Contemporary Topics In Immunobiology

Author : Max Cooper
Publisher : Springer Science & Business Media
Page : 277 pages
File Size : 48,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468430455

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Contemporary Topics in Immunobiology by Max Cooper Pdf

Contemporary immunobiology is an ever-diversifying field that embraces many aspects of cellular and humoral immune responsiveness. This includes the phylogeny, ontogeny, induction, regulation, expression, and differentiation of the immune-cell series, as well as the relationship of these to the pathogenesis of many disease processes. It is clearly beyond the limitations of each volume in this series to comprehensively cover progress in each of these fields. Three general areas of contemporary investigations are discussed in the current issue: cellular events of B cell differentiation, including antigen recognition and respon siveness of B lymphocytes; regulation of the immune response by T cells, and the roles of this regulatory system in allotype suppression and in autoimm unity; and the genetic control of immune responses and its possible relation to disease pathogenesis. Analysis of responsiveness of B lymphocytes has been greatly aided by the availability of athymic nude mice. The immunological responsiveness of these mice to a wide range of stimuli has been reviewed and analyzed by H. H. Wortis. This article concludes with the provocative thesis that in the future "nudes will supply new rather than confirmatory data . . . (especially regarding) the develop ment of neoplasia. " In contrast to the studies on the congenitally athymic mice, G. F.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 48,6 Mb
Release : 1972
Category : Electronic
ISBN : OCLC:1414958074

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Contemporary Topics in Immunobiology by Anonim Pdf

Author : Fernando Salinas
Publisher : Springer
Page : 304 pages
File Size : 51,9 Mb
Release : 1985-07-01
Category : Medical
ISBN : 0306419556

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Immune Complexes and Human Cancer by Fernando Salinas Pdf

Immune Complexes and Human Cancer, the fifteenth volume of Contem porary Topics in Immunobiology, is a compilation of information derived from recent studies on the role of circulating immune complexes (CIC) in the patho genic manifestations of a variety of human cancers. Technical improvements in the detection of CIC in body fluids have resulted in data that indicate that CIC do occur in different types of cancer. In addition, tumor-associated antigens and antibodies have been detected in immune complexes of cancer patients' sera. Until recently the exact role and clinical relevance of immune complexes have been the subject of debate, partially because of the problems encountered in measuring immune complexes. But these problems are being confronted as more accurate measurement protocols are developed. Technical refinements, along with strict protocols, have provided evidence of heterogeneity in CIC, a factor that makes accurate detection of immune complexes in cancer patients difficult. Recent insights indicate that the measurement of immune complexes in cancer patients may be clinically useful not only as a tumor marker, but also in regard to the deranged immune response of tumor-bearing hosts and other disorders such as nephrotic syndrome, immune anemias, and clotting dysfunction.

Author : Osis Stutman
Publisher : Springer Science & Business Media
Page : 397 pages
File Size : 43,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468430547

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Contemporary Topics in Immunobiology, Vol. 7:T Cells by Osis Stutman Pdf

And even I can remember A day when historians left blanks in their writings, I mean for things they didn't know. -Ezra Pound, Canto XIII * The prefaces to the previous volumes of this series have all expressed in various ways the actual motivation behind these collective efforts. There was agreement in most instances that we are facing some kind of publication explosion, and that the present type of compact and personalized reviews may be of help, from both a conceptual and a purely informational standpoint. The aims of the series were, and still are, to focus attention on the rapidly changing fields within the realm of immunology, and to present in each chapter the summation of results generated by an investigator or group of Investigators, either as an analysis of their own work or as a correlation of such work with the general field in question. The present volume does not differ in its construction from its predecessors, although it does concentrate on a single target, the T lymphocyte and its biology. The selection of subjects as well as contributors has been the sole responsi bility of this editor; however, the actual format and length of the individual contributions was left to the discretion and inspiration of the different authors. Even the styles, ranging from the concise statement to the meticulously detailed review, attest to the freedom of format.

Author : John J. Marchalonis
Publisher : Springer Science & Business Media
Page : 305 pages
File Size : 54,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461591313

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Contemporary Topics in Immunobiology by John J. Marchalonis Pdf

