Contemporary Approaches To Mitigating Antibacterial Drug Resistance

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Contemporary Approaches to Mitigating Antibacterial Drug Resistance

Grewal, Ajmer Singh,Dhingra, Ashwani Kumar,Nepali, Kunal,Deswal, Geeta,Srivastav, Arun Lal
Contemporary Approaches to Mitigating Antibacterial Drug Resistance Book PDF

Author : Grewal, Ajmer Singh,Dhingra, Ashwani Kumar,Nepali, Kunal,Deswal, Geeta,Srivastav, Arun Lal
Publisher : IGI Global
Page : 384 pages
File Size : 40,5 Mb
Release : 2024-04-01
Category : Medical
ISBN : 9798369315415

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Contemporary Approaches to Mitigating Antibacterial Drug Resistance by Grewal, Ajmer Singh,Dhingra, Ashwani Kumar,Nepali, Kunal,Deswal, Geeta,Srivastav, Arun Lal Pdf

In infectious disease management, antibacterial agents have long been viewed as pivotal tools in the relentless battle against microorganisms. However, the escalating threat of antibacterial drug resistance has emerged as a formidable challenge to global health. Contemporary Approaches to Mitigating Antibacterial Drug Resistance delves into the heart of this critical issue, exploring the mechanisms, consequences, and innovative strategies to counteract the surge of resistance, a phenomenon becoming increasingly pervasive and threatening worldwide. Antibacterial drug resistance, a pressing public health concern, transcends geographical boundaries. In regions where antibiotic accessibility and overuse prevail, resistance rates soar, giving rise to the ominous "superbugs." This book unravels the intricacies of drug resistance, examining its impact on infectious disease management, healthcare economics, and societal well-being. The exploration begins with a foundational understanding of antibacterial drug resistance, navigating through the intricate mechanisms that drive its rapid proliferation. Environmental and genetic factors, often overlooked, are dissected for their roles in fostering resistance. The book explores the interplay of antibacterial drugs with micro-biodiversity, shedding light on the indirect repercussions on human and environmental ecosystems. The primary audience, encompassing undergraduate and postgraduate students, medical practitioners, academicians, and researchers, will find in-depth insights into emerging therapeutic targets and recent advances in drug development. The secondary audience, including authorities in antibacterial drug resistance and institutional libraries, will discover a valuable resource addressing the multifaceted dimensions of this global menace.

Emerging Modalities in Mitigation of Antimicrobial Resistance

Nadeem Akhtar,Kumar Siddharth Singh,Prerna,Dinesh Goyal
Emerging Modalities in Mitigation of Antimicrobial Resistance Book PDF

Author : Nadeem Akhtar,Kumar Siddharth Singh,Prerna,Dinesh Goyal
Publisher : Springer Nature
Page : 569 pages
File Size : 53,7 Mb
Release : 2022-01-31
Category : Medical
ISBN : 9783030841263

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Emerging Modalities in Mitigation of Antimicrobial Resistance by Nadeem Akhtar,Kumar Siddharth Singh,Prerna,Dinesh Goyal Pdf

Antimicrobial resistance (AMR) is one of the deadliest threats to global public health. This book focuses on dynamics in the landscape of AMR while informing about the latest technologies and strategies to mitigate it. The menace of AMR in different niches, routes of penetration across various domains, socio-economic impact, and the need for a 'One Health' approach in mitigating AMR has been emphasized. Factors involved in AMR, underlying mechanisms, and pharmacometrics in developing antimicrobials are highlighted. Emphasis is given to emerging technologies that are sustainable, scalable, and applicable to the global community, such as big data analytics, bioactive agents, phage therapy, and nanotechnology. The book also explores current and alternative treatment strategies to combat AMR, emphasizing the use of nanoparticles to target pathogens and as a viable alternative to antibiotics.

Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine

National Academies Of Sciences Engineeri,National Academies of Sciences Engineering and Medicine,Health And Medicine Division,Board On Population Health And Public He,Board on Population Health and Public Health Practice,Committee on the Long-Term Health and Economic Effects of Antimicrobial Resistance in the United States
Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine Book PDF

Author : National Academies Of Sciences Engineeri,National Academies of Sciences Engineering and Medicine,Health And Medicine Division,Board On Population Health And Public He,Board on Population Health and Public Health Practice,Committee on the Long-Term Health and Economic Effects of Antimicrobial Resistance in the United States
Publisher : National Academies Press
Page : 128 pages
File Size : 46,6 Mb
Release : 2022-07-20
Category : Medical
ISBN : 0309269458

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Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine by National Academies Of Sciences Engineeri,National Academies of Sciences Engineering and Medicine,Health And Medicine Division,Board On Population Health And Public He,Board on Population Health and Public Health Practice,Committee on the Long-Term Health and Economic Effects of Antimicrobial Resistance in the United States Pdf

The National Strategy for Combating Antibiotic Resistant Bacteria, published in 2014, sets out a plan for government work to mitigate the emergence and spread of resistant bacteria. Direction on the implementation of this strategy is provided in five-year national action plans, the first covering 2015 to 2020, and the second covering 2020 to 2025. Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine evaluates progress made against the national strategy. This report discusses ways to improve detection of resistant infections and estimate the risk to human health from environmental sources of resistance. In addition, the report considers the effect of agricultural practices on human and animal health and animal welfare and ways these practices could be improved, and advises on key drugs and diseases for which animal-specific test breakpoints are needed.

Improving Food Safety Through a One Health Approach

Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Improving Food Safety Through a One Health Approach Book PDF

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 418 pages
File Size : 49,8 Mb
Release : 2012-09-10
Category : Medical
ISBN : 9780309259361

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Improving Food Safety Through a One Health Approach by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Globalization of the food supply has created conditions favorable for the emergence, reemergence, and spread of food-borne pathogens-compounding the challenge of anticipating, detecting, and effectively responding to food-borne threats to health. In the United States, food-borne agents affect 1 out of 6 individuals and cause approximately 48 million illnesses, 128,000 hospitalizations, and 3,000 deaths each year. This figure likely represents just the tip of the iceberg, because it fails to account for the broad array of food-borne illnesses or for their wide-ranging repercussions for consumers, government, and the food industry-both domestically and internationally. A One Health approach to food safety may hold the promise of harnessing and integrating the expertise and resources from across the spectrum of multiple health domains including the human and veterinary medical and plant pathology communities with those of the wildlife and aquatic health and ecology communities. The IOM's Forum on Microbial Threats hosted a public workshop on December 13 and 14, 2011 that examined issues critical to the protection of the nation's food supply. The workshop explored existing knowledge and unanswered questions on the nature and extent of food-borne threats to health. Participants discussed the globalization of the U.S. food supply and the burden of illness associated with foodborne threats to health; considered the spectrum of food-borne threats as well as illustrative case studies; reviewed existing research, policies, and practices to prevent and mitigate foodborne threats; and, identified opportunities to reduce future threats to the nation's food supply through the use of a "One Health" approach to food safety. Improving Food Safety Through a One Health Approach: Workshop Summary covers the events of the workshop and explains the recommendations for future related workshops.

Antimicrobial Resistance

World Health Organization
Antimicrobial Resistance Book PDF

Author : World Health Organization
Publisher : Unknown
Page : 232 pages
File Size : 54,8 Mb
Release : 2014
Category : Medical
ISBN : 9241564741

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Antimicrobial Resistance by World Health Organization Pdf

Summary report published as technical document with reference number: WHO/HSE/PED/AIP/2014.2.

