Micro Electrode Dot Array Digital Microfluidic Biochips

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Micro-Electrode-Dot-Array Digital Microfluidic Biochips

Zipeng Li,Krishnendu Chakrabarty,Tsung-Yi Ho,Chen-Yi Lee
Micro Electrode Dot Array Digital Microfluidic Biochips Book PDF

Author : Zipeng Li,Krishnendu Chakrabarty,Tsung-Yi Ho,Chen-Yi Lee
Publisher : Springer
Page : 144 pages
File Size : 55,8 Mb
Release : 2018-12-14
Category : Technology & Engineering
ISBN : 9783030029647

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Micro-Electrode-Dot-Array Digital Microfluidic Biochips by Zipeng Li,Krishnendu Chakrabarty,Tsung-Yi Ho,Chen-Yi Lee Pdf

This book provides an insightful guide to the design, testing and optimization of micro-electrode-dot-array (MEDA) digital microfluidic biochips. The authors focus on the characteristics specific for MEDA biochips, e.g., real-time sensing and advanced microfluidic operations like lamination mixing and droplet shape morphing. Readers will be enabled to enhance the automated design and use of MEDA and to develop a set of solutions to facilitate the full exploitation of design complexities that are possible with standard CMOS fabrication techniques. The book provides the first set of design automation and test techniques for MEDA biochips. The methods described in this book have been validated using fabricated MEDA biochips in the laboratory. Readers will benefit from an in-depth look at the MEDA platform and how to combine microfluidics with software, e.g., applying biomolecular protocols to software-controlled and cyberphysical microfluidic biochips.

Error-Tolerant Biochemical Sample Preparation with Microfluidic Lab-on-Chip

Sudip Poddar,Bhargab B. Bhattacharya
Error Tolerant Biochemical Sample Preparation with Microfluidic Lab on Chip Book PDF

Author : Sudip Poddar,Bhargab B. Bhattacharya
Publisher : CRC Press
Page : 240 pages
File Size : 43,5 Mb
Release : 2022-07-27
Category : Technology & Engineering
ISBN : 9781000612738

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Error-Tolerant Biochemical Sample Preparation with Microfluidic Lab-on-Chip by Sudip Poddar,Bhargab B. Bhattacharya Pdf

Microfluidic biochips have gained prominence due to their versatile applications to biochemistry and health-care domains such as point-of-care clinical diagnosis of tropical and cardiovascular diseases, cancer, diabetes, toxicity analysis, and for the mitigation of the global HIV crisis, among others. Microfluidic Lab-on-Chips (LoCs) offer a convenient platform for emulating various fluidic operations in an automated fashion. However, because of the inherent uncertainty of fluidic operations, the outcome of biochemical experiments performed on-chip can be erroneous even if the chip is tested a priori and deemed to be defect-free. This book focuses on the issues encountered in reliable sample preparation with digital microfluidic biochips (DMFBs), particularly in an error-prone environment. It presents state-of-the-art error management techniques and underlying algorithmic challenges along with their comparative discussions. Describes a comprehensive framework for designing a robust and error-tolerant biomedical system which will help in migrating from cumbersome medical laboratory tasks to small-sized LOC-based systems Presents a comparative study on current error-tolerant strategies for robust sample preparation using DMFBs and reports on efficient algorithms for error-tolerant sample dilution using these devices Illustrates how algorithmic engineering, cyber-physical tools, and software techniques are helpful in implementing fault tolerance Covers the challenges associated with design automation for biochemical sample preparation Teaches how to implement biochemical protocols using software-controlled microfluidic biochips Interdisciplinary in its coverage, this reference is written for practitioners and researchers in biochemical, biomedical, electrical, computer, and mechanical engineering, especially those involved in LOC or bio-MEMS design.

