Cooperativity Theory In Biochemistry

Author : T.L. Hill
Publisher : Springer Science & Business Media
Page : 468 pages
File Size : 44,7 Mb
Release : 2013-03-07
Category : Science
ISBN : 9781461250821

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Cooperativity Theory in Biochemistry by T.L. Hill Pdf

During the past few decades we have witnessed an era of remarkable growth in the field of molecular biology. In 1950 very little was known of the chemical constitution of biological systems, the manner in which information was trans mitted from one organism to another, or the extent to which the chemical basis of life is unified. The picture today is dramatically different. We have an almost bewildering variety of information detailing many different aspects of life at the molecular level. These great advances have brought with them some breath-taking insights into the molecular mechanisms used by nature for rep licating, distributing and modifying biological information. We have learned a great deal about the chemical and physical nature of the macromolecular nucleic acids and proteins, and the manner in which carbohydrates, lipids and smaller molecules work together to provide the molecular setting of living sys tems. It might be said that these few decades have replaced a near vacuum of information with a very large surplus. It is in the context of this flood of information that this series of monographs on molecular biology has been organized. The idea is to bring together in one place, between the covers of one book, a concise assessment of the state of the subject in a well-defined field. This will enable the reader to get a sense of historical perspective-what is known about the field today-and a description of the frontiers of research where our knowledge is increasing steadily.

Author : Terrell L. Hill
Publisher : Unknown
Page : 459 pages
File Size : 55,8 Mb
Release : 1985-01-01
Category : Cooperative binding (Biochemistry)
ISBN : 3540961038

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Cooperativity Theory in Biochemistry by Terrell L. Hill Pdf

Author : Arieh Y. Ben-Naim
Publisher : Springer Science & Business Media
Page : 358 pages
File Size : 54,7 Mb
Release : 2013-03-09
Category : Science
ISBN : 9781475733020

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Cooperativity and Regulation in Biochemical Processes by Arieh Y. Ben-Naim Pdf

This is the first book that attempts to study the origin of cooperatvity in binding systems from the molecular point of view. The molecular approach provides a deeper insight into the mechanism of cooperativity and regulation, than the traditional phenomenological approach. This book uses the tools of statistical mechanics to present the molecular theory of cooperativity. Cooperativity is used in a variety of processes-such as loading and unloading of oxygen at relatively small pressure differences; maintaining an almost constant concentration of various compounds in living cells; and switching on and off the reading of genetic information. This book may be used as a textbook by graduate students in Chemistry, Biochemistry and Biophysics, and will also be of interest to researchers in theoretical biochemistry.

Author : M. Weissbluth
Publisher : Springer Science & Business Media
Page : 187 pages
File Size : 45,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642808012

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Hemoglobin by M. Weissbluth Pdf

Approximately one third of the mass of a mammalian red blood cell is hemo globin. Its major function is to bind oxygen at the partial pressure prevailing in the lungs and to release it to the tissues where the partial pressure is lower. The process whereby hemoglobin performs this essential physiological role is characterized by a cooperative interaction among its constituent subunits. A great deal of research effort has been devoted to this interaction, going back at least as far as the fitst decade of this century. Moreover, cooperativity in hemo globin is probably not unique; it may well be one instance of a general class of interactions that occur in biological molecules. Certain enzymes with a variety of regulatory and catalytic functions, for example, contain several sites which interact in a highly specific manner such that the affinity of a given site for the substrate is markedly influenced by the state of binding at the other sites. But whereas we know very little of the structure of most enzymes of this type, hemo globin is one of a very small number of biological molecules whose immensely intricate machinery has been revealed to us. We owe this insight to the group under the leadership of M. F. PERUTZ in Cambridge, England, whose research over a period of several decades culminated in a detailed description of the three dimensional structure.

Author : Arieh Ben-Naim
Publisher : Unknown
Page : 368 pages
File Size : 41,8 Mb
Release : 2014-01-15
Category : Electronic
ISBN : 1475733038

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Cooperativity and Regulation in Biochemical Processes by Arieh Ben-Naim Pdf

Author : Jo M. Holt,Michael L. Johnson,Gary K. Ackers
Publisher : Elsevier
Page : 315 pages
File Size : 44,5 Mb
Release : 2004-04-02
Category : Science
ISBN : 9780080497174

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Energetics of Biological Macromolecules, Part D by Jo M. Holt,Michael L. Johnson,Gary K. Ackers Pdf

