Conceptual Breakthroughs In The Evolutionary Biology Of Aging

Author : Kenneth R. Arnold,Michael R. Rose
Publisher : Elsevier
Page : 308 pages
File Size : 40,5 Mb
Release : 2022-12-15
Category : Science
ISBN : 9780128215456

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Conceptual Breakthroughs in The Evolutionary Biology of Aging by Kenneth R. Arnold,Michael R. Rose Pdf

Conceptual Breakthroughs in the Evolutionary Biology of Aging continues the innovative Conceptual Breakthroughs series by providing a comprehensive outline of the major breakthroughs that built the evolutionary biology of aging as a leading scientific field. Following the evolutionary study of aging from its humble origins to the present, the book's chapters treat the field's breakthroughs one at a time. Users will find a concise and accessible analysis of the science of aging viewed through an evolutionary lens. Building upon widely-cited studies conducted by author Michael Rose, this book covers 30 subsequent years of growth and development within the field. The book highlights key publications for those who are not experts in the field, providing an important resource for researchers. Given the prevailing interest in changing the aging process dramatically, it is a powerful tool for readers who have a vested interest in understanding its causes and future control measures. Reviews cell-molecular theories of aging in the light of evolutionary biology Offers an evolutionary analysis of prospects for mitigating aging not commonly discussed within private and public sectors Provides readers with a radically different perspective on contemporary biological gerontology, specifically through the lens of evolutionary biology

Author : Michael R. Rose
Publisher : Oxford University Press
Page : 236 pages
File Size : 51,9 Mb
Release : 1994-10-27
Category : Science
ISBN : 9780198022725

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Evolutionary Biology of Aging by Michael R. Rose Pdf

This unique book looks at the biology of aging from a fundamentally new perspective, one based on evolutionary theory rather than traditional concepts which emphasize molecular and cellular processes. The basis for this approach lies in the fact that natural selection, as a powerful determining force, tends to decline in importance with age. Many of the characteristics we associate with aging, the author argues, are more the result of this decline than any mechanical imperative contained within organic structures. This theory in turn yields the most fruitful avenues for seeking answers to the problem of aging, and should be recognized as the intellectual core of gerontology and the foundation for future research. The author ably surveys the vast literature on aging, presenting mathematical, experimental, and comparative findings to illustrate and support the central thesis. The result is the first complete synthesis of this vital field. Evolutionary biologists, gerontologists, and all those concerned with the science of aging will find it a stimulating, strongly argued account.

Author : Kenneth R. Arnold,Michael R. Rose
Publisher : Academic Press
Page : 310 pages
File Size : 42,8 Mb
Release : 2023-07-10
Category : Science
ISBN : 9780128215463

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Conceptual Breakthroughs in The Evolutionary Biology of Aging by Kenneth R. Arnold,Michael R. Rose Pdf

Conceptual Breakthroughs in the Evolutionary Biology of Aging continues the innovative Conceptual Breakthroughs series by providing a comprehensive outline of the major breakthroughs that built the evolutionary biology of aging as a leading scientific field. Following the evolutionary study of aging from its humble origins to the present, the book's chapters treat the field’s breakthroughs one at a time. Users will find a concise and accessible analysis of the science of aging viewed through an evolutionary lens. Building upon widely-cited studies conducted by author Michael Rose, this book covers 30 subsequent years of growth and development within the field.The book highlights key publications for those who are not experts in the field, providing an important resource for researchers. Given the prevailing interest in changing the aging process dramatically, it is a powerful tool for readers who have a vested interest in understanding its causes and future control measures. Reviews cell-molecular theories of aging in the light of evolutionary biology Offers an evolutionary analysis of prospects for mitigating aging not commonly discussed within private and public sectors Provides readers with a radically different perspective on contemporary biological gerontology, specifically through the lens of evolutionary biology

Author : Anonim
Publisher : Unknown
Page : 236 pages
File Size : 52,6 Mb
Release : 1994
Category : Electronic
ISBN : 160256034X

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Evolutionary Biology of Aging by Anonim Pdf

The author of this monograph proposes an evolutionary theory of senescence - that the force of natural selection declines proportionally with age after the onset of reproduction. He elaborates with evidence from cell biology, physiology and gerontology.

Author : Michael R. Rose
Publisher : Oxford University Press
Page : 189 pages
File Size : 45,8 Mb
Release : 2005-09-15
Category : Science
ISBN : 9780198039860

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The Long Tomorrow by Michael R. Rose Pdf