Security of Biochip Cyberphysical Systems

Shayan Mohammed,Sukanta Bhattacharjee,Yong-Ak Song,Krishnendu Chakrabarty,Ramesh Karri
Security of Biochip Cyberphysical Systems Book PDF

Author : Shayan Mohammed,Sukanta Bhattacharjee,Yong-Ak Song,Krishnendu Chakrabarty,Ramesh Karri
Publisher : Springer Nature
Page : 135 pages
File Size : 54,5 Mb
Release : 2022-03-28
Category : Technology & Engineering
ISBN : 9783030932749

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Security of Biochip Cyberphysical Systems by Shayan Mohammed,Sukanta Bhattacharjee,Yong-Ak Song,Krishnendu Chakrabarty,Ramesh Karri Pdf

This book provides readers with a valuable guide to understanding security and the interplay of computer science, microfluidics, and biochemistry in a biochip cyberphysical system (CPS). The authors uncover new, potential threat and trust-issues to address, as this emerging technology is poised to be adapted at a large scale. Readers will learn how to secure biochip CPS by leveraging the available resources in different application contexts, as well as how to ensure intellectual property (IP) is protected against theft and counterfeits. This book enables secure biochip CPS design by helping bridge the knowledge gap at the intersection of the multi-disciplinary technology that drives biochip CPS.

Exact Design of Digital Microfluidic Biochips

Oliver Keszocze,Robert Wille,Rolf Drechsler
Exact Design of Digital Microfluidic Biochips Book PDF

Author : Oliver Keszocze,Robert Wille,Rolf Drechsler
Publisher : Springer
Page : 134 pages
File Size : 44,7 Mb
Release : 2018-06-11
Category : Technology & Engineering
ISBN : 9783319909363

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Exact Design of Digital Microfluidic Biochips by Oliver Keszocze,Robert Wille,Rolf Drechsler Pdf

This book presents exact, that is minimal, solutions to individual steps in the design process for Digital Microfluidic Biochips (DMFBs), as well as a one-pass approach that combines all these steps in a single process. All of the approaches discussed are based on a formal model that can easily be extended to cope with further design problems. In addition to the exact methods, heuristic approaches are provided and the complexity classes of various design problems are determined. Presents exact methods to tackle a variety of design problems for Digital Microfluidic Biochips (DMFBs); Describes an holistic, one-pass approach solving different design steps all at once; Based on a formal model of DMFBs that is easily adaptable to deal with further design tasks.

Computer-Aided Design of Microfluidic Very Large Scale Integration (mVLSI) Biochips

Kai Hu,Krishnendu Chakrabarty,Tsung-Yi Ho
Computer Aided Design of Microfluidic Very Large Scale Integration mVLSI Biochips Book PDF

Author : Kai Hu,Krishnendu Chakrabarty,Tsung-Yi Ho
Publisher : Springer
Page : 142 pages
File Size : 45,7 Mb
Release : 2017-04-05
Category : Technology & Engineering
ISBN : 9783319562551

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Computer-Aided Design of Microfluidic Very Large Scale Integration (mVLSI) Biochips by Kai Hu,Krishnendu Chakrabarty,Tsung-Yi Ho Pdf

This book provides a comprehensive overview of flow-based, microfluidic VLSI. The authors describe and solve in a comprehensive and holistic manner practical challenges such as control synthesis, wash optimization, design for testability, and diagnosis of modern flow-based microfluidic biochips. They introduce practical solutions, based on rigorous optimization and formal models. The technical contributions presented in this book will not only shorten the product development cycle, but also accelerate the adoption and further development of modern flow-based microfluidic biochips, by facilitating the full exploitation of design complexities that are possible with current fabrication techniques.

Languages, Design Methods, and Tools for Electronic System Design

Tom J. Kazmierski,Sebastian Steinhorst,Daniel Große
Languages Design Methods and Tools for Electronic System Design Book PDF

Author : Tom J. Kazmierski,Sebastian Steinhorst,Daniel Große
Publisher : Springer Nature
Page : 197 pages
File Size : 43,5 Mb
Release : 2019-12-20
Category : Technology & Engineering
ISBN : 9783030315856

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Languages, Design Methods, and Tools for Electronic System Design by Tom J. Kazmierski,Sebastian Steinhorst,Daniel Große Pdf

This book brings together a selection of the best papers from the twenty-first edition of the Forum on specification and Design Languages Conference (FDL), which took place on September 10-12, 2018, in Munich, Germany. FDL is a well-established international forum devoted to dissemination of research results, practical experiences and new ideas in the application of specification, design and verification languages to the design, modeling and verification of integrated circuits, complex hardware/software embedded systems, and mixed-technology systems. Covers Assertion Based Design, Verification & Debug; Includes language-based modeling and design techniques for embedded systems; Covers design, modeling and verification of mixed physical domain and mixed signal systems that include significant analog parts in electrical and non-electrical domains; Includes formal and semi-formal system level design methods for complex embedded systems based on the Unified Modelling Language (UML) and Model Driven Engineering (MDE).

