Computer Simulation Study Of Collective Phenomena In Dense Suspensions Of Red Blood Cells Under Shear

Author : Timm Krüger
Publisher : Springer Science & Business Media
Page : 169 pages
File Size : 42,9 Mb
Release : 2012-10-02
Category : Science
ISBN : 9783834823762

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Computer Simulation Study of Collective Phenomena in Dense Suspensions of Red Blood Cells under Shear by Timm Krüger Pdf

The rheology of dense red blood cell suspensions is investigated via computer simulations based on the lattice Boltzmann, the immersed boundary, and the finite element methods. The red blood cells are treated as extended and deformable particles immersed in the ambient fluid. In the first part of the work, the numerical model and strategies for stress evaluation are discussed. In the second part, the behavior of the suspensions in simple shear flow is studied for different volume fractions, particle deformabilities, and shear rates. Shear thinning behavior is recovered. The existence of a shear-induced transition from a tumbling to a tank-treading motion is demonstrated. The transition can be parameterized by a single quantity, namely the effective capillary number. It is the ratio of the suspension stress and the characteristic particle membrane stress. At the transition point, a strong increase in the orientational order of the red blood cells and a significant decrease of the particle diffusivity are observed. However, the average cell deformation shows no signature of the transition.

Author : Heinrich Krüger
Publisher : Springer Science & Business Media
Page : 169 pages
File Size : 51,5 Mb
Release : 2012-07-18
Category : Science
ISBN : 9783834823755

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Computer Simulation Study of Collective Phenomena in Dense Suspensions of Red Blood Cells under Shear by Heinrich Krüger Pdf

The rheology of dense red blood cell suspensions is investigated via computer simulations based on the lattice Boltzmann, the immersed boundary, and the finite element methods. The red blood cells are treated as extended and deformable particles immersed in the ambient fluid. In the first part of the work, the numerical model and strategies for stress evaluation are discussed. In the second part, the behavior of the suspensions in simple shear flow is studied for different volume fractions, particle deformabilities, and shear rates. Shear thinning behavior is recovered. The existence of a shear-induced transition from a tumbling to a tank-treading motion is demonstrated. The transition can be parameterized by a single quantity, namely the effective capillary number. It is the ratio of the suspension stress and the characteristic particle membrane stress. At the transition point, a strong increase in the orientational order of the red blood cells and a significant decrease of the particle diffusivity are observed. However, the average cell deformation shows no signature of the transition.

Author : Ivan Cimrak,Iveta Jancigova
Publisher : CRC Press
Page : 191 pages
File Size : 44,6 Mb
Release : 2018-09-06
Category : Mathematics
ISBN : 9781351378666

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Computational Blood Cell Mechanics by Ivan Cimrak,Iveta Jancigova Pdf

Simulating blood cells for biomedical applications is a challenging goal. Whether you want to investigate blood flow behavior on the cell scale, or use a blood cell model for fast computational prototyping in microfluidics, Computational Blood Cell Mechanics will help you get started, and show you the path forward. The text presents a step-by-step approach to cell model building that can be adopted when developing and validating models for biomedical applications, such as filtering and sorting cells, or examining flow and deformations of individual cells under various conditions. It starts with basic building-blocks that, together, model the red blood cell membrane according to its physical properties, before moving on to discuss several issues that may pose problems along the way, and finally leads to suggestions on how to set up computational experiments. More details available at www.compbloodcell.eu

Author : João M. F. Rodrigues,Pedro J. S. Cardoso,Jânio Monteiro,Roberto Lam,Valeria V. Krzhizhanovskaya,Michael H. Lees,Jack J. Dongarra,Peter M.A. Sloot
Publisher : Springer
Page : 659 pages
File Size : 44,6 Mb
Release : 2019-06-07
Category : Computers
ISBN : 9783030227340

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Computational Science – ICCS 2019 by João M. F. Rodrigues,Pedro J. S. Cardoso,Jânio Monteiro,Roberto Lam,Valeria V. Krzhizhanovskaya,Michael H. Lees,Jack J. Dongarra,Peter M.A. Sloot Pdf