The conquest of aging is now within our grasp. It hasn't arrived yet, writes Michael R. Rose, but a scientific juggernaut has started rolling and is picking up speed. A long tomorrow is coming. In The Long Tomorrow, Rose offers us a delightfully written account of the modern science of aging, spiced with intriguing stories of his own career and leavened with the author's engaging sense of humor and rare ability to make contemporary research understandable to nonscientists. The book ranges from Rose's first experiments while a graduate student--counting a million fruit fly eggs, which took 3,000 hours over the course of a year--to some of his key scientific discoveries. We see how some of his earliest experiments helped demonstrate that "the force of natural selection" was key to understanding the aging process--a major breakthrough. Rose describes how he created the well-known Methuselah Flies, fruit flies that live far longer than average. Equally important, Rose surveys the entire field, offering colorful portraits of many leading scientists and shedding light on research findings from around the world. We learn that rodents given fifteen to forty percent fewer calories live about that much longer, and that volunteers in Biosphere II, who lived on reduced caloric intake for two years, all had improved vital signs. Perhaps most interesting, we discover that aging hits a plateau and stops. Popular accounts of Rose's work have appeared in The New Yorker, Time magazine, and Scientific American, but The Long Tomorrow is the first full account of this exciting new science written for the general reader. "Among his peers, Rose is considered a brilliantly innovative scientist, who has almost single-handedly brought the evolutionary theory of aging from an abstract notion to one of the most exciting topics in science."--Malcolm Gladwell, The New Yorker

Author : Laurence Mueller
Publisher : Academic Press
Page : 206 pages
File Size : 45,5 Mb
Release : 2019-11-19
Category : Science
ISBN : 9780128160145

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Conceptual Breakthroughs in Evolutionary Ecology by Laurence Mueller Pdf

Although biologists recognize evolutionary ecology by name, many only have a limited understanding of its conceptual roots and historical development. Conceptual Breakthroughs in Evolutionary Ecology fills that knowledge gap in a thought-provoking and readable format. Written by a world-renowned evolutionary ecologist, this book embodies a unique blend of expertise in combining theory and experiment, population genetics and ecology. Following an easily-accessible structure, this book encapsulates and chronologizes the history behind evolutionary ecology. It also focuses on the integration of age-structure and density-dependent selection into an understanding of life-history evolution. Covers over 60 seminal breakthroughs and paradigm shifts in the field of evolutionary biology and ecology Modular format permits ready access to each described subject Historical overview of a field whose concepts are central to all of biology and relevant to a broad audience of biologists, science historians, and philosophers of science

Author : Laurence D. Mueller,Casandra L. Rauser,Michael R. Rose
Publisher : OUP USA
Page : 225 pages
File Size : 44,7 Mb
Release : 2011-07-29
Category : Health & Fitness
ISBN : 9780199754229

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Does Aging Stop? by Laurence D. Mueller,Casandra L. Rauser,Michael R. Rose Pdf

Does Aging Stop? shatters the conventional beliefs on which aging research has been based for the last fifty years.

Author : Michael R. Rose,Caleb E. Finch
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 50,9 Mb
Release : 2013-03-09
Category : Science
ISBN : 9789401716710

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Genetics and Evolution of Aging by Michael R. Rose,Caleb E. Finch Pdf

Aging is one of those subjects that many biologists feel is largely unknown. Therefore, they often feel comfortable offering extremely facile generalizations that are either unsupported or directly refuted in the experimental literature. Despite this unfortunate precedent, aging is a very broad phenomenon that calls out for integration beyond the mere collecting together of results from disparate laboratory organisms. With this in mind, Part One offers several different synthetic perspectives. The editors, Rose and Finch, provide a verbal synthesis of the field that deliberately attempts to look at aging from both sides, the evolutionary and the molecular. The articles by Charlesworth and Clark both provide population genetic perspectives on aging, the former more mathematical, the latter more experimental. Bell takes a completely different approach, arguing that aging may not be the result of evolutionary forces. Bell's model instead proposes that aging could arise from the progressive deterioration of chronic host pathogen interactions. This is the first detailed publication of this model. It marks something of a return to the type of aging theories that predominated in the 1950's and 1960's, theories like the somatic mutation and error catastrophe theories. We hope that the reader will be interested by the contrast in views between the articles based on evolutionary theory and that of Bell. MR. Rose and C. E. Finch (eds. ), Genetics and Evolution of Aging, 5-12, 1994. © 1994 Kluwer Academic Publishers. The J aniform genetics of aging 2 Michael R. Rosel & Caleb E.

Author : Theodore Goldsmith
Publisher : Azinet
Page : 31 pages
File Size : 52,9 Mb
Release : 2011-05-08
Category : Medical
ISBN : 9780978870911

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An Introduction to Biological Aging Theory by Theodore Goldsmith Pdf

Why do we age? The answer to this question is critical to our ability to prevent and treat highly age-related diseases such as cancer and heart disease that now cause the deaths of most people in the developed world. This short book provides an overview of biological aging theories including history, current status, major scientific controversies, and implications for the future of medicine. Major topics include: human mortality as a function of age, aging mechanisms and processes, the programmed vs. non-programmed aging controversy, empirical evidence on aging, and the feasibility of anti-aging and regenerative medicine. Evolution theory is essential to aging theories. Theorists have been struggling for 150 years to explain how aging, deterioration, and consequent death fit with Darwin’s survival of the fittest concept. This book explains how continuing genetics discoveries have produced changes in the way we think about evolution that in turn lead to new thinking about the nature of aging.

Author : Theodore C. Goldsmith
Publisher : Azinet
Page : 201 pages
File Size : 48,6 Mb
Release : 2006
Category : Aging
ISBN : 9780978870904

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The Evolution of Aging by Theodore C. Goldsmith Pdf

Goldsmith provides a historical review of biological aging theories including underlying evolution and genetics issues and describes exciting recent discoveries and new theories that are causing renewed interest in aging-by-design.

