Cooperativity And Regulation In Biochemical Processes

Author : Arieh Y. Ben-Naim
Publisher : Springer Science & Business Media
Page : 358 pages
File Size : 41,7 Mb
Release : 2013-03-09
Category : Science
ISBN : 9781475733020

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Cooperativity and Regulation in Biochemical Processes by Arieh Y. Ben-Naim Pdf

This is the first book that attempts to study the origin of cooperatvity in binding systems from the molecular point of view. The molecular approach provides a deeper insight into the mechanism of cooperativity and regulation, than the traditional phenomenological approach. This book uses the tools of statistical mechanics to present the molecular theory of cooperativity. Cooperativity is used in a variety of processes-such as loading and unloading of oxygen at relatively small pressure differences; maintaining an almost constant concentration of various compounds in living cells; and switching on and off the reading of genetic information. This book may be used as a textbook by graduate students in Chemistry, Biochemistry and Biophysics, and will also be of interest to researchers in theoretical biochemistry.

Author : Arieh Ben-Naim
Publisher : Unknown
Page : 368 pages
File Size : 53,7 Mb
Release : 2014-01-15
Category : Electronic
ISBN : 1475733038

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Cooperativity and Regulation in Biochemical Processes by Arieh Ben-Naim Pdf

Author : Max F. Perutz
Publisher : CUP Archive
Page : 124 pages
File Size : 49,8 Mb
Release : 1990-05-17
Category : Medical
ISBN : 0521386489

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Mechanisms of Cooperativity and Allosteric Regulation in Proteins by Max F. Perutz Pdf

Author : Thomas W. Traut
Publisher : Springer Science & Business Media
Page : 255 pages
File Size : 45,8 Mb
Release : 2007-09-11
Category : Science
ISBN : 9780387728919

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Allosteric Regulatory Enzymes by Thomas W. Traut Pdf

This book covers the most recent developments in the analysis of allosteric enzymes and provides a logical introduction to the limits for enzyme function as dictated by the factors that are limits for life. The book presents a complete description of all the mechanisms used for changing enzyme activity. It is extensively illustrated to clarify kinetic and regulatory properties. Eight enzymes are used as model systems after extensive study of their mechanisms. Wherever possible, the human form of the enzyme is used to illustrate the regulatory features.

Author : Jo M. Holt,Michael L. Johnson,Gary K. Ackers
Publisher : Elsevier
Page : 315 pages
File Size : 40,8 Mb
Release : 2004-04-02
Category : Science
ISBN : 9780080497174

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Energetics of Biological Macromolecules, Part D by Jo M. Holt,Michael L. Johnson,Gary K. Ackers Pdf

This volume focuses on the cooperative binding aspects of energetics in biological macromolecules. Methodologies such as NMR, small-angle scattering techniques for analysis, calorimetric analysis, fluorescence quenching, and time resolved FRET measurements are discussed. *Methods for Evaluating Cooperativity in a Dimeric Hemoglobin*Multiple-Binding of Ligands to a Linear Biopolymer*Fluorescence Quenching Methods to Study Protein-Nucleic Acid Interactions*Linked Equilibria in Biotin Repressor Function: Thermodynamic, Structural and Kinetic Analysis

Author : Gerhard Swiegers
Publisher : John Wiley & Sons
Page : 532 pages
File Size : 50,6 Mb
Release : 2012-10-30
Category : Science
ISBN : 9780470566671

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Bioinspiration and Biomimicry in Chemistry by Gerhard Swiegers Pdf

Can we emulate nature's technology in chemistry? Through billions of years of evolution, Nature has generated some remarkable systems and substances that have made life on earth what it is today. Increasingly, scientists are seeking to mimic Nature's systems and processes in the lab in order to harness the power of Nature for the benefit of society. Bioinspiration and Biomimicry in Chemistry explores the chemistry of Nature and how we can replicate what Nature does in abiological settings. Specifically, the book focuses on wholly artificial, man-made systems that employ or are inspired by principles of Nature, but which do not use materials of biological origin. Beginning with a general overview of the concept of bioinspiration and biomimicry in chemistry, the book tackles such topics as: Bioinspired molecular machines Bioinspired catalysis Biomimetic amphiphiles and vesicles Biomimetic principles in macromolecular science Biomimetic cavities and bioinspired receptors Biomimicry in organic synthesis Written by a team of leading international experts, the contributed chapters collectively lay the groundwork for a new generation of environmentally friendly and sustainable materials, pharmaceuticals, and technologies. Readers will discover the latest advances in our ability to replicate natural systems and materials as well as the many impediments that remain, proving how much we still need to learn about how Nature works. Bioinspiration and Biomimicry in Chemistry is recommended for students and researchers in all realms of chemistry. Addressing how scientists are working to reverse engineer Nature in all areas of chemical research, the book is designed to stimulate new discussion and research in this exciting and promising field.