The five-volume set LNCS 11536, 11537, 11538, 11539, and 11540 constitutes the proceedings of the 19th International Conference on Computational Science, ICCS 2019, held in Faro, Portugal, in June 2019. The total of 65 full papers and 168 workshop papers presented in this book set were carefully reviewed and selected from 573 submissions (228 submissions to the main track and 345 submissions to the workshops). The papers were organized in topical sections named: Part I: ICCS Main Track Part II: ICCS Main Track; Track of Advances in High-Performance Computational Earth Sciences: Applications and Frameworks; Track of Agent-Based Simulations, Adaptive Algorithms and Solvers; Track of Applications of Matrix Methods in Artificial Intelligence and Machine Learning; Track of Architecture, Languages, Compilation and Hardware Support for Emerging and Heterogeneous Systems Part III: Track of Biomedical and Bioinformatics Challenges for Computer Science; Track of Classifier Learning from Difficult Data; Track of Computational Finance and Business Intelligence; Track of Computational Optimization, Modelling and Simulation; Track of Computational Science in IoT and Smart Systems Part IV: Track of Data-Driven Computational Sciences; Track of Machine Learning and Data Assimilation for Dynamical Systems; Track of Marine Computing in the Interconnected World for the Benefit of the Society; Track of Multiscale Modelling and Simulation; Track of Simulations of Flow and Transport: Modeling, Algorithms and Computation Part V: Track of Smart Systems: Computer Vision, Sensor Networks and Machine Learning; Track of Solving Problems with Uncertainties; Track of Teaching Computational Science; Poster Track ICCS 2019 Chapter “Comparing Domain-decomposition Methods for the Parallelization of Distributed Land Surface Models” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Author : Wolfgang E. Nagel,Dietmar H. Kröner,Michael M. Resch
Publisher : Springer
Page : 529 pages
File Size : 44,5 Mb
Release : 2018-02-16
Category : Computers
ISBN : 9783319683942

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High Performance Computing in Science and Engineering ' 17 by Wolfgang E. Nagel,Dietmar H. Kröner,Michael M. Resch Pdf

This book presents the state-of-the-art in supercomputer simulation. It includes the latest findings from leading researchers using systems from the High Performance Computing Center Stuttgart (HLRS) in 2017. The reports cover all fields of computational science and engineering ranging from CFD to computational physics and from chemistry to computer science with a special emphasis on industrially relevant applications. Presenting findings of one of Europe’s leading systems, this volume covers a wide variety of applications that deliver a high level of sustained performance.The book covers the main methods in high-performance computing. Its outstanding results in achieving the best performance for production codes are of particular interest for both scientists and engineers. The book comes with a wealth of color illustrations and tables of results.

Author : Huilin Ye,Zhiqiang Shen,Ying Li
Publisher : Morgan & Claypool Publishers
Page : 112 pages
File Size : 42,8 Mb
Release : 2020-01-02
Category : Science
ISBN : 9781643277929

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Multiscale Modeling of Vascular Dynamics of Micro- and Nano-particles by Huilin Ye,Zhiqiang Shen,Ying Li Pdf

Recent advances witness the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance the efficacy and specificity, the control and guidance of drug carriers in vasculature has become crucial. Current bottlenecks in the optimal design of drug carrying particles are the lack of knowledge about the transport of particles, adhesion on endothelium wall and subsequent internalization into diseased cells. To study the transport and adhesion of particle in vasculature, the authors have made great efforts to numerically investigate the dynamic and adhesive motions of particles in the blood flow. This book discusses the recent achievements from the establishment of fundamental physical problem to development of multiscale model, and finally large scale simulations for understanding transport of particle-based drug carriers in blood flow.

Author : P. Jesper Sjöström
Publisher : Frontiers Media SA
Page : 168 pages
File Size : 54,5 Mb
Release : 2021-07-21
Category : Science
ISBN : 9782889710652

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Frontiers in Synaptic Neuroscience - Editor's Pick 2021 by P. Jesper Sjöström Pdf

Author : Timm Krüger,Halim Kusumaatmaja,Alexandr Kuzmin,Orest Shardt,Goncalo Silva,Erlend Magnus Viggen
Publisher : Springer
Page : 694 pages
File Size : 54,7 Mb
Release : 2016-11-07
Category : Science
ISBN : 9783319446493

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The Lattice Boltzmann Method by Timm Krüger,Halim Kusumaatmaja,Alexandr Kuzmin,Orest Shardt,Goncalo Silva,Erlend Magnus Viggen Pdf

This book is an introduction to the theory, practice, and implementation of the Lattice Boltzmann (LB) method, a powerful computational fluid dynamics method that is steadily gaining attention due to its simplicity, scalability, extensibility, and simple handling of complex geometries. The book contains chapters on the method's background, fundamental theory, advanced extensions, and implementation. To aid beginners, the most essential paragraphs in each chapter are highlighted, and the introductory chapters on various LB topics are front-loaded with special "in a nutshell" sections that condense the chapter's most important practical results. Together, these sections can be used to quickly get up and running with the method. Exercises are integrated throughout the text, and frequently asked questions about the method are dealt with in a special section at the beginning. In the book itself and through its web page, readers can find example codes showing how the LB method can be implemented efficiently on a variety of hardware platforms, including multi-core processors, clusters, and graphics processing units. Students and scientists learning and using the LB method will appreciate the wealth of clearly presented and structured information in this volume.