Design and Testing of Digital Microfluidic Biochips

Yang Zhao,Krishnendu Chakrabarty
Design and Testing of Digital Microfluidic Biochips Book PDF

Author : Yang Zhao,Krishnendu Chakrabarty
Publisher : Springer Science & Business Media
Page : 207 pages
File Size : 42,9 Mb
Release : 2012-07-25
Category : Technology & Engineering
ISBN : 9781461403708

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Design and Testing of Digital Microfluidic Biochips by Yang Zhao,Krishnendu Chakrabarty Pdf

This book provides a comprehensive methodology for automated design, test and diagnosis, and use of robust, low-cost, and manufacturable digital microfluidic systems. It focuses on the development of a comprehensive CAD optimization framework for digital microfluidic biochips that unifies different design problems. With the increase in system complexity and integration levels, biochip designers can utilize the design methods described in this book to evaluate different design alternatives, and carry out design-space exploration to obtain the best design point.

Digital Microfluidic Biochips

Krishnendu Chakrabarty,Fei Su
Digital Microfluidic Biochips Book PDF

Author : Krishnendu Chakrabarty,Fei Su
Publisher : CRC Press
Page : 216 pages
File Size : 43,5 Mb
Release : 2018-10-03
Category : Technology & Engineering
ISBN : 9781351837538

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Digital Microfluidic Biochips by Krishnendu Chakrabarty,Fei Su Pdf

Digital Microfluidic Biochips focuses on the automated design and production of microfluidic-based biochips for large-scale bioassays and safety-critical applications. Bridging areas of electronic design automation with microfluidic biochip research, the authors present a system-level design automation framework that addresses key issues in the design, analysis, and testing of digital microfluidic biochips. The book describes a new generation of microfluidic biochips with more complex designs that offer dynamic reconfigurability, system scalability, system integration, and defect tolerance. Part I describes a unified design methodology that targets design optimization under resource constraints. Part II investigates cost-effective testing techniques for digital microfluidic biochips that include test resource optimization and fault detection while running normal bioassays. Part III focuses on different reconfiguration-based defect tolerance techniques designed to increase the yield and dependability of digital microfluidic biochips. Expanding upon results from ongoing research on CAD for biochips at Duke University, this book presents new design methodologies that address some of the limitations in current full-custom design techniques. Digital Microfluidic Biochips is an essential resource for achieving the integration of microfluidic components in the next generation of system-on-chip and system-in-package designs.

Emerging Topics in Hardware Security

Mark Tehranipoor
Emerging Topics in Hardware Security Book PDF

Author : Mark Tehranipoor
Publisher : Springer Nature
Page : 602 pages
File Size : 45,5 Mb
Release : 2021-04-30
Category : Technology & Engineering
ISBN : 9783030644482

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Emerging Topics in Hardware Security by Mark Tehranipoor Pdf

This book provides an overview of emerging topics in the field of hardware security, such as artificial intelligence and quantum computing, and highlights how these technologies can be leveraged to secure hardware and assure electronics supply chains. The authors are experts in emerging technologies, traditional hardware design, and hardware security and trust. Readers will gain a comprehensive understanding of hardware security problems and how to overcome them through an efficient combination of conventional approaches and emerging technologies, enabling them to design secure, reliable, and trustworthy hardware.

Secure and Trustworthy Cyberphysical Microfluidic Biochips

Jack Tang,Mohamed Ibrahim,Krishnendu Chakrabarty,Ramesh Karri
Secure and Trustworthy Cyberphysical Microfluidic Biochips Book PDF

Author : Jack Tang,Mohamed Ibrahim,Krishnendu Chakrabarty,Ramesh Karri
Publisher : Springer
Page : 144 pages
File Size : 54,8 Mb
Release : 2019-05-28
Category : Technology & Engineering
ISBN : 9783030181635

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Secure and Trustworthy Cyberphysical Microfluidic Biochips by Jack Tang,Mohamed Ibrahim,Krishnendu Chakrabarty,Ramesh Karri Pdf

This book describes novel hardware security and microfluidic biochip design methodologies to protect against tampering attacks in cyberphysical microfluidic biochips (CPMBs). It also provides a general overview of this nascent area of research, which will prove to be a vital resource for practitioners in the field.This book shows how hardware-based countermeasures and design innovations can be a simple and effective last line of defense, demonstrating that it is no longer justifiable to ignore security and trust in the design phase of biochips.