The problem that virtually all cells have in discriminating between "self" and "non-self" molecules and cells has been considered at great length in immuno biology. However, cells that clearly are incapable of carrying out mammalian type immune functions can exhibit exquisite specificity in their capacity to discriminate among syngeneic, allogeneic, and xenogeneic cells. In this volume of Contemporary Topics in Immunobiology we have chosen to consider the general problem of self/non-self discrimination as it is manifest in recognition reactions of plants and invertebrates and in the evolutionary development of the immune response of vertebrates. A broad, many-faceted approach is taken toward fundamental issues in immunobiology in order to develop innovative concepts of receptor function as well as to delineate traditional views. The capacity of plants to discriminate between self and non-self is addressed in Chapter 1 by R. B. Knox and Adrienne E. Clarke. These authors provide examples of cell-cell recognition in plants that parallel those occurring in in vertebrates and vertebrates. In general, tolerance (acceptance) of grafts is re stricted to plants within closely related genera. Recognition is mediated by callus cells, which proliferate at wound surfaces in higher plants, and there is a correlation between cell and tissue type and antigenic markers detectable with the use of mammalian antibodies. Certain flowering plants exhibit precise discrimination in fertilization, when pollen must be from the same species, but fertilization occurs only if the pollen is genetically non-self.

Author : William O. Weigle
Publisher : Unknown
Page : 0 pages
File Size : 51,8 Mb
Release : 1976
Category : Immunology
ISBN : LCCN:79179761

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Contemporary Topics in Immunobiology by William O. Weigle Pdf

Author : Noel Warner
Publisher : Springer Science & Business Media
Page : 281 pages
File Size : 52,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468409222

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Contemporary Topics in Immunobiology by Noel Warner Pdf

In this current volume of Contemporary Topics in Immunobiology we have chosen to continue with the multiple-theme approach that was developed in Volumes 1, 3, and 5 of this series. Immunobiology still shows little sign of decreasing its active growth rate, but rather is continuing to broaden its range of interests and applications, particularly as new techniques and methods are adapted from other fields of medical research. This present volume reflects both several of the more classical areas of immunology now addressed in the light of contemporary immunology, and several newer directions that have been taken in other fields. The general subject of T-cell heterogeneity and functions of T-cell subpop ulations is addressed in Chapters 1 and 2. The potential role of genes of the major histocompatibility complex in controlling the immune functions of T lymphocytes still remains a major unresolved issue in immunogenetics, and the current status of this problem is excellently reviewed by J. F. A. P. Miller. The further elucidation of functional subpopulations of human T lymphocytes has been particularly hampered by the lack of available markers for character izing and isolating such sUbpopulations. A major step in this direction has been made by L. Moretta, M. Ferrarini, and M. D. Cooper, who review their ex perience with Fc-receptor-bearing human T-Iymphocyte populations.

Author : A. Davies
Publisher : Springer Science & Business Media
Page : 371 pages
File Size : 54,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468409192

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Contemporary Topics in Immunobiology by A. Davies Pdf

This second volume of Contemporary Topics in Immunobiology considers many aspects of thymus dependency in order to exemplify the role of the thy mus in different species and different immunological responses. It is not in tended to be a compendium of the responses which have been shown to be thymus dependent but rather to illustrate for the reader the criteria he should apply in thinking about the significance of the thymus in immune responses. We are grateful to the editors and publishers of the Annals of the New York Academy of Science, the Australian Journal of Experimental Biology and Medical Science, Clinical and Experimental Immunology, Immunology, the Journal of Experimental Medicine, the Journal of Immunology, Laboratory Investigation, Nature, and the Proceedings of the Royal Society of Medicine and to Springer-Verlag, Berlin, for permission to reproduce illustrations. Specific references are given in the text. We would also like to thank the contributors for their time and energy and willingness to submit to the editorial red pencils. The exercise of these censori ous instruments meant that the manuscripts had to be reorganized and retyped. Mrs. J. Pettis, Mrs. A. Inglefield, and Miss M. Butt all helped, and we are most grateful to them. A.J.S.D. R.L.e.

Author : Osias Stutman
Publisher : Unknown
Page : 128 pages
File Size : 43,6 Mb
Release : 1977
Category : T cells
ISBN : OCLC:630199302

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Contemporary topics in immunobiology. 7. T cells by Osias Stutman Pdf

Author : R. Porter
Publisher : Springer Science & Business Media
Page : 265 pages
File Size : 44,7 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9781468428414

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Contemporary Topics in Molecular Immunology by R. Porter Pdf

The distinction between molecular immunology and immunobiology is neces sarily arbitrary. The most rapid progress is usually made in the blurred area between the two, when the chemist is aware of the full significance of the biological problems, and the biologist is alert to the contribution that a knowl edge of molecular structure can be made to their solution. The range of scientific disciplines able to contribute to research in immunology, which this approach brings, is reflected in the present volume. Protein chemists worked out the arrangement of the polypeptide chains and the amino acid sequences of antibodies and X-ray crystallographers the three dimensional structure, but more precise definition of the amino acid side chain positions in the combining site is required for an understanding of the subtleties of antibody specificity. That this can be achieved with physical techniques such as nuclear magnetic resonance has been shown by R. A. Dwek, and in his chapter he summarizes these results with a minimum of technical detail. The immune response has been shown to be dependent on complex cellular interactions and further progress will be facilitated by investigation of the molecular basis of these interactions. This necessitates study of the structure and organization of the molecules in the surfaces of lymphocytes and other cells.