Author : Giacinto Libertini,Graziamaria Corbi,Valeria Conti,Olga Shubernetskaya,Nicola Ferrara
Publisher : Springer Nature
Page : 413 pages
File Size : 51,8 Mb
Release : 2021-05-25
Category : Social Science
ISBN : 9783030737740

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Evolutionary Gerontology and Geriatrics by Giacinto Libertini,Graziamaria Corbi,Valeria Conti,Olga Shubernetskaya,Nicola Ferrara Pdf

This book provides concrete scientific basis that we can conceive the possibility of modifying or even completely canceling aging process, despite the fact that aging is commonly regarded as the result of the overall effects of many uncontrollable degenerative phenomena. The authors illustrate in detail the mechanisms by which cells and the whole organism age. Actions by which it is possible, or will be possible within a limited time, to operate for modifying aging are also debated. The discussion is conducted within the frame and the concepts of evolutionary medicine, which is also indispensable for distinguishing between the manifestations of aging and: (i) diseases that worsen with age, and (ii) acceleration of normal aging rates, caused by unhealthy lifestyle habits and other avoidable factors. The book also discusses the impact of aging on overall mortality and the strange situation that, according to official statistics, aging does not exist as cause of death. This book is a turning point between a gerontology and geriatrics conceived as the study and vain treatment of an incurable condition and one in which these disciplines examine the how and why of a physiological phenomenon that can be modified up to a possible total control. This means transforming the medical prevention and treatment of physiological aging from the greatest failure to the greatest success of medicine.

Author : Morton Rothstein
Publisher : Wiley
Page : 392 pages
File Size : 40,8 Mb
Release : 1990-04-30
Category : Science
ISBN : 0471566977

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Review of Biological Research in Aging by Morton Rothstein Pdf

Author : James R. Carey
Publisher : Princeton University Press
Page : 305 pages
File Size : 42,5 Mb
Release : 2021-01-12
Category : Science
ISBN : 9780691224084

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Longevity by James R. Carey Pdf

Despite our deep interest in mortality, little is known about why some individuals live to middle age and others to extreme old age. Life span, mortality, and aging present some of the most profound mysteries in biology. In Longevity, James Carey draws on unprecedented data to develop a biological and demographic framework for identifying the key factors that govern aging, life span, and mortality in humans and other animals. Carey presents the results of a monumental, twelve-year, National Institute on Aging-funded research project on the determinants of longevity using data from the life tables of five million Mediterranean fruit flies, the most comprehensive set of life table studies ever on the mortality dynamics of a single species. He interprets the fruit fly data within the context of human aging and the aging process in general to identify the determinants of mortality. Three key themes emerge: the absence of species-specific life span limits, the context-specific nature of the mortality rate, and biodemographic linkages between longevity and reproduction. A powerful foundation for the emerging field of biodemography and a rich framework for considering the future of human life span, Longevity will be an indispensable resource for readers from a range of fields including population biology, demography, gerontology, ecology, evolutionary biology, and medical research.

Author : Nicolas Musi,Peter Hornsby
Publisher : Academic Press
Page : 469 pages
File Size : 49,8 Mb
Release : 2021-01-19
Category : Education
ISBN : 9780128162835

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Handbook of the Biology of Aging by Nicolas Musi,Peter Hornsby Pdf

Handbook of the Biology of Aging, Ninth Edition, provides a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology. The book focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and metabolomics methodologies applied to aging related problems. Sections cover longevity pathways and interventions that modulate aging, innovative tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, and much more. Assists researchers in keeping abreast of research and clinical findings outside their subdiscipline Helps medical, behavioral and social gerontologists understand what basic scientists and clinicians are discovering Includes new chapters on genetics, evolutionary biology, bone aging, and epigenetic control Examines the diverse research being conducted in the study of the biology of aging

Author : P. Calow
Publisher : Springer Science & Business Media
Page : 172 pages
File Size : 43,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461334309

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Life Cycles by P. Calow Pdf

As time progresses, biology becomes more and more fragmented and specialized and it becomes increasingly difficult to see how all the dis- ! parate facts fit together. It is completely proper that biologists should have sought to reduce complex biological wholes into their parts, and it is natural that studies on the products of this reduction should have diverged from more holistic studies on evolution and ecology. Yet the biological parts, what they do and how they are organized are products of an evolutionary process which fits organisms for life in particular ecological circumstances. Physiology, developmental biology, ecology and evolutionary biology must not be allowed to grow too far apart, therefore, because all these disciplines and the way their subject matters interact are crucial to understanding organisms - and it is this, it seems to me, which is the fundamental goal of the biological sciences. This book has been written in the spirit of unification and synthesis. It is, in a sense, a general biology of the organism - not, however, of organisms as static unchanging systems, but of organisms as dynamic entities which progress through a definite cycle of events from birth to maturity. The central theme, therefore, will be the life cycle, and the book is organized around the three main phases which are characteristic of all life cycles; growth (Part II), reproduction (Part III) and ageing (Part IV).