When Antibiotics Fail

The Expert Panel on the Potential Socio-Economic Impacts of Antimicrobial Resistance in Canada
When Antibiotics Fail Book PDF

Author : The Expert Panel on the Potential Socio-Economic Impacts of Antimicrobial Resistance in Canada
Publisher : Council of Canadian Academies
Page : 268 pages
File Size : 50,7 Mb
Release : 2019-11-12
Category : Medical
ISBN : 9781926522753

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When Antibiotics Fail by The Expert Panel on the Potential Socio-Economic Impacts of Antimicrobial Resistance in Canada Pdf

When Antibiotics Fail examines the current impacts of AMR on our healthcare system, projects the future impact on Canada’s GDP, and looks at how widespread resistance will influence the day-to-day lives of Canadians. The report examines these issues through a One Health lens, recognizing the interconnected nature of AMR, from healthcare settings to the environment to the agriculture sector. It is the most comprehensive report to date on the economic impact of AMR in Canada.

Drug Discovery Targeting Drug-Resistant Bacteria

Prashant Kesharwani,Sidharth Chopra,Arunava Dasgupta
Drug Discovery Targeting Drug Resistant Bacteria Book PDF

Author : Prashant Kesharwani,Sidharth Chopra,Arunava Dasgupta
Publisher : Academic Press
Page : 434 pages
File Size : 52,7 Mb
Release : 2020-05-15
Category : Medical
ISBN : 9780128184813

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Drug Discovery Targeting Drug-Resistant Bacteria by Prashant Kesharwani,Sidharth Chopra,Arunava Dasgupta Pdf

Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful. Written by scientists with extensive industrial experience in drug discovery Provides a balanced view of the field, including its challenges and future directions Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war

Mechanisms of antibiotic resistance

Jun Lin,Kunihiko Nishino,Marilyn C. Roberts,Marcelo Tolmasky,Rustam I. Aminov,Lixin Zhang
Mechanisms of antibiotic resistance Book PDF

Author : Jun Lin,Kunihiko Nishino,Marilyn C. Roberts,Marcelo Tolmasky,Rustam I. Aminov,Lixin Zhang
Publisher : Frontiers Media SA
Page : 226 pages
File Size : 46,5 Mb
Release : 2015-06-01
Category : Antibiotics
ISBN : 9782889195268

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Mechanisms of antibiotic resistance by Jun Lin,Kunihiko Nishino,Marilyn C. Roberts,Marcelo Tolmasky,Rustam I. Aminov,Lixin Zhang Pdf

Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.

Antimicrobial Resistance in Developing Countries

Aníbal de J. Sosa,Denis K. Byarugaba,Carlos F. Amábile-Cuevas,Po-Ren Hsueh,Samuel Kariuki,Iruka N. Okeke
Antimicrobial Resistance in Developing Countries Book PDF

Author : Aníbal de J. Sosa,Denis K. Byarugaba,Carlos F. Amábile-Cuevas,Po-Ren Hsueh,Samuel Kariuki,Iruka N. Okeke
Publisher : Springer Science & Business Media
Page : 554 pages
File Size : 51,9 Mb
Release : 2009-10-08
Category : Science
ISBN : 9780387893709

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Antimicrobial Resistance in Developing Countries by Aníbal de J. Sosa,Denis K. Byarugaba,Carlos F. Amábile-Cuevas,Po-Ren Hsueh,Samuel Kariuki,Iruka N. Okeke Pdf

Avoiding infection has always been expensive. Some human populations escaped tropical infections by migrating into cold climates but then had to procure fuel, warm clothing, durable housing, and crops from a short growing season. Waterborne infections were averted by owning your own well or supporting a community reservoir. Everyone got vaccines in rich countries, while people in others got them later if at all. Antimicrobial agents seemed at first to be an exception. They did not need to be delivered through a cold chain and to everyone, as vaccines did. They had to be given only to infected patients and often then as relatively cheap injectables or pills off a shelf for only a few days to get astonishing cures. Antimicrobials not only were better than most other innovations but also reached more of the world’s people sooner. The problem appeared later. After each new antimicrobial became widely used, genes expressing resistance to it began to emerge and spread through bacterial populations. Patients infected with bacteria expressing such resistance genes then failed treatment and remained infected or died. Growing resistance to antimicrobial agents began to take away more and more of the cures that the agents had brought.