Author : Daniel Goldfarb
Publisher : McGraw Hill Professional
Page : 400 pages
File Size : 55,8 Mb
Release : 2010-12-06
Category : Science
ISBN : 9780071633659

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Biophysics DeMYSTiFied by Daniel Goldfarb Pdf

Learn BIOPHYSICS without expending a lot of ENERGY! Interested in unraveling the physics of living things? Here's your starting point. Biophysics Demystified is the fast and easy way to understand this fascinating topic. Written in a step-by-step format, this practical guide begins with an introduction to the science of biophysics, covering biophysical techniques and applications. Next, you'll learn the principles of physics, biology, and chemistry required to understand biophysics, including free energy, entropy, and statistical mechanics. Biomolecules and the forces that influence their structure and conformation are also covered, as are protein, nucleic acid, and membrane biophysics. Detailed examples and concise explanations make it easy to understand the material, and end-of-chapter quizzes and a final exam help reinforce key concepts. It's a no-brainer! You'll get: Molecular, subcellular, physiological, anatomical, and environmental biophysics The laws of thermodynamics as they apply to biophysical systems Forces affecting conformation in biological molecules The composition and structure of carbohydrates, lipids, proteins, and nucleic acids The fluid mosaic model Simple enough for a beginner, but challenging enough for an advanced student, Biophysics Demystified makes this interdisciplinary subject easy to master.

Author : Niels Bindslev
Publisher : Co-Action Publishing
Page : 430 pages
File Size : 49,5 Mb
Release : 2008
Category : Chemical models
ISBN : 9789197707107

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Drug-Acceptor Interactions by Niels Bindslev Pdf

Drug-Acceptor Interactions: Modeling theoretical tools to test and evaluate experimental equilibrium effects suggests novel theoretical tools to test and evaluate drug interactions seen with combinatorial drug therapy. The book provides an in-depth, yet controversial, exploration of existing tools for analysis of dose-response studies at equilibrium or steady state. The book is recommended reading for post-graduate students and researchers engaged in the study of systems biology, networks, and the pharmacodynamics of natural or industrial drugs, as well as for medical clinicians interested in drug application and combinatorial drug therapy. Even people without mathematical skills will be able to follow the pros and cons of reaction schemes and their related distribution equations. Chapter 9 is a hands-on guide for software to plot, fit and analyze one's own data.

Author : Robert A. Meyers
Publisher : John Wiley & Sons
Page : 484 pages
File Size : 51,6 Mb
Release : 2020-02-03
Category : Science
ISBN : 9783527684311

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Translational Nanomedicine by Robert A. Meyers Pdf

The largest high-level encyclopedia on molecular medicine is now publishing a topical volume on Nanomedicine. The long awaited volume gives a comprehensive overview on nanomaterials in drug delivery, imaging and as therapeutics.

Author : Ulf Schmitz
Publisher : Logos Verlag Berlin GmbH
Page : 192 pages
File Size : 47,7 Mb
Release : 2015-06-29
Category : MicroRNA.
ISBN : 9783832540050

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An investigation of microRNA target regulation mechanisms using an integrative approach by Ulf Schmitz Pdf

This work is a showcase for the integration of systems biology and bioinformatics tools, algorithms and models for deciphering biological phenomena. More specifically, it integrates (i) prediction algorithms for identifying and characterizing molecular interactions, (ii) structural modelling of molecule complexes, (iii) network analysis approaches, and (iv) mathematical modelling and simulation. Two comprehensive workflows are implemented for the analysis of collective target gene regulation by microRNAs and for the prediction of cooperating microRNA pairs and their mutual target genes. In two case studies mechanisms of fine-tuned target gene regulation are revealed for different cellular processes and the phenomenon of cooperative target regulation is identified as frequent mechanism of gene regulation in humans.