Designing Droplet Microfluidic Networks

Andreas Grimmer,Robert Wille
Designing Droplet Microfluidic Networks Book PDF

Author : Andreas Grimmer,Robert Wille
Publisher : Springer
Page : 145 pages
File Size : 52,7 Mb
Release : 2019-07-04
Category : Technology & Engineering
ISBN : 9783030207137

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Designing Droplet Microfluidic Networks by Andreas Grimmer,Robert Wille Pdf

This book describes automatic methods for the design of droplet microfluidic networks. The authors discuss simulation and design methods which support the design process of droplet microfluidics in general, as well as design methods for a dedicated droplet routing mechanism, namely passive droplet routing. The methods discussed allow for simulating a microfluidic design on a high-abstraction level, which facilitates early validation of whether a design works as intended, automatically dimensioning a microfluidic design, so that constraints like flow conditions are satisfied, and automatically generating meander designs for the respective needs and fabrication settings. Dedicated methods for passive droplet routing are discussed and allow for designing application-specific architectures for a given set of experiments, as well as generating droplet sequences realizing the respective experiments. Together, these methods provide a comprehensive “toolbox" for designers working on droplet microfluidic networks in general and an integrated design flow for the passive droplet routing mechanism in particular. Provides both a comprehensive “toolbox" for designers working on droplet microfluidic networks in general and an integrated design flow for the passive droplet routing mechanism in particular; Describes for the first time CAD methods for droplet microfluidic networks, along with the first integrated design process; Includes open source implementations, in order to reach the largest possible user group within the domain of microfluidics.

Emerging Electronic Devices, Circuits and Systems

Chandan Giri,Takahiro Iizuka,Hafizur Rahaman,Bhargab B. Bhattacharya
Emerging Electronic Devices Circuits and Systems Book PDF

Author : Chandan Giri,Takahiro Iizuka,Hafizur Rahaman,Bhargab B. Bhattacharya
Publisher : Springer Nature
Page : 465 pages
File Size : 47,8 Mb
Release : 2023-06-01
Category : Technology & Engineering
ISBN : 9789819900558

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Emerging Electronic Devices, Circuits and Systems by Chandan Giri,Takahiro Iizuka,Hafizur Rahaman,Bhargab B. Bhattacharya Pdf

The book constitutes peer-reviewed proceedings of a workshop on Emerging Electronics Devices, Circuits, and Systems (EEDCS) held in conjunction with International Symposium on Devices, Circuits, and Systems (ISDCS 2022). The book focuses on the recent development in devices, circuits, and systems. It also discusses innovations, trends, practical challenges, and solutions adopted in device design, modeling, fabrication, characterization, and their circuit implementation with pertinent system applications. It will be useful for researchers, developers, engineers, academicians, and students.

Security Opportunities in Nano Devices and Emerging Technologies

Mark Tehranipoor,Domenic Forte,Garrett S. Rose,Swarup Bhunia
Security Opportunities in Nano Devices and Emerging Technologies Book PDF

Author : Mark Tehranipoor,Domenic Forte,Garrett S. Rose,Swarup Bhunia
Publisher : CRC Press
Page : 586 pages
File Size : 41,5 Mb
Release : 2017-11-22
Category : Computers
ISBN : 9781351965897

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Security Opportunities in Nano Devices and Emerging Technologies by Mark Tehranipoor,Domenic Forte,Garrett S. Rose,Swarup Bhunia Pdf

The research community lacks both the capability to explain the effectiveness of existing techniques and the metrics to predict the security properties and vulnerabilities of the next generation of nano-devices and systems. This book provides in-depth viewpoints on security issues and explains how nano devices and their unique properties can address the opportunities and challenges of the security community, manufacturers, system integrators, and end users. This book elevates security as a fundamental design parameter, transforming the way new nano-devices are developed. Part 1 focuses on nano devices and building security primitives. Part 2 focuses on emerging technologies and integrations.

Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber-Physical Microfluidic Platforms

Mohamed Ibrahim,Krishnendu Chakrabarty
Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber Physical Microfluidic Platforms Book PDF

Author : Mohamed Ibrahim,Krishnendu Chakrabarty
Publisher : CRC Press
Page : 349 pages
File Size : 52,6 Mb
Release : 2020-05-31
Category : Technology & Engineering
ISBN : 9781000082661

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Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber-Physical Microfluidic Platforms by Mohamed Ibrahim,Krishnendu Chakrabarty Pdf

A microfluidic biochip is an engineered fluidic device that controls the flow of analytes, thereby enabling a variety of useful applications. According to recent studies, the fields that are best set to benefit from the microfluidics technology, also known as lab-on-chip technology, include forensic identification, clinical chemistry, point-of-care (PoC) diagnostics, and drug discovery. The growth in such fields has significantly amplified the impact of microfluidics technology, whose market value is forecast to grow from $4 billion in 2017 to $13.2 billion by 2023. The rapid evolution of lab-on-chip technologies opens up opportunities for new biological or chemical science areas that can be directly facilitated by sensor-based microfluidics control. For example, the digital microfluidics-based ePlex system from GenMarkDx enables automated disease diagnosis and can bring syndromic testing near patients everywhere. However, as the applications of molecular biology grow, the adoption of microfluidics in many applications has not grown at the same pace, despite the concerted effort of microfluidic systems engineers. Recent studies suggest that state-of-the-art design techniques for microfluidics have two major drawbacks that need to be addressed appropriately: (1) current lab-on-chip systems were only optimized as auxiliary components and are only suitable for sample-limited analyses; therefore, their capabilities may not cope with the requirements of contemporary molecular biology applications; (2) the integrity of these automated lab-on-chip systems and their biochemical operations are still an open question since no protection schemes were developed against adversarial contamination or result-manipulation attacks. Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber-Physical Microfluidic Platforms provides solutions to these challenges by introducing a new design flow based on the realistic modeling of contemporary molecular biology protocols. It also presents a microfluidic security flow that provides a high-level of confidence in the integrity of such protocols. In summary, this book creates a new research field as it bridges the technical skills gap between microfluidic systems and molecular biology protocols but it is viewed from the perspective of an electronic/systems engineer.

Hardware/Software Co-Design and Optimization for Cyberphysical Integration in Digital Microfluidic Biochips

Yan Luo,Krishnendu Chakrabarty,Tsung-Yi Ho
Hardware Software Co Design and Optimization for Cyberphysical Integration in Digital Microfluidic Biochips Book PDF

Author : Yan Luo,Krishnendu Chakrabarty,Tsung-Yi Ho
Publisher : Springer
Page : 197 pages
File Size : 44,8 Mb
Release : 2014-08-06
Category : Technology & Engineering
ISBN : 9783319090061

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Hardware/Software Co-Design and Optimization for Cyberphysical Integration in Digital Microfluidic Biochips by Yan Luo,Krishnendu Chakrabarty,Tsung-Yi Ho Pdf

This book describes a comprehensive framework for hardware/software co-design, optimization, and use of robust, low-cost, and cyberphysical digital microfluidic systems. Readers with a background in electronic design automation will find this book to be a valuable reference for leveraging conventional VLSI CAD techniques for emerging technologies, e.g., biochips or bioMEMS. Readers from the circuit/system design community will benefit from methods presented to extend design and testing techniques from microelectronics to mixed-technology microsystems. For readers from the microfluidics domain, this book presents a new design and development strategy for cyberphysical microfluidics-based biochips suitable for large-scale bioassay applications. • Takes a transformative, “cyberphysical” approach towards achieving closed-loop and sensor feedback-driven biochip operation under program control; • Presents a “physically-aware” system reconfiguration technique that uses sensor data at intermediate checkpoints to dynamically reconfigure biochips; • Enables readers to simplify the structure of biochips, while facilitating the “general-purpose” use of digital microfluidic biochips for a wider range of applications.