Ethics and Drug Resistance: Collective Responsibility for Global Public Health

Euzebiusz Jamrozik,Michael Selgelid
Ethics and Drug Resistance Collective Responsibility for Global Public Health Book PDF

Author : Euzebiusz Jamrozik,Michael Selgelid
Publisher : Springer
Page : 448 pages
File Size : 53,6 Mb
Release : 2021-08-21
Category : Philosophy
ISBN : 303027876X

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Ethics and Drug Resistance: Collective Responsibility for Global Public Health by Euzebiusz Jamrozik,Michael Selgelid Pdf

This Open Access volume provides in-depth analysis of the wide range of ethical issues associated with drug-resistant infectious diseases. Antimicrobial resistance (AMR) is widely recognized to be one of the greatest threats to global public health in coming decades; and it has thus become a major topic of discussion among leading bioethicists and scholars from related disciplines including economics, epidemiology, law, and political theory. Topics covered in this volume include responsible use of antimicrobials; control of multi-resistant hospital-acquired infections; privacy and data collection; antibiotic use in childhood and at the end of life; agricultural and veterinary sources of resistance; resistant HIV, tuberculosis, and malaria; mandatory treatment; and trade-offs between current and future generations. As the first book focused on ethical issues associated with drug resistance, it makes a timely contribution to debates regarding practice and policy that are of crucial importance to global public health in the 21st century.

Handbook of Research on Nano-Strategies for Combatting Antimicrobial Resistance and Cancer

Saravanan, Muthupandian,Gopinath, Venkatraman,Deekonda, Karthik
Handbook of Research on Nano Strategies for Combatting Antimicrobial Resistance and Cancer Book PDF

Author : Saravanan, Muthupandian,Gopinath, Venkatraman,Deekonda, Karthik
Publisher : IGI Global
Page : 559 pages
File Size : 50,7 Mb
Release : 2021-02-12
Category : Medical
ISBN : 9781799850502

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Handbook of Research on Nano-Strategies for Combatting Antimicrobial Resistance and Cancer by Saravanan, Muthupandian,Gopinath, Venkatraman,Deekonda, Karthik Pdf

Multidrug-resistant bacteria play a significant role in public health by destroying the potency of existing antibiotics. Meanwhile, cancer remains one of the most common health problems that impact society, resulting in many deaths worldwide. Novel strategies are required to combat antimicrobial resistance and create efficient anticancer drugs that could revolutionize treatment. Nanomedicine is one such innovation that plays a significant role in developing alternative and more effective treatment strategies for antimicrobial resistance and cancer theranostics. The Handbook of Research on Nano-Strategies for Combatting Antimicrobial Resistance and Cancer is an essential scholarly resource that examines (1) how to overcome the existing, traditional approaches to combat antimicrobial resistance and cancer; (2) how to apply multiple mechanisms to target the cancer cells and microbes; and (3) how the nanomaterials can be used as carriers. Featuring a range of topics such as bacteriophage, nanomedicine, and oncology, this book is ideal for molecular biologists, microbiologists, nanotechnologists, academicians, chemists, pharmacists, oncologists, researchers, healthcare professionals, and students.

New Strategies Combating Bacterial Infection

Iqbal Ahmad,Farrukh Aqil
New Strategies Combating Bacterial Infection Book PDF

Author : Iqbal Ahmad,Farrukh Aqil
Publisher : John Wiley & Sons
Page : 322 pages
File Size : 49,9 Mb
Release : 2008-11-21
Category : Science
ISBN : 9783527622948

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New Strategies Combating Bacterial Infection by Iqbal Ahmad,Farrukh Aqil Pdf

Combating bacterial infections calls for a multidisciplinary approach and this is what is on offer here. Written by an experienced international team of researchers from various fields ranging from biotechnology to traditional medicine, the book provides complete and comprehensive coverage of topics relevant to new antibacterial drugs. This ready reference and handbook adopts a novel approach, focusing on combating multi-drug resistance in bacteria by developing antibacterials with new target sites, using new advances in drug discovery as well as natural products. Divided into three sections, the first describes the problem of drug resistance and the need for new drugs, while the second treats recent trends and new classes of drugs, including relevant developments in transcriptomics and proteomics leading to new antimicrobial drug discovery, and a new generation of antibiotics and non-antibiotics. The third section on natural products discusses the antibacterial action of phytocompounds, plant extracts, essential oils and honey as well as the role of probiotics in bacterial infections. Invaluable to students of medicine, pharmaceutical sciences, phytomedicine and microbiology and all those wanting to know about the possibilities and limitations of new antibacterial drugs. Furthermore, its coverage of plants and other natural products makes this relevant to the pharmaceutical and herbal industries.