This volume focuses on the cooperative binding aspects of energetics in biological macromolecules. Methodologies such as NMR, small-angle scattering techniques for analysis, calorimetric analysis, fluorescence quenching, and time resolved FRET measurements are discussed. *Methods for Evaluating Cooperativity in a Dimeric Hemoglobin*Multiple-Binding of Ligands to a Linear Biopolymer*Fluorescence Quenching Methods to Study Protein-Nucleic Acid Interactions*Linked Equilibria in Biotin Repressor Function: Thermodynamic, Structural and Kinetic Analysis

Author : Anonim
Publisher : Academic Press
Page : 292 pages
File Size : 44,5 Mb
Release : 2016-10-25
Category : Science
ISBN : 9780128050811

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Advances in Physical Organic Chemistry by Anonim Pdf

Advances in Physical Organic Chemistry series is the definitive resource for authoritative reviews of work in physical organic chemistry. It aims to provide a valuable source of information not only for physical organic chemists applying their expertise to both novel and traditional problems, but also for non-specialists across diverse areas who identify a physical organic component in their approach to research. Its hallmark is a quantitative, molecular level understanding of phenomena across a diverse range of disciplines. Reviews the application of quantitative and mathematical methods to help readers understand chemical problems Provides the chemical community with authoritative and critical assessments of the many aspects of physical organic chemistry Covers organic, organometallic, bioorganic, enzymes, and materials topics Presents the only regularly published resource for reviews in physical organic chemistry Written by authoritative experts who cover a wide range of topics that require a quantitative, molecular-level understanding of phenomena across a diverse range of disciplines

Author : J. Lyklema
Publisher : Elsevier
Page : 787 pages
File Size : 46,5 Mb
Release : 1995-10-17
Category : Technology & Engineering
ISBN : 9780080507125

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Fundamentals of Interface and Colloid Science by J. Lyklema Pdf

Interface and colloid science is an important, though often under-valued, branch of science. It has applications and ramifications in domains as disparate as agriculture, mineral dressing, oil recovery, chemical industry, biotechnology, medical science, and many more. Proper application of interface and colloid science requires factual knowledge and insight into the many basic laws of physics and chemistry upon which it is based. Fundamentals of Interface and Colloid Science is the first book to cover this field in the depth neccessary to be a valuable reference and an excellent textbook.From the beginning to the end of the book, systems of growing complexity are treated gradually. The presentation is particularly suited to emphasize that interfaces are not autonomous phases. As a rule, interfacial properties can be varied only by changing the adjoining phases, so that the properties of these bulk phases must be understood first. The text also recognizes common principles behind a variety of phenomena, and helps the reader to understand them and to develop and improve processes. The systematic treatment of the material in the book makes this clear, and makes the text itself an important contribution to the field. Systematic treatment of information An excellent addition to volume I Two chapters contributed by other experts in the field Uses a deductive approach to increase the order of complexity Written by a leading expert in the field Two chapters contributed by other outstanding scientists Uses a systematic and deductive approach First comprehensive review of the topic

Author : James M. Bower,Hamid Bolouri
Publisher : MIT Press
Page : 386 pages
File Size : 42,9 Mb
Release : 2001
Category : Computers
ISBN : 0262524236

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Computational Modeling of Genetic and Biochemical Networks by James M. Bower,Hamid Bolouri Pdf

How new modeling techniques can be used to explore functionally relevant molecular and cellular relationships.

Author : Terrell L. Hill
Publisher : Springer Science & Business Media
Page : 317 pages
File Size : 49,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461247364

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Linear Aggregation Theory in Cell Biology by Terrell L. Hill Pdf

During the past few decades we have witnessed an era of remarkable growth in the field of molecular biology. In 1950 very little was known ofthe chemical constitution of biological systems, the manner in which information was transmitted from one organism to another, or the extent to which the chemical basis oflife is unified. The picture today is dramatically different. We have an almost bewildering variety of information detailing many different aspects of life at the molecular level. These great advances have brought with them some breathtaking insights into the molecular mechanisms used by nature for replicating, distributing, and modifying biological information. We have learned a great deal about the chemical and physical nature of the macromo lecular nucleic acids and proteins, and the manner in which carbohydrates, lipids, and smaller molecules work together to provide the molecular setting ofliving systems. It might be said that these few decades have replaced a near vacuum of information with a very large surplus. It is in the context ofthis flood of information that this series of monographs on molecular biology has been organized. The idea is to bring together in one place, between the covers of one book, a concise assessment of the state of the subject in a well-defined field. This will enable the reader to get a sense of historical perspective-what is known about the field today-and a descrip tion of the frontiers of research where our knowledge is increasing steadily.