Author : Oguz Baskurt,Björn Neu,Herbert J. Meiselman
Publisher : CRC Press
Page : 326 pages
File Size : 50,9 Mb
Release : 2011-09-28
Category : Medical
ISBN : 9781439841808

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Red Blood Cell Aggregation by Oguz Baskurt,Björn Neu,Herbert J. Meiselman Pdf

Red blood cells in humans—and most other mammals—have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this really happen in blood circulation? And do these rouleaux formations have a useful function? The first book to offer a comprehensive review of the subject, Red Blood Cell Aggregation tackles these and other questions related to red blood cell (RBC) aggregates. The book covers basic, clinical, and physiological aspects of this important biophysical phenomenon and integrates these areas with concepts in bioengineering. It brings together state-of-the-art research on the determinants, mechanisms, and measurement and effects of RBC aggregation as well as on variations and comparative aspects. After an introductory overview, the book outlines factors and conditions that affect RBC aggregation. It presents the two hypotheses—the bridging model and the depletion model—that provide potential mechanisms for the adhesive forces that lead to the regular packing of the cells in rouleaux formations. The book also reviews the methods used to quantify RBC aggregation in vitro, focusing on their importance in clinical practice. Chapters discuss the effect of RBC aggregation on the in vitro rheology of blood as well as on tube flow. The book also looks at what happens in the circulation when red blood cells aggregate and examines variations due to physiological and pathophysiological challenges. The concluding chapter explores the formation of red blood cell aggregates in other mammals. Written by leading researchers in the field, this is an invaluable resource for basic science, medical, and clinical researchers; graduate students; and clinicians interested in mammalian red blood cells.

Author : Jan Mewis,Norman J. Wagner
Publisher : Cambridge University Press
Page : 417 pages
File Size : 55,9 Mb
Release : 2012
Category : Science
ISBN : 9780521515993

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Colloidal Suspension Rheology by Jan Mewis,Norman J. Wagner Pdf

Presented in an accessible and introductory manner, this is the first book devoted to the comprehensive study of colloidal suspensions.

Author : Sauro Succi
Publisher : Oxford University Press
Page : 784 pages
File Size : 45,6 Mb
Release : 2018-04-13
Category : Technology & Engineering
ISBN : 9780192538857

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The Lattice Boltzmann Equation: For Complex States of Flowing Matter by Sauro Succi Pdf

Flowing matter is all around us, from daily-life vital processes (breathing, blood circulation), to industrial, environmental, biological, and medical sciences. Complex states of flowing matter are equally present in fundamental physical processes, far remote from our direct senses, such as quantum-relativistic matter under ultra-high temperature conditions (quark-gluon plasmas). Capturing the complexities of such states of matter stands as one of the most prominent challenges of modern science, with multiple ramifications to physics, biology, mathematics, and computer science. As a result, mathematical and computational techniques capable of providing a quantitative account of the way that such complex states of flowing matter behave in space and time are becoming increasingly important. This book provides a unique description of a major technique, the Lattice Boltzmann method to accomplish this task. The Lattice Boltzmann method has gained a prominent role as an efficient computational tool for the numerical simulation of a wide variety of complex states of flowing matter across a broad range of scales; from fully-developed turbulence, to multiphase micro-flows, all the way down to nano-biofluidics and lately, even quantum-relativistic sub-nuclear fluids. After providing a self-contained introduction to the kinetic theory of fluids and a thorough account of its transcription to the lattice framework, this text provides a survey of the major developments which have led to the impressive growth of the Lattice Boltzmann across most walks of fluid dynamics and its interfaces with allied disciplines. Included are recent developments of Lattice Boltzmann methods for non-ideal fluids, micro- and nanofluidic flows with suspended bodies of assorted nature and extensions to strong non-equilibrium flows beyond the realm of continuum fluid mechanics. In the final part, it presents the extension of the Lattice Boltzmann method to quantum and relativistic matter, in an attempt to match the major surge of interest spurred by recent developments in the area of strongly interacting holographic fluids, such as electron flows in graphene.

Author : Rui A. Lima,Graça Minas,Susana Catarino
Publisher : MDPI
Page : 174 pages
File Size : 49,7 Mb
Release : 2019-12-03
Category : Technology & Engineering
ISBN : 9783039218240

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Micro/Nano Devices for Blood Analysis by Rui A. Lima,Graça Minas,Susana Catarino Pdf