Author : Michael Kraus,Bernhard Wolf
Publisher : CRC Press
Page : 250 pages
File Size : 55,7 Mb
Release : 1995-07-31
Category : Science
ISBN : 0849347726

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Structured Biological Modelling by Michael Kraus,Bernhard Wolf Pdf

Structured Biological Modelling presents a straightforward introduction for computer-aided analysis, mathematical modelling, and simulation of cell biological systems. This unique guide brings together the physiological, structural, molecular biological, and theoretical aspects of the signal transduction network that regulates growth and proliferation in normal and tumor cells. It provides comprehensive survey of functional and theoretical features of intracellular signal processing and introduces the concept of cellular self-organization. Exemplified by oscillatory calcium waves, strategies for the design of computer experiments are presented that can assist or even substitute for time-consuming biological experiments. The presented minimal model for proliferation-associated signal transduction clearly shows the alterations of the cellular signal network involved in neoplastic growth. This book will be useful to cell and molecular biologists, oncologists, physiologists, theoretical biologists, computer scientists, and all other researchers and students studying functional aspects of cellular signaling.

Author : N. Le Novère
Publisher : Springer Science & Business Media
Page : 569 pages
File Size : 40,6 Mb
Release : 2012-07-20
Category : Medical
ISBN : 9789400738584

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Computational Systems Neurobiology by N. Le Novère Pdf

Computational neurosciences and systems biology are among the main domains of life science research where mathematical modeling made a difference. This book introduces the many different types of computational studies one can develop to study neuronal systems. It is aimed at undergraduate students starting their research in computational neurobiology or more senior researchers who would like, or need, to move towards computational approaches. Based on their specific project, the readers would then move to one of the more specialized excellent textbooks available in the field. The first part of the book deals with molecular systems biology. Functional genomics is introduced through examples of transcriptomics and proteomics studies of neurobiological interest. Quantitative modelling of biochemical systems is presented in homogeneous compartments and using spatial descriptions. A second part deals with the various approaches to model single neuron physiology, and naturally moves to neuronal networks. A division is focused on the development of neurons and neuronal systems and the book closes on a series of methodological chapters. From the molecules to the organ, thinking at the level of systems is transforming biology and its impact on society. This book will help the reader to hop on the train directly in the tank engine.

Author : Bernard L. Horecker,Earl R. Stadtman
Publisher : Elsevier
Page : 315 pages
File Size : 48,8 Mb
Release : 2014-06-28
Category : Science
ISBN : 9781483217093

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Current Topics in Cellular Regulation by Bernard L. Horecker,Earl R. Stadtman Pdf

Current Topics in Cellular Regulation, Volume 10 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation. Organized into six chapters, this volume begins with an overview of the enzymes that exhibit half-of-the-sites activity. This text then examines the two different aspects of cyclic AMP-mediated systems. Other chapters consider the possible role of citrate synthase in the regulation of the citric acid cycle. This book discusses as well the regulation of the pentose phosphate pathway. The final chapter reviews the evidence for the occurrence of futile cycles at three control points in the metabolism of glucose, namely, at the level of glucose phosphorylation, at the interconversion of fructose mono- and biophosphates, and between pyruvate and phosphenol pyruvate. This book is a valuable resource for biochemists, biologists, and research workers.

Author : Robert A. Meyers
Publisher : John Wiley & Sons
Page : 766 pages
File Size : 55,6 Mb
Release : 2015-06-08
Category : Science
ISBN : 9783527334827

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Synthetic Biology, 2 Volumes by Robert A. Meyers Pdf

These two volumes contain a selection of updated articles from the acclaimed Meyers Encyclopedia of Molecular Cell Biology and Molecular Medicine, the most authoritative resource in cell and molecular biology, combined with new articles by "founding fathers" in the field. The work is divided into six sections: + Biological Basis + Modeling + Modular Parts and Circuits + Synthetic Genomes + Diseases and Therapeutics + Chemicals Production. Ideally suited as advanced reading for students and postdocs, and with all current research trends covered by an impressive number of leading figures in the field, this is the first choice reference for research institutions.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 48,6 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf