Conn S Translational Neuroscience

Author : P. Michael Conn
Publisher : Academic Press
Page : 776 pages
File Size : 45,8 Mb
Release : 2016-09-28
Category : Medical
ISBN : 9780128025963

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Conn's Translational Neuroscience by P. Michael Conn Pdf

Conn’s Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn’s Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance Features contributions from leading global basic and clinical investigators in the field Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes Relates and translates the current science to the understanding of neurological disorders and their treatment

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 44,5 Mb
Release : 2024-05-21
Category : Electronic
ISBN : OCLC:1403182849

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Translational Neuroscience by Anonim Pdf

Author : Karoly Nikolich,Steven E. Hyman
Publisher : MIT Press
Page : 319 pages
File Size : 45,8 Mb
Release : 2015-08-21
Category : Medical
ISBN : 9780262029865

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Translational Neuroscience by Karoly Nikolich,Steven E. Hyman Pdf

Experts from academia and industry discuss how to create a new, more effective translational neuroscience drawing on novel technology and recent discoveries. Today, translational neuroscience faces significant challenges. Available therapies to treat brain and nervous system disorders are extremely limited and dated, and further development has effectively ceased. Disinvestment by the private sector occurred just as promising new technologies in genomics, stem cell biology, and neuroscience emerged to offer new possibilities. In this volume, experts from both academia and industry discuss how novel technologies and reworked translation concepts can create a more effective translational neuroscience. The contributors consider such topics as using genomics and neuroscience for better diagnostics and biomarker identification; new approaches to disease based on stem cell technology and more careful use of animal models; and greater attention to human biology and what it will take to make new therapies available for clinical use. They conclude with a conceptual roadmap for an effective and credible translational neuroscience—one informed by a disease-focused knowledge base and clinical experience. Contributors Tobias M. Böckers, Thomas Bourgeron, Karl Broich, Nils Brose, Bruce N. Cuthbert, Ilka Diester, Gül Dölen, Guoping Feng, Richard Frackowiak, Raquel E. Gur, Stephan Heckers, Franz Hefti, David M. Holtzman, Steven E. Hyman, Nancy Ip, Cynthia Joyce, Tobias Kaiser, Edward H. Koo, Walter J. Koroshetz, Katja S. Kroker, Robert C. Malenka, Isabelle Mansuy, Eliezer, Masliah, Yuan Mei, Andreas Meyer-Lindenberg, Lennart Mucke, Pierluigi Nicotera, Karoly Nikolich, Michael J. Owen, Menelas N. Pangalos, Alvaro Pascual-Leone, Joel S. Perlmutter, Trevor W. Robbins, Lee L. Rubin, Akira Sawa, Mareike Schnaars, Bernd Sommer, Maria Grazia Spillantini, Laura Spinney, Matthew W. State, Marius Wernig

Author : Mark H. Tuszynski
Publisher : Unknown
Page : 584 pages
File Size : 47,5 Mb
Release : 2016
Category : Medicine
ISBN : 1489976531

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Translational Neuroscience by Mark H. Tuszynski Pdf

Translational Neuroscience offers a far-reaching and insightful series of perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic, thereby transforming the treatment of human nervous system disorders. Great advances in the fields of basic neuroscience, molecular biology, genomics, gene therapy, cell therapy, stem cell biology, information technology, neuro devices, rehabilitation and others over the last 20 years have generated unprecedented opportunities to treat heretofore untreatable disorders of the nervous system. This book provides a wide-ranging yet detailed sample of many of these efforts, together with the methods for pursuing clinical translation and assessing clinical outcomes. Among the topics covered are Alzheimer's disease, Parkinson's disease, stroke, multiple sclerosis, epilepsy, motor neuron disease, pain, inborn errors of metabolism, brain tumors, spinal cord injury, neuroprosthetics, rehabilitation and clinical trial design/consideration. Translational Neuroscience is aimed at basic neuroscientists, translational neuroscientists and clinicians who seek to gain a perspective on the nature and promise of translational therapies in the current era. Both students and established professionals will benefit from the content.

Author : Anonim
Publisher : Elsevier
Page : 455 pages
File Size : 55,8 Mb
Release : 1995-04-13
Category : Science
ISBN : 008053645X

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PCR in Neuroscience by Anonim Pdf

The volumes in this series include contemporary techniques significant to a particular branch of neuroscience. They are an invaluable aid to the student as well as the experienced researcher not only in developing protocols in neuroscience but in disciplines where research is becoming closely related to neuroscience. Each volume of Methods in Neurosciences contains an index, and each chapter includes references. Dr. Conn became Editor-in-Chief of the series beginning with Volume 15, so each subsequent volume could be guest-edited by an expert in that specific field. This further strengthens the depth of coverage in Methods in Neurosciences for students and researchers alike. Direct application of PCR to fresh or frozen clinical specimens (e.g., blood and solid tissue) Complete retrieval of novel expressed genes by PCR without screening a library Quantitation by PCR Mutagenesis by PCR PCR in AIDS research Simple and effective protocols for PCR on archival specimens

Author : Sven Braeutigam,Peter Kenning
Publisher : Oxford University Press
Page : 304 pages
File Size : 45,5 Mb
Release : 2022-03-16
Category : Psychology
ISBN : 9780192507297

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An Integrative Guide to Consumer Neuroscience by Sven Braeutigam,Peter Kenning Pdf

Consumer neuroscience is a complex, interdisciplinary, and emerging field that cuts across psychology, neuroscience, and consumer research. The book provides a comprehensive overview of the foundations and applications of modern consumer neuroscience, exploring a wide range of established and emergent topics in the field, making it the ideal resource for anyone looking to broaden their knowledge base. The content provides a thorough, high-level guide to the mathematical, technological, and theoretical aspects of consumer neuroscience, alongside a wide range of specific applications situated within a scientific context. The book includes chapters on cognitive processes and behaviors, the human brain, mathematical concepts, and neuroscience technologies. It considers the difference of individual, social and commercial neuroscience through the lens of gender differences, aging and ethics, amongst other concepts, enabling the reader to adopt an holistic view of the field and discover new research directions. This is enhanced by the inclusion of consolidating questions and answers for each chapter alongside numerous images to enhance the reader's understanding of the topic. The book is an essential read for the aspiring researcher or practitioner striving for an in-depth understanding of the field and its ramifications.

Author : Jennifer Sweeton
Publisher : W. W. Norton & Company
Page : 279 pages
File Size : 48,8 Mb
Release : 2021-11-30
Category : Psychology
ISBN : 9780393714142

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Eight Key Brain Areas of Mental Health and Illness by Jennifer Sweeton Pdf

Bridging the gap between neuroscience and clinical therapy. In this handbook, clinical psychologist and bestselling author Jennifer Sweeton details the eight main areas of the brain affected by mental illness, how brain changes show up in the therapy room as symptoms and behaviors, and the types of therapies and psychotherapeutic techniques research has shown can heal the brain. Areas covered are the thalamus, amygdala, hippocampus, insula, nucleus accumbens, anterior cingulate, ventromedial prefrontal cortex, and dorsolateral prefrontal cortex. No longer will you need to feel unsure when referencing basic brain functions related to behavioral health. After reading this book, you will feel confident and excited about your ability to take a client-centered, strategic, brain-based approach to treatment planning. Chapter summaries and tables of brain region, mental health condition, and therapeutic approach are included for easy reference.

Author : P. Michael Conn
Publisher : Academic Press
Page : 602 pages
File Size : 54,7 Mb
Release : 2013-10-22
Category : Technology & Engineering
ISBN : 9781483259512

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Computers and Computations in the Neurosciences by P. Michael Conn Pdf

Methods in Neurosciences, Volume 10: Computers and Computations in the Neurosciences discusses the use of computers in the neurosciences. The book deals with data collection, analysis, and modeling, with emphasis on the use of computers. Section I involves data collection using a personal microcomputer system. One paper presents a tutorial on using a PC-based motor control composed of an electronic circuit to adjust the motion of a light microscope stage through a software program. Other papers discuss computer methods in nuclei cartography and a computer-assisted quantitative receptor autoradiography in studying receptor density distribution. Section II deals with data analysis and some computer programs for kinetic modeling of gene expression in neurons. The book also discusses a computerized analysis of opioid receptor heterogeneity by ligand binding in test animals using computerized programs instead of employing manual or graphical methods. Computerized curve-fitting allows the researcher to utilize a more precise mathematical model to describe the binding of one ligand to one class of sites. Section III evaluates data modeling and simulations and describes the practicality of using computers to design model ion channels. Another paper discusses a graphical interaction program called MEMPOT to simulate an electrophysiological investigation of the properties of the membrane potential in stimulated cells. The book also presents a quantitative data gathered from computer simulation of the factors that affect neuronal density per measured sections. The book is suitable for microbiologists, biochemists, neuroscientists, and researchers in the field of medical research, as well as for advanced computer programmers in medical research work.