Author : Jeffries Wyman,Stanley J. Gill
Publisher : University Science Books
Page : 358 pages
File Size : 53,6 Mb
Release : 1990
Category : Science
ISBN : 0935702563

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Binding and Linkage by Jeffries Wyman,Stanley J. Gill Pdf

Ligand-macromolecule interactions are of fundamental importance in the control of biological processes. This book applies the principles of linkage thermodynamics to polyfunctional macromolecular systems under equilibrium conditions, and describes the binding, linkage, and feedback phenomena that lead to control of complex metabolic processes. The first chapter sets out the different processes (conformational changes, changes in state of aggregation, phase changes) involving biological macromolecules which are affected by chemical variables (such as ligands) or physical variables (such as temperature and pressure). The general effects of ligands on micromolecular conformations and interactions are illustrated with specific examples from the respiratory proteins, electron-transport proteins, and nucleic acid binding proteins. Subsequent chapters develop these themes, and describe in detail how the mathematics of regulation and control can be applied to macromolecules in biological system.

Author : Ron Elber
Publisher : World Scientific
Page : 422 pages
File Size : 55,7 Mb
Release : 1996
Category : Science
ISBN : 9810221967

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Recent Developments in Theoretical Studies of Proteins by Ron Elber Pdf

Experts provide a unique and broad perspective of the theoretical tools available today to analyze protein structure and function. Topics at the frontier of computational biophysics, such as dynamics and thermodynamics of proteins, reaction path studies, optimization techniques, analytical theories of protein folding, sequence alignment algorithms and electrostatics of proteins are discussed in a pedagogical and complete way. Those entering the field will find the book to be a useful introduction. It will also serve as a complementary text to existing ones that focus on just one of the above subjects.

Author : Anonim
Publisher : Academic Press
Page : 485 pages
File Size : 51,8 Mb
Release : 1998-06-24
Category : Science
ISBN : 9780080582245

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Linkage Thermodynamics of Macromolecular Interactions by Anonim Pdf

This volume commemorates the 50th anniversary of the appearance in Volume 4 in 1948 of Dr. Jeffries Wyman's famous paper in which he "laid down" the foundations of linkage thermodynamics. Experts in this area contribute articles on the state-of-the-art of this important field and on new developments of the original theory. Among the topics covered in this volume are electrostatic contributions to molecular free energies in solution; site-specific analysis of mutational effects in proteins; allosteric transitions of the acetylcholine receptor; and deciphering the molecular code of hemoglobin allostery.

Author : Kenny B. Lipkowitz,Donald B. Boyd
Publisher : John Wiley & Sons
Page : 464 pages
File Size : 50,8 Mb
Release : 2009-09-22
Category : Science
ISBN : 9780470126172

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Reviews in Computational Chemistry by Kenny B. Lipkowitz,Donald B. Boyd Pdf

THIS BOOK HAS SIX TUTORIALS AND REVIEWS WRITTEN BY INVITED EXPERTS. FIVE CHAPTERS TEACH TOPICS IN QUANTUM MECHANICS AND MOLECULAR SIMULATIONS. THE SIXTH CHAPTER EXPLAINS HOW PROGRAMS FOR CHEMICAL STRUCTURE DRAWING WORK. AN EDITORIAL DISCUSSES SOME OF THE MOST WELL-KNOWN PERSONAGES IN COMPUTATIONAL CHEMISTRY. FROM REVIEWS OF THE SERIES "Anyone who is doing or intends to do computational research on molecular structure and design should seriously consider purchasing this book for his or her personal library."-JOURNAL OF COMPUTATIONAL CHEMISTRY. "These reviews are becoming regarded as the standard reference among both specialists and novices in the expanding field of computational chemistry." -JOURNAL OF MOLECULAR GRAPHICS AND MODELLING. "[This book is] written for newcomers learning about molecular modeling techniques as well as for seasoned professionals who need to acquire expertise in areas outside their own."-JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCE.

Author : Sangdun Choi
Publisher : Springer Science & Business Media
Page : 549 pages
File Size : 55,6 Mb
Release : 2008-05-17
Category : Science
ISBN : 9781597455312

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Introduction to Systems Biology by Sangdun Choi Pdf

This book provides an introductory text for undergraduate and graduate students who are interested in comprehensive biological systems. The authors offer a broad overview of the field using key examples and typical approaches to experimental design. The volume begins with an introduction to systems biology and then details experimental omics tools. Other sections introduce the reader to challenging computational approaches. The final sections provide ideas for theoretical and modeling optimization in systemic biological researches. The book is an indispensable resource, providing a first glimpse into the state-of-the-art in systems biology.