The development of micro- and nanodevices for blood analysis is an interdisciplinary subject that demands the integration of several research fields, such as biotechnology, medicine, chemistry, informatics, optics, electronics, mechanics, and micro/nanotechnologies. Over the last few decades, there has been a notably fast development in the miniaturization of mechanical microdevices, later known as microelectromechanical systems (MEMS), which combine electrical and mechanical components at a microscale level. The integration of microflow and optical components in MEMS microdevices, as well as the development of micropumps and microvalves, have promoted the interest of several research fields dealing with fluid flow and transport phenomena happening in microscale devices. Microfluidic systems have many advantages over their macroscale counterparts, offering the ability to work with small sample volumes, providing good manipulation and control of samples, decreasing reaction times, and allowing parallel operations in one single step. As a consequence, microdevices offer great potential for the development of portable and point-of-care diagnostic devices, particularly for blood analysis. Moreover, the recent progress in nanotechnology has contributed to its increasing popularity, and has expanded the areas of application of microfluidic devices, including in the manipulation and analysis of flows on the scale of DNA, proteins, and nanoparticles (nanoflows). In this Special Issue, we invited contributions (original research papers, review articles, and brief communications) that focus on the latest advances and challenges in micro- and nanodevices for diagnostics and blood analysis, micro- and nanofluidics, technologies for flow visualization, MEMS, biochips, and lab-on-a-chip devices and their application to research and industry. We hope to provide an opportunity to the engineering and biomedical community to exchange knowledge and information and to bring together researchers who are interested in the general field of MEMS and micro/nanofluidics and, especially, in its applications to biomedical areas.

Author : Federico Toschi,Marcello Sega
Publisher : Springer Nature
Page : 309 pages
File Size : 52,5 Mb
Release : 2019-09-25
Category : Science
ISBN : 9783030233709

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Flowing Matter by Federico Toschi,Marcello Sega Pdf

This open access book, published in the Soft and Biological Matter series, presents an introduction to selected research topics in the broad field of flowing matter, including the dynamics of fluids with a complex internal structure -from nematic fluids to soft glasses- as well as active matter and turbulent phenomena. Flowing matter is a subject at the crossroads between physics, mathematics, chemistry, engineering, biology and earth sciences, and relies on a multidisciplinary approach to describe the emergence of the macroscopic behaviours in a system from the coordinated dynamics of its microscopic constituents. Depending on the microscopic interactions, an assembly of molecules or of mesoscopic particles can flow like a simple Newtonian fluid, deform elastically like a solid or behave in a complex manner. When the internal constituents are active, as for biological entities, one generally observes complex large-scale collective motions. Phenomenology is further complicated by the invariable tendency of fluids to display chaos at the large scales or when stirred strongly enough. This volume presents several research topics that address these phenomena encompassing the traditional micro-, meso-, and macro-scales descriptions, and contributes to our understanding of the fundamentals of flowing matter. This book is the legacy of the COST Action MP1305 “Flowing Matter”.

Author : C. Ross Ethier,Craig A. Simmons
Publisher : Cambridge University Press
Page : 10 pages
File Size : 54,8 Mb
Release : 2007-03-12
Category : Technology & Engineering
ISBN : 9781139461825

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Introductory Biomechanics by C. Ross Ethier,Craig A. Simmons Pdf

Introductory Biomechanics is a new, integrated text written specifically for engineering students. It provides a broad overview of this important branch of the rapidly growing field of bioengineering. A wide selection of topics is presented, ranging from the mechanics of single cells to the dynamics of human movement. No prior biological knowledge is assumed and in each chapter, the relevant anatomy and physiology are first described. The biological system is then analyzed from a mechanical viewpoint by reducing it to its essential elements, using the laws of mechanics and then tying mechanical insights back to biological function. This integrated approach provides students with a deeper understanding of both the mechanics and the biology than from qualitative study alone. The text is supported by a wealth of illustrations, tables and examples, a large selection of suitable problems and hundreds of current references, making it an essential textbook for any biomechanics course.

Author : National Research Council,Division on Engineering and Physical Sciences,Board on Physics and Astronomy,Committee on Condensed-Matter and Materials Physics
Publisher : National Academies Press
Page : 325 pages
File Size : 41,6 Mb
Release : 1999-05-21
Category : Technology & Engineering
ISBN : 9780309063494

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Condensed-Matter and Materials Physics by National Research Council,Division on Engineering and Physical Sciences,Board on Physics and Astronomy,Committee on Condensed-Matter and Materials Physics Pdf

This book identifies opportunities, priorities, and challenges for the field of condensed-matter and materials physics. It highlights exciting recent scientific and technological developments and their societal impact and identifies outstanding questions for future research. Topics range from the science of modern technology to new materials and structures, novel quantum phenomena, nonequilibrium physics, soft condensed matter, and new experimental and computational tools. The book also addresses structural challenges for the field, including nurturing its intellectual vitality, maintaining a healthy mixture of large and small research facilities, improving the field's integration with other disciplines, and developing new ways for scientists in academia, government laboratories, and industry to work together. It will be of interest to scientists, educators, students, and policymakers.