Author : Edwin Cooper
Publisher : Springer Science & Business Media
Page : 307 pages
File Size : 55,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468430486

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Contemporary Topics in Immunobiology by Edwin Cooper Pdf

This fourth volume of Contemporary Topics In Immunobiology treats in vertebrate immunity. Specifically, the results represent several approaches to humoral and cellular immunity. It is evident that invertebrates do have function ing immune systems. For example, cellular immunity is characterized by both specificity and memory, but it is still problematical whether vertebrate immune capacity evolved directly from invertebrates. Most of the manuscripts were formally presented at the International Symposium on Invertebrate Pathology, University of Minnesota, August 1972, held in connection with the 25th anniversary celebration of the American Insti tute of Biological Sciences. I wish to express my appreciation to the contributors and to beg their indulgence in what may have been overzealous editing. This was done, though, in the interest of clarity and to seek uniformity. Because of earlier problems, time limitations did not permit consultations between submission of manuscripts and final editing. For assistance, I extend a special note of gratitude to Mrs. Lois Gehringer who unselfishly retyped many of the manuscripts. The preparation of this volume was aided partially by NSF Grant GB17767, two grants from The California Institute for Cancer Research, and a grant from The Brown-Hazen Corporation. E.L.C. Contents Introduction: General Comments and a Note on Taxonomy ....................... .

Author : M. Hanna
Publisher : Springer Science & Business Media
Page : 199 pages
File Size : 55,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468430424

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Contemporary Topics in Immunobiology by M. Hanna Pdf

Investigators, teachers, and practitioners in the biomedical sciences are keenly aware of the current crisis in scientific communications. With well over a thousand biomedical journals producing new issues each month, and with approximately five hundred new technical books in biomedicine being 1 published each year, not to mention the proliferation of information-ex change meetings, it is all too clear that we are in danger of being inundated by a flood of tables, figures, and hypotheses. The problem is particularly acute in immunology, as the rate of information production is increasing geometrically, and immunological approaches have been extended into other biological and medical fields to further diversify the research over a vast literature. Abstracting and information-retrieval services do much to improve the investigator's lot, but do not offer solutions for one particularly distressing aspect of the crisis. In the midst of our informational overabundance, one often finds that interrelationships between an investigator's collective findings are becoming blurred, or that the relation of his total work to the field are not clear. Although review articles are indispensable in fixing the status of a given problem, they do not provide the detailed attention to a single author's work that is needed.

Author : Noel Lawrence Warner,Max D. Cooper
Publisher : Unknown
Page : 272 pages
File Size : 42,9 Mb
Release : 1978
Category : Immunology
ISBN : OCLC:849994866

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Contemporary Topics in Immunobiology, V.8 by Noel Lawrence Warner,Max D. Cooper Pdf

Author : R. Porter
Publisher : Unknown
Page : 272 pages
File Size : 42,7 Mb
Release : 2014-01-15
Category : Electronic
ISBN : 146842842X

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Contemporary Topics in Molecular Immunology by R. Porter Pdf

Author : F. P. Inman,W. J. Mandy
Publisher : Springer Science & Business Media
Page : 258 pages
File Size : 49,5 Mb
Release : 2013-11-22
Category : Medical
ISBN : 9781461589303

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Contemporary Topics in Molecular Immunology by F. P. Inman,W. J. Mandy Pdf

There are many unanswered questions regarding the molecular nature of antibodies, components of complement, and other substances which participate in the immune response. The list of substances which need to be analyzed chemically is increasing. Plasma cell products, of course, have long been of great interest because the most prevalent ones are immunoglobulins. Other cell types, however, are the source of the broad spectrum of additional substances which classically fall into the sanctum of the molecular immunologist. It is these substances, and especially those more recently discovered, which are responsible for the broadening investigative interests of immunologists. In this volume we have provided you with descriptions of research being done with immunoglobulins and with complement. Additionally, we have in cluded two reports that deal with molecules which are among the more recent acquisitions of the molecular immunologist. The components of complement are known to react in a cascading manner which results in the lysis of cellular antigens. The first step in the classical pathway requires the activation of CI by the antibody-antigen aggregates. This volume of Contemporary Topics in Molecular Immunology begins with the report of Reid and Porter which describes their investigation of the mechanism of activation of C I. Their descriptions of C I q and of the reaction of C I with immunoglobulins are especially intriguing. It is clearly apparent from their report that activation of the components of complement is a complex phenome non.