Handbook of Antimicrobial Coatings

Atul Tiwari
Handbook of Antimicrobial Coatings Book PDF

Author : Atul Tiwari
Publisher : Elsevier
Page : 596 pages
File Size : 43,9 Mb
Release : 2017-09-22
Category : Technology & Engineering
ISBN : 9780128119839

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Handbook of Antimicrobial Coatings by Atul Tiwari Pdf

Handbook of Antimicrobial Coatings is the first comprehensive work on the developments being made in the emerging field of antimicrobial coatings. Crucial aspects associated with coating research are presented in the form of individual chapters. Particular close attention has been given to essential aspects necessary to understand the properties of novel materials. The book introduces the reader to progress being made in the field, followed by an outline of applications in different areas. Various methods and techniques of synthesis and characterization are detailed as individual chapters. Chapters provide insight into the ongoing research, current trends and technical challenges in this rapidly progressing field. The covered topics were chosen so that they can be easily understood by new scholars as well as advanced learners. No book has been written on this topic thus far with so much crucial information for materials scientists, engineers and technologists. Offers the first comprehensive work on developments being made in the emerging field of antimicrobial coatings Features updates written by leading experts in the field of anti-microbial coatings Includes discussions of coatings for novel materials Provides various methods and techniques of synthesis and characterization detailed in individual chapters

Sustainable Agriculture Reviews 49

Harsh Panwar,Chetan Sharma,Eric Lichtfouse
Sustainable Agriculture Reviews 49 Book PDF

Author : Harsh Panwar,Chetan Sharma,Eric Lichtfouse
Publisher : Springer Nature
Page : 446 pages
File Size : 42,9 Mb
Release : 2021-01-07
Category : Medical
ISBN : 9783030582593

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Sustainable Agriculture Reviews 49 by Harsh Panwar,Chetan Sharma,Eric Lichtfouse Pdf

This book presents advanced therapies based on new and complementary drugs, and alternative techniques and strategies, such as phages, probiotics, flavonoids, essential oils, cellulose, peptides, nano delivery, iron starvation and vaccines.

Antiviral Drug Resistance

Douglas D. Richman
Antiviral Drug Resistance Book PDF

Author : Douglas D. Richman
Publisher : Wiley
Page : 324 pages
File Size : 40,6 Mb
Release : 1996-12-02
Category : Medical
ISBN : 0471961205

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Antiviral Drug Resistance by Douglas D. Richman Pdf

The study of antiviral drug resistance has provided important insights into the structure of virus enzymes, the functions of certain genes, mechanisms of action of antiviral drugs, the design of new antiviral compounds and the pathogenesis of viral diseases. The emergence of resistant strains must be explored at all stages of drug development: during the preclinical evaluation of candidate compounds; during the early clinical evaluation of new drugs; and as part of epidemiological surveillance for the prevalence of resistance during use of approved treatments. Accumulating understanding of antiviral drug resistance thus reflects progress in the chemotherapy of viral infection. Antiviral Drug Resistance provides state-of-the-art coverage of the basic and clinical aspects of this subject. It deals with the basic science, including the mechanisms of drug resistance and drug action, genetics of drug resistance, cross resistance, and X-ray crystallographic structural aspects of resistance, as well as the clinical aspects, including issues of assay of susceptibility of clinical isolates, descriptive aspects of emergence of reduced susceptibility, and clinical significance and impact of resistance. As such this unique volume will be essential to basic researchers in drug discovery and viral pathogenesis, as well as clinicians involved in antiviral chemotherapy.