Author : Gunther Hellmann,Jens Steffek
Publisher : Policy Press
Page : 320 pages
File Size : 53,9 Mb
Release : 2023-10
Category : International relations
ISBN : 9781529220476

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Praxis As a Perspective on International Politics by Gunther Hellmann,Jens Steffek Pdf

Bringing together leading figures in the study of international relations, this collection explores praxis as a perspective on international politics and law. It builds on the transdisciplinary work of Friedrich Kratochwil to reveal the scope, limits and blind spots of praxis theorizing.

Author : Ilene Robeck,Melvin Pohl,Michael Weaver,Mark Weiner,Herbert Malinoff,Cory Waller,William Haning
Publisher : Oxford University Press
Page : 352 pages
File Size : 41,5 Mb
Release : 2018-03-15
Category : Psychology
ISBN : 9780190265380

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The American Society of Addiction Medicine Handbook on Pain and Addiction by Ilene Robeck,Melvin Pohl,Michael Weaver,Mark Weiner,Herbert Malinoff,Cory Waller,William Haning Pdf

The American Society of Addiction Medicine Handbook on Pain and Addiction provides clinical considerations and guidelines for the clinician treating patients with pain and addiction. Produced by the largest medical society dedicated to the improvement of addiction care, the book takes an evidence-based approach and uses articles from both the literature and well-regarded organizations and government agencies including NIDA, CDC, SAMHSA, PCSS-O, and ASAM itself. The ASAM Handbook is structured in five sections that cover the core concepts of addressing pain and addiction; diagnosis and treatment; treating pain in patients with, or at risk for, co-occuring addiction; treating substance use disorders (SUD) and addiction in patients with co-occuring pain; and adapting treatment to the needs of specific populations. Each chapter ends with suggestions for further reading on the topics discussed. This book is ideal for primary care providers, mental health clinicians, SUD clinicians, and pain clinicians who wish to bridge the knowledge gaps related to treating patients with pain and addiction. To learn more about the American Society of Addiction Medicine, and its commitment to providing the best resources for addiction clinicians, please visit http://www.asam.org.

Author : Ivana Špelić,Alka Mihelić-Bogdanić,Anica Hursa Šajatović
Publisher : CRC Press
Page : 228 pages
File Size : 41,9 Mb
Release : 2019-06-20
Category : Technology & Engineering
ISBN : 9780429750656

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Standard Methods for Thermal Comfort Assessment of Clothing by Ivana Špelić,Alka Mihelić-Bogdanić,Anica Hursa Šajatović Pdf

Providing detailed analysis of the thermal comfort assessment of clothing as the basis for developing standards, this book discusses the thermal protective role of clothing as a way of modelling heat transfer from the body, general thermal regulation of humans, and the importance of globally accepted test methods and standards to improve quality. New materials and discoveries in the study of thermal comfort necessitate the need for standard improvements and update. The development of international standards and the unification of testing methods is of crucial significance to ensure cost reduction and health protection. The book promotes instruments, methods, implementation of unified specifications, and the definition of standards so that a clear quality management system can be established, for both production systems and testing methods. It discusses standards in ergonomics of the thermal environment, clothing thermal characteristics, and subjective assessment of thermal comfort, which allows for systematic control of the measuring methods and the services and final products that are distributed on the global market. This book is aimed at industry professionals, researchers, and advanced students working in textile and clothing engineering, comfort testing, and ergonomics.

Author : Showkat Ahmad Ganie,Aarif Ali,Muneeb U. Rehman,Azher Arafah
Publisher : Elsevier
Page : 392 pages
File Size : 46,9 Mb
Release : 2023-06-13
Category : Medical
ISBN : 9780443153372

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Pharmacogenomics by Showkat Ahmad Ganie,Aarif Ali,Muneeb U. Rehman,Azher Arafah Pdf

