of the OM2 data PATH CHIP - Architecture and design of system controllers, and the design of the OM2 controller CHIP - System timing - Highly concurrent systems - Physics of computational systems.

Paper Based Sensors

Anonim
Paper Based Sensors Book PDF

Author : Anonim
Publisher : Elsevier
Page : 480 pages
File Size : 46,7 Mb
Release : 2020-06-13
Category : Science
ISBN : 9780444643469

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Paper Based Sensors by Anonim Pdf

Paper Based Sensors, Volume 89, the latest release in this comprehensive series that gathers the most important issues relating to the design and application of these cost-effective devices used in many industries, including health and environment diagnostics, safety and security, chemistry, optics, electrochemistry, nanoscience and nanotechnologies, presents the latest updates in the field. Chapters in this new release include Exploring paper as a substrate for electrochemical micro-devices, Paper-based sensors for application in biological compound detection, Printed paper-based (bio)sensors: design, fabrication and applications, Paper-based electrochemical sensing devices, Multifarious aspects of electrochemical paper-based (bio)sensors, Paper Based Biosensors for Clinical and Biomedical Applications, and more. Provides updates on the latest design in paper-based sensors using various nano and micromaterials Includes optical/electrical-based detection modes integrated within paper-based platforms Covers applications of paper-based platforms in diagnostics and other industries

Languages, Design Methods, and Tools for Electronic System Design

Tom J. Kazmierski,Sebastian Steinhorst,Daniel Große
Languages Design Methods and Tools for Electronic System Design Book PDF

Author : Tom J. Kazmierski,Sebastian Steinhorst,Daniel Große
Publisher : Springer Nature
Page : 197 pages
File Size : 51,7 Mb
Release : 2019-12-20
Category : Technology & Engineering
ISBN : 9783030315856

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Languages, Design Methods, and Tools for Electronic System Design by Tom J. Kazmierski,Sebastian Steinhorst,Daniel Große Pdf

This book brings together a selection of the best papers from the twenty-first edition of the Forum on specification and Design Languages Conference (FDL), which took place on September 10-12, 2018, in Munich, Germany. FDL is a well-established international forum devoted to dissemination of research results, practical experiences and new ideas in the application of specification, design and verification languages to the design, modeling and verification of integrated circuits, complex hardware/software embedded systems, and mixed-technology systems. Covers Assertion Based Design, Verification & Debug; Includes language-based modeling and design techniques for embedded systems; Covers design, modeling and verification of mixed physical domain and mixed signal systems that include significant analog parts in electrical and non-electrical domains; Includes formal and semi-formal system level design methods for complex embedded systems based on the Unified Modelling Language (UML) and Model Driven Engineering (MDE).