Pharmacogenomics: From Discovery to Clinical Implementation is a complete reference aimed at building a solid foundation of the key concepts in this fast-moving knowledge area. The editors lined up a group of worldwide experts to contribute to the book. Following a consistent chapter structure, the authors cover the foundational aspects of pharmacogenomics in the first four chapters of the book that include basic concepts, drug metabolism, drug discovery and development, and testing. The second part of the book is dedicated to detailed studies of key health conditions and the potential therapeutic applications of pharmacogenomics. Diseases covered include diabetes, cardiovascular diseases, psychiatric disease, cancer, pulmonary and respiratory diseases, viral diseases, gastroenterology, autoimmune diseases, immunosuppressants, and, finally, an overview of computational resources. Pharmacogenomics: From Discovery to Clinical Implementation is the perfect resource for pharmaceutical science graduate students to learn the key concepts of the area. Researchers and graduate students in the related fields of Genetics, pharmacoepidemiology, molecular biology, and medicinal chemistry will also benefit of the structured approach of the book. Provides an in-depth review of pharmacogenomics and its role in drug discovery/metabolism and its clinical impacts Describes the practice of pharmacogenomics in the treatment of diabetes, cancers, cardiovascular diseases, psychiatric disorders, pulmonary diseases, infectious, gastroenterology, and autoimmune diseases Uses a consistent chapter structure to support understanding of the fundamental concepts in the area

Author : Anonim
Publisher : Elsevier
Page : 582 pages
File Size : 42,6 Mb
Release : 2022-08-12
Category : Medical
ISBN : 9780128234945

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The Temporal Lobe by Anonim Pdf

The Temporal Lobe, Volume 187 covers the exponential growth of studies on the relationships between brain and language/cognition, many of which involved the temporal lobe. This volume summarizes research on the anatomy and function of the temporal lobe under both normal and pathological conditions. In addition, it discusses the interactions of the temporal lobe with other brain structures. The book highlights the role of the temporal lobe in language processing as well as vision, object, face recognition and processing. The book also discusses the temporal lobe's role in reading, speech and the processing of color, music, action and memory. Temporal lobe disorders, assessments and treatments are also covered, including encephalitis, Alzheimer’s, epilepsy, Korsakov’s syndrome, and more. Summarizes research on the anatomy and function of the temporal lobe Identifies the importance of the temporal lobe to language and speech Includes how the temporal lobe interacts with other brain structures Reviews disorders of the temporal lobe, including dementia, encephalitis, and more

Author : Aaron Marcus,Wentao Wang
Publisher : Springer
Page : 608 pages
File Size : 49,6 Mb
Release : 2019-07-10
Category : Computers
ISBN : 9783030235703

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Design, User Experience, and Usability. Design Philosophy and Theory by Aaron Marcus,Wentao Wang Pdf

The four-volume set LNCS 11583, 11584, 11585, and 11586 constitutes the proceedings of the 8th International Conference on Design, User Experience, and Usability, DUXU 2019, held as part of the 21st International Conference, HCI International 2019, which took place in Orlando, FL, USA, in July 2019. The total of 1274 papers and 209 posters included in the 35 HCII 2019 proceedings volumes was carefully reviewed and selected from 5029 submissions. DUXU 2019 includes a total of 167 regular papers, organized in the following topical sections: design philosophy; design theories, methods, and tools; user requirements, preferences emotions and personality; visual DUXU; DUXU for novel interaction techniques and devices; DUXU and robots; DUXU for AI and AI for DUXU; dialogue, narrative, storytelling; DUXU for automated driving, transport, sustainability and smart cities; DUXU for cultural heritage; DUXU for well-being; DUXU for learning; user experience evaluation methods and tools; DUXU practice; DUXU case studies.

Author : Lalit Kumar,Yashwant Pathak
Publisher : Elsevier
Page : 864 pages
File Size : 53,5 Mb
Release : 2022-06-21
Category : Technology & Engineering
ISBN : 9780323914710

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Nanocarriers for Drug-Targeting Brain Tumors by Lalit Kumar,Yashwant Pathak Pdf

Nanocarriers for Drug-Targeting Brain Tumors covers different types of nanocarriers and their design and development for targeting drugs to the brain. The book also presents case studies and the mechanism of action of nanocarriers in drug targeting to a specific site. This helps researchers and clinicians understand the design, development and mechanism of action of nanocarriers. As brain tumors continue to be a significant health problem globally, and very complex for targeting drugs, conventional dosage forms are not very effective and side-effects are a major concern. Functionalized nanocarriers can address these problems. Furthermore, the targeting of nanocarriers is preferred for reducing toxicity and improving the effectiveness of the drugs. However, there is a need for understanding the design and development of formulation with the mechanism of action of nanocarriers for brain targeting. Provides information on the design and development of nanocarriers for targeting brain tumors Outlines the working principles of different nanocarriers for targeting brain tumors Includes case studies of different nanocarriers for targeting brain tumors